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以白细胞介素15拮抗剂为载体的融合毒素IL15M-PEΔ293的研制

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生物工程学报 2005年第1期21卷 42-46页

作者：牛云飞郑颖毛晓华发育与疾病相关基因教育部重点实验室东南大学基础医学院发育生物学与遗传学系南京210009

IL 15及IL 15受体 (IL 15R)阳性细胞在成人T淋巴细胞性白血病 (ATL)、多发性骨髓瘤及炎症性自身免疫性疾病病理过程中起着重要作用。为研制特异的可消除IL 15受体阳性异常细胞的新型导向药物 ,将人IL 15拮抗剂 (IL 15M)基因片段与人工... 详细信息

IL 15及IL 15受体 (IL 15R)阳性细胞在成人T淋巴细胞性白血病 (ATL)、多发性骨髓瘤及炎症性自身免疫性疾病病理过程中起着重要作用。为研制特异的可消除IL 15受体阳性异常细胞的新型导向药物 ,将人IL 15拮抗剂 (IL 15M)基因片段与人工改造的绿脓杆菌外毒素 (PE)变异体 (PEΔ2 93)基因按正确的阅读框架融合 ,定向克隆在pET16b表达载体T7启动子的下游 ,得到质粒pET IL15M PEΔ2 93。从大肠杆菌相应重组菌株中通过Ni2 + NTA亲和层析纯化出融合蛋白IL15M PEΔ2 93。IL15M PEΔ2 93对IL 15R阳性红白血病细胞系K5 6 2及其多药耐药细胞系K5 6 2 AO2 均具有杀伤作用 ,对IL 15R阴性细胞系Jur kat则没有明显的杀伤作用 ,而且过量的重组IL 15可以完全阻断融合蛋白对K5 6 2的细胞毒效应 ,说明融合蛋白的细胞毒作用具有靶向性。这些结果提示本文构建的融合蛋白在与IL 15 IL 15R异常表达相关的疾病甚至耐药性肿瘤的治疗中具有潜在的应用价值。

关键词：白细胞介素15 绿脓杆菌外毒素融合蛋白

双向不等围压煤岩破坏能量演化机理与能量强度准则

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安全与环境学报 2016年第6期16卷 59-65页

作者：王云飞郑晓娟赵洪波王立平河南理工大学土木工程学院河南焦作454000 焦作师范高等专科学校管理学院河南焦作454000

结合室内单轴试验和颗粒流与Fish语言程序对杨村矿煤岩进行了不同围压组合试验,研究双向不等围压煤岩的强度、能量演化机制,并基于能量原理导出能量强度准则。结果表明:随围压比增大,煤岩屈服段对应应变幅宽先增后减,峰后软化段应力降明... 详细信息

结合室内单轴试验和颗粒流与Fish语言程序对杨村矿煤岩进行了不同围压组合试验,研究双向不等围压煤岩的强度、能量演化机制,并基于能量原理导出能量强度准则。结果表明:随围压比增大,煤岩屈服段对应应变幅宽先增后减,峰后软化段应力降明显,残余强度减小;可释放弹性应变能随应变增加在峰值前不断增大,但增速越来越小,峰后初期快速减小,然后保持较低水平;随围压比增大,煤岩在较大轴向应变下出现内部损伤,高围压比下峰前一定应变范围吸收的能量全部用于内部损伤裂隙形成和扩展所需的表面能,揭示了高围压比要比低围压比煤岩破坏时内部损伤程度严重;高围压比煤岩在较大第一、第二主应力作用下峰后弹性应变能释放更加容易;煤岩弹性储能极限与围压比存在线性变化规律,将弹性储能极限与能量演化结合导出能量强度准则,准则方程包含岩性常数和3个主应力,考虑了岩石破坏的综合因素,计算精度比Hoek-Brown准则和Drucker-Prager准则更具优势,能很好地表达岩石强度特性。

关键词：安全工程煤岩双向不等围压能量演化能量强度准则 Drucker-Prager准则 Hoek-Brown准则

Vibrational relaxation dynamics in transient grating spectroscopy studied by rate equations based on time-dependent correlation function

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Chinese Physics B 2012年第4期21卷 245-248页

作者：于国洋宋云飞何兴郑贤旭谭多旺陈军杨延强 Center for Condensed Matter Science and Technology Department of PhysicsHarbin Institute of TechnologyHarbin 150001China National Key Laboratory of Shock Wave and Detonation Physics Institute of Fluid PhysicsChina Academy of Engineering PhysicsMianyang 621900China

A modified model, a set of rate equations based on time-dependent correlation function, is used to study vibrational relaxation dynamics in transient grating spectroscopy. The dephasing, the population dynamics, and the vibrational coherence concerning two vibrational states are observed respectively in organic dye IR780 perchlorate molecules doped polyvinyl alcohol matrix. The result shows that in addition to the information concerning system-environment interaction and vibrational coherence, the vibrational energy transfer can be described by this modified model.

