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Fhe reference values for semen parameters of 1213 ertile men in Guangdong Province in China

Asian Journal of Andrology 2015年第2期17卷 298-303,I0011页

作者： yun-ge tang Key Laboratory of Male Reproductive and genetics National Health and Family Planning Commission Guangzhou 510600 China Department of Male Reproduction Family Planning Research Institute of Guangdong Guangzhou 510600 China Human Sperm Bank of Guangdong Province Guanzghou 510600 China Reproductive Medicine Center Family Planning Research Institute of Guangdong Guangzhou 510600 China.

Semen samples were collected from 1213 fertile men whose partners had a time-to-pregnancy （TTP） _〈12 months in Guangdong Province in Southern China, and semen parameters including semen volume, sperm concentration, total counts, motility, and morphology were evaluated according to the World Health Organization （WHO） 2010 guideline. All semen parameters analyzed were normal in ~62.2% of the total samples, whereas 37.8% showed at least one of the semen parameters below normal threshold values. The fifth centiles （with 95% confidence intervals） were 1.3 （1.2-1.5） ml for semen volume, 20 x 106 （18x106- 20x106） m1-1 for sperm concentration, 40 x 106 （38x106-44x106） per ejaculate for total sperm counts, 48% （47%-53%） for vitality, 39% （36%-43%） for total motility, 25% （23%-27%） for sperm progressive motility, 5.0% （4%,5%） for normal morphology. The pH values ranged from 7.2 to 8.0 with the mean ~ standard deviation at 7.32 ~ 0.17. No effects of age and body mass index were found on semen parameters. Occupation, smoking and alcohol abuse, varicocele appeared to decrease semen quality. Sperm concentration, but not sperm morphology, is positively correlated with TTP, whereas vitality is negatively correlated with TTP. Our study provides the latest reference values for the semen parameters of Chinese fertile men in Guangdong Province, which are close to those described in the new WHO guidelines （5th Edition）.

关键词： Chinese fertile men semen parameters semen quality time-to-pregnancy

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Reproductive outcomes of intracytoplasmic sperm injection using testicular sperm and ejaculated sperm in patients with AZFc microdeletions:a systematic review and meta-analysis

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Asian Journal of Andrology 2021年第5期23卷 495-500页

作者： Yu Zhou Cun-Can Deng Wu-Jiang Liu Huang Liu Hou-Bin Zheng yun-ge tang Xin-Zong Zhang Jun-Hong Deng Department of Urology The First Affiliated HospitalJinan UniversityGuangzhou 510630China NHC Key Laboratory of Male Reproduction and genetics Family Planning Research Institute of Guangdong ProvinceGuangzhou 510600China Digestive Diseases Center The Seventh Affiliated Hospital of Sun Yat-sen UniversityShenzhen 518107China Department of Andrology Guangzhou First People's HospitalSchool of MedicineSouth China University of TechnologyGuangzhou 510180China

Studies have explored the assisted reproductive technology(ART)outcomes of Y-chromosome azoospermia factor c(AZFc)microdeletions,but the effect of sperm source on intracytoplasmic sperm injection(ICSI)remains *** determine the ART results of ICSI using testicular sperm and ejaculated sperm from males with AZFc microdeletions,we searched Embase,Web of Science,and PubMed to conduct a systematic review and *** first meta-analysis results for 106 cycles in five studies showed no significant differences in the live birth rate between the testicular sperm group and the ejaculated sperm group(risk ratio:0.97,95%confidence interval[CI]:0.73-1.28,P=0.82).The second meta-analysis of 106 cycles in five studies showed no difference in the abortion rate between the testicular sperm group and ejaculated sperm group(risk ratio:1.06,95%Cl:0.54-2.06,P=0.87).The third meta-analysis of 386 cycles in seven studies showed no significant difference in clinical pregnancy rates between the testicular sperm group and the ejaculated sperm group(risk ratio:1.24,95%Cl:0.66-2.34,P=0.50).Inevitable heterogeneity weakened our ***,our results indicated that testicular sperm and ejaculated sperm yield similar ART outcomes,representing a meaningful result for clinical *** properly designed studies are needed to further confirm our conclusions.

