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肾嗜酸性空泡状肿瘤7例临床病理学分析

中华病理学杂志 2024年第9期53卷 910-915页

作者：王彦庄洁李玉军计晓彬李云霞张月娟于文娟种道臣张伟蒋艳霞青岛大学附属医院病理科青岛266003 海军第九七一医院病理科青岛266071 济宁市第一人民医院病理科济宁272002

目的探讨肾嗜酸性空泡状肿瘤(eosinophilic vacuolated tumor,EVT)的临床病理学特点及诊断、鉴别诊断。方法收集2010年1月至2021年12月青岛大学附属医院(6例)和海军第九七一医院(1例)形态学典型、病理诊断无异议的肾EVT,进行组织形态学... 详细信息

目的探讨肾嗜酸性空泡状肿瘤(eosinophilic vacuolated tumor,EVT)的临床病理学特点及诊断、鉴别诊断。方法收集2010年1月至2021年12月青岛大学附属医院(6例)和海军第九七一医院(1例)形态学典型、病理诊断无异议的肾EVT,进行组织形态学观察、免疫组织化学染色,并对2例进行全外显子测序。另选取同期诊断的肾嗜酸细胞瘤(RO)22例、嗜酸型嫌色细胞肾细胞癌(eChRCC)17例进行比较。结果男性4例,女性3例。年龄29~61岁(平均年龄42岁)。临床上,7例均系体检发现,瘤体直径1.5~4.5 cm,结节状,边界清楚,切面灰红、灰白色,实性,质软。镜下观察:瘤组织呈巢团状或实性排列,伴有多少不等的腺泡状或小囊状结构,瘤细胞胞质嗜酸,胞质内均可见大而突出的透明空泡,核圆形,核仁明显,4例局部可见核周空晕,1例见灶状分布、胞质稀少、核深染的小细胞成分。所有病例均未见坏死和核分裂象。3例存在水肿性间质。免疫组织化学染色:7例肿瘤均呈CD117、Cathepsin K阳性,波形蛋白、细胞角蛋白(CK)7阴性,CK20散在或斑片状阳性,Ki-67阳性指数1%~4%。全外显子测序显示2例肿瘤均存在MTOR基因突变。统计学分析表明,EVT与RO中Cathepsin K、CD10、S-100A1和Cyclin D1的表达(P<0.05)及EVT与eChRCC中Cathepsin K、CD10、CK7和claudin7的表达(P<0.001)差异有统计学意义。7例随访4~96个月(平均50个月),均未见复发或转移。结论肾EVT是一种在形态学、免疫表型与RO、eChRCC均有重叠、与TSC/MTOR通路密切相关的少见肾肿瘤,嗜酸性胞质内可见大而突出的透明空泡以及存在显著的核仁是该肿瘤的重要组织学特征。联合应用系列免疫组织化学抗体有助于EVT的诊断与鉴别诊断。该肿瘤生物学行为通常惰性,预后良好。

关键词：肾肿瘤空泡诊断鉴别

急性脑梗死静脉溶栓治疗短期预后不良预测模型的建立及验证

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中国实用神经疾病杂志 2024年第6期27卷 747-752页

作者：李云霞李晓晖吕雪梅杨妍妍陈文武河南大学第一附属医院河南开封475000

目的评估入院指标与急性脑梗死溶栓治疗患者短期临床预后的相关性,建立并验证预后不良的预测模型。方法回顾性分析2020-01—2023-12河南大学第一附属医院的165例急性脑梗死溶栓治疗患者的资料。根据溶栓90 d后改良Rankin量表(mRS)评分... 详细信息

目的评估入院指标与急性脑梗死溶栓治疗患者短期临床预后的相关性,建立并验证预后不良的预测模型。方法回顾性分析2020-01—2023-12河南大学第一附属医院的165例急性脑梗死溶栓治疗患者的资料。根据溶栓90 d后改良Rankin量表(mRS)评分将患者分为预后良好组及预后不良组,并进行组间单因素分析和多因素Logistic回归分析,分析血清生物学标志物联合相关临床评估量表与急性脑梗死溶栓治疗患者预后的关系,建立预后预测模型并进行验证。结果共纳入165例患者,预后良好126例,预后不良39例。单因素分析和多因素Logistic回归分析显示,糖尿病史、高NIHSS评分及白细胞、中性粒细胞、D-二聚体升高是急性脑梗死溶栓治疗患者90 d预后不良的独立预测因子。ROC曲线分析表明,糖尿病史、NIHSS评分、白细胞、中性粒细胞、D-二聚体评估急性脑梗死患者90 d预后不良的曲线下面积(AUC)分别0.677、0.826、0.876、0.765、0.863,灵敏度分别为51.3%、82.1%、89.7%、79.5%、79.5%,特异度分别为84.1%、77.8%、77.8%、64.3%、86.5%。以上指标联合构建预后预测模型,该模型具有较好的区分度、临床可用性和校准度。结论结合独立预测因子建立的预后不良风险预测模型清晰简易,可在患者入院时准确预测患者预后,帮助临床早期选择合理干预措施,改善患者预后。