关键词： transient grating population dynamics vibrational energy transfer

马来酸替加色罗中有机溶剂残留量的气相色谱法测定

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复旦学报（医学版） 2004年第1期31卷 93-95,98页

作者：沙云菲赵政高敏洁许盈段更利复旦大学药学院药物分析教研室上海200032 上海华源生命科学研究开发有限公司上海200063

目的测定马来酸替加色罗中甲醇、乙醇、丙酮、乙醚、石油醚、乙酸乙酯、碘甲烷、冰醋酸、戊胺、草酸二乙酯和二甲基甲酰胺的含量。方法采用毛细管气相色谱法,色谱系统为:HP—5色谱柱;程序升温;载气为氮气;检测器为FID;外标法计算含量... 详细信息

目的测定马来酸替加色罗中甲醇、乙醇、丙酮、乙醚、石油醚、乙酸乙酯、碘甲烷、冰醋酸、戊胺、草酸二乙酯和二甲基甲酰胺的含量。方法采用毛细管气相色谱法,色谱系统为:HP—5色谱柱;程序升温;载气为氮气;检测器为FID;外标法计算含量。结果在各色谱条件下,测得各溶剂的线性良好(r>0.99);平均回收率86.87％～98.45％;RSD 1.34％～6.56％;最低检出量0.29～1.06ng;4批样品中11种有机溶剂残留量均符合要求。结论经方法学试验验证,该方法灵敏、准确、可靠,适用于本品有机溶剂残留量的测定。

关键词：马来酸替加色罗有机溶剂残留量气相色谱法含量测定甲醇乙醇丙酮乙醚石油醚

TiB、TiC和Y_(2)O_(3)增强钛基复合材料的蠕变行为和组织演变

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Transactions of Nonferrous Metals Society of China 2023年第2期33卷 467-480页

作者：徐丽娟郑云飞梁振泉韩世维薛祥肖树龙田竟陈玉勇哈尔滨工业大学金属精密热加工国家重点实验室哈尔滨150001 哈尔滨工业大学材料科学与工程学院哈尔滨150001

采用感应熔炼法制备(TiB+TiC)和(TiB+TiC+Y_(2)O_(3))增强钛基复合材料。蠕变试验在650℃和120~160 MPa下进行,通过XRD、SEM和TEM对铸态试样和蠕变试样的显微组织演变进行详细表征。结果表明,两种复合材料的铸态组织均为网篮组织。在相... 详细信息

采用感应熔炼法制备(TiB+TiC)和(TiB+TiC+Y_(2)O_(3))增强钛基复合材料。蠕变试验在650℃和120~160 MPa下进行,通过XRD、SEM和TEM对铸态试样和蠕变试样的显微组织演变进行详细表征。结果表明,两种复合材料的铸态组织均为网篮组织。在相同的蠕变条件下,添加Y_(2)O_(3)的复合材料具有更低的稳态蠕变速率。蠕变后,在α/β界面、溶解的β相和增强体周围有硅化物析出,这些硅化物对位错有很强的钉扎作用。因为存在贯穿TiB晶须的层错结构,所以TiB周围的硅化物尺寸明显大于TiC和Y_(2)O_(3)周围的硅化物尺寸。蠕变变形主要受溶质阻力控制,位错运动还受到α/β界面、增强相和硅化物的影响。

关键词：钛基复合材料显微组织蠕变行为硅化物

UAVs cooperative task assignment and trajectory optimization with safety and time constraints

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Defence Technology（防务技术） 2023年第2期20卷 149-161页

作者： Duo zheng yun-fei Zhang Fan Li Peng Cheng UAV Autonomous Control Institute Beijing Institute of TechnologyBeijing100081China Shanghai Institute of Mechanical and Electrical Engineering Shanghai201100China CASIC Research Institute of Intelligent Decision Engineering Wuhan100074China

This paper proposes new methods and strategies for Multi-UAVs cooperative attacks with safety and time constraints in a complex *** triangle is designed to construct a map of the complex flight environment for aerial ***-Map,Safe Flight Corridor(SFC),and Relative Safe Flight Corridor(RSFC)are applied to ensure each UAV flight trajectory's *** using such techniques,it is possible to avoid the collision with obstacles and collision between ***-curve is further developed to ensure that multi-UAVs can simultaneously reach the target at the specified time,and the trajectory is within the flight *** trajectory tracking controller is also designed based on model predictive control to track the planned trajectory *** simulation and experiment results are presented to verifying developed strategies of Multi-UAV cooperative attacks.

