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Journal of Clinical and Nursing Research 2024年第8期8卷 83-91页

作者： yunjing zhang Yuting Zheng Affiliated Children Hospital of Kunming Medical University Kunming 650103Yunnan ProvinceChina

Objective:The study reviews status,main time nodes and hospital discharge services for family caregivers of children with Kawasaki disease complicated by coronary artery aneurysm to provide references for the development of hospital discharge preparation services for medical personnel and ***:CAL of Kawasaki disease is the main cause of acquired heart disease in children,but there is not enough research on the readiness for hospital ***:Systematic review of observational and interventional studies.

关键词： Hospital discharge plan Family caregivers Kawasaki disease Systematic review

Preliminary assessment of the data appropriateness of electronic health records for real-world studies:A survey of hospitals in a developing region in China

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Chinese Medical Journal 2024年第9期137卷 1130-1131页

作者： Yuelin Yu Lin Zhuo Ruogu Meng Wanqian Guo Yuanyuan Chen yunjing zhang Ying Chen Hongjing Shi Zhi Lin Siyan Zhan Shengfeng Wang Department of Epidemiology and Biostatistics School of Public HealthPeking UniversityBeijing 100191China Research Center of Clinical Epidemiology Peking University Third HospitalBeijing 100191China National Institute of Health Data Science Peking UniversityBeijing 100191China Health Science Center Peking UniversityBeijing 100191China

To the Editor:Assessment of data appropriateness is a process to answer whether electronic health records(EHRs)from routine healthcare practices couldt intended study purposes,for example,available to be proceeded,with enough individual records,with relevant information able to be extracted from records,etc.[1-3]This has been increasingly underscored as a prerequisite when using EHRs(one important type of real-world data[RWD])for scientic purposes.[4-6]Although controversies remain on the denitions,types and assessment methods of the dimensions of RWD appropriateness,the latest ofcial guidelines(i.e.,from the *** and Drug Administration[FDA][4]and China National Medical Products Administration[NMPA][6])suggest that the assessment start from a preliminary stage on variable existence,and subsequently deepen into the issue of data value(such as missing value,outliers,etc.),as the preliminary assessment is the foundation of the overall RWD appropriateness.[7]Little is known about the appropriateness of EHRs in developing regions,which feature high visit volumes and a great number of ***,this study aimed to preliminarily investigate RWD appropriateness from hospitals in developing regions from the perspective of core variables’comparison.

关键词： electronic dimensions records

Recent advances in engineered nanomaterials for acute kidney injury theranostics

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Nano Research 2021年第4期14卷 920-933页

作者： Lefeng Wang yunjing zhang Yangyang Li Jianghua Chen Weiqiang Lin Kidney Disease Center the First Affiliated Hospital Zhejiang University School of MedicineInstitute of NephrologyZhejiang UniversityHangzhou 310003China Key Laboratory of Kidney Disease Prevention and Control Technology Hangzhou 310003China The Fourth Affiliated Hospital Institute of Translational Medicine Zhejiang University School of MedicineJinhua 322000China Key Laboratory of Womens Reproductive Health Research of Zhejiang Province Womens Hospital Zhejiang University School of Mediciney Hangzhou 310006China

Acute kidney injury(AKI),has become the focus of increasing attention due to its high risk of *** early diagnosis and treatment of AKI significantly reduce the risk of renal tissue damage and kidney ***,the efficient early diagnosis and treatment approach for AKI remains a *** screening via precise nanomaterial theranostics is a new alternative *** study summarizes the recent advances in functional nanomaterials in the early detection and treatment of *** challenges and problems in the use of nanomaterials for AKI in clinical applications are also *** is anticipated that highlighting these new advances will lay the foundation for further translational research on the promising application of nanomaterials for AKI.

