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Current and future perspectives on the regulation and functions of miR-545 in cancer development

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Cancer Pathogenesis and Therapy 2024年第3期2卷 142-154页

作者： Jinze Shen Xinming Su Qurui wang Yufei Ke Tianyu Zheng yunan Mao Zehua wang Jingyin Dong Shiwei Duan Key Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province School of MedicineHangzhou City UniversityHangzhouZhejiang 310015China

Micro ribonucleic acids(miRNAs)are a highly conserved class of single-stranded non-coding *** the miR-545/374a cluster,miR-545 resides in the intron of the long non-coding RNA(lncRNA)FTX on *** precursor form,pre-miR-545,is cleaved to generate two mature miRNAs,miR-545-3p and ***,these two miRNAs exhibit distinct aberrant expression patterns in different cancers;however,their expression in colorectal cancer remains ***,miR-545-3p is affected by 15 circular RNAs(circRNAs)and 10 long non-coding RNAs(lncRNAs),and it targets 27 protein-coding genes(PCGs)that participate in the regulation of four signaling *** contrast,miR-545-5p is regulated by one circRNA and five lncRNAs,it targets six PCGs and contributes to the regulation of one signaling *** miR-545-3p and miR-545-5p affect crucial cellular behaviors,including cell cycle,proliferation,apoptosis,epithelial-mesenchymal transition,invasion,and *** low miR-545-3p expression is associated with poor prognosis in three cancer types,studies on miR-545-5p are yet to be ***-545-3p operates within a diverse range of regulatory networks,thereby augmenting the efficacy of cancer chemotherapy,radiotherapy,and ***,miR-545-5p enhances immunotherapy efficacy by inhibiting T-cell immunoglobulin and mucin-domain containing-3(TIM-3)*** summary,miR-545 holds immense potential as a cancer biomarker and therapeutic *** aberrant expression and regulatory mechanisms of miR-545 in cancer warrant further investigation.

关键词： miR-545 Competing endogenous RNA Cell behavior Biomarker Therapeutic drug Immunotherapy

Constructing thermoresponsive PNIPAM-based microcarriers for cell culture and enzyme-free cell harvesting

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Chinese Chemical Letters 2024年第7期35卷 412-416页

作者： yunan Yuan Zhimin Luo Jie Chen Chaoliang He Kai Hao Huayu Tian CAS Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei 230026China College of Chemistry and Chemical Engineering Xiamen UniversityXiamen 361005China Jilin Biomedical Polymers Engineering Laboratory Changchun 130022China Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province(IKKEM) Xiamen 361005China

The development of large-scale cell cultivation and non-invasive cell harvesting is highly desired in various fields,including biological regeneration and pharmaceutical *** using traditional microcarriers for cell culture,trypsinization is often necessary during cell collection,leading to partial cells *** this work,we developed a thermoresponsive glass microcarrier modified with poly(γ-propargyl-L-glutamate)(PPLG)and poly(N-isopropylacrylamide)(PNIPAM).We utilized these microcarriers for three-dimensional cell culture and enzyme-free cell harvesting,and the results indicated that the prepared microcarriers exhibited excellent non-invasive cell culture performance.

关键词： Microcarrier Temperature-responese PNIPAM Polymers Cell culture

Integrated analyses of transcriptomics and network pharmacology reveal leukocyte characteristics and functional changes in subthreshold depression,elucidating the curative mechanism of Danzhi Xiaoyao powder

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Journal of Traditional Chinese Medical Sciences 2024年第1期11卷 3-20页

作者： Kunyu Li Leiming You Jianhua Zhen Guangrui Huang Ting wang Yanan Cai yunan Zhang Anlong Xu School of Life Sciences Bejing University of Chinese MedicineBeijing 102488China School of Life Sciences Sun Yat-Sen UniversityGuangzhou 510006Chin

Objective:To investigate the molecular mechanism and identify potential drugs for subthreshold depression(SD),and elucidate the detalied mechanism of Danzhi Xiaoyao powder(DZXY)in ***:Using RNA-sequencing,we identified differentially expressed genes(DEGs)in leukocytes of SD compared to healthy controls,deciphered their functions and pathways,and identified the hub genes of *** also assessed changes in leukocyte transcription factor activity in patients with SD using the TELis *** Connectivity Map database was retrieved to screen candidate drugs for *** on network pharmacology,we elucidated the"multi-component,multi-target,and multi-pathway"mechanism of DZXY in the treatment of ***:We identified 1080 DEGs(padj<0.05 and|log2(fold change)l≥1&protein coding)in the leukocytes of patients with *** DEGs,including hub genes,were primarily involved in immune and inflammatory response-related *** factor activity analysis revealed similarities between the leukocyte transcriptome profile in SD and the conserved transcriptional response to adversities in immune *** Map analysis identified 28 potential drugs for SD treatment,particularly SB-202190 and *** the"Direct Compounds-Direct Targets-Pathways"network for DZXY and SD revealed the curative mechanisms of DZXY in SD,primarily including inflammatory response,lipid metabolism,immune response,and other ***:These results provide new insights into the characteristics and functional changes of leukocytes in SD,partially illustrate the pathogenesis of SD,and suggest potential drugs for *** curative mechanisms of DZXY in SD are also partially elucidated.

