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Microstructure evolution of 7050 aluminum forgings during surface cumulative plastic deformation

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Transactions of Nonferrous Metals Society of China 2025年第1期35卷 45-59页

作者： Jian-liang HU Ze-xiong zhang Cheng XING Xiu-jiang WU Shi-quan HUANG Hong BO Key Laboratory of Advanced Forging&Stamping Technology and Science Ministry of EducationYanshan UniversityQinhuangdao 066004China State Key Laboratory of Precision Manufacturing for Extreme Service Performance Central South UniversityChangsha 410083China College of Mechanical Engineering Yanshan UniversityQinhuangdao 066004China Hebei Engineering Technology Research Center of Metal Precision Plastic Processing Yanshan UniversityQinhuangdao 066004China State Key Laboratory of Metastable Materials Science and Technology Yanshan UniversityQinhuangdao 066004China

To elucidate the mechanisms of regulating the microstructure uniformity in 7050 aluminum forgings through surface cumulative plastic deformation(SCPD),the microstructure under different solution treatments was investigated using metallographic observation(OM),electron backscatter diffraction(EBSD),transmission electron microscopy(TEM),and X-ray diffraction(XRD).The findings demonstrate that the most uniform microstructure in the forgings is achieved with a solution treatment at 470℃for 30 *** SCPD process generates a significant number of needle-shaped precipitates,resulting in a higher dislocation density and stored *** treatments alleviate the pinning effect of second-phase particles and facilitate static recrystallization(SRX)in forgings,leading to a reduction in grain ***,mechanical testing results demonstrate 7%−13%increase in tensile strength and more uniform elongation of the forgings in different directions.

关键词： microstructure homogeneity surface cumulative plastic deformation(SCPD) static recrystallization(SRX) dislocation density

Environment-friendly Ca2+/Cr3+co-doping LaAlO3 ceramics with excellent infrared radiation performance for energy-saving

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JOURNAL OF ADVANCED CERAMICS 2025年第1期14卷 205-214页

作者： Yuan, Xinglai Wang, Qinghu Wu, Runke Sang, Shaobai Xu, Yibiao liang, Xiong Pan, Liping Fan, Bingbing Li, Yawei zhang, Rui Li, Jiangtao Volkova, Olena Wuhan Univ Sci & Technol State Key Lab Refractories & Met Joint Int Res Lab Refractories & Met Wuhan 430081 Peoples R China Zhengzhou Univ Sch Mat Sci & Engn Zhengzhou 450001 Peoples R China Henan Acad Sci Inst Adv Ceram Zhengzhou 450046 Peoples R China Chinese Acad Sci Tech Inst Phys & Chem Beijing 100190 Peoples R China TU Bergakad Freiberg Inst Iron & Steel Technol D-09599 Freiberg Germany

Ca2+/Cr3+ co-doped LaAlO3 infrared (IR) ceramics have been proven to be potential energy-saving materials for high- temperature industries because of their high emissivity and high- temperature stability. However, Cr6+ formation commonly occurs in materials and poses environmental and health risks, such as Cr6+ dissolution in water and CrO3(g) volatilization. In this study, we combined high emissivity with in situ detoxification by introducing residual Al2O3 into Ca2+/Cr3+ co-doped LaAlO3 ceramics. Compared with the undoped ceramics, the addition of 20 wt% residual Al2O3 resulted in a 78.5% reduction to 18.44 mg/kg (lower than the EU standard of 20 mg/kg) in Cr6+ dissolution and a decrease in 77.8% CrO3(g) volatilization. This significant detoxification effect can be attributed to the formation of CaAl12-xCrxO19. Additionally, as the residual Al2O3 content increased from 5 to 20 wt%, the ceramics maintained high emissivity, above 0.896 in the near-infrared band and 0.781 in the mid-infrared band. Furthermore, the IR coating effectively increased the surface temperature (from 767.1 to 790.7 degrees C/min) and the heat radiation of the heating source, increasing the heating rate from 31.7 to 34.6 degrees C/min during water heating. This work offers a promising approach for designing environmentally friendly IR ceramics with excellent IR performance for energy-saving applications in the high-temperature industry.

