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西洋参-红花有效成分治疗早期糖尿病肾病的网络药理学和实验验证

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世界中医药 2024年第14期19卷 2072-2080页

作者：周婷屈凯陈志永李宁刘厚利武云丁焱霖谢磊许建秦西安国际医学中心西安710100 陕西省中医医院西安710003 陕西省中医药研究院西安710003

目的:通过网络药理学、分子对接技术及细胞实验探讨西洋参-红花有效成分治疗早期糖尿病肾病(DN)的作用机制。方法:运用中药系统药理学数据库与分析平台(TCMSP)获得西洋参-红花活性成分的干扰靶点,再与GeneCards、TTD等数据库中早期DN基... 详细信息

目的:通过网络药理学、分子对接技术及细胞实验探讨西洋参-红花有效成分治疗早期糖尿病肾病(DN)的作用机制。方法:运用中药系统药理学数据库与分析平台(TCMSP)获得西洋参-红花活性成分的干扰靶点,再与GeneCards、TTD等数据库中早期DN基因靶点相映射即为交集靶点。采用STRING数据库构建蛋白质-蛋白质相互作用(PPI)网络,运用Cytoscape 3.8.2软件筛选出核心靶点;通过DAVID数据库进行基因本体(GO)富集分析和京都基因和基因组百科全书(KEGG)富集分析,运用Cytoscape 3.8.2软件进行“有效成分-关键靶点-通路-疾病”网络图展示;通过Autodock Tools软件进行分子对接,采用MTT法检测有效成分对脂多糖(LPS)诱导的人肾小球系膜细胞(HMC)活性,利用酶联免疫吸附试验检测有效成分对炎症介质的影响。结果:得到西洋参-红花治疗早期DN的活性成分有24个,对应的药物靶点207个,其中72个和早期DN相关。网络拓扑参数分析得出了肿瘤坏死因子(TNF)、白细胞介素-6(IL-6)、IL-1β等15个关键靶点,KEGG通路分析筛选出晚期糖基化终末产物(AGE)-AGE受体(RAGE)、TNF、低氧诱导因子-1(HIF-1)、IL-17、核因子κB等20个信号通路;分子对接表明IL-6与槲皮素、木犀草素、黄芩素、人参皂苷rh2稳定结合。细胞实验得出西洋参-红花活性成分槲皮素、木犀草素、黄芩素能显著抑制IL-6、TNF-α和IL-1β表达。结论:本研究初步证实西洋参-红花有效成分能有效抑制早期DN炎症,对肾脏具有保护作用,为后期深入研究提供了依据。

关键词：西洋参-红花早期糖尿病肾病网络药理学分子对接细胞实验晚期糖基化终末产物-晚期糖基化终末产物受体信号通路炎症介质

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Seat inventory control methods for Chinese passenger railways

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Journal of Central South University 2014年第4期21卷 1672-1682页

作者：包云刘军马敏书孟令云 State Key Laboratory of Rail Traffic Control and Safety (Beijing Jiaotong University) School of Traffic and Transportation Beijing Jiaotong University

Railway seat inventory control strategies play a crucial role in the growth of profit and train load factor. The railway passenger seat inventory control problem in China was addressed. Chinese passenger railway operation features and seat inventory control practice were analyzed firstly. A dynamic demand forecasting method was introduced to forecast the coming demand in a ticket booking period. By clustering, passengers' historical ticket bookings were used to forecast the demand to come in a ticket booking period with least squares support vector machine. Three seat inventory control methods: non-nested booking limits, nested booking limits and bid-price control, were modeled under a single-fare class. Different seat inventory control methods were compared with the same demand based on ticket booking data of Train T15 from Beijing West to Guangzhou. The result shows that the dynamic non-nested booking limits control method performs the best, which gives railway operators evidence to adjust the remaining capacity in a ticket booking period.

关键词： seat inventory control Chinese passenger railway revenue management booking limits bid-price

Stenting for Aorto-Ostial In-Stent Restenosis via Side Strut of an Excessively Protruding Stent Guided by Intracoronary Imaging

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Chinese Medical Journal 2018年第22期131卷 2767-2768页

作者： Yu Du Ying-Xin Zhao Wei liu Jian-Wei Zhang Zhen-xian Yan Yu-Jie Zhou Department of Cardiology Beijing Anzhen HospitalCapital Medical UniversityBeijing Institute of Heart Lung and Blood Vessel DiseaseBeijing Key Laboratory of Precision Medicine of Coronary Atherosclerotic DiseaseClinical Center for Coronary Heart DiseaseBeijing 100029China

To the Editor:A 54-year-old man was admitted for progressive chest *** years ago,the patient had surgical aortic valve replacement (SAVR),and preoperative multislice computed tomography (MSCT)showed no coronary stenosis.A year after SAVR,he presented with chest pain,and coronary angiogram revealed an isolated ostial left main coronary artery (LMCA) stenosis [Figure 1a].A 4.0mm × 18.0mm stent (Medtronic Vascular, Santa Rosa,CA,USA)was implanted without a high-pressure postdilation [Figure 1b].The patient was discharged on aspirin, ticagrelor (replaced with clopidogrel after 3months),and statins. Unfortunately,the stent was found to protrude into the aorta by approximately 10mm by MSCT at 4-month follow-up [Figure 1c].

