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miR-29b upregulates miR-195 by targeting DNMT3B in tongue squamous cell carcinoma

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Science Bulletin 2016年第3期61卷 212-219页

作者： Ling-fei Jia yun-fei zheng Ming-Yue Lyu Yi-Ping Huang Ye-Hua Gan Department of Oral and Maxillofacial Surgery PekingUniversity School and Hospital of Stomatology Beijing 100081China Central Laboratory Peking University School and Hospital ofStomatology Beijing 100081 China Department of Implantology Peking University School andHospital of Stomatology Beijing 100081 China Department of Orthodontics Peking University School andHospital of Stomatology Beijing 100081 China

MicroRNAs play important roles in the devel- opment and progression of various cancers, including tongue squamous cell carcinoma （TSCC）. miR-29b and miR-195 have been reported to be tumor suppressors in TSCC. Here, we investigated the expression of miR-29b and miR- 195 and their relationship in TSCC. Our data showed that miR-29b and miR-195 were significantly downregulated in TSCC com- pared with their matched nonmalignant tissues in 60 paired samples. The level of miR-29b was positively correlated with that of miR-195 in TSCC and the matched nonmalignant tissues. Moreover, miR-29b overexpression induced the demethylation of CpG islands upstream of miR-195 via targeting DNMT3B, leading to the upregulation of miR-195 in TSCC cell lines. Following DNMT3B silencing, the expression of miR-195 was increased and the methylation of CpG islands upstream of miR-195 was reduced. Although overexpression of miR-29b alone significantly increased miR- 195 expression, co-transfection of miR-29b with DNMT3B resulted in no change in miR-195 expression. Taken together, our results demonstrated that miR-29b could upregulate miR- 195 by directly targeting DNMT3B in TSCC. The interaction between miR-29b and miR-195 might provide new insights in developing novel therapeutic approaches of TSCC.

关键词： miRNA miR-29b miR-195 DNMT3B Tongue squamous cell carcinoma

Cerebral protective effect of nicorandil premedication on patients undergoing liver transplantation

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Hepatobiliary & Pancreatic Diseases International 2012年第2期11卷 132-136页

作者： yun-fei Xia,zheng-Ping Wang,Ya-Chun Zhou,Tao Yan and Shi-Tong Li Department of Anesthesiology, Shanghai First People’s Hospital, Medical College, Shanghai Jiaotong University, Shanghai 200080, China Department of Anesthesiology Shanghai First People's Hospital Medical College Shanghai Jiaotong University Shanghai 200080 China Shanghai China

BACKGROUND:Neurological injury is a common complication in the early period after liver transplantation,posing an enormous obstacle to treatment efficiency and patient *** is a mitochondrial ATP-sensitive potassium channel(mitoK ATP) *** has been reported to be effective in reducing brain injury in recent ***,it is still unclear whether nicorandil has cerebral protective effect in patients undergoing liver ***:Fifty patients scheduled for liver transplantation were randomly divided into a nicorandil group(group N)(n=25),in which patients received 10 mg nicorandil through a nasogastric tube 30 minutes before induction of anesthesia,and a control group(group C)(n=25) who received 10 mL normal *** Mini-Mental State Examination(MMSE) was performed before anesthesia(day 0),and on days 3 and 7 after *** samples were obtained before induction of anesthesia(T1),and at 12(T2) and 36 hours(T3) after surgery for determination of serum neuron-specific enolase(NSE) and S100β protein(S100β) ***:During surgery,5 patients in each group were eliminated due to severe reperfusion or renal ***,20 patients remained in each *** MMSE scores after operation were significantly lower than those before operation in group ***,there was no difference at days 3 and 7 compared with day 0 in group *** NSE concentrations after surgery were significantly higher than baseline(at T1) in both groups,except at T3 in group *** S100β concentration after surgery was significantly higher than baseline(at T1) in both *** MMSE scores at days 3 and 7 in group N were significantly higher than those in group *** concentrations of serum NSE and S100β at T2 and T3 in group N were significantly lower than those in group ***:Oral nicorandil,as a premedication before liver transplantation,improves postoperative MMSE *** also attenuates the increase of NSE and S100β

关键词： nicorandil premedication liver transplantation cerebral protection

Optimizing the key parameter to accelerate the recovery of AMOC under a rapid increase of greenhouse gas forcing

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Atmospheric and Oceanic Science Letters 2025年第1期18卷 39-45页

作者： Haolan Ren fei zheng Tingwei Cao Qiang Wang International Center for Climate and Environment Science(ICCES) Institute of Atmospheric PhysicsChinese Academy of SciencesBeijingChina University of Chinese Academy of Sciences BeijingChina College of Oceanography Hohai UniversityNanjingChina CAS Key Laboratory of Ocean Circulation and Waves Institute of OceanologyChinese Academy of Sciences and Pilot National Laboratory for Marine Science and Technology(Qingdao)QingdaoChina