关键词： infrared (IR) radiation energy-saving environmentally friendly Cr6+suppression LaAlO3

Study on the diagnostic criteria of syndrome of dampness obstruction in idiopathic membranous nephropathy based on expert consensus

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Journal of Traditional Chinese Medicine 2025年第1期45卷 167-175页

作者： WANG Dan HUANG Xiaoyan LI Ping HONG Xiaofan zhang Yumin WANG Rongrong BAO Kun liang Xing Nephrology Department Qianxinan Autonomous Prefecture Hospital of Traditional Chinese Medicine Nephrology Department Guangdong Provincial Hospital of Chinese Medicine Guangdong Provincial Key Laboratory of Chinese Medicine for Prevention and Treatment of Refractory Chronic Disease the Second Affiliated Hospital of Guangzhou University of Chinese Medicine State Key Laboratory of Dampness Syndrome of Chinese Medicine the Second Affiliated Hospital of Guangzhou University of Chinese Medicine State Key Laboratory of Dampness Syndrome of Chinese Medicine The Second Affiliated Hospital of Guangzhou University of Chinese Medicine Guangdong-Hong Kong-Macau Joint Lab on Chinese Medicine and Immune Disease Research

OBJECTIVE: To reach consensus on the diagnostic criteria of syndrome of dampness obstruction in idiopathic membranous nephropathy(IMN) patients by literature research and expert investigation(interviews and a Delphi method). METHODS: Our study was consistent with T/CACM 1336-2020. We searched the monographs and references published in the past 40 years(1983-2022), and established the diagnostic criteria pool of waterdampness syndrome and dampness-turbidity syndrome in Traditional Chinese Medicine(TCM) based on literature by using frequency statistics and correlation analysis. Expert investigation(interview method and two rounds of Delphi method) was used to form the diagnostic criteria of water-dampness syndrome and dampnessturbidity syndrome of idiopathic membranous nephropathy. Clinical diagnostic test research was carried out, and compared with “Diagnostic Criteria for dampness syndrome”(T/CACM 1454-2023) to evaluate the authenticity, reliability and clinical application value of the standard. RESULTS: A total of 122 relevant guides, standards, monographs and documents were included through searching books and Chinese databases. Four experts were interviewed and two rounds of delphi method(75 experts nationwide) were carried out. The experts' opinions are relatively concentrated and the differences are small. Based on the weight of each index, the diagnostic criteria indexes of water-dampness syndrome and dampness-turbidity syndrome were selected. After discussion by the core group members, the diagnostic model of "necessary symptoms and optional symptoms" was established, and the final diagnostic criteria of waterdampness syndrome and dampness-turbidity syndrome were established. One hundred and ninety-one inpatients and outpatients of Guangdong Provincial Hospital of Chinese Medicine from January 2021 to February 2023 were included in Diagnostic test study. There was no statistical difference in gender, age and course of disease(P > 0.05). The sensitivity and s

关键词： combination of disease and syndrome diagnostic tests, routine glomerulonephritis, membranous syndrome diagnostic criteria syndrome of dampness obstruction

TRIM66-HP1γ remodels the chromatin through phase separation

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生物物理学报（英文） 2025年第1期11卷 18-33页

作者： Siyuan Shen Feng Chen Yifan zhang Fudong Li Xuebiao Yao Dan Liu yunyu Shi liang zhang Center for Advanced Interdisciplinary Science and Biomedicine of IHM Division of Life Sciences and Medicine University of Science and Technology of China Hefei 230027 China Ministry of Education Key Laboratory for Membraneless Organelles and Cellular Dynamics University of Science and Technology of China Hefei 230027 China Hefei National Research Center for Cross disciplinary Science University of Science and Technology of China Hefei 230027 China

