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中山市大气中正构烷烃的污染特征和来源分析

山西化工 2024年第3期44卷 258-260页

作者：陈莉莉何蕴琦利雪儿黄海荣刘小珍张颖姬广东省中山生态环境监测站广东中山528400

为探究中山市大气中正构烷烃的污染特征,于2022年利用苏玛罐采样、大气预浓缩-气相色谱质谱联用技术对中山市大气中的正构烷烃进行采样分析,并对大气中正构烷烃的主要组成、浓度特征、来源和臭氧生成潜势进行了分析研究。研究表明,中山... 详细信息

为探究中山市大气中正构烷烃的污染特征,于2022年利用苏玛罐采样、大气预浓缩-气相色谱质谱联用技术对中山市大气中的正构烷烃进行采样分析,并对大气中正构烷烃的主要组成、浓度特征、来源和臭氧生成潜势进行了分析研究。研究表明,中山市大气中检测出11种正构烷烃,总质量浓度为27.71μg/m3,浓度占比较大的为乙烷、正丙烷、正丁烷、正戊烷和正己烷,该5种化合物共占正构烷烃总浓度的87.69%。分析了乙烷、正丙烷、正丁烷、正戊烷和正己烷的臭氧生成潜势(OFP),正丁烷和正戊烷臭氧生成潜势的贡献较大,二者总占比为70.34%。

关键词：中山市正构烷烃污染特征来源臭氧生成潜势

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中山市大气中醛酮类化合物的污染特征研究

山西化工 2024年第5期44卷 248-250页

作者：陈莉莉利雪儿何蕴琦黄海荣张颖姬刘小珍广东省中山生态环境监测站广东中山528400

为探究中山市大气中醛酮类化合物污染特征,于2022年6月份、12月份,利用苏玛罐采样、大气预浓缩-气相色谱质谱联用技术对中山市大气中的醛酮类化合物进行采样分析,并对大气中醛酮类化合物的主要组成、浓度特征进行了分析研究。研究表明:... 详细信息

为探究中山市大气中醛酮类化合物污染特征,于2022年6月份、12月份,利用苏玛罐采样、大气预浓缩-气相色谱质谱联用技术对中山市大气中的醛酮类化合物进行采样分析,并对大气中醛酮类化合物的主要组成、浓度特征进行了分析研究。研究表明:中山市大气中检测出15种醛酮化合物,总质量浓度为54.16μg/m^(3),浓度占比较大的为甲醛、乙醛、丙酮和2-丁酮,它们的质量浓度关系为2-丁酮>丙酮>乙醛>甲醛,该4种化合物共占醛酮类化合物总质量浓度的82.47%。同时分析了甲醛、乙醛、丙酮和2-丁酮四种醛酮类化合物的臭氧生成潜势(OFP),甲醛和乙醛臭氧生成潜势的贡献较大,二者总占比为74.72%。

关键词：中山市醛酮类化合物污染特征

Multifunction-oriented high-mobility polymer semiconductors

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National Science Review 2024年第3期11卷 16-19页

作者： Mingliang Zhu Yunlong Guo yunqi Liu Beijing National Laboratory for Molecular Sciences Organic Solids Laboratory Institute of Chemistry Chinese Academy of Sciences School of Chemical Sciences University of Chinese Academy of Sciences

The discovery of conductive polyacetylene has initiated interdisciplinary research into condensed matter physics and synthetic chemistry in organic electronics. Unlike their inorganic and small-molecule counterparts, polymer semiconductors possess the inherent advantages of facile solution processing,large-area manufacturing, excellent mechanical strength and intrinsic flexibility.

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Defective EMC1 drives abnormal retinal angiogenesis via Wnt/β-catenin signaling and may be associated with the pathogenesis of familial exudative vitreoretinopathy

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Genes & Diseases 2023年第6期10卷 2572-2585页

作者： Shujin Li Mu Yang Rulian Zhao Li Peng Wenjing Liu Xiaoyan Jiang yunqi he Erkuan Dai Lin Zhang Yeming Yang Yi Shi Peiquan Zhao Zhenglin Yang Xianjun Zhu The Sichuan Provincial Key Laboratory for Human Disease Gene Study Center for Medical GeneticsDepartment of Laboratory MedicineSichuan Provincial People's HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuan 610072China Research Unit for Blindness Prevention of the Chinese Academy of Medical Sciences(2019RU026) Sichuan Academy of Medical Sciences and Sichuan Provincial People's HospitalChengduSichuan 610072China Department of Ophthalmology Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China Key Laboratory of Tibetan Medicine Research Chinese Academy of Sciences and Qinghai Provincial Key Laboratory of Tibetan Medicine ResearchNorthwest Institute of Plateau BiologyXiningQinghai 810008China

