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Effect of particle composition and consolidation degree on the wave-induced liquefaction of soil beds

Acta Oceanologica Sinica 2024年第2期43卷 11-22页

作者： Zhiyuan Chen yupeng ren Guohui Xu Meng Li Shandong Provincial Key Laboratory of Marine Environment and Geological Engineering Ocean University of ChinaQingdao 266100China Marine Ecological Restoration and Smart Ocean Engineering Research Center of Hebei Province Qinhuangdao 066000China Key Laboratory of Marine Environment and Ecology(Ocean University of China) Ministry of EducationQingdao 266100China Key Laboratory of Submarine Geoscience and Prospecting Techniques(Ocean University of China) Ministry of EducationQingdao 266100China

The wave-induced liquefaction of seabed is responsible for causing damage to marine structures.Particle composition and consolidation degree are the key factors affecting the pore water pressure response and liquefaction behavior of the seabed under wave action.The present study conducted wave flume experiments on silt and silty fine sand beds with varying particle compositions.Furthermore,a comprehensive analysis of the differences and underlying reasons for liquefaction behavior in two different types of soil was conducted from both macroscopic and microscopic perspectives.The experimental results indicate that the silt bed necessitates a lower wave load intensity to attain the liquefaction state in comparison to the silty fine sand bed.Additionally,the duration and development depth of liquefaction are greater in the silt bed.The dissimilarity in liquefaction behavior between the two types of soil can be attributed to the variation in their permeability and plastic deformation capacity.The permeability coefficient and compression modulus of silt are lower than those of silty fine sand.Consequently,silt is more prone to the accumulation of pore pressure and subsequent liquefaction under external loading.Prior research has demonstrated that silt beds with varying consolidation degrees exhibit distinct initial failure modes.Specifically,a dense bed undergoes shear failure,whereas a loose bed experiences initial liquefaction failure.This study utilized discrete element simulation to examine the microscopic mechanisms that underlie this phenomenon.

关键词： wave flume liquefaction pore water pressure consolidation permeability experiment discrete element simulation

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Efficacy and safety of low-dose cyclophosphamide combined with lenvatinib, pembrolizumab and TACE for unresectable hepatocellular carcinoma:A single-center, prospective,single-arm clinical trial

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Chinese Journal of Cancer Research 2024年第2期36卷 114-123页

作者： yupeng ren Yuxuan Li Mingbo Cao Yongchang Tang Feng Yuan Gaoyuan Yang Zhiwei He Zheng Shi Xiaorui Su Zhicheng Yao Meihai Deng Department of Hepatobiliary Surgery the Third Affiliated HospitalSun Yat-sen UniversityGuangzhou 510630China Department of General Surgery Qilu HospitalShandong UniversityJinan 250012China Department of Hepatobiliary Surgery the First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510120China Department of Hepatobiliary and Pancreatic Surgery the Third Affiliated HospitalSun Yat-sen UniversityGuangzhou 510630China

Objective: Unresectable hepatocellular carcinoma(uHCC) continues to pose effective treatment options. The objective of this study was to assess the efficacy and safety of combining low-dose cyclophosphamide with lenvatinib, pembrolizumab and transarterial chemoembolization(TACE) for the treatment of uHCC.Methods: From February 2022 to November 2023, a total of 40 patients diagnosed with uHCC were enrolled in this small-dose, single-center, single-arm, prospective study. They received a combined treatment of low-dose cyclophosphamide with lenvatinib, pembrolizumab, and TACE. Study endpoints included progression-free survival(PFS), objective response rate(ORR), and safety assessment. Tumor response was assessed using the modified Response Evaluation Criteria in Solid Tumors(mRECIST), while survival analysis was conducted through KaplanMeier curve analysis for overall survival(OS) and PFS. Adverse events(AEs) were evaluated according to the National Cancer Institute Common Terminology Criteria for Adverse Events(version 5.0).Results: A total of 34 patients were included in the study. The median follow-up duration was 11.2 [95% confidence interval(95% CI), 5.3-14.6] months, and the median PFS(mPFS) was 15.5(95% CI, 5.4-NA) months.Median OS(mOS) was not attained during the study period. The ORR was 55.9%, and the disease control rate(DCR) was 70.6%. AEs were reported in 27(79.4%) patients. The most frequently reported AEs(with an incidence rate >10%) included abnormal liver function(52.9%), abdominal pain(44.1%), abdominal distension and constipation(29.4%), hypertension(20.6%), leukopenia(17.6%), constipation(17.6%), ascites(14.7%), and insomnia(14.7%). Abnormal liver function(14.7%) had the most common grade 3 or higher AEs.Conclusions: A combination of low-dose cyclophosphamide with lenvatinib, pembrolizumab, and TACE is safe and effective for u HCC, showcasing a promising therapeutic strategy for managing uHCC.

