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A large-scale fatal outbreak of Pasteurella multocida among wild rodents in southwestern China

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Journal of Biosafety and Biosecurity 2020年第2期2卷 91-98页

作者： Chun-Hong Du Yong Huang Jia-Fu Jiang Zi-Hou Gao Na Jia Shan Yang Chao-Nian Chen Shun-Gao Ma Yu-Ying Liang Bao-Gui Jiang Wei-Hong Sang Peng Wang yun Liang yun-zhi zhang Ji-Hua Zhou Shui-Ping Chen Frans Jongejan zhi-Zhong Song Yi-Gang Tong Wu-Chun Cao State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and EpidemiologyBeijingPR China yunnan Institute for Endemic Diseases Control and Prevention Dali YunnanPR China Puer Center for Disease Control and Prevention PuerYunnanPR China Simao Prefecture Center for Disease Control and Prevention PuerYunnanPR China DaLi Bai Autonomous Prefecture People’Hospital YunnanPR China Fifth Medical Center of PLA General Hospital BeijingPR China Utrecht Centre for Tick-borne Diseases(UCTD) Faculty of Veterinary MedicineUtrecht UniversityYalelaan 13584 CL UtrechtThe Netherlands College of Life Science and Technology Beijing University of Chemical Technology.BeijingPR China

Background:Pasteurella multocida is an important and old zoonotic pathogen worldwide which has an impressive host spectrum including numerous domestic and wild animals as well as birds,causing specific diseases or outbreak with great economic *** has never been reported that *** can cause an epidemic in wild *** June 5–17,2016,more than 1000 rodent deaths of an unknown cause quickly spread in the PuEr City,yunnan province,southwestern ***:The rodents in affected areas and outside of the epidemic areas were collected and screened for possible known pathogens including Yersinia pestis,rabies virus and hantavirus as well as other *** possible bacterial pathogens were isolated both by culture medium and by mouse inoculation in *** isolates were identified by the Vitek GNI card and PCR assays for 16S rRNA *** pathogen strains were selected for whole genome sequencing ***:A total of 123 rodents were collected from 25 sample sites at affected area,among of which,all 119 dead rodents were negative for the pathogen under consideration except ***,and all four live rodents were negative for *** addition,480 rodents collected from other 23 counties outside of the epidemic area in yunnan were negative for with ***.A total of 14 strains of ***(six directly isolated from the field rodents and eight from the experimental mice that were injected with the organ substrates from the dead rodents)belonged to serogroup A and serogroup F represented by 9 N and 20 N were identified in these epidemic *** genome sequencing revealed that the serogroup F strain shared 99%similarity to *** Pm70 from chicken,but contained a 50 k bp insertion *** serogroup A strain shared 95%similarity to *** FDAARGOS_385 from a human patient,but contained four large structural *** abnormalities were identified in the livers,lungs,hearts and brains of the ino

关键词： Pasteurella multocida Serotypes A Serotypes F Rodents Outbreak China

Composition optimization and performance prediction for ultra-stable water-based aerosol based on thermodynamic entropy theory

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Defence Technology（防务技术） 2024年第3期33卷 437-446页

作者： Tingting Kang Canjun Yan Xinying Zhao Jingru Zhao Zixin Liu Chenggong Ju Xinyue zhang yun zhang Yan Wu College of Chemical Engineering and Materials Science Tianjin University of Science and TechnologyNo.29 13th AvenueEconomic and Technologic Development ZoneTianjin 300457China Tianjin Key Laboratory of Brine Chemical Engineering and Resource Eco-utilization Tianjin University of Science and TechnologyTianjin 300457China College of Meteorology and Oceanography National University of Defense TechnologyChangsha 410073China

Water-based aerosol is widely used as an effective strategy in electro-optical countermeasure on the battlefield used to the preponderance of high efficiency,low cost and ***,the stability of the water-based aerosol is always unsatisfactory due to the rapid evaporation and sedimentation of the aerosol *** efforts have been devoted to improve the stability of water-based aerosol by using additives with different composition and ***,the lack of the criterion and principle for screening the effective additives results in excessive experimental time consumption and *** the stabilization time of the aerosol is still only 30 min,which could not meet the requirements of the perdurable ***,to improve the stability of water-based aerosol and optimize the complex formulation efficiently,a theoretical calculation method based on thermodynamic entropy theory is *** the factors that influence the shielding effect,including polyol,stabilizer,propellant,water and cosolvent,are considered within *** ultra-stable water-based aerosol with long duration over 120 min is obtained with the optimal fogging agent composition,providing enough time for fighting the electro-optic *** design guideline for choosing the additives with high phase transition temperature and low phase transition enthalpy is also proposed,which greatly improves the total entropy change and reduce the absolute entropy change of the aerosol cooling process,and gives rise to an enhanced stability of the water-based *** theoretical calculation methodology contributes to an abstemious time and space for sieving the water-based aerosol with desirable performance and stability,and provides the powerful guarantee to the homeland security.