Endoplasmic reticulum(ER)membrane protein complex(EMC)is required for the co-translational insertion of newly synthesized multi-transmembrane *** EMC function in different cell types has been implicated in multiple *** inducible genetic mouse models,we revealed defects in retinal vascularization upon endothelial cell(EC)specific deletion of Emc1,the largest subunit of *** of Emc1 in ECs led to reduced vascular progression and vascular density,diminished tip cell sprouts,and vascular *** then performed an unbiased transcriptomic analysis on human retinal microvascular endothelial cells(HRECs)and revealed a pivotal role of EMC1 in theβ-catenin signaling *** in-vitro and in-vivo experiments proved that loss of EMC1 led to compromisedβ-catenin signaling activity through reduced expression of Wnt receptor FZD4,which could be restored by lithium chloride(LiCl)*** by these findings,we screened genomic DNA samples from familial exudative vitreoretinopathy(FEVR)patients and identified one heterozygous variant in EMC1 that co-segregated with FEVR phenotype in the ***-vitro expression experiments revealed that this variant allele failed to facilitate the expression of FZD4 on the plasma membrane and activate theβ-catenin signaling pathway,which might be a main cause of *** conclusion,our findings reveal that variants in EMC1 gene cause compromisedβ-catenin signaling activity,which may be associated with the pathogenesis of FEVR.

关键词： Angiogenesis β-catenin signaling EMC1 Familial exudative vitreoretinopathy LiCl

The ER membrane protein complex subunit Emc3 controls angiogenesis via the FZD4/WNT signaling axis

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Science China(Life Sciences) 2021年第11期64卷 1868-1883页

作者： Mu Yang Shujin Li Wenjing Liu† Xiao Li yunqi he Yeming Yang Kuanxiang Sun Lin Zhang Wanli Tian Lixin Duan Huafu Chen Dezhong Yao Zhenglin Yang Xianjun Zhu Sichuan Provincial Key Laboratory for Human Disease Gene Study Department of Medical GeneticsSichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengdu 610072China Research Unit for Blindness Prevention of Chinese Academy of Medical Sciences(2019RU026) Sichuan Academy of Medical Sciences and Sichuan Provincial People’s HospitalChengdu 610072China Key Laboratory of Tibetan Medicine Research Chinese Academy of Sciences and Qinghai Provincial Key Laboratory of Tibetan Medicine ResearchNorthwest Institute of Plateau BiologyXining 810008China Department of Ophthalmology Shangqiu First People’s HospitalShangqiu 476000China Natural Products Research Center Institute of Chengdu BiologySichuan Translational Medicine HospitalChinese Academy of SciencesChengdu 610072China College of Life Sciences and Technology University of Electronic Science and Technology of ChinaChengdu 610072China

The endoplasmic reticulum(ER) membrane protein complex(EMC) regulates the synthesis and quality control of membrane proteins with multiple transmembrane domains. One of the membrane spanning subunits, EMC3, is a core member of the EMC complex that provides essential hydrophilic vestibule for substrate insertion. here, we show that the EMC subunit Emc3 plays critical roles in the retinal vascular angiogenesis by regulating Norrin/Wnt signaling. Postnatal endothelial cell(EC)-specific deletion of Emc3 led to retarded retinal vascular development with a hyperpruned vascular network, the appearance of bluntended, aneurysm-like tip endothelial cells(ECs) with reduced numbers of filopodia and leakage of erythrocytes at the vascular front. Diminished tube formation and cell proliferation were also observed in EMC3 depleted human retinal endothelial cells(HRECs). We then discovered a critical role for EMC3 in expression of FZD4 receptor of β-catenin signaling using RNA sequencing, real-time quantitative PCR(RT-q PCR) and luciferase reporter assay. Moreover, augmentation of Wnt activity via lithium chloride(Li Cl) treatment remarkably enhanced β-catenin signaling and cell proliferation of HRECs. Additionally, Li Cl partially reversed the angiogenesis defects in Emc3-c KO mice. Our data reveal that Emc3 plays essential roles in angiogenesis through direct control of FZD4 expression and Norrin/β-catenin signaling.

关键词： ER membrane protein complex Emc3 angiogenesis cell proliferation lithium chloride Wnt

The combination of gut microbiota-depleted treatment and fecal microbiota transplantation is an important strategy to verify the efficacy of Traditional Chinese Medicine though modulation of gut dysbiosis

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Journal of Traditional Chinese Medicine 2024年第1期44卷 222-223页

作者： XING yunqi LI Junxiang YUAN Yali MAO Tangyou Gastroenterology Department Dongfang HospitalBeijing University of Chinese MedicineBeijing 100078China Department of hepatology Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai 201203China

To the Editors:We read with great interest the study recently published by Sun et al 1 entitled“Electroacupuncture at Tianshu(ST25)and Zusanli(ST36)alleviates stress-induced irritable bowel syndrome in mice by modulating gut microbiota and corticotropin-releasing factor”in which the microbial details of electroacupuncture(EA)-induced protection in irritable bowel syndrome(IBS)were investigated.