关键词： Stenting Aorto-Ostial In-Stent Restenosis via Side Strut

Two new indole derivatives as anion receptors for detecting fluoride ion

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Chinese Chemical Letters 2013年第11期24卷 962-966页

作者： Xiu-Ming liu Qiang Zhao Yue Li Wei-Chao Song Ya-Ping Li Ze Chang xian-He Bu Department of Chemistry Tianjin Key Lab of Metal and Molecule-based Material Chemistry Synergetic Innovation Center of Chemical Science and Engineering Nankai University

Two new compounds（1 and 2）based on indole were successfully synthesized and *** display highly selective response to Fàin aqueous DMSO medium and pure DMSO with remarkable color and fluorescent ***,both receptors m... 详细信息

关键词： Anions Fluorescent Recognition Colorimetric

儿童青少年精神障碍患者家长自杀倾向及危险因素分析

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广东医学 2024年第8期45卷 1017-1021页

作者：王芸陈长浩夏磊王芳刘寰忠安徽医科大学附属巢湖医院精神科安徽合肥238000 宿州市第二人民医院精神科安徽宿州234000

目的探讨儿童青少年精神障碍患者家长自杀倾向及其危险因素,并构建自杀倾向的预测模型。方法采用横断面调查的方法,收集2022年8月至2023年7月就诊于安徽省内两所医院共299名儿童青少年精神障碍家长的社会人口学资料,并采用自杀相关的标... 详细信息

目的探讨儿童青少年精神障碍患者家长自杀倾向及其危险因素,并构建自杀倾向的预测模型。方法采用横断面调查的方法,收集2022年8月至2023年7月就诊于安徽省内两所医院共299名儿童青少年精神障碍家长的社会人口学资料,并采用自杀相关的标准化问题、患者健康问卷-9(PHQ-9)以及多伦多述情障碍量表(TAS-20)分别评估调查对象自杀倾向、抑郁症状及述情障碍的程度。结果自杀倾向的总体检出率为15.4%,其中自杀意念、自杀计划和自杀未遂检出率分别为11.0%、3.3%和8.0%。Logistic回归分析结果显示,躯体疾病史、抑郁症状、述情障碍以及情感辨别不能因子与较高的自杀倾向风险有关(均P<0.05)。基于回归分析结果,构建预测患儿家长自杀倾向风险预测模型,并绘制受试者工作特征(ROC)曲线下面积(AUC)为0.80(95%CI:0.72~0.87,P<0.05)。结论儿童青少年精神障碍患者家长自杀倾向检出率较高,提示临床上在注重青少年精神障碍患者的同时,亦不能忽视患儿家长的心理健康,应加强对患儿和家长的护理,必要时应提供个体化的综合干预措施。

关键词：儿童青少年精神障碍家长自杀危险因素述情障碍

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Duration-dependent regulation of autophagy by isoflurane exposure in aged rats

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Neuroscience Bulletin 2015年第4期31卷 505-513页

作者： Zheng-Qian Li Lun-Xu Li Na Mo Yi-yun Cao Bolati Kuerban Yao-xian Liang Dong-Sheng Fan De-Hua Chui xiang-Yang Guo Department of Anesthesiology Peking University Third Hospital Cancer Hospital and Institute Chinese Academy of Medical Sciences and Peking Union Medical College Department of Neurology Peking University Third Hospital Department of Nephrology Peking University Third Hospital