Atlantic Meridional Overturning Circulation(AMOC)plays a central role in long-term climate variations through its heat and freshwater transports,which can collapse under a rapid increase of greenhouse gas forcing in climate *** studies have suggested that the deviation of model parameters is one of the major factors in inducing inaccurate AMOC *** this work,with a low-resolution earth system model,the authors try to explore whether a reasonable adjustment of the key model parameter can help to re-establish the AMOC after its *** a new optimization strategy,the extra freshwater flux(FWF)parameter is determined to be the dominant one affecting the AMOC’s *** traditional ensemble optimal interpolation(EnOI)data assimilation and new machine learning methods are adopted to optimize the FWF parameter in an abrupt 4×CO_(2) forcing experiment to improve the adaptability of model parameters and accelerate the recovery of *** results show that,under an abrupt 4×CO_(2) forcing in millennial simulations,the AMOC will first collapse and then re-establish by the default FWF parameter ***,during the parameter adjustment process,the saltier and colder sea water over the North Atlantic region are the dominant factors in usefully improving the adaptability of the FWF parameter and accelerating the recovery of AMOC,according to their physical relationship with FWF on the interdecadal timescale.

关键词： Recovery of AMOC 4×CO_(2)forcing Key parameter Parameter estimation Data assimilation Machine learning

Twin tubal ectopic pregnancy-A report of two cases and literature review

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Twin tubal ectopic pregnancy-A report of two cases and liter...

Characterization of hot deformation and microstructure evolution of a new metastableβtitanium alloy

2013年浙江省妇科肿瘤学术年会暨省级医学继续教育项目“宫颈癌筛查及子宫颈疾病规范化诊治”学习班

作者： Hua Zhu Qing Zhou Han-Chu Wang fei-yun zheng Department of Obstetrics and Gynecology The First Affiliated Hospital of Wenzhou Medical College

Twin tubal ectopic pregnancies are rare occurrences. Two cases are *** first was a 32-year-old woman with abdominal pain and vaginal bleeding 30 days after she accepted IVF-ET. P-hCG and ultrasound suggested ectopic *** patient underwent right *** P-hCG and ultrasound suggested left ectopic pregnancy after the surgery,a second laparoscopic surgery was *** 2,a 36-year-old multiparous presented with 45 days of amenorrhea and abdominal *** displayed a gestational sac in the right adnexa with double fetal cardiac motion *** salpingectomy was *** etiologies and diagnosis are discussed and a brief review of literature is presented.

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Transactions of Nonferrous Metals Society of China 2022年第5期32卷 1513-1529页

作者： Zhao-qi CHEN Li-juan XU Shou-zhen CAO Jian-kai YANG yun-fei zheng Shu-long XIAO Jing TIAN Yu-yong CHEN National Key Laboratory for Precision Hot Processing of Metals Harbin Institute of TechnologyHarbin 150001China School of Materials Science and Engineering Harbin Institute of TechnologyHarbin 150001China College of Mechanical and Electrical Engineering Huangshan UniversityHuangshan 245021China

The hot deformation characteristics of as-forged Ti−3.5Al−5Mo−6V−3Cr−2Sn−0.5Fe−0.1B−0.1C alloy within a temperature range from 750 to 910℃and a strain rate range from 0.001 to 1 s^(-1) were investigated by hot compression *** stress−strain curves show that the flow stress decreases with the increase of temperature and the decrease of strain *** microstructure is sensitive to deformation *** dynamic recrystallization(DRX)grains appear while the temperature reaches 790℃at a constant strain rate of 0.001 s^(-1) and strain rate is not higher than 0.1 s^(-1) at a constant temperature of 910℃.The work-hardening rateθis calculated and it is found that DRX prefers to happen at high temperature and low strain *** constitutive equation and processing map were *** average activation energy of the alloy is 242.78 kJ/mol and there are few unstable regions on the processing map,which indicates excellent hot *** the strain rate of 0.1 s^(-1),the stress−strain curves show an abnormal shape where there are two stress peaks *** can be attributed to the alternation of hardening effect,which results from the continuous dynamic recrystallization(CDRX)and the rotation of DRX grains,and dynamic softening mechanism.