关键词： Ultra-stable Water-based aerosol Thermodynamic entropy Composition optimization Performance prediction

Lightweight Dual‑Functional Segregated Nanocomposite Foams for Integrated Infrared Stealth and Absorption‑Dominant Electromagnetic Interference Shielding

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Nano-Micro Letters 2024年第11期16卷 38-55页

作者： Zhonglei Ma Ruochu Jiang Jiayao Jing Songlei Kang Li Ma Kefan zhang Junxian Li Yu zhang Jianbin Qin Shuhuan yun Guangcheng zhang MOE Key Laboratory of Material Physics and Chemistry Under Extraordinary Conditions Shaanxi Key Laboratory of Macromolecular Science and TechnologySchool of Chemistry and Chemical EngineeringNorthwestern Polytechnical UniversityXi’an 710072People’s Republic of China College of Chemistry and Chemical Engineering Key Laboratory of Auxiliary Chemistry and Technology for Chemical IndustryMinistry of EducationShaanxi University of Science and TechnologyXi’an 710072People’s Republic of China Department of Mechanical and Industrial Engineering University of Toronto5 King’s College RoadTorontoON M5S 3G8Canada Chongqing Innovation Center Northwestern Polytechnical UniversityChongqing 401135People’s Republic of China

Lightweight infrared stealth and absorption-dominant electromagnetic interference(EMI)shielding materials are highly desirable in areas of aerospace,weapons,military and wearable ***,lightweight and high-efficiency dual-functional segregated nanocomposite foams with microcellular structures are developed for integrated infrared stealth and absorption-dominant EMI shielding via the efficient and scalable supercritical CO_(2)(SC-CO_(2))foaming combined with hydrogen bonding assembly and compression molding *** obtained lightweight segregated nanocomposite foams exhibit superior infrared stealth performances benefitting from the synergistic effect of highly effective thermal insulation and low infrared emissivity,and outstanding absorption-dominant EMI shielding performances attributed to the synchronous construction of microcellular structures and segregated ***,the segregated nanocomposite foams present a large radiation temperature reduction of 70.2℃ at the object temperature of 100℃,and a significantly improved EM wave absorptivity/reflectivity(A/R)ratio of 2.15 at an ultralow Ti_(3)C_(2)T_(x) content of 1.7 vol%.Moreover,the segregated nanocomposite foams exhibit outstanding working reliability and stability upon dynamic compression *** results demonstrate that the lightweight and high-efficiency dual-functional segregated nanocomposite foams have excellent potentials for infrared stealth and absorption-dominant EMI shielding applications in aerospace,weapons,military and wearable electronics.

关键词： Segregated nanocomposite foams Microcellular structures Infrared stealth EMI shielding Low infrared emissivity

Improved simulation of winter wheat yield in North China Plain by using PRYM-Wheat integrated dry matter distribution coefficient

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Journal of Integrative Agriculture 2024年第4期23卷 1381-1392页

作者： Xuan Li Shaowen Wang Yifan Chen Danwen zhang Shanshan Yang Jingwen Wang Jiahua zhang yun Bai Sha zhang Research Center for Remote Sensing and Digital Earth College of Computer Science and TechnologyQingdao UniversityQingdao266071China Center for Geospatial Information Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China School of Geographical Sciences Hebei Normal UniversityShijiazhuang 050024China