关键词： Subthreshold depression Leukocyte mRNAbiomarker CTRA Transcription factor activity CMap Danzhi Xiaoyaopowder Networkpharmacology

供应链稳定视角下跨境电商与物流融合发展路径研究

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商业经济研究 2022年第6期 107-110页

作者：王宇楠辽宁对外经贸学院信息管理学院辽宁大连116052

维持供应链的稳定性,是我国积极应对全球复杂的市场环境与贸易严峻形势,在逆势中增强自主可控能力、获得市场竞争力的关键所在。本文基于供应链稳定的视角,研究了我国跨境电商与物流融合发展的路径。核心思路是基于跨境电商与物流在技... 详细信息

维持供应链的稳定性,是我国积极应对全球复杂的市场环境与贸易严峻形势,在逆势中增强自主可控能力、获得市场竞争力的关键所在。本文基于供应链稳定的视角,研究了我国跨境电商与物流融合发展的路径。核心思路是基于跨境电商与物流在技术业务和运作上的融合,构建内部稳定机制和外部稳定机制,其中内部稳定机制主要根据不同的流通阶段,基于系统模块、企业主体和关系路径,构建自由选择机制、信息共享机制和利益分配机制;外部稳定机制则主要是通过海关协议约束、政府管理与政策扶持,为两者融合提供外部环境保障。最后,为有效实现该机制的运作,本文从技术、营商环境和设施供给三个层面提出了相关的对策建议。

关键词：供应链稳定跨境电商物流融合发展

Transition metal doped mesoporous titania with a crystalline framework as catalysts for oxidation of p-bromotoluene to pbromobenzaldehyde

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Frontiers of Chemical Science and Engineering 2008年第3期2卷 296-300页

作者： Zehui YANG Lihui YIN Encai OU yunan wang Li PENG Jiaqiang wang Department of Applied Chemistry Key Laboratory of Medicinal Chemistry for Natural Resource(Yunnan University)Ministry of EducationYunnan UniversityKunming 650091China Yantai Shougang Dongxing(Group)Co. Yantai 264006China

Transition metal M(M=Mn,Fe,Co,Ni,Cu,and Zn)doped mesoporous titania with a crystalline framework was employed as catalysts for the oxidation of p-bromotoluene(PBT)to p-bromobenzaldehyde(BBD)in acetic acid using aqueous hydrogen peroxide as *** was found that mesoporous TiO_(2) doped with those metals(Fe,Co and Ni)whose atomic radii are relatively smaller exhibited higher conversion rate of *** these catalysts,the Co/meso-TiO_(2) exhibited high substrate conversion and good product(p-bromobenzaldehyde)selectivity plus it can be reused once with almost the same *** effect of different Ti/Co(molar)ratio on the activities of Co/meso-TiO_(2) was also investigated.

关键词： Oxidation p-Bromotoluene p-Bromobenzaldehyde Crystalline cobalt mesoporous titania

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论合同解除权诉讼上行使的性质及司法规则

安徽大学学报:哲学社会科学版 2023年第5期47卷 105-112页

作者：王毓男牛翔华东政法大学知识产权学院上海200042 浙江工商大学长三角(先行)法治研究院浙江杭州310012

《民法典》第562条~566条规定的合同解除权是一种普通形成权,可以在诉讼外及诉讼上自由行使。不同于形成诉权,合同解除权行使之诉为确认之诉。合同解除权诉讼上行使的效果应依实体法的规定处理。原告撤回诉讼、变更诉讼请求为继续履行... 详细信息

《民法典》第562条~566条规定的合同解除权是一种普通形成权,可以在诉讼外及诉讼上自由行使。不同于形成诉权,合同解除权行使之诉为确认之诉。合同解除权诉讼上行使的效果应依实体法的规定处理。原告撤回诉讼、变更诉讼请求为继续履行等或与被告达成调解的,合同是否已经解除,应根据解除意思是否到达对方及行使解除权的行为是否具备实体法规定的要件进行判断。经相对人同意,解除权人可撤销解除合同的意思表示,但若因此损害第三方利益且第三方提起诉讼的,法院应依实体法的规定审查前诉中合同解除的期间,并作出相应处理。

