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Comparable effects of Jiedu Granule, a compound Chinese herbal medicine, and sorafenib for advanced hepatocellular carcinoma: A prospective multicenter cohort study

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Journal of Integrative Medicine 2020年第4期18卷 319-325页

作者： He-tong Zhao Yong-bin Meng Xiao-feng Zhai Bin-bin Cheng Sha-sha Yu Man Yao Hui-xia Yin Xu-ying Wan yun-ke yang Hui Liu Feng Shen Chang-quan Ling School of Traditional Chinese Medicine Naval Medical UniversityShanghai 200433China Department of Integrated Traditional Chinese and Western Medicine Eastern Hepatobiliary Surgery HospitalNaval Medical UniversityShanghai 200433China Department of Integrative Medicine Zhongshan HospitalFudan UniversityShanghai 200032China The Third Department of Hepatic Surgery Eastern Hepatobiliary Surgery HospitalNaval Medical UniversityShanghai 200433China

Objective:Sorafenib has been extensively used for the treatment of advanced hepatocellular carcinoma(HCC),and Chinese herbal medicine has also been used to manage advanced *** present work evaluates the effectiveness and safety of Jiedu(JD)Granule,a compound of traditional Chinese herbal medicine,side-by-side with sorafenib for the treatment of advance ***:Patients with advanced HCC receiving treatment with JD Granule or sorafenib were enrolled from December 2014 to March *** primary endpoint was overall survival(OS).The secondary endpoints were progression-free survival(PFS)and *** score matching(PSM)analysis was used to control for possible selection bias from the study group allocation ***:Of the 325 patients included,161 received JD Granule and 164 received *** significant differences were found in OS or PFS among patients receiving JD Granule compared to sorafenib(P>0.05).Median OS of the two study groups was 6.83 months(95%confidence interval[CI]:5.83–9.47)in the group receiving JD Granule and 8 months(95%CI:6.67–9.80)in the group receiving sorafenib,with half-,1-and 2-year survival rates of 53.6%,31.2%and 13.2%vs 60.1%,35.5%and 14.2%,*** after PSM,the median survival time did not differ between the JD Granule group(9.03 months;95%CI:6.37–14.2)and the sorafenib group(7.93 months;95%CI:6.5–9.97),with comparable half-,1-and 2-year survival *** most common adverse events(AEs)were diarrhea(13.7%)and fatigue(5.6%)in the JD Granule group,and hand-foot skin reaction(46.3%)and diarrhea(36.6%)in the sorafenib *** JD Granule was more cost-effective than sorafenib treatment for advanced ***:Compared to sorafenib,JD Granule was more cost-effective and caused fewer AEs for the treatment of Chinese patients with advanced HCC.

关键词： Carcinoma,hepatocellular Jiedu Granule Sorafenib Chinese herbal medicine

The Research of Forest Soil Organic Carbon Accumulation in Dabie Mountain

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Meteorological and Environmental Research 2011年第3期2卷 39-42页

作者： yang Shu-yun,yang ke-feng,ZHANG Xin-tong,WANG Jun Anhui Agricultural University,Hefei 230036,China

In subtropical to warm temperate transitional zone of the Dabie Mountains hinterland forest topsoil as the research object this text,through the different levels of soil bulk density,organic carbon content of the determination of analytical studies in the area of forest surface soil organic carbon *** of the ecological role of small environment,the study area within the soil bulk density increased with depth,surface soil porosity,and bulk density from top to bottom in *** measuring points are the 0-10 cm surface layer soil organic carbon content are highest,content between 67.232-61.940 g/kg,this,because the forest soil organic carbon important source withers and falls in the vegetation stack and *** measuring point organic carbon along with depth change characteristic slightly different,low elevation the measuring point soil organic carbon content increases the monotonous drop along with the depth,the elevation is high,the measuring point slightly has in the 30-40 cm depth content *** comprehensive bulk specific gravity factor computation,the 0-40 cm soil organic carbon total content slightly has along with altitude above sea level’s rise increases,each square meter organic carbon content between 16 560.5-18 354.6 g,studies the region 0-40 cm soil organic carbon content mean value by 3 measuring points mean value achievement,then this region 0-40 cm soil organic carbon density approximately 174.3 t/hm2;Refers to the related research between the surface layer and the 0-100 cm soil layer organic carbon content relational reckoning,studies the region 0-100 cm soil organic carbon density to be possible to reach 233.9 t/hm2,it indicated that the Dabie Mountain area forest soil system has the giant organic carbon capacity.