Current evidence suggests a central role for autophagy in many inflammatory brain disorders, including Alzheimer＇s disease （AD）. Furthermore, it is also well accepted that some inhalation anesthetics, such as isoflurane, may cause AD- like neuropathogenesis and resultant postoperative cognitive dysfunction, especially in the elderly population. However, the impact of inhalation anesthetics on autophagic components in the brain remains to be documented. Hence, our objective was to investigate the effects of different durations of isoflurane exposure on hippocampus-dependent learning and hippocarnpal autophagy in aged rats. Aged Sprague-Dawley rats （20 months old） were randomly exposed to 1.5% isoflurane or 100% oxygen for 1 or 4 h. Animals were then trained in the Morris water maze （4 trials/day for 5 consecutive days）. Hippocampal phagophore formation markers, beclin 1 and protein microtubule-associated protein 1 light chain-3B （LC3B）, as well as p62, an indicator of autophagic flux, were quantified by western blotting. There was no significant difference in the escape latencies and time spent in the target quadrant, as well as hippocampal expression of beclin 1, LC3B- II, and p62 at 24 h post-anesthesia between the 1-h isoflurane-exposed rats and their controls （P 〉0.05）. Four-hour exposure to isoflurane resulted in spatial learning and memory deficits, as evidenced by prolonged escape latencies on days 4 and 5 post- anesthesia and less time spent in the target quadrant than sham-exposed animals （P 〈0.05）. These events were accompanied by a decline in hippocampal expression of LC3B-I, LC3B-II, and beclin 1 24 h after isoflurane （P 〈0.01 and P 〈0.05）. Nevertheless, no significant change in p62 expression was found. Further kinetics study of autophagic changes induced by 4 h of isoflurane showed a transient upregulation of LC3B-I, LC3B-II, and beclin 1 at the end of exposure and a subsequent striking decrease within 12-24 h post-anesthesia （P 〈0.05）. Hippocampal p62

关键词： autophagy phagophore formation cognitive dysfunction

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趋同化视域下国际学生实践教育探索

高教学刊 2024年第S2期10卷 15-18页

作者：万永敏邢露萍刘芸秦海燕南京工业大学海外教育学院南京211816

趋同化视域下开展国际学生实践教育,是践行习近平总书记加强教育“走出去与引进来”相结合的重要指示精神,贯彻落实教育部等三部门发布的《学校招收和培养国际学生管理办法》的重要举措。培养“知华友华亲华”来华留学生,加强中外学生... 详细信息

趋同化视域下开展国际学生实践教育,是践行习近平总书记加强教育“走出去与引进来”相结合的重要指示精神,贯彻落实教育部等三部门发布的《学校招收和培养国际学生管理办法》的重要举措。培养“知华友华亲华”来华留学生,加强中外学生中国情怀国际视野培育,推动文化冲突向文化融合转变,具有重要的理论意义和重大的实践价值。该文通过理论研究和实践探索,在构建人类命运共同体背景下,充分考虑国际学生趋同化管理中的文化差异,坚持“同中有异、异中求同”的基本原则,构建“双向趋同”中外文化融合的实践教育有机体系理论,探索中外学生“同堂实习、同行实践”实践教育新模式,实现国际学生趋同管理和文化融合培养实践教育的新突破。

关键词：趋同化国际学生实践教育同堂实习同行实践

Scientific workflow execution system based on mimic defense in the cloud environment

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Frontiers of Information Technology & Electronic Engineering 2018年第12期19卷 1522-1536页

作者： Ya-wen WANG Jiang-xing WU yun-fei GUO Hong-chao HU Wen-yan liu Guo-zhen CHENG National Digital Switching System Engineering Technology Research Center

With more large-scale scientific computing tasks being delivered to cloud computing platforms, cloud workflow systems are designed for managing and arranging these complicated tasks. However, multi-tenant coexistence service mode of cloud computing brings serious security risks, which will threaten the normal execution of cloud workflows. To strengthen the security of cloud workflows, a mimic cloud computing task execution system for scientific workflows is proposed. The idea of mimic defense contains mainly three aspects: heterogeneity, redundancy, and dynamics. For heterogeneity, the diversities of physical servers, hypervisors, and operating systems are integrated to build a robust system framework. For redundancy, each sub-task of the workflow will be executed simultaneously by multiple executors. Considering efficiency and security, a delayed decision mechanism is proposed to check the results of task execution. For dynamics, a dynamic task scheduling mechanism is devised for switching workflow execution environment and shortening the life cycle of executors, which can confuse the adversaries and purify task executors. Experimental results show that the proposed system can effectively strengthen the security of cloud workflow execution.

关键词： Scientific workflow Mimic defense Cloud security Intrusion tolerance

Repeat mid-urethral sling in management of recurrent or persistent stress urinary incontinence

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Chinese Medical Journal 2020年第3期133卷 367-368页

作者： xian-Hui liu Hao Hu Wei-Yu Zhang Huan-Rui Wang Qi Wang Ke-Xin Xu Department of Urology Peking University People's HospitalBeijing 100044China.

According to the International Continence Society,stress urinary incontinence(SUI)was defined as involuntary leakage on effort or exertion,or on sneezing or *** prevalence of SUI varies among different age groups and is reportedly 48%(29%-75%).⑴The mid-urethral sling(MUS)procedure is currently considered the gold standard in the surgical treatment of SUL The long-term cure rate of SUI using MUS ranges from 76.9%to 90.0%.11,21 However,incontinence persists in approximately 20%of SUI patients who underwent MUS procedure,and they require further treatment.

关键词： urinary incontinence urethral