关键词： metastableβtitanium alloy hot deformation behavior microstructure evolution abnormal flow behavior

Dual-ligand chiral MOFs exhibiting circularly polarized room temperature phosphorescence for anti-counterfeiting

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Science China Chemistry 2025年

作者： Hongrui zheng Qingqing Wang Xinchao Wang fei Wang Shangda Li Jian Zhang State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences Fujian Key Laboratory of Polymer Materials College of Chemistry and Materials Science Fujian Normal University

Advanced chiral optical materials exhibiting circularly polarized room-temperature phosphorescence（CPRTP） possess significant research value. This study facilitates the synthesis of chiral metal-organic frameworks（CMOFs） with good CPRTP performance by implementing a dual-ligand strategy. By self-assembling the luminescent ligand H2BIIM with the chiral ligands L-or D-H2IDPA in the presence of Zn（II） ions, two robust three-dimensional（3D） CMOFs were successfully constructed. These complexes demonstrated intense fluorescence and exhibited prolonged yellow room-temperature phosphorescence（RTP） with a duration of up to 6 s. Notably, they exhibited both circularly polarized fluorescence(glum= ±7.57 × 10-3) and CPRTP(glum=±2.68 × 10-3). These unique properties were effectively utilized in the creation of multi-color anti-counterfeiting patterns,underscoring their promising potential for a wide range of applications.

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Precise gradient separation of nanoparticles using reduced graphene oxide-polyoxomolybdate membranes

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Science China Chemistry 2025年第01期 209-216页

作者： Yixin Yang Wanlei Zhao Ruoxuan zheng Hongqiang Li Wei Chen Yu-fei Song State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical Technology Quzhou Institute for Innovation in Resource Chemical Engineering

The purification and size sieving of nanoparticles （NPs） represents a significant scientific ***,the r GO-polyoxometalates (POMs=PMo12,Mo132and Mo368) membranes were fabricated successfully via a simple and scalable POMsassisted in-situ photoreduction *** the mass ratio of r GO to PMo12was 1:30,the resultant r GO-PMo12membranes with highly ordered and uniform nanochannels of 1.0 nm can be obtained,which showed an accurate carbon quantum dots（CQDs） separation with a cut-off size approximately 1.0 *** increase of the size of the interlayered POMs from PMo12（1.0 nm）,{Mo132}（2.9 nm） to{Mo368}（3.8 nm）,the resultant r GO-PMo12,r GO-Mo132and r GO-Mo368exhibited precise gradient separation of CQDs and Au nanoparticles by size exclusion *** results pave a promising way to construct new twodimensional （2D） membranes for highly efficient size-selective separation.

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基于耦合界面键合效应的石墨烯磨损研究

原子与分子物理学报 2025年第6期42卷 66-75页

作者：郑云飞卢艳武汉科技大学冶金装备及其控制教育部重点实验室武汉430081 武汉科技大学机械传动与制造工程湖北省重点实验室武汉430081 武汉科技大学精密制造研究院武汉430081

石墨烯作为二维固体润滑材料,其超滑特性不仅是物理作用结果,其化学键结构机制下的摩擦化学现象,是深入理解石墨烯摩擦性能的关键.本文采用分子动力学(MD)方法构建了多重层数石墨烯增强不同粗糙形貌的金属基底模型,实现了其与金刚石尖... 详细信息

石墨烯作为二维固体润滑材料,其超滑特性不仅是物理作用结果,其化学键结构机制下的摩擦化学现象,是深入理解石墨烯摩擦性能的关键.本文采用分子动力学(MD)方法构建了多重层数石墨烯增强不同粗糙形貌的金属基底模型,实现了其与金刚石尖端滑动过程的动态分析,揭示了考虑尖端与石墨烯之间存在界面键时石墨烯层的理化耦合作用下的磨损机理.研究结果表明:当考虑金刚石尖端与石墨烯之间化学键合时,石墨烯发生磨损破裂的临界载荷相对于不考虑界面化学键时的值减小,这是由于界面键的形成会剥离石墨烯导致石墨烯断裂所致;金属基底的粗糙度也是决定石墨烯发生磨损破裂时临界载荷的重要因素之一,当粗糙度增大,临界载荷减小,同时通过增加石墨烯层的层数(增韧)来提高石墨烯发生磨损破裂失效的临界载荷.

关键词：石墨烯层界面键分子动力学磨损破裂

维普期刊数据库博看期刊

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“全面二孩”政策后我国人口态势趋势变动

人口与发展 2016年第5期22卷 2-14页

作者：罗雅楠程云飞郑晓瑛北京大学人口研究所北京100871

利用多状态人口预测模型,以2010年人口普查数据为基期数据,结合现有对未来生育水平、死亡水平、流动迁移水平以及教育转换等研究结果设定预测参数,预测了"全面二孩"政策启动后2010-2030年期间我国人口和人力资本态势趋势变化。比较不同... 详细信息

利用多状态人口预测模型,以2010年人口普查数据为基期数据,结合现有对未来生育水平、死亡水平、流动迁移水平以及教育转换等研究结果设定预测参数,预测了"全面二孩"政策启动后2010-2030年期间我国人口和人力资本态势趋势变化。比较不同生育率方案下,"全面二孩"分城乡分性别人口规模、年龄结构和教育结构的变化,为"全面二孩"政策实施后人口发展和社会经济政策的制定与调整提供参考。

关键词：人口预测 PDE模型人力资本二孩政策