关键词：急性脑梗死溶栓预后风险预测模型影响因素

pH-Responsive Polycarbonate Copolymer-based Nanoparticles for Targeted Anticancer Drug Delivery

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Chemical Research in Chinese Universities 2018年第6期34卷 1041-1050页

作者： li yunxia DU Wenjuan FU Zhiguang WANG Huanhuan WANG Jiexin LE Yuan ZHANG Jianjun WEN Ning Department of Stomatology the General Hospital of Chinese PLA Beijing 100853 P. R. China Department of Oncology the General Hospital of Chinese PLA Beijing 100853 P. R. China College of Chemical Engineering Beijing University of Chemical Technology Beijing 100029 P. R. China

A smart polycarbonate（PCA） copolymer-based nanoparticle（NanoPCA） with pH-responsive, long-term stability, and tumor targeting ability was successfully developed by synthesizing and assembling a series of functional PCA-based copolymers including poly（2-amino-l,3-propanediol carbonate-co-L-lactide）[P（CA-co-LA）], poly（2- amino-1,3-propanediol carbonate-co-L-lactide）-g-methoxy-poly（ethylene glycol）[P（CA-co-LA）-g-MPEG], and poly（2-amino-1,3-propanediol carbonate-co-L-lactide）-g-poly（ethylene glycol）-cyclic（Arg-Gly-Asp-D-Phe-Lys） [P（CA-co-LA）-g-PEG-cRGD] for targeted anticancer drug delivery, pH-Responsive studies demonstrated that the loading doxorubicin（DOX） released faster from NanoPCA at acidic conditions due to protonation effects of P（CA-co-LA） copolymers. Furthermore, the in vitro and in vivo investigations demonstrate that the DOX-loaded NanoPCA exhibited significant tumor targeting ability, outstanding antitumor effect and excellent biological safety in the treatment of oral squamous cell carcinoma（OSCC）. Therefore, this work provides a promising drug delivery plat-form for cancer therapy and other applications.

关键词： Polycarbonate copolymer-based nanoparticle(NanoPCA) pH-Responsive Tumor targeting ability Oral squamous cell carcinoma(OSCC)

Genetic analysis and gene fine mapping of a rolling leaf mutant (rl_(11(t))) in rice (Oryza sativa L.)

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Chinese Science Bulletin 2010年第17期55卷 1763-1769页

作者： ZHOU Yong FANG yunxia ZHU JinYan li ShengQiang GU Fei GU MingHong liANG GuoHua Jiangsu Key Laboratory for Crop Genetics and Physiology/Jiangsu Key Laboratory of Plant Functional Genomics Yangzhou University Yangzhou 225009 China

The exploration of new genes controlling rice leaf shape is an important foundation for rice functional genomics and plant architecture improvement. In the present study, we identified a rolling leaf mutant from indica variety Yuefeng B, named rl11(t), which exhibited reduced plant height, rolling and narrow leaves. Leaves in rl11(t) mutant showed abnormal number and morphology of veins compared with those in wild type plants. In addition, rl11(t) mutant was less sensitive to the inhibitory effect of auxin than the wild type. Genetic analysis suggested that the mutant was controlled by a single recessive gene. Gene Rl11(t) was initially mapped between SSR markers RM6089 and RM124 on chromosome 4. Thirty-two new STS markers around the Rl11(t) region were developed for fine mapping. A physical map encompassing the Rl11(t) locus was constructed and the target gene was finally delimited to a 31.6 kb window between STS4-25 and STS4-26 on BAC AL606645. This provides useful information for cloning of Rl11(t) gene.

关键词：功能基因组学精细定位遗传分析突变体 Oryza 水稻动叶叶片形状

洞庭湖流域全新世孢粉记录的植被、气候变化及人类活动

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第四纪研究 2024年第3期44卷 780-792页

作者：赵琳曾瑶瑶杨祎琪夏威曹现勇郑卓李云霞刘利丹申忠伟饶志国洞庭湖流域生态环境变化与固碳增汇湖南省重点实验室湖南师范大学地理科学学院湖南长沙410081 中国科学院青藏高原研究所古生态与人类适应团队北京100101 中国科学院青藏高原研究所青藏高原地球系统与资源环境全国重点实验室北京100101 中山大学地球科学与工程学院广东省地球动力作用与地质灾害重点实验室广东珠海519082

