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Causal relationship between feelings and cognitive decline:An univariable and multivariable Mendelian randomization study

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World Journal of Psychiatry 2024年第3期14卷 421-433页

作者： Juan Liu Lin Liu Yi-Xin hu Jian-hua Li Xiao Zou Hao-yun Zhang Li Fan Department of Cardiology The Second Medical Center&National Clinical Research Center for Geriatric DiseasesChinese PLA General HospitalBeijing 100853China Department of Pulmonary and Critical Care Medicine The Second Medical Center&National Clinical Research Center for Geriatric DiseasesChinese PLA General HospitalBeijing 100853China The Fourth Department of Geriatric Health Care The Second Medical Center&National Clinical Research Center for Geriatric DiseasesChinese PLA General HospitalBeijing 100853China Department of Anesthesiology First Medical Center of Chinese PLA General HospitalBeijing 100853China

BACKGROUND While the impact of depression on cognition is well-documented,the relationship between feelings and cognition has received limited *** To explore the potential association between feelings and cognition with a twosample Mendelian randomization(MR)*** Our analysis utilized genome-wide association data on various feelings(fed-up feelings,n=453071;worrier/anxious feelings,n=450765;guilty feelings,n=45-0704;nervous feelings,n=450700;sensitivity/hurt feelings,n=449419;miserableness,n=454982;loneliness/isolation,n=455364;happiness,n=152348)in the European population and their impact on cognitive functions(intelligence,n=269867).Conducting a univariable MR(UVMR)analysis to assess the relationship between feelings and *** this analysis,we applied the inverse variance weighting(IVW),weighted median,and MR Egger ***,we performed sensitivity analysis(leave-one-out analysis),assessed heterogeneity(using MR-PRESSO and Cochran’s Q test),and conducted multiple validity test(employing MR-Egger regression).Subsequently,a multivariable MR(MVMR)analysis was employed to examine the impact of feelings on *** served as the primary method in the multivariable analysis,complemented by median-based and MR-Egger *** In this study,UVMR indicated that sensitivity/hurt feelings may have a negative causal effect on cognition(OR=0.63,95%CI:0.43-0.92,P=0.017).After adjustment of other feelings using MVMR,a direct adverse causal effect on cognition was observed(OR_(MVMR)=0.39,95%CI:0.17-0.90,P_(MVMR)=0.027).While a potential increased risk of cognitive decline was observed for fed-up feelings in the UVMR analysis(ORUVMR=0.64,95%CI:0.42-0.97,PUVMR=0.037),this effect disappeared after adjusting for other feelings(OR_(MVMR)=1.42,95%CI:0.43-4.74,P_(MVMR)=0.569).These findings were generally consistent across MV-IVW,median-based,and MR-Egger ***-Egger regression revealed pleiotropy in the impact of worrier/anxious

关键词： Mendelian randomization analysis Feelings Cognition Intelligence

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Study on Durability of Recycled Aggregate Concrete in High-Temperature and Complex Environments

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Journal of World Architecture 2024年第5期8卷 66-71页

作者： Xiaoqing hu Yao Tong xuan Min Rongchong Xu Chongqing Institute of Engineering Chongqing 400056China

Recycled aggregate concrete refers to a new type of concrete material made by processing waste concrete materials through grading,crushing,and cleaning,and then mixing them with cement,water,and other materials in a certain gradation or *** type of concrete is highly suitable for modern construction waste disposal and reuse and has been widely used in various construction *** can also be used as an environmentally friendly permeable brick material to promote the development of modern green ***,practical applications have found that compared to ordinary concrete,the durability of this type of concrete is more susceptible to high-temperature and complex *** on this,this paper conducts theoretical research on its durability in high-temperature and complex environments,including the current research status,existing problems,and application prospects of recycled aggregate concrete’s durability in such *** is hoped that this analysis can provide some reference for studying the influence of high-temperature and complex environments on recycled aggregate concrete and its subsequent application strategies.