关键词： acute kidney injury nanomaterials early detection therapy translational applications

基于改进SARSA算法的航空器滑行路径规划

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郑州航空工业管理学院学报 2024年第1期42卷 43-48页

作者：张云景王昊王帅孟斌郑州航空工业管理学院民航学院河南郑州450046 河海大学江苏南京211100

航空器滑行是机场运行中最重要的一环,缩短滑行时间也是提高机场运行效率的主要手段。为了改变仅依靠人工进行机坪管制的现状,文章针对航空器滑行的特殊环境,利用改进SARSA算法对航空器的滑行路径进行规划,并通过仿真验证了该算法在规... 详细信息

航空器滑行是机场运行中最重要的一环,缩短滑行时间也是提高机场运行效率的主要手段。为了改变仅依靠人工进行机坪管制的现状,文章针对航空器滑行的特殊环境,利用改进SARSA算法对航空器的滑行路径进行规划,并通过仿真验证了该算法在规划路径长度和迭代次数方面优于传统SARSA算法,进而更好地为管制员决策提供辅助参考。

关键词：强化学习路径规划模拟退火策略 SARSA算法

不同性别人群外周血单核细胞与高密度脂蛋白胆固醇比与甲状腺乳头状癌的关联性研究

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中国全科医学 2024年第25期27卷 3159-3163,3170页

作者：李志勇李国华黄鹏飞张云静娄贤哲赵俊暕华北理工大学附属医院医学检验科河北省唐山市063200 河北省唐山市第二医院功能检查科河北省唐山市063200 华北理工大学河北省唐山市063200

背景甲状腺癌(TC)是内分泌系统最常见的恶性肿瘤,近年来其发病率增长迅速。甲状腺乳头状癌(PTC)是最常见的甲状腺癌类型,占所有TC的80%。尽管手术治疗、放射性碘治疗、促甲状腺激素(TSH)抑制治疗和新型靶向药物治疗取得一定疗效,但是早... 详细信息

背景甲状腺癌(TC)是内分泌系统最常见的恶性肿瘤,近年来其发病率增长迅速。甲状腺乳头状癌(PTC)是最常见的甲状腺癌类型,占所有TC的80%。尽管手术治疗、放射性碘治疗、促甲状腺激素(TSH)抑制治疗和新型靶向药物治疗取得一定疗效,但是早期诊断和干预才是阻止其发生、发展的关键,然而目前临床上PTC相关敏感性指标仍然缺乏。目的探讨脂代谢、炎症相关指标与PTC的相关性。方法选择2018年1月—2020年12月华北理工大学附属医院诊治的PTC患者作为病例组(n=370),根据病例组性别和年龄匹配同期体检健康人群为对照组(n=1112)。收集两组年龄、性别、吸烟情况、BMI、外周血白细胞计数(WBC)、血小板计数(PLT)、淋巴细胞计数(LYM)、单核细胞计数(MON)、中性粒细胞计数(NEU)、空腹血糖(FBG)、丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、尿素(UREA)、肌酐(Cr)、尿酸(UA),计算中性粒细胞与淋巴细胞比(NLR)、血小板与淋巴细胞比(PLR)、淋巴细胞与单核细胞比(LMR)、单核细胞与高密度脂蛋白胆固醇比(MHR),分析其与PTC的相关性及其诊断价值。结果与对照组比较,病例组患者外周血中WBC、LYM、MON、LDL-C、MHR均高于对照组(P<0.001)。不同性别PTC患者PLR、LYM、MHR比较,差异有统计学意义(P<0.05)。在相关性分析中,女性PTC患者MHR指标与肿瘤大小呈正相关(r=0.582,P<0.05);而男性PTC患者MHR与肿瘤大小的相关性较弱(r=0.355,P<0.05)。二元Logistic回归分析结果显示:在女性PTC患者中,PLR为保护因素(OR=0.475,P=0.004),LYM、MHR为危险因素[(OR=1.605,P=0.044)、(OR=2.659,P<0.001)];在男性患者中:PLR(OR=0.280,P=0.011)、MHR(OR=0.312,P=0.029)为保险因素。MHR在男女PTC患者中的AUC分别为0.548和0.652,提示MHR指标在女性PTC患者的诊断价值高于男性。结论MHR与PTC的发生相关联,在女性中是独立危险因素,在男性中是保护因素。