本研究选择洞庭湖流域内湖南十万古田泥炭(SWGT)、贵州梵净山九龙池湿地(JLC)和湖北江陵剖面(JL)三处研究点。SWGT钻孔深度为250 cm,通过AMS 14C测年使用Bacon软件进行线性插值建立年龄-深度模型,最底部年代达到约11.6 *** B.P.;JLC钻... 详细信息

本研究选择洞庭湖流域内湖南十万古田泥炭(SWGT)、贵州梵净山九龙池湿地(JLC)和湖北江陵剖面(JL)三处研究点。SWGT钻孔深度为250 cm,通过AMS 14C测年使用Bacon软件进行线性插值建立年龄-深度模型,最底部年代达到约11.6 *** B.P.;JLC钻孔深度为400 cm,通过AMS 14C测年使用Clam软件进行线性插值建立年龄-深度模型,最底部年代达到约11.9 *** B.P.;JL剖面深度为594 cm,常规14C测年后经过树轮校正,用线性插值法内插和外推获得各对应深度的年代,最底部年代外推达到约9.4 *** B.P.。通过对SWGT进行孢粉分析,集合已发表的JLC和JL的孢粉分析结果,获得了早中全新世洞庭湖流域的植被和气候变化特征,并利用现代类比法(MAT)重建了三处研究点的人类活动指数(HII),探讨了全新世人类活动的影响。研究结果显示:1)全新世早期,花粉类型以Evergreen Quercus、Cyclobalanopsis、Castanopsis、Fagus、Carpinus等亚热带植物花粉类型为主,草本植物的花粉含量整体较低,此时植被主要是亚热带常绿阔叶林,气候温暖湿润,东亚夏季风(EASM)强度较强。2)全新世中期,约9.0~4.0 *** B.P.,乔木花粉含量最高,草本植物花粉含量最低,森林覆盖度最高。该阶段最主要特征是以Evergreen Quercus、Cyclobalanopsis为主的亚热带常绿阔叶树含量升高,气候更加暖湿,揭示了EASM强度进一步增强;尤其是6.0~4.0 *** B.P.之间,Evergreen Quercus、Cyclobalanopsis含量达到最高,气候最为暖湿,标志着全新世适宜期的出现。3)晚全新世,4.0 *** B.P.以来,HII出现最高值,反映了人类对环境影响更加剧烈;此时花粉数据显示较低的栎属、栲属、青冈栎属等植被含量,结合研究区出现较高的松属花粉百分比含量,表明人类大量砍伐阔叶森林,导致次生松树林扩张,与此同时,禾本科植物含量升高,揭示了人类活动开始在低海拔地区进行农业活动。4)太阳辐射、北半球高纬冰量和冰盖融化导致的融水通量等因素可能对早中全新世气候变化产生较大影响,而该区晚全新世记录更多受人类活动影响。本研究认为,在该区域利用孢粉进行全新世古气候定量重建时,很有必要对晚全新世人类活动信号进行识别。

关键词：孢粉记录植被和气候变化人类活动指数(HII) 洞庭湖流域全新世

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Holocene precipitationδ^18O as an indicator of temperature history in arid central Asia:an overview of recent advances

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Research in Cold and Arid Regions 2020年第6期12卷 371-379页

作者： ZhiGuo Rao YiPing Tian yunxia li HaiChun Guo XinZhu Zhang Guang Han XinPing Zhang College of Resources and Environmental Sciences Hunan Normal UniversityChangshaHunan 410081China

Holoceneδ^18O records from various archives(ice cores,cave stalagmites,and peat sediments)from the Xinjiang region of northwestern China,in arid central Asia(ACA),are all derived ultimately from local precipitationδ^18O(δ^18Op).Nevertheless,they have been proposed as indicators of different climatic parameters,such as wetness and temperature *** article summarizes previously reported records of moisture sources for the Xinjiang region and the results of modern observations conducted at an ice core site and a peat site in the Altai *** findings are used to propose that the overall positive trends in Holoceneδ^18O records from the various archives from the Xinjiang region primarily reflect the Holocene's long-term warming *** is concluded that more site-specific modern observations are needed to further elucidate the environmental significance of Holoceneδ^18O records from this region,especially for the separation of different seasonal temperature signals present withinδ^18O records.