关键词：合同解除权实体法诉讼法确认之诉形成之诉

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基于变步长LMS方法的磁悬浮飞轮振动抑制

动力学与控制学报 2022年第3期20卷 77-82页

作者：王雨楠刘昆中山大学航空航天学院广州510275

针对磁悬浮飞轮转子位移传感器扰动引起的多频谐波振动,提出一种基于最小均方差(LMS)的变步长算法实现谐波振动的有效抑制.建立模型对磁悬浮轴承转子的位移刚度系数κ_(h)和电流刚度系数k_(i)片进行辨识,以位移传感器扰动引起的八倍频... 详细信息

针对磁悬浮飞轮转子位移传感器扰动引起的多频谐波振动,提出一种基于最小均方差(LMS)的变步长算法实现谐波振动的有效抑制.建立模型对磁悬浮轴承转子的位移刚度系数κ_(h)和电流刚度系数k_(i)片进行辨识,以位移传感器扰动引起的八倍频噪声为抑制目标,在自适应LMS算法抑制电流扰动基础上,改进一种随转子位移信号频率变化而变化的变步长因子实现自动平衡,利用广义根轨迹分析了引入补偿后系统的闭环稳定性.仿真结果表明所提出的方法能够有效实现对八倍频振动的抑制.

关键词：主动磁悬浮轴承 LMS算法位移传感器扰动振动控制

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正弦脉动激励对气膜冷却特性的影响

中南大学学报（自然科学版） 2023年第7期54卷 2892-2903页

作者：王宇楠王春华李录博张靖周南京航空航天大学能源与动力学院航空飞行器热管理与能量利用工信部重点实验室江苏南京210016

为了探究正弦脉动激励对气膜冷却特性的影响,采用大涡模拟方法,针对具有正弦脉动特征的气膜冷却射流与平板主流的相干机制展开研究,在平均吹风比为0.5和1.5的条件下重点研究脉动频率和幅值对气膜冷却流动传热的影响。研究结果表明:在高... 详细信息

为了探究正弦脉动激励对气膜冷却特性的影响,采用大涡模拟方法,针对具有正弦脉动特征的气膜冷却射流与平板主流的相干机制展开研究,在平均吹风比为0.5和1.5的条件下重点研究脉动频率和幅值对气膜冷却流动传热的影响。研究结果表明:在高吹风比工况下,冷气脉动有助于提高气膜冷却性能,而在低吹风比工况下,作用效果完全相反;增大脉动幅值强化了肾形涡对的卷吸作用,而脉动频率变化的影响则不明显;在正弦脉动下,没有出现方波脉动那样大尺度的起动涡结构;与连续性射流相比,脉动射流可以显著提升气膜孔下游的湍流动能,但随着流向距离增加,脉动射流的影响变弱;功率谱密度分析结果表明,冷气脉动对小尺度涡旋能量的影响较明显。

关键词：射流脉动气膜冷却肾形涡正弦激励边界层大涡模拟冷却效率

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Bio-soft matter derived from traditional Chinese medicine:Characterizations of hierarchical structure,assembly mechanism,and beyond

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Journal of Pharmaceutical Analysis 2024年第6期14卷 823-839页

作者： Guiya Yang Yue Liu Yuying Hu Yue Yuan yunan Qin Quan Li Shuangcheng Ma School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing102488China Institute for Control of Chinese Traditional Medicine and Ethnic Medicine National Institutes for Food and Drug ControlBeijing100050China Tianjin Key Laboratory of Therapeutic Substance of Traditional Chinese Medicine School of Chinese Materia MedicaTianjin University of Traditional Chinese MedicineTianjin301617China Collaborative Innovation Center for Advanced Organic Chemical Materials Co-constructed by the Province and Ministry Ministry-of-Education Key Laboratory for the Synthesis and Application of Organic Functional MoleculesCollege of Chemistry and Chemical EngineeringHubei UniversityWuhan430062China

Structural and functional explorations on bio-soft matter such as micelles,vesicles,nanoparticles,aggregates or polymers derived from traditional Chinese medicine(TCM)has emerged as a new topic in the field of *** discovery of such cross-scaled bio-soft matter may provide a unique perspective for unraveling the new effective material basis of TCM as well as developing innovative medicine and *** the rapid rise of TCM-derived bio-soft matter,their hierarchical structure and assembly mechanism must be unambiguously probed for a further in-depth understanding of their pharmacological *** this review,the current emerged TCM-derived bio-soft matter assembled from either small molecules or macromolecules is introduced,and particularly the unambiguous elucidation of their hierarchical structure and assembly mechanism with combined electron microscopic and spectroscopic techniques is *** pros and cons of each technique are also *** future challenges and perspective of TCM-derived bio-soft matter are outlined,particularly the requirement for their precise in situ structural determination is highlighted.

关键词： Electron microscopy Spectroscopy Traditional Chinese medicine Bio-soft matter Structural characterization