关键词：甲状腺癌炎症指标性别差异肿瘤大小

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教育元宇宙背景下线上教学的虚实互促研究

高教学刊 2024年第18期10卷 10-13页

作者：孙怡峰吴疆张云景刘小虎汪永伟战略支援部队信息工程大学郑州450004 郑州航空工业管理学院郑州450015

元宇宙描绘未来的虚实共生、虚实链接。该文给出元宇宙背景下线上教学场景,针对线上教学中的学生“虚位”与作业“虚化”两个问题,分析线上教学的虚拟数字对象与物理实体对象的特点,提出采用多模态感知学生状态、推演式知识运用、区块... 详细信息

元宇宙描绘未来的虚实共生、虚实链接。该文给出元宇宙背景下线上教学场景,针对线上教学中的学生“虚位”与作业“虚化”两个问题,分析线上教学的虚拟数字对象与物理实体对象的特点,提出采用多模态感知学生状态、推演式知识运用、区块链数字作业价值信任和教师数字成果价值流动等虚实互促着力点,为提升线上教学质量提供支撑。

关键词：线上教学元宇宙作业抄袭学生虚位虚实互促

2019-2022年我国部分地区鸡滑液囊支原体分离株基因分型及vlhA基因进化分析

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中国家禽 2024年第6期46卷 112-117页

作者：翟路峰吴营霞金云云赵旭冉田克恭张云静逄文强国家兽用药品工程技术研究中心河南洛阳471003 普莱柯生物工程股份有限公司河南洛阳471000

为了解我国鸡滑液囊支原体(MS)的最新感染情况,试验对2019-2022年在我国河南、河北、山东、安徽、江苏5个省份收集的152份疑似MS感染的鸡病料进行MS分离鉴定,对分离的MS菌株进行基因分型,并对其vlhA基因5′端保守区域(76~421 nt)进行遗... 详细信息

为了解我国鸡滑液囊支原体(MS)的最新感染情况,试验对2019-2022年在我国河南、河北、山东、安徽、江苏5个省份收集的152份疑似MS感染的鸡病料进行MS分离鉴定,对分离的MS菌株进行基因分型,并对其vlhA基因5′端保守区域(76~421 nt)进行遗传进化分析。结果显示:共分离到29株MS菌株,除其中1株为E型外,其余28株均为L型;29株MS均处在一个大的进化分支,与国内流行菌株亲缘关系较近,与国外流行菌株亲缘关系较远。研究提示:近四年我国流行的MS菌株相对独立,各地流行菌株同源性较高。

关键词：鸡滑液囊支原体基因型 vlhA基因 L型

Fluvastatin protects against puromycin aminonucleoside-induced podocyte injury by inhibiting TRPC6

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Journal of Chinese Pharmaceutical Sciences 2022年第5期31卷 360-368页

作者： Hui Gao yunjing zhang Jing Lin Xifeng Sun Department of Urology Zibo Central HospitalZibo 255036China Department of Nephrology Zibo Central HospitalZibo 255036China Department of Cardiology Shaanxi Provincial People’s HospitalXian 710068China

In the present study,we aimed to investigate the effect of puromycin aminonucleoside(PAN)on the expression and distribution of transient receptor potential canonical 6(TRPC6)of murine podocytes and further study the protective mechanism of fluvastatin on podocyte injury by TRPC6 in *** were treated by PAN at different doses and at different time *** expressions of TRPC6 at mRNA and protein levels were *** immunofluorescent assay was used to observe the distribution of *** podocytes were then divided into four *** expressions of TRPC6 at mRNA and protein levels were *** intracellular calcium concentration of podocytes was measured with a laser-scanning confocal *** paracellular permeability to BSA was evaluated using Millicell-PCF *** expressions of TRPC6 at mRNA and protein levels were increased in a dose and time-dependent manner after exposure to *** showed that the expression intensity of TRPC6 was significantly increased,and the distribution of TRPC6 was changed after PAN was applied to *** fluvastatin intervention,PAN-induced up-regulation of TRPC6 was significantly *** ratio of the peak value of intracellular calcium to the basic calcium value in the PAN group was significantly higher after TRPC6 was activated by OAG,while it is obviously reversed under the action of *** podocyte permeability was significantly increased after 48 h of PAN treatment,while the above situation was effectively improved after fluvastatin *** changes of distribution and expression of TRPC6 were related to podocyte injury induced by *** could exert its protective effects on podocytes by down-regulating TRPC6.