关键词： Recycled aggregate concrete Construction engineering High-temperature and complex environment Durability

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Demonstration of controlled high-dimensional quantum teleportation

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Science China(Physics,Mechanics & Astronomy) 2024年第3期67卷 1-6页

作者： Min-Yu Lv Xiao-Min hu Neng-Fei Gong Tie-Jun Wang Yu Guo Bi-Heng Liu yun-Feng huang Chuan-Feng Li Guang-Can Guo CAS Key Laboratory of Quantum Information University of Science and Technology of ChinaHefei 230026China CAS Centerfor Excellence in Quantum Information and Quantum Physics University of Science and Technology of ChinaHefei230026China Hefei National Laboratory University of Science and Technology of ChinaHefei 230088China State Key Laboratory of Information Photonics and Optical Communications School of ScienceBeijing University of Posts and TelecommunicationsBeijing 100876China

Controlled quantum teleportation(CQT), which is regarded as the prelude and backbone for a genuine quantum internet, reveals the cooperation, supervision, and control relationship among the sender, receiver, and controller in the quantum network within the simplest unit. Compared with low-dimensional counterparts, high-dimensional CQT can exhibit larger information transmission capacity and higher superiority of the controller's authority. In this article, we report a proof-of-principle experimental realization of three-dimensional(3D) CQT with a fidelity of 97.4% ± 0.2%. To reduce the complexity of the circuit, we simulate a standard 4-qutrit CQT protocol in a 9×9-dimensional two-photon system with high-quality operations. The corresponding control powers are 48.1% ± 0.2% for teleporting a qutrit and 52.8% ± 0.3% for teleporting a qubit in the experiment, which are both higher than the theoretical value of control power in 2-dimensional CQT protocol(33%). The results fully demonstrate the advantages of high-dimensional multi-partite entangled networks and provide new avenues for constructing complex quantum networks.

关键词： high dimension quantum information quantum teleportation quantum nonlocality

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The importance of Righi-Leduc heat flux to the ablative Rayleigh-Taylor instability during a laser irradiating targets

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High Power Laser Science and Engineering 2024年第3期12卷 9-19页

作者： Ye Cui Xiao-hu Yang Yan-yun Ma Guo-Bo Zhang Bi-Hao Xu Ze-Hao Chen Ze Li Fu-Qiu Shao Jie Zhang Department of Nuclear Science and Technology National University of Defense TechnologyChangshaChina College of Advanced Interdisciplinary Studies National University of Defense TechnologyChangshaChina Department of Physics National University of Defense TechnologyChangshaChina Key Laboratory for Laser Plasmas(Ministry of Education) School of Physics and AstronomyShanghai Jiao Tong UniversityShanghaiChina Collaborative Innovation Centre of IFSA Shanghai Jiao Tong UniversityShanghaiChina

The Righi±Leduc heat flux generated by the self-generated magnetic field in the ablative Rayleigh±Taylor instability driven by a laser irradiating thin targets is studied through two-dimensional extended-magnetohydrodynamic *** perturbation structure gets into a low magnetization state though the peak strength of the self-generated magnetic field could reach hundreds of *** Righi±Leduc effect plays an essential impact both in the linear and nonlinear stages,and it deflects the total heat flux towards the spike *** to the case without the self-generated magnetic field included,less heat flux is concentrated at the spike tip,finally mitigating the ablative stabilization and leading to an increase in the velocity of the spike *** is shown that the linear growth rate is increased by about 10%and the amplitude during the nonlinear stage is increased by even more than 10%due to the feedback of the magnetic field,*** results reveal the importance of Righi±Leduc heat flux to the growth of the instability and promote deep understanding of the instability evolution together with the self-generated magnetic field,especially during the acceleration stage in inertial confinement fusion.