关键词： Multi-UAV Cooperative attacks Task assignment Trajectory optimization Safety constraints

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腹腔镜规则性左半肝切除治疗胆管结石的疗效

中国城乡企业卫生 2017年第6期32卷 17-19页

作者：程云飞曾长江裴志强易杰明仙桃市第一人民医院普外科湖北仙桃433000

目的探讨腹腔镜规则性左半肝切除治疗左肝胆管结石的临床疗效以及安全性。方法回顾性分析2006年1月-2012年12月仙桃市第一人民医院收治的左肝胆管结石的患者72例,其中行腹腔镜规则性左半肝切除术治疗患者36例为观察组,行开腹左半肝切除... 详细信息

目的探讨腹腔镜规则性左半肝切除治疗左肝胆管结石的临床疗效以及安全性。方法回顾性分析2006年1月-2012年12月仙桃市第一人民医院收治的左肝胆管结石的患者72例,其中行腹腔镜规则性左半肝切除术治疗患者36例为观察组,行开腹左半肝切除术治疗患者36例为对照组,比较两组手术中出血量、手术进行时间、术后排气时间、术后引流管拔管时间、术后住院时间及术后不良反应。结果两组手术均顺利完成。两组手术进行时间、术中出血量比较差异无统计学意义(P>0.05);观察组术后排气时间、腹腔引流量、术后引流管拔管时间以及术后住院时间均明显优于对照组,差异有统计学意义(P<0.05);观察组在发热及伤口感染率方面均明显低于对照组,差异有统计学意义(P<0.05)。结论相较于传统开腹左半肝切除,腹腔镜规则性左半肝切除治疗左肝胆管结石具有创伤小、安全性高、术后恢复快的特点,临床应用值得推广。

关键词：左肝胆管结石腹腔镜规则性左半肝切除

Smart and fast reinforcement design for anti-dip bedding rock slopes

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Journal of Rock Mechanics and Geotechnical Engineering 2023年第11期15卷 2943-2953页

作者： yun zheng Congxin Chen fei Meng Xiaodong Fu Wei Yuan State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan430071China University of Chinese Academy of Sciences Beijing100049China School of Civil Engineering and Architecture Wuhan University of TechnologyWuhan430070China Key Laboratory of Roads and Railway Engineering Safety Control of Ministry of Education Shijiazhuang Tiedao UniversityShijiazhuang050043China

Rock slopes are usually reinforced by a number of rock bolts due to the high efficiency and low ***,where should the rock bolts be installed is still a troublesome *** anti-dip bedding rock slopes(ABRSs),the installation position of rock bolts is a controlling factor that determines the reinforcement *** this work,a theoretical method is firstly proposed for assessing the stability of ABRSs reinforced by rock bolts using a limit equilibrium model.A comparison of theoretical calculations and numerical results was conducted to test the correctness of the theoretical *** on the stability assessment of ABRSs,we introduce adaptive moment estimation method(Adam)to optimize the installation location of rock *** Adam optimizer,the optimal layout of rock bolts with the maximum factor of safety can be determined,and the factor of safety of the slope increases by about 25%using the same amount of rock bolts but with different installation *** proposed method enables the fast stability analysis and supporting design for reinforced ABRSs,which paves the way to smart supporting design of slopes.

关键词： Rock slopes Toppling failure Rock bolts Stability assessment Smart analysis

Ported wall extension hydraulics

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Water Science and Engineering 2021年第1期14卷 65-71页

作者： fei-dong zheng Ping-yi Wang Jian-feng An yun Li College of River and Ocean Engineering Chongqing Jiaotong UniversityChongqing 400074China National Engineering Technology Research Center for Inland Waterway Regulation Chongqing 400074China State Key Laboratory of Hydrology-Water Resources and Hydraulic Engineering Nanjing 210029China

Ported wall extensions are important hydraulic structures used to reduce crosscurrents in upper approaches to *** effect of such extensions located upstream of a solid guard wall on flow characteristics depends on many factors,including geometric and hydraulic *** this study,the hydraulic performance of ported wall extensions was experimentally investigated in terms of the permeability coefficient,expanding angle,extension length,and flow *** results demonstrate that the dimensionless maximum transverse velocity is closely related to the permeability coefficient,expanding angle,and flow *** contrast,the dimensionless eddy length mainly depends on the permeability coefficient,expanding angle,and extension ***,the optimum permeability coefficient increases with the expanding angle or flow depth,and it is approximately constant for different extension *** results have the potential to provide direct guidance for the design of effective ported wall extensions in upper approaches to locks.

关键词： Ported wall extension Permeability coefficient Transverse velocity Eddy length Navigation safety