关键词： Dabie Mountain area Forest soil Organic carbon density China

基于开放式创新的制造业企业数字化转型路径研究

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管理案例研究与评论 2024年第5期17卷 816-833页

作者：云科洋李文天津财经大学商学院天津300222 内蒙古科技大学经济与管理学院包头014010 内蒙古自治区产业信息化与产业创新研究中心包头014010

为解决制造业企业数字化转型路径不明问题、防止转型悖论现象发生,基于开放式创新,通过单案例研究方法对长城汽车的数字化转型活动进行深入分析,识别出数字化转型的构成要素,即知识吸收、知识创造、知识整合、知识外溢和知识交互,同时... 详细信息

为解决制造业企业数字化转型路径不明问题、防止转型悖论现象发生,基于开放式创新,通过单案例研究方法对长城汽车的数字化转型活动进行深入分析,识别出数字化转型的构成要素,即知识吸收、知识创造、知识整合、知识外溢和知识交互,同时构建出制造业企业数字化转型路径模型;在此基础上,采用NK模型仿真方法验证数字化转型路径模型对其他制造业企业的适用性,最终得到清晰的数字化转型最优路径,即知识吸收→知识创造→知识整合→知识外溢→知识交互。研究结果有助于推动制造业企业的转型升级和经济的高质量发展。

关键词：数字化转型开放式创新案例研究仿真分析

补阳还五汤联合骨髓间充质干细胞移植对大脑中动脉栓塞模型整合素相关因子的影响

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中国组织工程研究 2017年第5期21卷 724-729页

作者：张运克杨俊红高峰段枫阳河南中医药大学河南省郑州市450056 河南中医药大学第一附属医院河南省郑州市450000 河南省医药科学研究院河南省郑州市450008

背景:前期研究发现,补阳还五汤联合骨髓间充质干细胞移植可发挥协同抗脑缺血损伤作用。目的:分析骨髓间充质干细胞移植联合补阳还五汤促进脑缺血血管新生的作用。方法:将96只SD大鼠随机分为4组,均制作大脑中动脉栓塞模型。联合组于造模... 详细信息

背景:前期研究发现,补阳还五汤联合骨髓间充质干细胞移植可发挥协同抗脑缺血损伤作用。目的:分析骨髓间充质干细胞移植联合补阳还五汤促进脑缺血血管新生的作用。方法:将96只SD大鼠随机分为4组,均制作大脑中动脉栓塞模型。联合组于造模前3 d灌胃给予补阳还五汤10 mL/kg,1次/d,造模成功后2 h灌胃1次,以后每12 h灌胃1次;局灶脑缺血2 h再灌注2 h后,干细胞组、联合组向脑室中注入骨髓间充质干细胞悬液,30 min后再注射抗CD34、CD45抗体;抗体组注射抗CD34、CD45抗体;模型组注射生理盐水。联合组于再灌注后12,24,36,48 h进行血清αVβ3水平及脑组织免疫组织化学、Q-PCR、免疫印迹检测,其余3组均于再灌注后36 h检测上述指标。结果与结论:(1)血清αVβ3水平:抗体组血清αVβ3水平低于模型组(P<0.05),干细胞组、联合组高于抗体组(P<0.05),且联合组再灌注不同时间点的血清αVβ3水平高于干细胞组(P<0.01);(2)免疫组织化学:抗体组CD34阳性细胞数量少于模型组(P<0.05),干细胞组、联合组高于抗体组(P<0.05);(3)Q-PCR与免疫印迹检测:与模型组相比,抗体组、干细胞组p FAK蛋白表达水平降低(P<0.05),FAK基因及蛋白表达变化不大;与其他组比较,联合组FAK蛋白(自再灌注后24 h开始)和p FAK蛋白(自再灌注12 h开始)显著升高(P<0.05,P<0.01),且随着再灌注时间延长有逐渐升高趋势;(4)结果表明:骨髓间充质干细胞移植联合补阳还五汤可逆转抗CD34+CD45抗体引起的血管内皮细胞数量减少、整合素αVβ3及其下游信号分子表达下降,促进血管新生。