The accurate simulation of regional-scale winter wheat yield is important for national food security and the balance of grain supply and demand in ***,most remote sensing process models use the“biomass×harvest index(HI)”method to simulate regional-scale winter wheat ***,spatiotemporal differences in HI contribute to inaccuracies in yield simulation at the regional ***-series dry matter partition coefficients(Fr)can dynamically reflect the dry matter partition of winter *** this study,Fr equations were fitted for each organ of winter wheat using site-scale *** equations were then coupled into a process-based and remote sensingdriven crop yield model for wheat(PRYM-Wheat)to improve the regional simulation of winter wheat yield over the North China Plain(NCP).The improved PRYM-Wheat model integrated with the fitted Fr equations(PRYM-Wheat-Fr)was validated using data obtained from provincial yearbooks.A 3-year(2000-2002)averaged validation showed that PRYM-Wheat-Fr had a higher coefficient of determination(R^(2)=0.55)and lower root mean square error(RMSE=0.94 t ha^(-1))than PRYM-Wheat with a stable HI(abbreviated as PRYM-Wheat-HI),which had R^(2) and RMSE values of 0.30 and 1.62 t ha^(-1),*** PRYM-Wheat-Fr model also performed better than PRYM-Wheat-HI for simulating yield in verification years(2013-2015).In conclusion,the PRYM-Wheat-Fr model exhibited a better accuracy than the original PRYM-Wheat model,making it a useful tool for the simulation of regional winter wheat yield.

关键词： dry matter partition remote sensing model winter wheat yield North China Plain

Nullification of GFTs fortifies bioactive folates in foxtail millet

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Journal of Integrative Plant Biology 2024年第8期66卷 1540-1543页

作者： Jianzhou Pang Wei zhang Yanyan zhang Shihui zhang Yannan Wang Hui zhi Chunyi zhang Qiuju Liang Xianmin Diao College of Life Science Hebei Normal UniversityShijiazhuang 050024China Dry Land Farming Institute of Hebei Academy of Agricultural and Forestry Sciences Key Laboratory of Crop Drought Tolerance Research of Hebei ProvinceHengshui 053000China Institute of Crop Sciences Chinese Academy of Agricultural SciencesState Key Laboratory of Crop Gene Resources and BreedingBeijing 100081China Biotechnology Research Institute Chinese Academy of Agricultural SciencesBeijing 100081China

Folates—tetrahydrofolate(THF)and its derivatives(also known collectively as vitamin B9)—are essential micronutrients for almost all living *** as carriers of one-carbon(C1)units,folates participate in the biosynthesis of numerous biomolecules and play central roles in cellular methylation reactions(Strobbe and Van Der Straeten,2017).

关键词： collective organisms vitamin

Skeletal phenotypes and molecular mechanisms in aging mice

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Zoological Research 2024年第4期45卷 724-746页

作者： Qiao Guan Yuan zhang zhi-Kun Wang Xiao-Hua Liu Jun Zou Ling-Li zhang School of Exercise and Health Shanghai University of SportShanghai 200438China College of Athletic Performance Shanghai University of SportShanghai 200438China

Aging is an inevitable physiological process,often accompanied by age-related bone loss and subsequent bone-related diseases that pose serious health *** on skeletal diseases caused by aging in humans is challenging due to lengthy study durations,difficulties in sampling,regional variability,and substantial ***,mice are preferred for such studies due to their similar motor system structure and function to humans,ease of handling and care,low cost,and short generation *** this review,we present a comprehensive overview of the characteristics,limitations,applicability,bone phenotypes,and treatment methods in naturally aging mice and prematurely aging mouse models(including SAMP6,POLG mutant,LMNA,SIRT6,ZMPSTE24,TFAM,ERCC1,WERNER,and KL/KL-deficient mice).We also summarize the molecular mechanisms of these aging mouse models,including cellular DNA damage response,senescence-related secretory phenotype,telomere shortening,oxidative stress,bone marrow mesenchymal stem cell(BMSC)abnormalities,and mitochondrial ***,this review aims to enhance our understanding of the pathogenesis of aging-related bone diseases.

关键词： Aging Premature aging Mice Bone Gene knockout

Design and fabrication of lightweight AlCrFeNiTi_(x) compositionally complex alloys with exceptional specific strength

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Rare Metals 2024年第7期43卷 3314-3328页

作者： Jun-zhi Li Wei-Zong Bao Jie Chen Bo-Hua Yu Kun Zuo Tian Gao Ze-yun Cai Guo-Qiang Xie School of Materials Science and Engineering Harbin Institute of Technology(Shenzhen)Shenzhen 518055China State Key Laboratory of Advanced Welding and Joining Harbin Institute of TechnologyHarbin 150001China

This study focuses on compositionally complex alloys(CCAs),aiming to achieve a balance between high strength and low density for new energy and aerospace *** composition of AlCrFeNiTi_(x) CCAs is strategically guided by employing density functional theory and the theoretical design of thermodynamic *** CCAs,particularly AlCrFeNiTi_(0.25) alloy,demonstrate remarkable specific yield strength(1640.8 MPa) and 22.7% maximum *** incorporation of Ti facilitates the formation of lightweight and high-strength L2_(1)phase,contributing to the overall high specific *** effects of grain boundary strengthening,solid solution strengthening,Orowan strengthening and Peierls flow stress further enhance *** exploration of micros tructural changes during fracture reveals the role of ordered phases in suppressing crack propagation and absorbing energy within disordered phases,thereby improving the toughness and fracture resistance of *** methods and discoveries establish a robust foundation for advancing the development of novel lightweight CCAs.

