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Genes & Diseases 2024年第4期11卷 109-112页

作者： Kaili Liao Yuhan Xu Bingying Lin Yuxuan Xie Qijun Yang Wenyige Zhang Beining Zhang Jiarong Wen Jingyi Wang Zimeng Li yunqi cheng Xiaozhong Wang Jiangxi Province Key Laboratory of Laboratory Medicine Jiangxi Provincial Clinical Research Center for Laboratory MedicineDepartment of Clinical LaboratoryThe Second Affiliated Hospital of Nanchang UniversityNanchangJiangxi 330006China Queen Mary College of Nanchang University NanchangJiangxi 330001China School of Public Health Nanchang UniversityNanchangJiangxi 330006China The Second Clinical Medical College Nanchang UniversityNanchangJiangxi 330006China The First Clinical Medical College of Nanchang University NanchangJiangxi 330006China

Pancreatic cancer is one of the most lethal malignant tumors in the *** advances in diagnosis and treatment,the five-year survival rate for pancreatic cancer patients remains only 9%.1 Pancreatic adenocarcinoma(PAAD)belongs to pancreatic cancer,which occupies 85%of the whole pancreatic cancer.2 Reversible modification of Ne-methyladenosine(m^(6)A)has been shown to be involved in cancer progression,resulting in up-regulation of oncogene expression or down-regulation of tumor-suppressing genes and may affect the prognosis of patients with pancreatic cancer.

关键词： patients cancer diagnosis

Transcriptomic analysis identifies a pan-cancer association of IL27 expression with cancer prognosis and immune microenvironment

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Genes & Diseases 2023年第2期10卷 393-395页

作者： Kaili Liao Jingyi Wang Zimeng Li Yuqiu Li yunqi cheng Yingcheng He Hongping Wan Xiaozhong Wang Department of Clinical Laboratory The Second Affiliated Hospital of Nanchang UniversityNanchangJiangxi 330006China School of Public Health Nanchang UniversityNanchangJiangxi 330006China Department of Pathology The First Affiliated Hospital of Nanchang UniversityNanchangJiangxi 330006China

Nowadays great progress has been made in targeted therapy and comprehensive therapy for a few cancers. But the prognosis of the vast majority of cancer patients is still weakness. It has been proven that inflammation can affect the development and treatment of cancer. Some previous studies have suggested that inflammation-related interleukins (ILs) play a significant role in the development of some cancers.1,2 ILs act as a considerable role in immunity,3 and inflammation affects the development of cancer. Therefore, the expression profile of IL gene may also be one of the vital markers of early pathological changes, occurrence and progression of cancer.4,5 Currently, studies on the expression of IL27 in cancer are still extremely limited. Our work comprehensively and systematically studied the IL27 gene expression in the generic cancer when compared with the existing IL27 gene related research experiment. We screened out cancer species linked with poor prognosis, and explored the correlation between IL27 gene expression and immune cell infiltration and immune microenvironment in these cancers further, providing an increasing number of the direct basis for subsequent studies. Our findings showed that IL27 can be used to assess prognosis and immune infiltration in patients with colon adenocarcinoma (COAD), glioblastoma multiforme (GBM), head and neck squamous cell carcinoma (HNSC), skin cutaneous melanoma (SKCM) and testicular germ cell tumors (TGCT) as a biomarker.

关键词： IL27 inflammation prognosis

探讨ANCA在嗜酸性肉芽肿性多血管炎分类中的价值

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中华临床免疫和变态反应杂志 2024年第2期18卷 110-118页

作者：刘怡彤程蕴琦彭敏张婷杨沛然施举红中国医学科学院北京协和医学院北京协和医院呼吸与危重症医学科北京100730 中国医学科学院北京协和医学院北京100730 呼吸和共病全国重点实验室生理学系中国医学科学院基础医学研究所北京协和医学院基础学院北京100005

目的嗜酸性肉芽肿性多血管炎(eosinophilic granulomatosis with polyangiitis,EGPA)中以血管炎为主要特征和以嗜酸性粒细胞浸润为主要特征的两种亚型分类标准尚未明确,本研究探讨EGPA两种亚型的准确、简明分类方式。方法回顾性收集2000... 详细信息

