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Apolipoprotein B100 analysis in microchip with electrochemical detection

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Chinese Chemical Letters 2011年第11期22卷 1343-1346页

作者： Cheng Cheng Liu yun Liu Hui xiang wang Yan Bo Qi Peng Yuan Yang Bao Hong Liu Department of Chemistry and Institute of Biomedical Science Fudan University Shanghai 200433 China

Apolipoprotein B100（apoB-100） is a major protein of the cholesterol-rich low-density lipoprotein（LDL） and reflects a better assessment of total atherogenic burden to the vascular system than *** this work,a simple and sensitive method has been developed to determine picoliter apoB-100s using the PMMA microfluidic chip coupled with electrochemical detection system. This method performs very well with a detectable linear range of 1-800 pg/mL and a detection limit of 1 pg/mL.A real serum sample has further been detected by this microchip-based *** results show that this kind of method is practicable and has the potential application in clinical analysis and diagnosis.

关键词： Microchip ApoB-100 Immunoassay Electrochemical detection

Studies on NaXe Clusters

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Chinese Chemical Letters 2001年第9期12卷 833-834页

作者： Jia Chang LIANG Zhi LIU Yi Min SHEN Xian Ping SUN Xi Zi ZENG Xiao yun LE xiang yun wang De Min wang Fu Chun YU Yong Ti CHEN College of sciences Civil Aviation Institute of ChinaTianjin 300300 Department of Chemistry Nankai UniversityTianjin 300071 Department of Radiology Wayne State UniversityDetroit MI 48201 USA Laboratory of Magnetic Resonance and Atomic and Molecular Physics Wuhan Institute of Phys.&Math.The Chincse Academy of SciencesWuhan 430071 Institute of Heavy lon Physics Peking UniversityBeijing 100871

The chemical shift of Na-23 in excimer NaXe was measured by using nuclear magnetic resonance (NMR) spectra, which is in good agreement with the theoretical value obtained by ab initio calculations. The bond length, dissociation energy, dipole of NaXe and Mulliken charges at Na and Xe in NaXe were calculated, respectively. The spectra of ultraviolet (UV) fluorescence and surface-enhanced Raman scattering of NaXe were also measured.

关键词： Xenon-ion-implanted NaCl crystal NaXe chemical shift ab initio calculation

Preparation and Biological Distribution of New BATOs

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Chinese Chemical Letters 1997年第1期8卷 81-82页

作者： Jing Tao wang xiang yun wang Yuan Fang LIU(Department of Technical Physics- Peking University, Beijing 100871)(The current address is: Institute of Photographic Chemistry, Academia Sinica, Bejing 100101) Department of Technical Physics Peking University Beijing 100871 China Institute of Photographic Chemistry Academia Sinica Beijing 100101 China

Seven new boronic acid adducts of technetium(III) tris(dioxime) (BATO) were prepared and the biodistribution in mice of Tc-99m labelled BATOs were determined. The uptake of 1.62%1D in mice heart at 2 min after injection of (TcCl)-Tc-99m(MeCDO)(3)BMe indicates high myocardial extraction of this BATO. (TcCl)-Tc-99m(MeCDO)(3)BMe shows promise as a myocardial perfusion imaging agent.

关键词： DMG Preparation and Biological Distribution of New BATOs

Simultaneous laparoscopic excision for rectal carcinoma and synchronous hepatic metastasis

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Chinese Medical Journal 2011年第19期124卷 2990-2992页

作者： CHEN Kai-yun xiang Guo-an wang Han-ning XIAO Fang-lian Department of General Surgery the Second People＇s Hospital of Guangdong Province Guangzhou Guangdong 510317 China

Background Rectal carcinoma patients are often accompanied by hepatic metastasis. The aim of this study was to evaluate the therapeutic efficacy of simultaneous laparoscopic excision for rectal carcinoma with synchronous hepatic *** A total of 41 patients with rectal carcinoma and synchronous hepatic metastasis detected by CT scan were included in this study. Among them, 23 patients underwent laparoscopic surgery and 18 patients underwent traditional open surgery to simultaneously remove the rectal tumor and hepatic metastasis lesions. All patients received postoperative adjuvant chemotherapy. All the patients were followed up from 36 to 72 months （mean 45.3 months）.Results All the operations were performed successfully and no patient was turned to open surgery in laparoscopic group. The mean blood loss, the mean postoperative hospital stay, the mean blood transfusion and the mean intestinal functional recovery time showed a significant difference between the two groups （P〈0.05）. The 1-, 3- and 5-year survival rates were 82.6%, 43.5% and 8.6% in the laparoscopic group, without significant difference compared with the open group （77.8%, 38.9% and 0）（P〉0.05）.Conclusions Simultaneous laparoscopic excision for rectal carcinoma and synchronous hepatic metastasis is safe and effective with similar survival achieved by the traditional open abdominal surgery.