关键词： amplitude linear growth rate Rayleigh-Taylor instability Righi-Leduc heat flux self-generated magnetic field

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Serotonin receptor 2B induces visceral hyperalgesia in rat model and patients with diarrhea-predominant irritable bowel syndrome

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World Journal of Gastroenterology 2024年第10期30卷 1431-1449页

作者： Zheng-Yang Li Yu-Qing Mao Qian hua Yong-Hong Sun Hai-Yan Wang xuan-Guang Ye Jing-Xian hu Ya-Jie Wang Miao Jiang Department of Gastroenterology Jinshan Hospital of Fudan UniversityShanghai 201508China Department of Gastroenterology Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China Department of Gastroenterology Dalian Friendship HospitalDalian 116001Liaoning ProvinceChina Department of Pathology Jinshan Hospital of Fudan UniversityShanghai 201508China

BACKGROUND Serotonin receptor 2B(5-HT2B receptor)plays a critical role in many chronic pain *** possible involvement of the 5-HT2B receptor in the altered gut sensation of irritable bowel syndrome with diarrhea(IBS-D)was investigated in the present *** To investigate the possible involvement of 5-HT2B receptor in the altered gut sensation in rat model and patients with *** Rectosigmoid biopsies were collected from 18 patients with IBS-D and 10 patients with irritable bowel syndrome with constipation who fulfilled the Rome IV criteria and 15 healthy *** expression level of the 5-HT2B receptor in colon tissue was measured using an enzyme-linked immunosorbent assay and correlated with abdominal pain *** IBS-D rat model was induced by intracolonic instillation of acetic acid and wrap *** in visceral sensitivity and 5-HT2B receptor and transient receptor potential vanilloid type 1(TRPV1)expression were examined following 5-HT2B receptor antagonist *** in visceral sensitivity after administration of the TRPV1 antago-INTRODUCTION Irritable bowel syndrome(IBS)is a chronic functional bowel disorder characterized by recurrent abdominal pain with altered bowel habits that affects approximately 15%of the population worldwide[1].IBS significantly impacts the quality of life of *** the pathogenesis of IBS is not completely understood,the role of abnormal visceral sensitivity in IBS has recently emerged[2,3].5-Hydroxytryptamine(5-HT)is known to play a key role in the physiological states of the gastrointestinal *** 5-HT levels in IBS with diarrhea(IBS-D)patients were greater than those in healthy controls[4],suggesting a possible role of 5-HT in the pathogenesis of *** serotonin receptor 2(5-HT2 receptor)family comprises three subtypes:5-HT2A,5-HT2B,and *** 5-HT2 receptors exhibit 46%-50%overall sequence identity,and all of these receptors preferentially bind to Gq/

关键词： Diarrhea-predominant irritable bowel syndrome Serotonin receptor 2B Transient receptor potential vanilloid type-1 Visceral hypersensitivity Abdominal pain

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Enhanced activation of peroxymonosulfate on layered molybdenum disulfide loaded with Co-La bimetallic oxide for efficient degradation of chloramphenicol

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Rare Metals 2024年第9期43卷 4628-4635页

作者： Yu-Ning Fan yun-Qiu Zhang San-Shuang Gao Zeng-hui Bi Yin Wang Shu-Xing Zhou Qian Liu Tian-Ping Lv Guang-Zhi hu Institute for Ecological Research and Pollution Control of Plateau Lakes School of Ecology and Environmental ScienceYunnan UniversityKunming 650504China hubei Key Laboratory of Low Dimensional Optoelectronic Materials and Devices Hubei University of Arts and ScienceXiangyang 441053China Institute for Advanced Study Chengdu UniversityChengdu 610106China

The use of transition metal-activated peroxymonosulfate(PMS)as an advanced oxidation technology has gained *** study developed a catalyst using cobaltDlanthanum bimetallic oxide supported on layered molybdenum disulfide(Mo S_(2))as a *** CoDLa/Mo S_(2)catalyst was synthesised through coprecipitation,followed by calcination with an optimised metal ratio of Co:La=2:1 to activate PMS and degrade trace chloramphenicol(CAP)in *** chemical composition of the catalyst was confirmed using X-ray diffraction(XRD)and X-ray photoelectron spectroscopy(XPS).At catalyst and PMS dosages of 0.1 and 0.5 g·L^(-1),respectively,the degradation rate of CAP was 95%with in 30 *** catalyst exhibitedstrong resistance to most interfering anions and maintained a high degradation rate at p H *** chromatographyDmass spectrometry analysis revealed the potential degradation pathways of CAP in the CoDLa/Mo S_(2)(2:1)/PMS *** other pollutants,such as oxytetracycline,complete degradation was achieved within 20 min,demonstrating the broad applicability of the CoDLa/Mo S_(2)(2:1)/PMS system for the degradation and removal of antibiotic organic contaminants.