关键词： Hepatocellular carcinoma lenvatinib low-dose cyclophosphamide pembrolizumab transarterial chemoembolization

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HIGH ORDER FINITE DIFFErenCE HERMITE WENO FAST SWEEPING METHODS FOR STATIC HAMILTON-JACOBI EQUATIONS

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Journal of Computational Mathematics 2023年第6期41卷 1064-1092页

作者： yupeng ren Yulong Xing Jianxian Qiu School of Mathematical Sciences Xiamen UniversityXiamenFujian 361005China Department of Mathematics The Ohio State UniversityColumbusOH 43210USA School of Mathematical Sciences and Fujian Provincial Key Laboratory of Mathematical Modeling and High-Performance Scientific Computing Xiamen UniversityXiamenFujian 361005China

In this paper,we propose a novel Hermite weighted essentially non-oscillatory(HWENO)fast sweeping method to solve the static Hamilton-Jacobi equations efficiently.During the HWENO reconstruction procedure,the proposed method is built upon a new finite difference fifth order HWENO scheme involving one big stencil and two small stencils.However,one major novelty and difference from the traditional HWENO framework lies in the fact that,we do not need to introduce and solve any additional equations to update the derivatives of the unknown functionϕ.Instead,we use the currentϕand the old spatial derivative ofϕto update them.The traditional HWENO fast sweeping method is also introduced in this paper for comparison,where additional equations governing the spatial derivatives ofϕare introduced.The novel HWENO fast sweeping methods are shown to yield great savings in computational time,which improves the computational efficiency of the traditional HWENO scheme.In addition,a hybrid strategy is also introduced to further reduce computational costs.Extensive numerical experiments are provided to validate the accuracy and efficiency of the proposed approaches.

关键词： Finite difference Hermite methods Weighted essentially non-oscillatory method Fast sweeping method Static Hamilton-Jacobi equations Eikonal equation

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High Order Finite Difference Hermite WENO Fixed-Point Fast Sweeping Method for Static Hamilton-Jacobi Equations

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Communications in Computational Physics 2022年第1期31卷 154-187页

作者： yupeng ren Yulong Xing Jianxian Qiu School of Mathematical Sciences Xiamen UniversityXiamenFujian 361005P.R.China Department of Mathematics The Ohio State UniversityColumbusOH 43210USA School of Mathematical Sciences and Fujian Provincial Key Laboratory of Mathematical Modeling and High-Performance Scientific Computing Xiamen UniversityXiamenFujian 361005P.R.China