关键词： assisted reproductive technology azoospermia factor c microdeletions ejaculated sperm live birth rate testicular sperm

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Enhanced autophagic clearance of amyloid-βvia histone deacetylase 6-mediated V-ATPase assembly and lysosomal acidification protects against Alzheimer's disease in vitro and in vivo

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Neural Regeneration Research 2025年第9期20卷 2633-2644页

作者： Zhimin Long Chuanhua ge Yueyang Zhao Yuanjie Liu Qinghua Zeng Qing tang Zhifang Dong Guiqiong He Institute of Neuroscience School of Basic Medical SciencesChongqing Medical UniversityChongqingChina Department of Anatomy Chongqing Medical UniversityChongqingChina Department of Physiology Chongqing Medical UniversityChongqingChina Pediatric Research Institute Children’s Hospital of Chongqing Medical UniversityChongqingChina Ministry of Education Key Laboratory of Child Development and Disorders Children’s Hospital of Chongqing Medical UniversityChongqingChina National Clinical Research Center for Child Health and Disorders Children’s Hospital of Chongqing Medical UniversityChongqingChina Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders Children’s Hospital of Chongqing Medical UniversityChongqingChina

Recent studies have suggested that abnormal acidification of lysosomes induces autophagic accumulation of amyloid-βin neurons,which is a key step in senile plaque ***,resto ring normal lysosomal function and rebalancing lysosomal acidification in neurons in the brain may be a new treatment strategy for Alzheimer's *** acetylation/deacetylation plays a central role in lysosomal ***,we show that inhibiting the classic microtubule deacetylase histone deacetylase 6 with an histone deacetylase 6 shRNA or thehistone deacetylase 6 inhibitor valproic acid promoted lysosomal reacidification by modulating V-ATPase assembly in Alzheimer's *** rthermore,we found that treatment with valproic acid markedly enhanced *** clearance of amyloid-βaggregates,and ameliorated cognitive deficits in a mouse model of Alzheimer's *** findings demonstrate a previously unknown neuroprotective mechanism in Alzheimer's disease,in which histone deacetylase 6 inhibition by valproic acid increases V-ATPase assembly and lysosomal acidification.

关键词： Alzheimer's disease amyloid-β APP/PS1 mice autophagy cognitive impairment histone deacetylase 6 lysosomal acidification microtubule acetylation valproic acid V-ATPase

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Hochschild(Co)homology of Galois Coverings of Grassmann Algebras

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Acta Mathematica Sinica,English Series 2009年第10期25卷 1693-1702页

作者： yun ge XU Xin tang School of Mathematics and Computer Science Hubei University Wuhan 430062 P.R. China Department of Mathematics and Computer Science Fayetteville State University Fayetteville NC 28301 USA

Let ∧ be the Z2-Galois covering of the Grassmann algebra A over a field k of characteristic not equal to 2. In this paper, the dimensional formulae of Hochschild homology and cohomology groups of ∧ are calculated explicitly. And the cyclic homology of∧ can also be calculated when the underlying field is of characteristic zero. As a result, we prove that there is an isomorphism from i≥1 HH^i（∧） to i≥1 HH^i（∧）.

关键词： Galois covering Grassmann algebra Hochschild (co)homology minimal projective resolution

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Deciphering fungal metabolon coupling tandem inverse-electrondemand Diels-Alder reaction and semipinacol rearrangement for the biosynthesis of spiro polycyclic alkaloids

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Science China Chemistry 2025年第01期 288-296页

作者： Shuai Liu Wen-Qiang Xu Ying-Tong Di Man-Cheng tang Ding-Kang Chen Ming-Ming Cao Yao-Wen Chang Hong-Yu tang Chun-Mao Yuan Jun-Bo Yang Zhi-Li Zuo Han Guo Zi-Fei Xu Ying Zeng yun-Dong Wu Xiao-Jiang Hao Key Laboratory of Phytochemistry and Natural Medicines (Chinese Academy of Sciences) Kunming Institute of Botany Chinese Academy of Sciences University of Chinese Academy of Sciences Lab of Computational Chemistry and Drug Design State Key Laboratory of Chemical Oncogenomics Peking University Shenzhen Graduate School Shenzhen Bay Laboratory State Key Laboratory of Microbial Metabolism School of Life Sciences & Biotechnology Shanghai Jiao Tong University State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical University Molecular Biology Experimental Center Germplasm Bank of Wild Species in Southwest China Kunming Institute of Botany Chinese Academy of Sciences yunnan Key Laboratory for Wild Plant Resources Kunming Institute of Botany Chinese Academy of Sciences Research Unit of Chemical Biology of Natural Anti-Virus Products Chinese Academy of Medical Sciences

In the intricate process of natural product biosynthesis, a metabolon can enhance metabolic flux by associating sequential enzymes. A fungal metabolon, comprising of flavin-dependent monooxygenase Spe F and P450 monooxygenase Spe G, is identified in the biosynthesis of spiro polycyclic alkaloids(+)-notoamide B and its diastereomer(+)-versicolamide B. Using notoamide E as a substance, Spe F/Spe G metabolon can control the stereoselectivity of its 2,3-epoxidation, followed by hydrogen atom ion at C-17 to generate reactive epoxide tau-m A with dienyl iminium unit. Subsequently,(+)-notoamide B and(+)-versicolamide B are produced via tandem nonenzymatic inverse-electron-demand Diels-Alder reaction and semipinacol rearrangement. This provides the first example of metabolon in the biosynthesis of spiro-prenylated indole alkaloids.