Chromatin contains not only heterochromatin (HC) and euchromatins (EC) but also facultative heterochromatin (fHC), which experience the dynamic remodeling between HCs and ECs by different regulators. The regulation of fHCs involves lots of different cell functions, like genomic stability and gene transcription. Heterochromatin protein 1 (HP1) recognizes methylated H3K9 and reshapes the chromatin into the fHCs through liquid–liquid phase separation (LLPS). Among the three members of the HP1 family, HP1α can condensate by itself and HP1β forms granules with the help of TRIM28, while the HP1γ cannot phase separation alone either and the coordinator is still unclear. So, in this study, we investigated the molecular mechanism of how HP1γ interacts with TRIM66 through PxVxL motif. Based on that, we examined the key regions that controlled the TRIM66-HP1γ co-phase separation behaviors both in vitro and in vivo. Furthermore, we proved that the liquid granules of TRIM66-HP1γ and chromatin highly correlated with H3K9me3 sites, which indicated the relationship with DNA damage response. Finally, combined with our previous study, we proposed the system for how TRIM66 remodeled the chromatin into compressed fHC through the TRIM66-HP1γ-H3K9me3 axis with liquid–liquid phase separation.

关键词： Chromatin TRIM66-HP1γ Facultative heterochromatin Phase separation

Acceptor concentration dependent Fo?rster resonance energy transfer in nanocrystal-molecule complexes revealed by spectral analysis

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Optoelectronics Letters 2025年

作者： Rongxin zhang Zixiang ZHOU Lei WANG Xin zhang Ying liang Guijie liang Hubei Key Laboratory of Low Dimensional Optoelectronic Materials and Devices， Hubei University of Arts and Science

A nanocrystal-molecule complex composed of CdSe donor and Rhodamine B (RhB) acceptor is prepared to investigate the effect of accepter-donor ratio on the Fo?rster resonance energy transfer (FRET) process. To highlight the FRET process， the energy level alignment between CdSe and RhB is purposefully designed and CdSe nanocrystal is coated with a wide band-gap ZnS shell. The carrier dynamics is observed via combined spectral analysis. The results reveal clear FRET process between the CdSe donor and RhB acceptor. The FRET is enhanced by increasing RhB/CdSe ratio and a gradual saturation will be present at high RhB concentration.

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Dietary Zn proteinate with moderate chelation strength alleviates heat stress‑induced intestinal barrier function damage by promoting expression of tight junction proteins via the A20/NF‑κB p65/MMP‑2 pathway in the jejunum of broilers

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Journal of Animal Science and Biotechnology 2025年第1期16卷 316-330页

作者： Yangyang Hu Weiyun zhang Ke Yang Xi Lin Hsiao‑Ching Liu Jack Odle Miles Todd See Xiaoyan Cui Tingting Li Shengchen Wang Xiudong Liao Liyang zhang Sufen Li yun Hu Xugang Luo Poultry Mineral Nutrition Laboratory College of Animal Science and TechnologyYangzhou UniversityYangzhou 225000China Hebei Normal University of Science and Technology Qinhuangdao 066004China Department of Animal Science North Carolina State UniversityRaleighNC 27695USA Mineral Nutrition Research Division State Key Laboratory of Animal NutritionInstitute of Animal ScienceChinese Academy of Agricultural SciencesBeijing 100193China