In this paper, we combine the nonlinear HWENO reconstruction in [43] andthe fixed-point iteration with Gauss-Seidel fast sweeping strategy, to solve the staticHamilton-Jacobi equations in a novel HWENO framework recently developed in [22].The proposed HWENO frameworks enjoys several advantages. First, compared withthe traditional HWENO framework, the proposed methods do not need to introduceadditional auxiliary equations to update the derivatives of the unknown function φ.They are now computed from the current value of φ and the previous spatial derivatives of φ. This approach saves the computational storage and CPU time, which greatlyimproves the computational efficiency of the traditional HWENO scheme. In addition,compared with the traditional WENO method, reconstruction stencil of the HWENOmethods becomes more compact, their boundary treatment is simpler, and the numerical errors are smaller on the same mesh. Second, the fixed-point fast sweeping methodis used to update the numerical approximation. It is an explicit method and doesnot involve the inverse operation of nonlinear Hamiltonian, therefore any HamiltonJacobi equations with complex Hamiltonian can be solved easily. It also resolves someknown issues, including that the iterative number is very sensitive to the parameterε used in the nonlinear weights, as observed in previous studies. Finally, to furtherreduce the computational cost, a hybrid strategy is also presented. Extensive numerical experiments are performed on two-dimensional problems, which demonstrate thegood performance of the proposed fixed-point fast sweeping HWENO methods.

关键词： Hermite method Weighted Essentially Non-Oscillatory(WENO)method fixedpoint iteration Hamilton-Jacobi equation hybrid strategy

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The failure propagation of weakly stable sediment:A reason for the formation of high-velocity turbidity currents in submarine canyons

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Journal of Oceanology and Limnology 2023年第1期41卷 100-117页

作者： yupeng ren Yi ZHANG Guohui XU Xingbei XU Houjie WANG Zhiyuan CHEN Shandong Provincial Key Laboratory of Marine Environment and Geological Engineering Qingdao 266100China Shandong Provincial Key Laboratory of Marine Environment and Geological Engineering Ocean University of ChinaQingdao 266100China Key Laboratory of Marine Environment and Ecology Ocean University of ChinaMinistry of EducationQingdao 266100China

The long-distance movement of turbidity currents in submarine canyons can transport large amounts of sediment to deep-sea plains.Previous studies show obvious differences in the turbidity current velocities derived from the multiple cables damage events ranging from 5.9 to 28.0 m/s and those of field observations between 0.15 and 7.2 m/s.Therefore,questions remain regarding whether a turbid fluid in an undersea environment can flow through a submarine canyon for a long distance at a high speed.A new model based on weakly stable sediment is proposed(proposed failure propagation model for weakly stable sediments,WS S-PFP model for short)to explain the high-speed and long-range motion of turbidity currents in submarine canyons through the combination of laboratory tests and numerical analogs.The model is based on two mechanisms:1)the original turbidity current triggers the destabilization of the weakly stable sediment bed and promotes the destabilization and transport of the soft sediment in the downstream direction and 2)the excitation wave that forms when the original turbidity current moves into the canyon leads to the destabilization and transport of the weakly stable sediment in the downstream direction.The proposed model will provide dynamic process interpretation for the study of deep-sea deposition,pollutant transport,and optical cable damage.

关键词： turbidity current excitation wave dense basal layer velocity WSS-PFP model

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Microstructure and Mechanical Properties of Ti–Ta Composites Prepared Through Cold Spray Additive Manufacturing

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Acta Metallurgica Sinica(English Letters) 2022年第9期35卷 1465-1476页

作者： Junrong Tang Naeem ul Haq Tariq Zhipo Zhao Mingxiao Guo Hanhui Liu yupeng ren Xinyu Cui Yanfang Shen Jiqiang Wang Tianying Xiong Shi-changxu Innovation Center for Advanced Materials Institute of Metal ResearchChinese Academy of SciencesShenyang110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang110016China Department of Metallurgy and Materials Engineering Pakistan Institute of Engineering and Applied SciencesNiloreIslamabadPakistan