关键词：间质干细胞梗塞,大脑中动脉中草药组织工程干细胞移植骨髓间充质干细胞补阳还五汤整合素抗CD34+CD45抗体脑中动脉栓塞血管新生疾病模型,动物大鼠国家自然科学基金

Role of nutrition in diabetes mellitus and infections

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World Journal of Clinical Cases 2025年第3期13卷 1-8页

作者： Xue-Lu Yu Li-yun Zhou Xiao Huang Xin-Yue Li Ming-ke Wang Ji-Shun yang Naval Medical Center of PLA Naval Medical UniversityShanghai 200052China

In this editorial,we have commented on the article that has been published in the recent issue of World Journal of Clinical *** authors have described a case of unilateral thyroid cyst and have opined that the acute onset of infection may be linked to diabetes mellitus(DM).We have focused on the role of nutrition in the association between DM and *** with DM are at a high risk of infection,which could also be attributed to nutrition-related *** interventions for patients with diabetes are mainly based on a low-calorie diet,which can be achieved by adhering to a low-carbohydrate ***,dietary fiber supplementation is recommended to maintain the diversity of the gut ***,high-quality protein can prevent the increased risk of infection due to *** of vitamins C,vitamins A,vitamins D,and folic acid improves blood sugar control and facilitates immune *** deficiencies augment the risk of infection,but the relationship with diabetes is mostly U-shaped and a good intake should be maintained.

关键词： Diabetes mellitus Infection Macronutrients Vitamins Minerals

Traditional herbal medicine in preventing recurrence after resection of small hepatocellular carcinoma: a multicenter randomized controlled trial

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Journal of Integrative Medicine 2013年第2期11卷 90-100页

作者： Xiao-feng Zhai Zhe Chen Bai Li Feng Shen Jia Fan Wei-ping Zhou yun-ke yang Jing Xu Xiao Qin Le-qun Li Chang-quan Ling Changhai Hospital of Traditional Chinese Medicine Second Military Medical University Department of Hepatic Surgery Eastern Hepatobiliary Surgery Hospital Second Military Medical University Liver Cancer Institute Fudan University Department of Traditional Chinese Medicine Zhongshan Hospital Fudan University Department of Hepatic Surgery the First Affiliated Hospital of Guangxi Medical University Department of Hepatobiliary Surgery Tumor Hospital of Guangxi Medical University

BACKGROUND： Disease recurrence is a main challenge in treatment of hepatocellular carcinoma （HCC）. There is no generally accepted method for preventing recurrence of HCC after resection. OBJECTIVE： To compare the efficacy of a traditional herbal medicine （THM） regimen and transarterial chemoembolization （TACE） in preventing recurrence in post-resection patients with small HCC. DESIGN, SETTING, PARTICIPANTS AND INTERVENTIONS： This is a multicenter, open- label, randomized, controlled study, which was undertaken in five centers of China. A total of 379 patients who met the eligibility criteria and underwent randomization were enrolled in this trial. One hundred and eighty-eight patients were assigned to the THM group and received Cinobufacini injection and Jiedu Granule, and the other 191 patients were assigned to the TACE group and received one single course of TACE. MAIN OUTCOME MEASURES： Primary outcome measures were the annual recurrence rate and the time to recurrence. Incidence of adverse events was regarded as the secondary outcome measure. RESULTS： Among the 364 patients who were included in the intention-to-treat analysis, 67 patients of the THM group and 87 of the TACE group had recurrence, with a hazard ratio of 0.695 （P = 0.048）. Median recurrence-free survival of the patients in the THM and TACE groups was 46.89 and 34.49 months, respectively. Recurrence rates at 1, 2 and 3 years were 17.7%, 33.0% and 43.5% for the THM group, and 28.8%, 42.5% and 54.0% for the TACE group, respectively （P = 0.026）. Multivariate analysis indicated that the THM regimen had a big advantage for prolonging the recurrence-free survival. Adverse events were mild and abnormality of laboratory indices of the two groups were similar. CONCLUSION： In comparison with TACE therapy, the THM regimen was associated with diminished risk of recurrence of small-sized HCC after resection, with comparable adverse events. TRIAL REGISTRTION IDENTIFIER： This trial was registered in the Chinese Cli