Background The aim of this study was to determine whether and how Zn proteinate with moderate chelation strength(Zn-Prot M)can alleviate heat stress(HS)-induced intestinal barrier function damage of broilers.A completely randomized design was used for comparatively testing the effects of Zn proteinate on HS and non-HS *** high temperature(HT),a 1(Control,HT-CON)+2(Zn source)×2(added Zn level)factorial arrangement of treatments was *** 2 added Zn sources were Zn-Prot M and Zn sulfate(ZnS),and the 2 added Zn levels were 30 and 60 mg/*** normal temperature(NT),a CON group(NT-CON)and pair-fed group(NT-PF)were *** The results showed that HS significantly reduced mRNA and protein expression levels of claudin-1,occludin,junctional adhesion molecule-A(JAMA),zonula occludens-1(ZO-1)and zinc finger protein A20(A20)in the jejunum,and HS also remarkably increased serum fluorescein isothiocyanate dextran(FITC-D),endotoxin and interleukin(IL)-1βcontents,serum diamine oxidase(DAO)and matrix metalloproteinase(MMP)-2 activities,nuclear factor kappa-B(NF-κB)p65 mRNA expression level,and protein expression levels of NF-κB p65 and MMP-2 in the ***,dietary supplementation with Zn,especially organic Zn as Zn-Prot M at 60 mg/kg,significantly decreased serum FITC-D,endotoxin and IL-1βcontents,serum DAO and MMP-2 activities,NF-κB p65 mRNA expression level,and protein expression levels of NF-κB p65 and MMP-2 in the jejunum of HS broilers,and notably promoted mRNA and protein expression levels of claudin-1,ZO-1 and *** Our results suggest that dietary Zn,especially 60 mg Zn/kg as Zn-Prot M,can alleviate HS-induced intestinal barrier function damage by promoting the expression of TJ proteins possibly via induction of A20-mediated suppression of the NF-κB p65/MMP-2 pathway in the jejunum of HS broilers.

关键词： A20/NF-κB p65/MMP-2 pathway Broiler Heat stress Intestinal barrier function Tight junction proteins Zn

Canopy structural heterogeneity drives α and β species-genetic diversity correlations in a Chinese subtropical forest

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Plant Diversity 2025年第1期47卷 106-114页

作者： Zhiliang Yao Xia Pan Xin Yang Xiaona Shao Bin Wang yun Deng Zhiming zhang Qiaoming Li Luxiang Lin CAS Key Laboratory of Tropical Forest Ecology Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesKunming 650223YunnanChina University of Chinese Academy of Sciences Beijing 100049China School of Ecology and Environment Hainan UniversityHaikou 570228HainanChina State Forestry and Grassland Administration Key Laboratory of Silviculture in Downstream Areas of the Yellow River Mountain Tai Forest Ecosystem Research Station of State Forestry and Grassland AdministrationForestry College of Shandong Agricultural UniversityTai'an 271018ShandongChina School of Ecology and Environmental Sciences&yunnan Key Laboratory for Plateau Mountain Ecology and Restoration of Degraded Environments Yunnan UniversityKunming 650500YunnanChina National Forest Ecosystem Research Station at Xishuangbanna Mengla 666303YunnanChina

Patterns and drivers of species–genetic diversity correlations(SGDCs)have been broadly examined across taxa and ecosystems and greatly deepen our understanding of how biodiversity is ***,few studies have examined the role of canopy structural heterogeneity,which is a defining feature of forests,in shaping ***,we determine what factors contribute toα-andβ-species–genetic diversity correlations(i.e.,α-andβ-SGDCs)in a Chinese subtropical *** this purpose,we used neutral molecular markers to assess genetic variation in almost all adult individuals of the dominant tree species,Lithocarpus xylocarpus,across plots in the Ailaoshan National Natural *** also quantified microhabitat variation by quantifying canopy structure heterogeneity with airborne laser scanning on 201-ha subtropical forest *** found that speciesα-diversity was negatively correlated with geneticα-*** structural heterogeneity was positively correlated with speciesα-diversity but negatively correlated with geneticα-*** contrasting effects contributed to the formation of a negativeα-***,we found that canopy structural heterogeneity increases speciesα-diversity and decreases geneticα-diversity by reducing the population size of target ***β-diversity,in contrast,was positively correlated with geneticβ-*** in canopy structural heterogeneity between plots had non-linear parallel effects on the two levels ofβ-diversity,while geographic distance had a relatively weak effect onβ-*** study indicates that canopy structural heterogeneity simultaneously affects plot-level community species diversity and population genetic diversity,and species and genetic turnover across plots,thus drivingα-andβ-SGDCs.