In this study, an innovative approach was used to fabricate Ti–Ta composite biomaterials through cold spray additive manufacturing followed by a diff usion treatment. The microstructure and mechanical properties of the composites were investigated in detail using field emission scanning electron microscopy, electron backscatter diff raction, 3D X-ray computed tomography, tensile test, nanohardness test and resonance vibration test. The obtained results indicated that the prepared composites have inhomogeneity in their microstructure and composition. A unique microstructure, composed of Ti-rich, Ta-rich and diff usion regions, was evolved in the composites due to incomplete diff usion between Ti and Ta splats. Further, Kirkendall pores were formed in the composites due to uneven diff usion of the two phases(of Ti and Ta) during high-temperature heat treatment. The prepared composites simultaneously showed low elastic modulus and high tensile strength which is required for a good biomaterial. Low elastic modulus was associated with the residual pores and the alloying eff ect of Ta in Ti, while high tensile strength was related to the solid solution strengthening eff ects. The obtained results indicated that the prepared Ti–Ta composites have a great potential to become a new candidate for biomedical applications.

关键词： Ti–Ta composites Cold spray additive manufacturing(CSAM) Biomaterials Mechanical properties X-ray computed tomography(XCT)

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Advancements in understanding mechanisms of hepatocellular carcinoma radiosensitivity:A comprehensive review

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Chinese Journal of Cancer Research 2023年第3期35卷 266-282页

作者： Gaoyuan Yang Huamei Yan Yongchang Tang Feng Yuan Mingbo Cao yupeng ren Yuxuan Li Zhiwei He Xiaorui Su Zhicheng Yao Meihai Deng Department of Hepatobiliary Surgery The Third Affiliated HospitalSun Yat-sen UniversityGuangzhou 510630China Department of Radiation Oncology The Third Affiliated HospitalSun Yat-sen UniversityGuangzhou 510630China Department of General Surgery Qilu HospitalShandong UniversityJinan 250012China Department of General Surgery The First Affiliated HospitalGuangzhou Medical UniversityGuangzhou 511436China Department of Hepatobiliary and Pancreatic Surgery The Third Affiliated HospitalSun Yat-sen UniversityGuangzhou 510630China

Primary liver cancer is a significant health problem worldwide.Hepatocellular carcinoma(HCC)is the main pathological type of primary liver cancer,accounting for 75%-85%of cases.In recent years,radiotherapy has become an emerging treatment for HCC and is effective for various stages of HCC.However,radiosensitivity of liver cancer cells has a significant effect on the efficacy of radiotherapy and is regulated by various factors.How to increase radiosensitivity and improve the therapeutic effects of radiotherapy require further exploration.This review summarizes the recent research progress on the mechanisms affecting sensitivity to radiotherapy,including epigenetics,transportation and metabolism,regulated cell death pathways,the microenvironment,and redox status,as well as the effect of nanoparticles on the radiosensitivity of liver cancer.It is expected to provide more effective strategies and methods for clinical treatment of liver cancer by radiotherapy.

关键词： Hepatocellular carcinoma radiosensitivity epigenetics non-coding RNA cell death metabolism tumor microenvironment reactive oxygen species nanoparticle

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花生蛋白的高静压联合酶法改性及其性质

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中国油脂 2024年第6期49卷 47-52页

作者：刘加艳任宇鹏郭立河南应用技术职业学院郑州450042 郑州远洋油脂工程技术有限公司郑州450018

为促进花生蛋白的深加工和更广泛的应用,采用高静压联合碱性蛋白酶酶法改性花生蛋白。通过单因素试验考察了静压力、pH、酶添加量、酶解时间和酶解温度对花生蛋白溶解度的影响,在此基础上,采用正交试验优化花生蛋白联合改性工艺条件,并... 详细信息