关键词： TRPC6 Podocyte Puromycin aminonucleoside Fluvastatin Calcium

The CRL3^(BTBD9) E3 ubiquitin ligase complex targets TNFAIP1 for degradation to suppress cancer cell migration

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Signal Transduction and Targeted Therapy 2020年第1期5卷 1984-1992页

作者： Lihui Li Wenjuan zhang Yue Liu Xiaojun Liu Lili Cai Jihui Kang yunjing zhang Wenlian Chen Changsheng Dong Yanmei zhang Mingsong Wang Wenyi Wei Lijun Jia Cancer Institute Longhua HospitalShanghai University of Traditional Chinese MedicineShanghaiChina Cancer Institute Fudan University Shanghai Cancer CenterFudan UniversityShanghaiChina Department of Laboratory Medicine Huadong HospitalAffiliated to Fudan UniversityShanghaiChina Xinhua Hospital Shanghai Jiaotong UniversityShanghaiChina Department of Pathology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA

Tumor necrosis factor alpha-induced protein 1(TNFAIP1)modulates a plethora of important biological processes,including tumorigenesis and cancer cell ***,the regulatory mechanism of TNFAIP1 degradation remains largely *** the present study,with a label-free quantitative proteomic approach,TNFAIP1 was identified as a novel ubiquitin target of the Cullin-RING E3 ubiquitin ligase(CRL)*** importantly,Cul3-ROC1(CRL3),a subfamily of CRLs,was identified to specifically interact with TNFAIP1 and promote its polyubiquitination and ***,BTBD9,a specific adaptor component of CRL3 complex,was further defined to bind and promote the ubiquitination and degradation of TNFAIP1 in *** such,downregulation of BTBD9 promoted lung cancer cell migration by upregulating the expression of TNFAIP1,whereas TNFAIP1 deletion abrogated this ***,bioinformatics and clinical sample analyses revealed that BTBD9 was downregulated while TNFAIP1 was overexpressed in human lung cancer,which was associated with poor overall survival of *** together,these findings reveal a previously unrecognized mechanism by which the CRL3^(BTBD9) ubiquitin ligase controls TNFAIP1 degradation to regulate cancer cell migration.

关键词： TNFAIP1 CRL complex

EDU-GAN:Edge Enhancement Generative Adversarial Networks with Dual-Domain Discriminators for Inscription Images Denoising

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Computers, Materials & Continua 2024年第7期80卷 1633-1653页

作者： yunjing Liu Erhu zhang Jingjing Wang Guangfeng Lin Jinghong Duan School of Mechanical and Precision Instrument Engineering Xi’an University of TechnologyXi’an710048China Department of Information Science Xi’an University of TechnologyXi’an710054China School of Faculty of Painting Packaging Engineering and Digital MediaXi’an University of TechnologyXi’an710048China School of Computer Science and Engineering Xi’an University of TechnologyXi’an710048China

Recovering high-quality inscription images from unknown and complex inscription noisy images is a challenging research *** fromnatural images,character images pay more attention to stroke ***,existingmodelsmainly consider pixel-level informationwhile ignoring structural information of the character,such as its edge and glyph,resulting in reconstructed images with mottled local structure and character *** solve these problems,we propose a novel generative adversarial network(GAN)framework based on an edge-guided generator and a discriminator constructed by a dual-domain U-Net framework,i.e.,*** existing frameworks,the generator introduces the edge extractionmodule,guiding it into the denoising process through the attention mechanism,which maintains the edge detail of the restored inscription ***,a dual-domain U-Net-based discriminator is proposed to learn the global and local discrepancy between the denoised and the label images in both image and morphological domains,which is helpful to blind denoising *** proposed dual-domain discriminator and generator for adversarial training can reduce local artifacts and keep the denoised character structure *** to the lack of a real-inscription image,we built the real-inscription dataset to provide an effective benchmark for studying inscription image *** experimental results show the superiority of our method both in the synthetic and real-inscription datasets.

关键词： Dual-domain discriminators inscription images denoising edge-guided generator