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精液分析区域性外部质量控制研究

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生殖与避孕 2015年第12期35卷 888-892页

作者：王奇玲唐运革邓顺美庄嘉明李月华唐雨倩陈曦马婷马春杰国家卫生和计划生育委员会男性生殖与遗传重点实验室广东省计划生育科学技术研究所人类精子库广州510600

目的:探讨精液分析区域性外部质量控制实践中参评实验室检测结果的准确性和结果的可比性。方法:制作2个水平的精子浓度、活动率和正常形态率的质控品发放给参评实验室进行外部质量控制测试,分析质控结果。评价指标为均值和实验室间变异... 详细信息

目的:探讨精液分析区域性外部质量控制实践中参评实验室检测结果的准确性和结果的可比性。方法:制作2个水平的精子浓度、活动率和正常形态率的质控品发放给参评实验室进行外部质量控制测试,分析质控结果。评价指标为均值和实验室间变异系数(CV)。结果:精子浓度、前向运动精子百分率(PR)和正常形态精子百分率(NR)CV分别为34.09%、24.96%和62.01%;各实验室精子浓度、PR结果差异均无统计学意义(P>0.05),NR差异有统计学意义(P<0.05)。结论:外部质控结果CV较大,尤其正常形态精子的检测结果,提示技术人员亟需进行规范培训,开展标准化精液分析质量控制活动,提高分析结果的重复性和准确性。

关键词：精液分析区域性外部质量控制平均变异值变异系数(CV)

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Surface plasmon resonance scattering and absorption of biofunctionalized gold nanoparticles for targeted cancer imaging and laser therapy

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Science China(Technological Sciences) 2011年第9期54卷 2358-2362页

作者： ge yun KANG Bin School of Electronics Science and Engineering Naniing University Naniing 210093 China College of Materials Science and Technology Nanjing University of Aeronautics and Astronautics Nanjing 210016 China

The localized surface plasmon resonance of gold nanoparticles enables them to be excellent light scattering sensing reagents and efficient lignt-heat convertors for potential diagnostics and *** this work,gold nanoparticles of 15 nm in size were synthesized and conjugated with a kind of arginine-glycine-aspartic acid peptide(RGD)to target the cancer *** a conventional dark field microscope,the scattering images from normal and cancer cells are very *** a few of gold nanoparticles bind to the membrane of normal cells due to nonspecific *** for cancer cells,the concentration of gold nanoparticles inside cancer cells is much higher than that inside normal cells,showing a strong light scattering *** exposing these cells to an external laser irradiation,cancer cells were selectively destructed because of the heat conversion of gold nanoparticles inside them,but normal cells still kept alive due to the absence of gold nanoparticles in *** results incidated that gold nanoparticles might be potential contrast reagents for targeted cancer imaging and laser therapy.

关键词： surface plasmon gold nanoparticles cancer imaing laser therapy

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Carbon Chain Length Determines Inhibitory Potency of Perfluoroalkyl Sulfonic Acids on Human Placental 3β-Hydroxysteroid Dehydrogenase 1:Screening,Structure-Activity Relationship,and In Silico Analysis

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Biomedical and Environmental Sciences 2023年第11期36卷 1015-1027页

作者： tang Lu Ming MAO Bai Ping ZHANG Bing Ru LI Jing Jing tang yun Bing LI Hui Tao ge Ren Shan Department of Emergency Medicine The Second Affiliated Hospital and Yuying Children Hospital of Wenzhou Medical UniversityWenzhou 325000ZhejiangChina Department of Anesthesiology The Second Affiliated Hospital and Yuying Children Hospital of Wenzhou Medical UniversityWenzhou 325000ZhejiangChina Department of Obstetrics and Gynecology The Second Affiliated Hospital and Yuying Children Hospital of Wenzhou Medical UniversityWenzhou 325000ZhejiangChina Key Laboratory of Structural Malformations in Children of Zhejiang Province Wenzhou 325000ZhejiangChina