关键词： catalyst molybdenum disulfide

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Sulfone-functionalized stable molecular single crystals for photocatalytic hydrogen evolution

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SusMat 2024年第3期4卷 240-250页

作者： Xunliang hu Xiaoju Yang Bingyi Song Zhen Zhan Ruixue Sun Yantong Guo Li-Ming Yang xuan Yang Chun Zhang Irshad hussain Xiaoyan Wang Bien Tan Key Laboratory of Material Chemistry for Energy Conversion and Storage Ministry of Education Hubei Key Laboratory of Material Chemistry and Service FailureSchool of Chemistry and Chemical EngineeringHuazhong University of Science and TechnologyWuhanChina Department of Applied Physics The Hong Kong Polytechnic UniversityKowloonHong KongChina College of Life Science&Technology Huazhong University of Science and TechnologyWuhanChina Department of Chemistry and Chemical Engineering SBA School of Science and EngineeringLahore University of Management SciencesLahorePakistan

Highly crystalline organic semiconductors are ideal materials for photocatalytic hydrogen evolution in water ***,the instability and complex synthesis processes of most reported organic molecule-based photocatalysts restrict their *** this study,we introduce benzo[1,2-b:4,5-bʹ]bis[1]benzothiophene-3,9-dicarboxylic acid,5,5,11,11-tetraoxide(FSOCA),a highly crystalline,stable molecular crystal that is easy to synthesize and serves as an efficient photocatalyst for the hydrogen evolution *** exhibits high efficiency in sacrificial hydrogen evolution reaction(760μmol h^(−1),76 mmol g^(−1)h^(−1)at 330 mW cm^(−2);570μmol h^(−1),57 mmol g^(−1)h^(−1)at 250 mW cm^(−2)),and FSOCA remains stable during photocatalysis for up to 400 *** and theoretical studies confirmed the presence of hydrogen bonds between the sulfone group and the sacrificial agent(ascorbic acid).This interaction significantly improved the oxidation reaction kinetics and boosted the photocatalytic *** study presents a scalable and convenient approach to synthesize highly crystalline,active,and stable organic photocatalysts with potential applications in large-scale photocatalysis.

关键词： exceptional durability molecular single crystals photocatalytic water splitting

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Dietary copper requirement of broilers fed a corn-soybean meal diet during 22—42 d of age

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Animal Nutrition 2024年第1期16卷 96-104页

作者： Ling Zhu Wei Wu Bingxin Wu yun hu Liyang Zhang Weiyun Zhang Tingting Li Xiaoyan Cui Feiyu Gao Ding Li Xugang Luo Shengchen Wang Poultry Mineral Nutrition Laboratory College of Animal Science and TechnologyYangzhou UniversityYangzhou 225000China Mineral Nutrition Research Division State Key Laboratory of Animal NutritionInstitute of Animal ScienceChinese Academy of Agricultural SciencesBeijing 100193China

This research was to assess the dietary copper(Cu)requirement of broiler chickens fed a practical cornsoybean meal diet during 22—42 d of age.A total of 288 numbered Arbor Acres male broilers at 22 d of age were randomly allotted 6 treatments with 8 replicate cages(6 broilers per cage)per *** were fed a Cu-unsupplemented corn-soybean meal basal diet(control,containing 7.36 mg Cu/kg)or the basal diet added with 3,6,9,12,or 15 mg Cu/kg from CuSO_(4)·5H_(2)O for 21 ***,asymptotic and broken-line models were fitted and the best fitted models were selected to determine dietary Cu *** results revealed that the contents of Cu in serum and liver,m RNA expression levels of Cu-and zinc-containing superoxide dismutase(CuZnSOD)in liver and monoamine oxidase b(MAO B)in heart,as well as protein expression level of CuZnSOD in liver were affected(P<0.05)by supplemental Cu levels,and the above indices varied linearly and quadratically(P<0.05)with increasing Cu *** Cu requirements assessed according to the best fitted broken-line models(P<0.05)of the above indexes were 10.45—13.81 mg/*** was concluded that mRNA expression levels of CuZnSOD in liver and MAO B in heart,as well as liver CuZnSOD protein expression level were new specific sensitive biomarkers for estimating dietary Cu requirements,and the dietary Cu requirement was recommended to be 14 mg/kg to support Cu metabolic needs related to key Cucontaining enzymes in broilers fed the corn-soybean meal diet during 22—42 d of age,which was higher than the dietary Cu requirement(8 mg/kg)for broilers at the corresponding stage suggested by the Chinese Feeding Standard of Chicken.