关键词： Lightweight Compositionally complex alloys Specific yield strength

Role of savolitinib in advanced gastric adenocarcinoma with meningeal carcinomatosis and cerebellar metastasis:A case report

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World Journal of Clinical Cases 2024年第15期12卷 2636-2641页

作者： zhi-yun Weng Wen-Ye Huang Bin-Kan Shi Jian-Jia Pan Department of Hematology The Affiliated Yueqing Hospital of Wenzhou Medical UniversityYueqing 325600Zhejiang ProvinceChina

BACKGROUND Brain metastases(BM)are very rare in gastric adenocarcinoma(GaC),and patients with BMs have a higher mortality rate due to stronger tumor ***,its pathogenesis remains *** testing revealed cellular-mesenchymal epithelial transition factor receptor(MET)***,treatment with savolitinib,a small molecule inhibitor of c-Met,was *** SUMMARY A 66-year-old woman was diagnosed with advanced GaC 6 months prior to presentation due to back *** and meningeal metastases were observed during candonilimab combined with oxaliplatin and capecitabine *** patient experienced frequent generalized seizures and persistent drowsiness in the emergency *** testing of cerebrospinal fluid and peripheral blood revealed increased MET *** discussing treatment options with the patient,savolitinib tablets were *** a month of treatment,the intracranial lesions shrank *** BM is very rare in advanced GaC,especially in meningeal cancer,that is characterized by rapid disease *** are very few effective treatment options available;however,technological breakthroughs in genomics have provided a basis for personalized ***,MET amplification may be a key driver of BM in gastric cancer;however,this conclusion requires further investigation.

关键词： Cellular-mesenchymal epithelial transition factor receptor Savolitinib Meningeal carcinomatosis Gastric adenocarcinoma Case report

Adhesion strength of tetrahydrofuran hydrates is dictated by substrate stiffness

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Petroleum Science 2024年第1期21卷 667-673页

作者： Yan-Wen Lin Tong Li Yi zhang Wei-Wei Yan Xiao-Ming Chen zhi-Sen zhang Jian-Yang Wu Department of Physics Research Institute for Biomimetics and Soft MatterJiujiang Research Institute and Fujian Provincial Key Laboratory for Soft Functional Materials ResearchXiamen UniversityXiamen361005FujianChina Key Laboratory of Marine Materials and Related Technologies Zhejiang Key Laboratory of Marine Materials and Protective TechnologiesNingbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo315201ZhejiangChina Key Laboratory of Icing and Anti/De-icing China Aerodynamics Research and Development CenterMianyang621000SichuanChina Micro-and Nano-technology Research Center State Key Laboratory for Manufacturing Systems EngineeringXi’an Jiaotong UniversityXi’an710049ShaanxiChina Electronic Materials Research Lab Key Laboratory of the Ministry of EducationXi’an Jiaotong UniversityXi’an710049ShaanxiChina NTNU Nanomechanical Lab Norwegian University of Science and Technology(NTNU)Trondheim7491Norway

Understanding the hydrate adhesion is important to tackling hydrate accretion in ***,the relationship between the Tetrahydrofuran(THF)hydrate adhesion strength(AS)and surface stiffness on elastic coatings is systemically examined by experimental shear force measurements and theoretical *** mechanical factor-elastic modulus of the coatings greatly dictates the hydrate AS,which is explained by the adhesion mechanics theory,beyond the usual factors such as wettability and structural ***,the hydrate AS increases with reducing the thickness of the elastic coatings,resulted from the decrease of the apparent surface elastic *** effect of critical thickness for the elastic materials with variable elastic modulus on the hydrate AS is also *** study provides deep perspectives on the regulation of the hydrate AS by the elastic modulus of elastic materials,which is of significance to design anti-hydrate surfaces for mitigation of hydrate accretion in petro-pipelines.

关键词： Hydrate Adhesion strength Elastic modulus Coatings