关键词： Dominant species Forest structure LiDAR Lithocarpus xylocarpus Speciesegenetic diversity correlation Subtropical evergreen broad-leaved forest

Flexible Graphene Field‑Effect Transistors and Their Application in Flexible Biomedical Sensing

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Nano-Micro Letters 2025年第2期17卷 252-313页

作者： Mingyuan Sun Shuai Wang Yanbo liang Chao Wang yunhong zhang Hong Liu Yu zhang Lin Han Institute of Marine Science and Technology Shandong UniversityQingdao 266237ShandongPeople’s Republic of China State Key Laboratory of Crystal Materials Shandong UniversityJinan 250100ShandongPeople’s Republic of China School of Integrated Circuits Shandong UniversityJinan 250100ShandongPeople’s Republic of China Shandong Engineering Research Center of Biomarker and Artificial Intelligence Application Jinan250100ShandongPeople’s Republic of China

Flexible electronics are transforming our lives by making daily activities more *** to this innovation are field-effect transistors(FETs),valued for their efficient signal processing,nanoscale fabrication,low-power consumption,fast response times,and ***,known for its exceptional mechanical properties,high electron mobility,and biocompatibility,is an ideal material for FET channels and *** combination of graphene and FETs has given rise to flexible graphene field-effect transistors(FGFETs),driving significant advances in flexible electronics and sparked a strong interest in flexible biomedical ***,we first provide a brief overview of the basic structure,operating mechanism,and evaluation parameters of FGFETs,and delve into their material selection and patterning *** ability of FGFETs to sense strains and biomolecular charges opens up diverse application *** specifically analyze the latest strategies for integrating FGFETs into wearable and implantable flexible biomedical sensors,focusing on the key aspects of constructing high-quality flexible biomedical ***,we discuss the current challenges and prospects of FGFETs and their applications in biomedical *** review will provide valuable insights and inspiration for ongoing research to improve the quality of FGFETs and broaden their application prospects in flexible biomedical sensing.

关键词： Flexible Graphene Field-effect transistor Wearable Implantable Biosensor

Metabolic reprogramming: a new option for the treatment of spinal cord injury

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Neural Regeneration Research 2025年第4期20卷 1042-1057页

作者： Jiangjie Chen Jinyang Chen Chao Yu Kaishun Xia Biao Yang Ronghao Wang Yi Li Kesi Shi Yuang zhang Haibin Xu Xuesong zhang Jingkai Wang Qixin Chen Chengzhen liang Department of Orthopedics The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhouZhejiang ProvinceChina Orthopedics Research Institute of Zhejiang University Zhejiang UniversityHangzhouZhejiang ProvinceChina Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province HangzhouZhejiang ProvinceChina Clinical Research Center of Motor System Disease of Zhejiang Province HangzhouZhejiang ProvinceChina Qiandongnan Prefecture People’s Hospital KailiGuizhou ProvinceChina Department of Orthopedics Fourth Medical CenterChinese PLA General HospitalBeijingChina

Spinal cord injuries impose a notably economic burden on society,mainly because of the severe after-effects they *** the ongoing development of various therapies for spinal cord injuries,their effectiveness remains ***,a deeper understanding of metabolism has opened up a new therapeutic opportunity in the form of metabolic *** this review,we explore the metabolic changes that occur during spinal cord injuries,their consequences,and the therapeutic tools available for metabolic *** spinal cord metabolism is characterized by independent cellular metabolism and intercellular metabolic ***,spinal cord injury results in metabolic disorders that include disturbances in glucose metabolism,lipid metabolism,and mitochondrial *** metabolic disturbances lead to corresponding pathological changes,including the failure of axonal regeneration,the accumulation of scarring,and the activation of *** rescue spinal cord injury at the metabolic level,potential metabolic reprogramming approaches have emerged,including replenishing metabolic substrates,reconstituting metabolic couplings,and targeting mitochondrial therapies to alter cell *** available evidence suggests that metabolic reprogramming holds great promise as a next-generation approach for the treatment of spinal cord *** further advance the metabolic treatment of the spinal cord injury,future efforts should focus on a deeper understanding of neurometabolism,the development of more advanced metabolomics technologies,and the design of highly effective metabolic interventions.

关键词： axons glycolysis metabolic reprogramming metabolism mitochondria neural regeneration neuroprotection oxidative phosphorylation spinal cord injury therapy