目的嗜酸性肉芽肿性多血管炎(eosinophilic granulomatosis with polyangiitis,EGPA)中以血管炎为主要特征和以嗜酸性粒细胞浸润为主要特征的两种亚型分类标准尚未明确,本研究探讨EGPA两种亚型的准确、简明分类方式。方法回顾性收集2000年1月—2023年11月北京协和医院呼吸内科、全科医学科、风湿免疫科等多科确诊的EGPA患者临床资料,将患者根据单纯抗中性粒细胞胞浆抗体(antineutrophil cytoplasmic antibodies,ANCA)、ANCA与组织病理活检结果相结合以及MIRRA标准三种分类方法分为不同的阳性组和阴性组,分析患者的临床特征。结果共纳入245例患者。根据ANCA结果分类时,阳性组51例,阴性组194例,相较于阴性组,阳性组患者的年龄(60.9比55.4)、NEUT%(59.12比51.87)、PLT(312.94比264.64)、ESR(55.40比27.62)、CRP(46.51比23.57)均较高,上述指标均达显著统计学意义;阳性组肾脏系统(47.1%比25.8%)和神经系统(72.5%比58.2%)的受累比例也显著高于阴性组。根据ANCA结果和组织病理活检结果分类时,阳性组88例,阴性组157例,两组间的分析结果与第一种分类方法一致。根据MIRRA标准分类时,MIRRA标准组患者161例,MIRRA非标准组患者84例,MIRRA标准组的NEUT%(55.39比49.58)显著高于MIRRA非标准组,而LY%(18.57比21.30)和HGB(128.80比136.36)显著低于MIRRA非标准组。结论根据ANCA结果可将EGPA患者分为血管炎亚型和嗜酸性粒细胞浸润亚型;尽管ANCA联合组织病理活检结果也可明确区分血管炎亚型与嗜酸性粒细胞浸润亚型,但由于病理活检存在风险,需根据患者的具体情况进行个体化评估;而MIRRA标准不能准确区分两类亚型。

关键词：嗜酸性肉芽肿性多血管炎抗中性粒细胞胞浆抗体 MIRRA研究

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城际列车开行方案评价模型的适用性分析

同济大学学报（自然科学版） 2008年第1期36卷 52-56页

作者：徐行方程赟奇同济大学运输管理工程系上海201804 阿尔斯通技术股务上海有限公司上海200021

应用两种基于模糊数学理论的评价模型,分别对相同城际列车开行方案进行评价,在得出相反结论的情况下,通过对两模型的比较分析,发现其中一个模型本身所存在的数理缺陷是导致相反结论产生的原因.根据矛盾产生的机理,给出了合理使用两种模... 详细信息

应用两种基于模糊数学理论的评价模型,分别对相同城际列车开行方案进行评价,在得出相反结论的情况下,通过对两模型的比较分析,发现其中一个模型本身所存在的数理缺陷是导致相反结论产生的原因.根据矛盾产生的机理,给出了合理使用两种模型的建议.

关键词：城际列车开行方案评价模型适用性

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人类命运共同体的生成逻辑与实践探赜

学术交流 2020年第2期 61-70页

作者：程运麒北京大学习近平新时代中国特色社会主义研究院北京100871

人类命运共同体理念的合理内核是对于人类共同价值利益的追求和共同的责任担当,体现的是中国在实现本国发展基础上对世界的合理观照。从历史发生学的角度看,人类命运共同体的生成逻辑经历了冲突的原点和互动中的初步萌发,目前正处于构... 详细信息

人类命运共同体理念的合理内核是对于人类共同价值利益的追求和共同的责任担当,体现的是中国在实现本国发展基础上对世界的合理观照。从历史发生学的角度看,人类命运共同体的生成逻辑经历了冲突的原点和互动中的初步萌发,目前正处于构建阶段。面对不合理的国际秩序、不均衡的发展、不理性的文化判断和不对等的责任义务,我们应该加快构建以合作共赢为核心的人类命运共同体。具体来说,要加强"一带一路"建设,以负责任的大国形象推进人类命运共同体构建。强化周边外交,以共同的价值观念推进人类命运共同体构建。参与全球治理,身体力行地推进人类命运共同体构建。当前,我们正处于抗击新型冠状肺炎的关键期,面对未来可能出现的全球性多点爆发,凝聚共识、共同作为和共担责任的人类命运共同体理念能够为抗击疫情提供几点启示。

关键词：人类命运共同体生成逻辑实践

TypeⅠcritical dynamical scalarization and descalarization in Einstein-Maxwell-scalar theory

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Science China(Physics,Mechanics & Astronomy) 2024年第2期67卷 40-58页

作者： Jia-Yan Jiang Qian Chen yunqi Liu Yu Tian Wei Xiong cheng-Yong Zhang Bin Wang Department of Physics and Siyuan Laboratory Jinan UniversityGuangzhou 510632China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China Center for Gravitation and Cosmology College of Physical Science and TechnologyYangzhou UniversityYangzhou 225009China Institute of Theoretical Physics Chinese Academy of SciencesBeijing 100190China School of Physics and Optoelectronics South China University of TechnologyGuangzhou 510641China School of Aeronautics and Astronautics Shanghai Jiao Tong UniversityShanghai 200240China

We investigated the critical dynamical scalarization and descalarization of black holes within the framework of the EinsteinMaxwell-scalar theory featuring higher-order coupling *** the critical scalarization and descalarization displayed first-order phase *** examining the nonlinear dynamics near the threshold,we always observed critical solutions that are linearly unstable static scalarized black *** critical dynamical scalarization and descalarization share certain similarities with the typeⅠcritical gravitational ***,their initial configurations,critical solutions,and final outcomes differ *** provide further insights into the dynamical results,we conducted a comparative analysis involving static solutions and perturbative analysis.