关键词： arid central Asia precipitationδ^18O Holocene temperature history ice core stalagmite peat

Degradation and mineralization of ciprofloxacin by gas–liquid discharge non-thermal plasma

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Plasma Science and Technology 2019年第1期21卷 52-62页

作者： Shuheng HU Xinghao liU Zimu XU Jiaquan WANG yunxia li Jie SHEN Yan LAN Cheng CHENG School of Resources and Environmental Engineering Hefei University of Technology Intelligent Manufacturing Technology Research Institute Hefei University of Technology Institute of Plasma Physics Chinese Academy of Sciences Center of Medical Physics and Technology Hefei Institutes of Physical Science Chinese Academy of Sciences Anhui Province Key Laboratory of Medical Physics and Technology Hefei Institutes of Physical ScienceChinese Academy of Sciences

A typical quinolones antibiotic ciprofloxacin(CIP) in aqueous solution was degraded by a gas–liquid discharge non-thermal plasma system. The discharge plasma power and the emission intensity of the excited reactive species(RS) generated in the gas phase were detected by the oscilloscope and the optical emission spectroscopy. The effects of various parameters on CIP degradation, i.e. input powers, initial concentrations addition of radical scavengers and p H values were investigated. With the increase of discharge power, the degradation efficiency increased but the energy efficiency significantly reduced. The degradation efficiency also reduced under high concentration of initial CIP conditions due to the competitive reactions between the plasma-induced RS with the degradation intermediates of CIP. Different radical scavengers(isopropanol and CCl_4) on ·OH and H· were added into the reaction system and the oxidation effects of ·OH radicals have been proved with high degradation capacity on ***, the long-term degradation effect on CIP in the plasma-treated aqueous solution proved that the long-lived RS(H_2O_2 and O_3, etc) might play key roles on the stay effect through multiple aqueous reactions leading to production of ·OH. The degradation intermediates were determined by the method of electrospray ionization(+)-mass spectroscopy, and the possible degradation mechanism were presented.

关键词： gas-liquid plasma ciprofloxacin mineralization degradation mechanism

Simultaneously enhancing the strength and ductility of as-extruded AlN/AZ91 composites via nano-precipitation and pyramidal slip

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Journal of Materials Science & Technology 2024年第5期172卷 240-254页

作者： Bin Zhang yunxia Sun Tuo liang Yunzhen li Tian li Jingchao Wang Ruiru Cai Changlin Yang State Key Laboratory of Solidification Processing Northwestern Polytechnical UniversityXi’an 710072China

Age hardening is often used to optimize the mechanical properties of as-deformed Mg-based materials in industry,whereas the improvement of strength is usually accompanied by the significant loss of ductility,which hinders the application of Mg-based materials in structural *** the present work,high strength-ductility synergy(the yield strength of 263±9 MPa,ultimate tensile strength of 398±7 MPa and elongation to fracture of 34%±1%)was realized in as-extruded AlN/AZ91 composites after optimiz-ing aging *** characterization shows that AlN particles induced a large number of geometrically necessary dislocations around the AlN/Mg interface during extrusion,which decreased the nucleation barrier and provided more heterogeneous nucleation sites forγ-Mg 17 Al 12 continuous ***,95%of residual dislocations in as-extruded AlN/AZ91 composites were annihilated dur-ing peak-aging,suppressing the growth and coarsening of continuous ***,high density of nano-sizedγ-Mg 17 Al 12 continuous precipitates was produced in as-extruded AlN/AZ91 composites af-ter *** tension,gliding dislocations bypassed sphericalγ-Mg 17 Al 12 nano-precipitates by Orowan looping rather than cutting mechanism,which induced a strong block on dislocation *** high yield strength was mainly attributed to the high density of non-shearableγ-Mg 17 Al 12 nano-precipitates with spherical morphology,which was different from other Mg-Al-based *** results of texture evolution and slip trace analysis demonstrated that the suppression of extension twinning and less basal slip was due to the enhanced activity of pyramidalc+aslip in as-extruded AlN/AZ91 com-posites after peak-aging during the room temperature tension,meanwhile,the dislocation density of as-extruded AlN/AZ91 composites was significantly decreased during peak-aging,then higher elongation to fracture was achieved.

关键词： Magnesium matrix composites Mechanical properties Precipitation Deformation mechanisms Non-basal slip

GENERAliZED SIMULATION MODEL FOR MILLED SURFACE TOPOGRAPHY-APPliCATION TO PERIPHERAL MILliNG

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Chinese Journal of Mechanical Engineering 2001年第2期14卷 121-126页

作者： Xu Anping Qu yunxia li Weimin School of Mechanical Engineering, Hebei University of Technology Zhang Dawei Huang Tian Tianjin University 河北工业大学机械学院天津天津大学天津

Based on analyzing various factors influencing milled surface topography, firstly, a generalized model for milled surface topography is proposed. Secondly, using the principles of transformation matrix and vector operation, the trajectory equation of cutting edge relative to workpiece is derived. Then, a three dimensional topography simulation algorithm is constructed through dividing the workpiece into regular grids. Finally, taking the peripheral milling process as an example, the generalized model is simplified, and the corresponding simulation examples are given. The results indicate that it is very efficient for the generalized model to be used to analyze and simulate the peripherally milled surface topography.

关键词： Generalized simulation model Arbitrary contour mill Peripheral milling process Surface topography