Objective This study aimed to compare 9 perfluoroalkyl sulfonic acids(PFSA)with carbon chain lengths(C4–C12)to inhibit human placental 3β-hydroxysteroid dehydrogenase 1(3β-HSD1),aromatase,and rat 3β-HSD4 *** Human and rat placental 3β-HSDs activities were determined by converting pregnenolone to progesterone and progesterone secretion in JEG-3 cells was determined using HPLC/MS–MS,and human aromatase activity was determined by *** PFSA inhibited human 3β-HSD1 structure-dependently in the order:perfluorooctanesulfonic acid(PFOS,half-maximum inhibitory concentration,IC50:9.03±4.83μmol/L)>perfluorodecanesulfonic acid(PFDS,42.52±8.99μmol/L)>perfluoroheptanesulfonic acid(PFHpS,112.6±29.39μmol/L)>perfluorobutanesulfonic acid(PFBS)=perfluoropentanesulfonic acid(PFPS)=perfluorohexanesulfonic acid(PFHxS)=perfluorododecanesulfonic acid(PFDoS)(ineffective at 100μmol/L).6:2FTS(1H,1H,2H,2H-perfluorooctanesulfonic acid)and 8:2FTS(1H,1H,2H,2H-perfluorodecanesulfonic acid)did not inhibit human 3β-*** and PFHpS are mixed inhibitors,whereas PFDS is a competitive ***,1–10μmol/L PFOS and PFDS significantly reduced progesterone biosynthesis in JEG-3 *** analysis revealed that PFSA binds to the steroid-binding site of human 3β-HSD1 in a carbon chain length-dependent *** 100μmol/L PFSA solutions did not affect rat 3β-HSD4 and human placental aromatase *** Carbon chain length determines inhibitory potency of PFSA on human placental 3β-HSD1 in a V-shaped transition at PFOS(C8),with inhibitory potency of PFOS>PFDS>PFHpS>PFBS=PFPS=PFHxS=PFDoS=6:2FTS=8:2FTS.

关键词： 3β-hydroxysteroid dehydrogenase 1 Docking analysis Perfluorooctanesulfonic acid Progesterone Structure-activityrelationship

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Effect of particle size on the thermal performance of NaNO3/SiC)2/C composite phase-change materials

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Particuology 2019年第3期17卷 169-175页

作者： Liang Liu Liqiong Wang Weichun ge Yanfeng ge yun Huang State Key Laboratory of Explosion Science and Technology Beijing Institute of Technology Beijing 100081 China State Key Laboratory of Multiphase Complex Systems Institute of Process Engineering Chinese Academy of Sciences Beijing 100190 China State Grid Liaoning Electric Power Supply Co. Ltd. Shenyang 110004 China

Storage of thermal energy is a key technology for energy conservation and application of renewable energy sources. In this paper, the thermal performance of inorganic composite phase-change materials (PCMs;NaNO3/SiO2/C) is studied under extreme thermal conditions and the effect of raw particle size is examined. We designed a thermal shock test platform with a diffusive combustion system and in-situ infrared thermal imaging. The influences of the heat flux magnitude and exposure time on the performance of the PCMs were examined under vertical thermal shock conditions. Leakage of molten salt in the composite PCMs was observed as the heat flux reached a threshold point. The morphology and thermal properties were characterized by ex-situ SEM, XRD, DSC, and BET. Raw particles with sizes in the range of 105-500 μm were used to synthesize the composite material and examine its role in thermal shock behavior. Our experiments showed that deterioration of the thermal storage density was slowed as the particle size was increased. This work provides useful guidance for improving the anti-thermal shock ability of future material designs.

关键词： Thermal storage Phase change material Particle size Thermal shock Decomposition temperature

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Hochschild (Co)homology of a Class of Nakayama Algebras

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Acta Mathematica Sinica,English Series 2008年第7期24卷 1097-1106页

作者： yun ge XU Dan WANG Faculty of Mathematics & Computer Science Hubei University Wuhan 430062 P. R. China

Let A = kQ/I be a finite-dimensional Nakayama algebra, where Q is an Euclidean diagram An for some n with cyclic orientation, and I is an admissible ideal generated by a single monomial relation. In this note we determine explicitly all the Hochschild homology and cohomology groups of A based on a detailed description of the Bardzell complex. Moreover, the cyclic homology of A can be calculated in the case that the underlying field is of characteristic zero.

关键词： Nakayama algebra Hochschild homology cyclic homology Hochschild cohomology

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