关键词： Copper Copper content Gene expression of copper-containing enzyme Requirement Broiler

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Cost analysis of radical resection of malignant breast tumors under the China Healthcare Security Diagnosis Related Groups payment system

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World Journal of Clinical Cases 2024年第20期12卷 4174-4179页

作者： yun-He hu Ai-Dong Li National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

BACKGROUND Breast cancer is one of the most common malignant tumors in women worldwide and poses a severe threat to their ***,this study examined patients who underwent breast cancer surgery,analyzed hospitalization costs and structure,and explored the impact of China Healthcare Security Diagnosis Related Groups(CHS-DRG)management on patient *** aimed to provide medical institutions with ways to reduce costs,optimize cost structures,reduce patient burden,and improve service *** To study the CHS-DRG payment system’s impact on breast cancer surgery *** Using the CHS-DRG(version 1.1)grouping criteria,4073 patients,who underwent the radical resection of breast malignant tumors from January to December 2023,were included in the JA29 group;1028 patients were part of the CHS-DRG payment system,unlike the *** an independent sample t-test,the length of hospital stay as well as total hospitalization,medicine and consumables,medical,nursing,medical technology,and management expenses were ***’s correlation coefficient was used to test the cost *** In terms of hospitalization expenses,patients in the CHS-DRG payment group had lower medical,nursing,and management expenses than those in the diagnosis-related group(DRG)non-payment *** patients in the DRG payment group,the factors affecting the total hospitalization cost,in descending order of relevance,were medicine and consumable costs,consumable costs,medicine costs,medical costs,medical technology costs,management costs,nursing costs,and length of hospital *** patients in the DRG nonpayment group,the factors affecting the total hospitalization expenses in descending order of relevance were medicines and consumable expenses,consumable expenses,medical technology expenses,the cost of medicines,medical expenses,nursing expenses,length of hospital stay,and management *** The CHS-DRG system can help control and reduce unnecessary m

关键词： China Healthcare Security Diagnosis Related Groups Real-world study Radical resection of malignant breast tumors Hospitalization costs Cost structure Average length of stay

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Property evolution and service life prediction of novel metallic materials for future lunar bases

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Rare Metals 2024年第10期43卷 5318-5331页

作者： Sen-Kuan Meng Rui-Song Zhu Hong-Liang Zheng Tong Gao Shi-Hao Jiang Wen-Hao Wang Shu-Hao Zhang Zi-Yuan Zhao xuan Ge Wei-Min Wang Li-Na hu Zheng Wang Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials (Ministry of Education) School of Materials Science and EngineeringShandong University Department of Chemistry and Bioscience Aalborg University

While lunar bases have been a focus of development in recent years, the complex and extreme environment of the lunar surface remains a considerable challenge for lunar exploration. Unlike those on Earth,lunar day and night temperature variations cause the properties of materials, especially metallic materials, to evolve in completely different manners. In this study, we investigated the property evolution of nine typical highperformance metallic materials using laboratory simulations of the extremely long-period lunar temperature environment. While lunation treatment improves the properties of all metallic materials, the microscopic mechanisms vary for amorphous and crystalline alloys with different structures. The treatment reduces both the loosely packed regions and heterogeneity in amorphous alloys while causing significant phase changes in crystalline alloys. Furthermore, a conservative prediction of the service life of metallic materials on lunar bases is provided based on analyzing microplastic events, followed by the practical material selection recommendations in various lunar application scenarios.

关键词： Lunar exploration Metallic glass Metallic material Property evolution

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