关键词： rectal tumor metastasis laparoscope hepatectomy

Kangfuxin solution alleviates esophageal stenosis after endoscopic submucosal dissection:A natural ingredient strategy

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World Journal of Gastroenterology 2025年第1期31卷 110-125页

作者： Xin Zhou Dan Ma Yi-xiang He Jing Jin Hong-Lian wang yun-Feng wang Fan Yang Jian-Qin Liu Jie Chen Zhi Li Department of Spleen and Stomach Diseases the Affiliated Traditional Chinese Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina The Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Digestive System Diseases of Luzhou City The Affiliated Traditional Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina Department of Gastroenterology Changhai HospitalNaval Medical UniversityShanghai 20082China Research Center of Integrated Chinese and Western Medicine The Affiliated Traditional Chinese Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina School of Integrated Traditional Chinese and Western Clinical Medicine North Sichuan Medical CollegeNanchong637100Sichuan ProvinceChina

BACKGROUND Esophageal stricture ranks among the most significant complications following endoscopic submucosal dissection(ESD).Excessive fibrotic repair is a typical pathological feature leading to stenosis after *** To examine the effectiveness and underlying mechanism of Kangfuxin solution(KFX)in mitigating excessive fibrotic repair of the esophagus *** Pigs received KFX at 0.74 mL/kg/d for 21 days after esophageal full circumferential *** examinations occurred on days 7 and 21 *** vitro,recombinant transforming growth factor(TGF)-β1(5 ng/mL)induced a fibrotic microenvironment in primary esophageal fibroblasts(pEsF).After 24 hours of KFX treatment(at 1.5%,1%,and 0.5%),expression ofα-smooth muscle actin-2(ACTA2),fibronectin(FN),and type collagen I was *** signaling was analyzed,including TGF-β1,Smad2/3,and phosphor-smad2/3(p-Smad2/3).RESULTS Compared to the Control group,the groups treated with KFX and prednisolone exhibited reduced esophageal stenosis,lower weight loss rates,and improved food tolerance 21 d after *** treatment,Masson staining revealed thinner and less dense collagen fibers in the submucosal ***,the expression of fibrotic effector molecules was notably ***,KFX downregulated the transduction levels of fibrotic functional molecules such as TGF-β1,Smad2/3,and p-Smad2/*** vitro,pEsF exposed to TGF-β1-induced fibrotic microenvironment displayed increased fibrotic activity,which was reversed by KFX treatment,leading to reduced activation of ACTA2,FN,and collagen *** 1.5%KFX treatment group showed decreased expression of p-Smad 2/3 in TGF-β1-activated *** KFX showed promise as a therapeutic option for post-full circumferential esophageal ESD strictures,potentially by suppressing fibroblast fibrotic activity through modulation of the TGF-β1/Smads signaling pathway.

关键词： Kangfuxin solution Natural component Endoscopic submucosal dissection Esophagus stricture Fibrosis

Mitophagy in acute central nervous system injuries:regulatory mechanisms and therapeutic potentials

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Neural Regeneration Research 2025年第9期20卷 2437-2453页

作者： Siyi Xu Junqiu Jia Rui Mao xiang Cao yun Xu Department of Neurology Nanjing Drum Tower HospitalClinical College of Jiangsu UniversityNanjingJiangsu ProvinceChina Department of Neurology Nanjing Drum Tower HospitalChinese Academy of Medical Science&Peking Union Medical CollegeNanjingJiangsu ProvinceChina Department of Neurology Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina State Key Laboratory of Pharmaceutical Biotechnology and Institute of Translational Medicine for Brain Critical Diseases Nanjing UniversityNanjingJiangsu ProvinceChina Jiangsu Key Laboratory for Molecular Medicine Medical School of Nanjing UniversityNanjingJiangsu ProvinceChina Nanjing Neurology Medical Center NanjingJiangsu ProvinceChina