关键词： hepatocellular carcinoma recurrence traditional Chinese medicine transarterial chemoembolization: randomized controlled trial

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产业匹配视角下的环京产研一体化圈建设策略

河北学刊 2025年第1期45卷 82-90页

作者：张可云黎思灏中国人民大学应用经济学院

打造环京产研一体化圈层是推动京津冀协同发展的创新举措,需要推动北京市制造业高新技术企业与环京区县的合作。但环京区县存在产业基础薄弱、与北京产业匹配度不高和产业投资联系不强的问题。两地发展差距过大、市郊铁路建设滞后和环... 详细信息

打造环京产研一体化圈层是推动京津冀协同发展的创新举措,需要推动北京市制造业高新技术企业与环京区县的合作。但环京区县存在产业基础薄弱、与北京产业匹配度不高和产业投资联系不强的问题。两地发展差距过大、市郊铁路建设滞后和环京区县营商环境不良是造成上述问题的主要原因。未来应当根据产业匹配度建立对口合作关系,进一步加强市际交通基础设施建设,降低企业营商成本。

关键词：京津冀环京区县产研一体高新技术企业上市公司异地投资

Mitophagy in acute central nervous system injuries:regulatory mechanisms and therapeutic potentials

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Neural Regeneration Research 2025年第9期20卷 2437-2453页

作者： Siyi Xu Junqiu Jia Rui Mao Xiang Cao yun Xu Department of Neurology Nanjing Drum Tower HospitalClinical College of Jiangsu UniversityNanjingJiangsu ProvinceChina Department of Neurology Nanjing Drum Tower HospitalChinese Academy of Medical Science&Peking Union Medical CollegeNanjingJiangsu ProvinceChina Department of Neurology Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina State key Laboratory of Pharmaceutical Biotechnology and Institute of Translational Medicine for Brain Critical Diseases Nanjing UniversityNanjingJiangsu ProvinceChina Jiangsu key Laboratory for Molecular Medicine Medical School of Nanjing UniversityNanjingJiangsu ProvinceChina Nanjing Neurology Medical Center NanjingJiangsu ProvinceChina

Acute central nervous system injuries,including ischemic stro ke,intracerebral hemorrhage,subarachnoid hemorrhage,traumatic brain injury,and spinal co rd injury,are a major global health *** optimal therapies and improving the long-term neurological functions of patients with acute central nervous system injuries are urgent *** are susceptible to damage after acute central nervous system injury,and this leads to the release of toxic levels of reactive oxygen species,which induce cell ***,a selective form of autophagy,is crucial in eliminating redundant or damaged mitochondria during these *** evidence has highlighted the significant role of mitophagy in acute central nervous system *** this review,we provide a comprehensive overview of the process,classification,and related mechanisms of *** also highlight the recent developments in research into the role of mitophagy in various acute central nervous system injuries and drug therapies that regulate *** the final section of this review,we emphasize the potential for treating these disorders by focusing on mitophagy and suggest future research paths in this area.

关键词： autophagy intracerebral hemorrhage ischemic stroke mitochondria mitochondrial biogenesis mitochondrial quality control mitophagy spinal cord injury subarachnoid hemorrhage traumatic brain injury

Ultrasonic Nondestructive Testing of Superplastic Solid-State Welding Joint for Different Steels

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Journal of Iron and Steel Research International 2002年第2期9卷 58-61页

作者： ZHANG ke-ke yang yun-lin CHEN Huai-dong XUE Jin Henan University of Science and Technology Xi'an Jiaotong University Huazhong University of Science and Technology

Based on quantitative microscopic examinations of welds and welding rate for different steels(40Cr and T10A) joint,which possess the ultra-fine microstructure after high frequency hardening(HFH) and salt-bath cyclic quenching(SCQ),the suitable defect grey scale threshold value was determined,and the welding rate of superplastic solid-state welding of different steels(40Cr and T10 A steel) was systematically inspected and analyzed by means of self-made ultrasonic imaging inspection *** experimental results showed that the superplastic solid-state weld of different steels can be inspected more accurately,reliably and quickly by this system,and the results were in good accordance with that of metallographic *** welding rate of superplastic welding is in linear relation with tensile strength of joint.

关键词： superplastic solid-state welding welding rate ultrasonic nondestructive testing