关键词： black hole(de)scalarization dynamical critical behavior attractor

基于UNIX下ILAS系统数据库的自动修复设计与实现

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中南民族大学学报（自然科学版） 2007年第3期26卷 81-83页

作者：成云启中南民族大学图书馆武汉430074

在介绍ILAS图书管理系统及专用数据库的同时,指出了该管理系统软件中对数据库修复方法的不足,提出了在UNIX系统下针对出错的数据库实现自动识别和自动修复的解决策略及实现方法.

关键词：图书馆自动化集成系统大型数据库管理系统重组压缩

Triple reverse order law for the Drazin inverse

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Applied Mathematics(A Journal of Chinese Universities) 2024年第1期39卷 55-68页

作者： WANG Hua ZHONG cheng-cheng College of Sciences Inner Mongolia University of TechnologyHohhot 010051China College of Engineering University of Jinan Quancheng CollegeYantai 265600China

In this paper,we investigate the reverse order law for Drazin inverse of three bound-ed linear operators under some commutation ***,the Drazin invertibility of sum is also obtained for two bounded linear operators and... 详细信息

关键词： Drazin inverse reverse order law space decomposition

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李季《社会主义史》马克思章的译介问题研究

重庆社会科学 2020年第8期 61-70页

作者：程运麒中国政法大学马克思主义学院北京102249

作为早期传播社会主义的白话文著作,李季翻译的《社会主义史》在20世纪20年代热销一时,毛泽东同志曾将其列为影响他接受并树立马克思主义信仰的三本书之一。受20世纪中国文化需求的驱动,李季选定《社会主义史》着手翻译。该著在马克思... 详细信息

作为早期传播社会主义的白话文著作,李季翻译的《社会主义史》在20世纪20年代热销一时,毛泽东同志曾将其列为影响他接受并树立马克思主义信仰的三本书之一。受20世纪中国文化需求的驱动,李季选定《社会主义史》着手翻译。该著在马克思主义专业术语的译介上兼有中国传统文化和日本文化的特点,这也是马克思主义早期传播的鲜明特色。但在一些重点词汇的译介上,李季更倾向于从汉语中选择新的对应词来取代日语词。这一方面体现了译介的发展脉络,另一方面也展现出译者将中华文化中心化的趋势。胡贻谷《泰西民法志》是克卡朴《社会主义史》的第一个中译本,与李季《社会主义史》在翻译动机与风格方面十分迥异,但在马克思的观点阐释和翻译策略方面却存在相似性。通过对两个译本的对比研究,可以进一步认识马克思主义早期译介的规律以及“归化”的翻译策略。

关键词：马克思主义早期传播《社会主义史》李季译介归化

Analysis of multi-objective optimisation method for main insulation structure configuration scheme of valve-side winding of ultra-high voltage converter transformer considering multi-field coupling

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High Voltage 2024年第2期9卷 296-308页

作者： Lijun Yang Zhidong cheng Li cheng Ruijin Liao State Key Laboratory of Power Transmission Equipment Technology School of Electrical EngineeringChongqing UniversityChongqingChina

Because DC conductivities of oil-paper materials can be easily affected by electric field and temperature,the electrical properties under electro-thermal coupling of oil-paper materials should be considered when optimising the insulation structure of valve-side winding of the converter *** on the finite element multi-physical field coupling simulation,the multi-objective optimisation of main insulation structure of valve-side winding is carried *** view of the high time consuming of multi-physical field calculation and the actual needs of an insulation structure optimisation,the Kriging method and technique for order preference by similarity to the ideal solution(TOPSIS)method are introduced,and combines them with NSGA-II to obtain a joint algorithm that can be used for the optimisation of insulation structure of the converter *** using the joint algorithm of multi-objective optimisation,the insulation structure configuration scheme of valve-side winding is *** can be seen from the experiment result that,on the one hand,the joint algorithm adopted can obtain the insulation structure configuration scheme that meets the design *** the other hand,when facing the configuration scheme optimisation under multi-field coupling,the computational time required by this method is only 0.15%of that required by original genetic algorithm.

关键词： converter insulation coupling