为促进花生蛋白的深加工和更广泛的应用,采用高静压联合碱性蛋白酶酶法改性花生蛋白。通过单因素试验考察了静压力、pH、酶添加量、酶解时间和酶解温度对花生蛋白溶解度的影响,在此基础上,采用正交试验优化花生蛋白联合改性工艺条件,并测定了联合改性花生蛋白的起泡性和泡沫稳定性、巯基和二硫键含量以及总还原能力。结果表明:花生蛋白联合改性最佳工艺条件为静压力300MPa、1g/100mL碱性蛋白酶(20万U/g)添加量3.0mL(100mL质量分数5%的花生蛋白溶液)、酶解时间60min、pH10、酶解温度50℃,在此条件下联合改性花生蛋白溶解度为(82.87±0.51)%;联合改性花生蛋白的起泡性、泡沫稳定性、巯基含量、总还原能力显著提高,二硫键含量显著下降。综上,高静压联合酶法改性改善了花生蛋白的理化性质及功能特性,有利于其深加工及更广泛的应用。

关键词：花生蛋白蛋白改性高静压碱性蛋白酶功能特性

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高铁隧道衬砌缺陷气动荷载影响研究

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中国铁路 2024年第2期 69-74,86页

作者：唐文国任玉鹏丁祥中国铁路兰州局集团有限公司甘肃兰州730030 中国铁路兰州局集团有限公司银川工程建设指挥部宁夏银川750000 中铁第五勘察设计院集团有限公司北京102600

随着高铁列车运行速度的提高,气动荷载成为隧道结构重要的附加荷载,尤其是素混凝土二次衬砌存在初始缺陷时,气动荷载将对衬砌安全有较大影响。针对素混凝土二次衬砌存在初始裂纹和厚度不足缺陷的情况,分别采用基于断裂力学的数值流形方... 详细信息

随着高铁列车运行速度的提高,气动荷载成为隧道结构重要的附加荷载,尤其是素混凝土二次衬砌存在初始缺陷时,气动荷载将对衬砌安全有较大影响。针对素混凝土二次衬砌存在初始裂纹和厚度不足缺陷的情况,分别采用基于断裂力学的数值流形方法和基于荷载-结构模型有限元法,对2种衬砌缺陷在气动荷载作用下的影响开展研究。研究结果表明:隧道素混凝土二次衬砌存在初始缺陷时,气动荷载对缺陷部位的耐久性和长期稳定性有很大影响;隧道衬砌存在裂纹时,在气动荷载作用下,裂纹尖端应力强度因子增大150%以上;衬砌厚度不足时,在气动荷载作用下,缺陷部位拉应力增大54%,衬砌处于“拉-压”循环受力状态。研究结果可为高铁隧道素混凝土结构的长期稳定性及耐久性设计提供参考。

关键词：高铁隧道气动荷载素混凝土二次衬砌初始缺陷

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基于迁移学习与残差网络的冰形图像预测

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飞行力学 2024年第2期42卷 1-6页

作者：任宇鹏岳静王强彭博易贤西南石油大学计算机科学学院四川成都610500 中国空气动力研究与发展中心结冰与防除冰重点实验室四川绵阳621000 空气动力学国家重点实验室四川绵阳621000

神经网络冰形预测方法中,风洞试验结冰数据具有较高精度的冰形特征,但试验成本昂贵、获得数据较少,未能得到充分利用,而大多数是针对数值计算数据开展研究。为此,提出了一种结合迁移学习和残差网络的图像化预测方法,以翼型截面图像和结... 详细信息

神经网络冰形预测方法中,风洞试验结冰数据具有较高精度的冰形特征,但试验成本昂贵、获得数据较少,未能得到充分利用,而大多数是针对数值计算数据开展研究。为此,提出了一种结合迁移学习和残差网络的图像化预测方法,以翼型截面图像和结冰工况参数为输入,二维冰形图像为输出,建立深度神经网络预测模型,实现高精度二维冰形预测。通过大量数值计算数据获得预训练模型,再加入少量风洞试验数据进行微调,实现冰形预测。结果表明,所提出的方法可以预测较高精度的二维翼型结冰图像,大部分冰形特征参数与风洞试验冰形的相对误差保持在15%以内。

关键词：冰形预测迁移学习残差网络风洞试验

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