关键词： releasing treatment details

Variants in the Wnt co-receptor LRP6 are associated with familial exudative vitreoretinopathy

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Journal of Genetics and Genomics 2022年第6期49卷 590-594页

作者： Shujin Li Mu Yang yunqi he Xiaoyan Jiang Rulian Zhao Wenjing Liu Lulin Huang Yi Shi Xiao Li Kuanxiang Sun Yeming Yang Periasamy Sundaresan Peiquan Zhao Zhenglin Yang Xianjun Zhu Sichuan Provincial Key Laboratory for Human Disease Gene Study Center for Medical GeneticsSichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuan 610072China Natural Products Research Center Institute of Chengdu BiologySichuan Translational Medicine HospitalChinese Academy of SciencesChengduSichuan 610072China Research Unit for Blindness Prevention of Chinese Academy of Medical Sciences(2019RU026) Sichuan Academy of Medical Sciences&Sichuan Provincial People’s HospitalChengduSichuan 610072China Department of Genetics Aravind Medical Research FoundationAravind Eye HospitalMaduraiIndia Department of Ophthalmology Xinhua Hospital Affiliated to Shanghai Jiaotong University School of MedicineShanghai 200092China henan Eye Institute Henan Eye HospitalPeople’s Hospital of Zhengzhou UniversityHenan Provincial People’s HospitalZhengzhouHenan 450003China

Familial exudative vitreoretinopathy(FEVR),an inherited eye disease,is characterized by abnormal retinal vascular development,such as neovascularization,vitreous hemorrhage,exudation,and retinal detachment(Criswick and Schepens,1969;Robitaille et al.,2002).FEVR is inherited as autosomal dominant,autosomal recessive,and X-linked patterns(de Crecchio et al.,1998).

关键词： familial vitreoretinopathy

Trends in Event Understanding and Caption Generation/Reconstruction in Dense Video:A Review

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Computers, Materials & Continua 2024年第3期78卷 2941-2965页

作者： Ekanayake Mudiyanselage Chulabhaya Lankanatha Ekanayake Abubakar Sulaiman Gezawa yunqi Lei Department of Computer Science Xiamen UniversityXiamen361005China Main Library Wayamba University of Sri LankaKuliyapitiya60200Sri Lanka School of Information Engineering Sanming UniversitySanming365004China

Video description generates natural language sentences that describe the subject,verb,and objects of the targeted *** video description has been used to help visually impaired people to understand the *** is also playing an essential role in devolving human-robot *** dense video description is more difficult when compared with simple Video captioning because of the object’s interactions and event *** learning is changing the shape of computer vision(CV)technologies and natural language processing(NLP).There are hundreds of deep learning models,datasets,and evaluations that can improve the gaps in current *** article filled this gap by evaluating some state-of-the-art approaches,especially focusing on deep learning and machine learning for video caption in a dense *** this article,some classic techniques concerning the existing machine learning were *** provides deep learning models,a detail of benchmark datasets with their respective *** paper reviews various evaluation metrics,including Bilingual EvaluationUnderstudy(BLEU),Metric for Evaluation of Translation with Explicit Ordering(METEOR),WordMover’s Distance(WMD),and Recall-Oriented Understudy for Gisting Evaluation(ROUGE)with their pros and ***,this article listed some future directions and proposed work for context enhancement using key scene extraction with object detection in a particular ***,how to improve the context of video description by analyzing key frames detection through morphological image ***,the paper discusses a novel approach involving sentence reconstruction and context improvement through key frame object detection,which incorporates the fusion of large languagemodels for refining *** ultimate results arise fromenhancing the generated text of the proposedmodel by improving the predicted text and isolating objects using various *** keyframes identify dense ev

关键词： Video description video to text video caption sentence reconstruction

Recent progress on rapid diagnosis of COVID-19 by point-of-care testing platforms

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Chinese Chemical Letters 2024年第3期35卷 66-75页

作者： Ya-Nan Tang Dingding Jiang Xuejun Wang yunqi Liu Dacheng Wei State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular ScienceFudan UniversityShanghai 200433China Institute of Molecular Materials and Devices Fudan UniversityShanghai 200433China

The outbreak of COVID-19 has drawn great attention around the ***-CoV-2 is a highly infectious virus with occult transmission by many mutations and a long incubation *** particular,the emergence of asymptomatic infections has made the epidemic even more ***,early diagnosis and timely management of suspected cases are essential measures to control the spread of the *** simple,portable,and accurate diagnostic techniques for SARS-CoV-2 is the key to epidemic *** advantages of point-of-care testing technology make it play an increasingly important role in viral detection and *** review summarizes the point-of-care testing platforms developed by nucleic acid detection,immunological detection,and nanomaterial-based biosensors ***,this paper provides a prospect for designing future highly accurate,cheap,and convenient SARS-CoV-2 diagnostic technology.

关键词： COVID-19 Point-of-care testing platforms Nucleic acid detection Asymptomatic infection Biosensors