Acute central nervous system injuries,including ischemic stro ke,intracerebral hemorrhage,subarachnoid hemorrhage,traumatic brain injury,and spinal co rd injury,are a major global health *** optimal therapies and improving the long-term neurological functions of patients with acute central nervous system injuries are urgent *** are susceptible to damage after acute central nervous system injury,and this leads to the release of toxic levels of reactive oxygen species,which induce cell ***,a selective form of autophagy,is crucial in eliminating redundant or damaged mitochondria during these *** evidence has highlighted the significant role of mitophagy in acute central nervous system *** this review,we provide a comprehensive overview of the process,classification,and related mechanisms of *** also highlight the recent developments in research into the role of mitophagy in various acute central nervous system injuries and drug therapies that regulate *** the final section of this review,we emphasize the potential for treating these disorders by focusing on mitophagy and suggest future research paths in this area.

关键词： autophagy intracerebral hemorrhage ischemic stroke mitochondria mitochondrial biogenesis mitochondrial quality control mitophagy spinal cord injury subarachnoid hemorrhage traumatic brain injury

Exponentiated Weibull大气湍流下PSK-OFDM机载光链路性能分析

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光电工程 2018年第2期45卷 25-32页

作者：张韵王翔赵尚弘蒙文赵静空军工程大学信息与导航学院陕西西安710077

本文研究了指向误差、气动光学效应及Exponentiated Weibull大气湍流联合效应对OFDM光链路通信性能的影响。其中OFDM链路采用PSK调制,应用Meijer G函数推导得到多载波条件下总平均误码率的闭合表达式。根据平均误码率闭合表达式进行了仿... 详细信息

本文研究了指向误差、气动光学效应及Exponentiated Weibull大气湍流联合效应对OFDM光链路通信性能的影响。其中OFDM链路采用PSK调制,应用Meijer G函数推导得到多载波条件下总平均误码率的闭合表达式。根据平均误码率闭合表达式进行了仿真,分析了不同大气湍流强度、PSK调制阶数、抖动标准差和波束宽度对误码率的影响。通过仿真分析证明基于Exponentiated Weibull大气湍流模型,在不同湍流强度条件下误码率随着发射功率的增加改善近似。当抖动标准差小于0.7及调制阶数小于4时,增大发射功率对改善链路误码率效果明显。

关键词：误码率 Exponentiated Weibull分布指向误差正交频分复用 PSK

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基于互信息的特征选择在入侵检测中的优化

西北大学学报（自然科学版） 2017年第5期47卷 666-673页

作者：刘云向婵王海花昆明理工大学信息工程与自动化学院云南昆明650500

在处理入侵检测中的大规模数据时,冗余和不相关的特征数据长期造成网络数据流量分类问题,这种特征会降低分类效率和精度,并影响系统的实时检测率。该文提出了一种新的基于互信息的特征选择算法(NMIFS),该算法能处理线性和非线性相关的... 详细信息

在处理入侵检测中的大规模数据时,冗余和不相关的特征数据长期造成网络数据流量分类问题,这种特征会降低分类效率和精度,并影响系统的实时检测率。该文提出了一种新的基于互信息的特征选择算法(NMIFS),该算法能处理线性和非线性相关的特征数据。在数据预处理的过程中,使用该算法选择出最优特征,然后结合常见的最小二乘支持向量机算法(LSSVM)对数据进行分类。采用入侵检测标准数据集KDD Cup 99对模型进行性能评估,对比其他新型的优化算法,结果表明NMIFS算法更有助于LSSVM算法实现更高的分类精度和效率,降低计算复杂度,同时提高模型的检测率。

关键词：入侵检测系统互信息特征选择分类检测率

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著者和编者都应重视文后参考文献的著录

图书馆论坛 2004年第1期24卷 62-65页

作者：杜云祥王桂枝解放军医学图书馆北京100039

参考文献是研究论著的重要组成部分,但参考文献著录错误非常普遍,有的可高达93 69%。结合《中华医学图书情报杂志》2002年自引中的错误分析了引起著录错误的原因,并提出了避免参考文献著录错误的对策。

关键词：《中华医学图书情报杂志》论文写作参考文献著录格式标准化著者编辑