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Association of vitamin D receptor and estrogen receptor-αgene polymorphism with peak bone mass and bone size in Chinese women

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Acta Pharmacologica Sinica 2004年第4期25卷 64-70页

作者： Yue-juan QIN1, Zhen-lin ZHANG, Qi-ren HUANG, Jin-wei HE, yun-qiu HU, Qi zhou, Jing-hui LU, Miao LI, Yu-juan LIU Center for Preventing and Treating Osteoporosis, Osteoporosis Research Unit, Shanghai JiaoTong UniversityAffiliated Sixth People’s Hospital, Shanghai 200233, China Center for Preventing and Treating Osteoporosis Osteoporosis Research Unit Shanghai JiaoTong University Affiliated Sixth People s Hospital Shanghai 200233 China. yuejuanQ@***

AIM: To investigate if vitamin D receptor (VDR) gene Apa I polymorphism and estrogen receptor-α (ER-α) gene Pvu II, Xba I polymorphisms are related to bone mineral density (BMD), bone mineral content (BMC) and bone size in premenopausal Chinese women. METHODS: The VDR Apa I genotype and ER-α Pvu II, Xba I genotype were determined by PCR-restriction fragment length polymorphism (RFLP) in 493 unrelated healthy women aged 20-40 years of Han nationality in Shanghai city. BMD (g/cm2), BMC (g), and bone areal size (BAS, cm2) at lumbar spine 1-4 (L1-4) and proximal femur (femoral neck, trochanter and Ward’s triangle) were measured by duel-energy X-ray absorptionmetry. RESULTS: All allele frequencies did not deviate from Hardy-Weinberg equilibrium. After pheno- types were adjusted for age, height, and weight, a significant association was found between VDR Apa I genotype and BMC variation at L1-4and Ward’s triangle (P<0.05), but not in BMD or BAS at lumbar spine and proximal femur. ER-α Pvu II, Xba I genotype was not related to BMC, BMD, and BAS at all sites. CONCLUSION: The study suggested that Apa I polymorphism in VDR gene may influence on attainment and maintenance of peak bone mass in premenopausal Chinese women.

关键词： bone density bone remodeling calcitriol receptors estrogen receptors restriction fragment length polymorphism gene frequency genotype female

研究片内多径分离技术在基于RSSI定位中的应用

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电子与信息学报 2011年第4期33卷 891-895页

作者：罗炬锋邱云周付耀先袁晓兵中国科学院上海微系统与信息技术研究所无线传感器网络与通信重点实验室上海200050

无线传感器网络中基于接收信号强度指示(RSSI)的定位易受多径干扰。传统的基于RSSI定位方法主要通过增加测距样本来抵抗多径干扰,而在物理层研究抗多径干扰的较少。该文将片内多径分离技术应用于基于RSSI的定位中,通过抽取每个码片的第... 详细信息

无线传感器网络中基于接收信号强度指示(RSSI)的定位易受多径干扰。传统的基于RSSI定位方法主要通过增加测距样本来抵抗多径干扰,而在物理层研究抗多径干扰的较少。该文将片内多径分离技术应用于基于RSSI的定位中,通过抽取每个码片的第1个采样点进行相关解扩得到分离多径后的直达径,并求其功率得到抗多径干扰的RSSI值。理论分析其多径的分离能力,信噪比损失情况。最后通过仿真比较了传统方法与该文方法求得的RSSI值方差,该文方法在多径信道下的方差更小。

关键词：无线传感器网络直接序列扩频定位接收信号强度指示片内多径分离

无线传感网中虚拟V-BLAST发射能量分配研究

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系统仿真学报 2008年第16期20卷 4421-4424页

作者：丁盛邱云周严凯朱明华刘海涛中科院上海微系统与信息技术研究所无线传感网与通信重点实验室上海200050

针对无线传感器网络能量受限的问题,提出一种适用于无线传感网的虚拟V-BLAST系统,并研究使各个传感器节点信号误码率最小的功率分配算法。提出了基于Karush-Kuhn-Tucker(KKT)条件的最优功率分配方案和基于等信干噪比(SINR)的次优功率分... 详细信息

针对无线传感器网络能量受限的问题,提出一种适用于无线传感网的虚拟V-BLAST系统,并研究使各个传感器节点信号误码率最小的功率分配算法。提出了基于Karush-Kuhn-Tucker(KKT)条件的最优功率分配方案和基于等信干噪比(SINR)的次优功率分配方案。仿真结果表明,采用发射功率分配的虚拟V-BLAST系统比传统等功率分配V-BLAST系统传输质量有了很大的提高,在相同误码率要求下,可以减少发射功率,延长网络寿命。

关键词：无线传感器网络 V-BLAST 发射功率分配虚拟MIMO

基于无线传感网的虚拟MIMO的能量有效性研究

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计算机工程 2007年第17期33卷 1-3,6页

作者：邱云周沈杰董少龙刘海涛中科院上海微系统与信息技术研究所上海200050

基于一种无线传感网模型,提出了一种新的虚拟MIMO结构,此结构不需要接收端协同,避免了以往虚拟MIMO结构中接收端协同的复杂性。文章从整个网络生存周期角度出发,分析并推导了在相同条件下虚拟MIMO相比SISO会有更小的能耗,此外,还考虑了... 详细信息

基于一种无线传感网模型,提出了一种新的虚拟MIMO结构,此结构不需要接收端协同,避免了以往虚拟MIMO结构中接收端协同的复杂性。文章从整个网络生存周期角度出发,分析并推导了在相同条件下虚拟MIMO相比SISO会有更小的能耗,此外,还考虑了基于导频序列信道估计对能耗的影响,仿真结果表明了协同虚拟MIMO比SISO情况下能最节省很多。

关键词：无线传感网 MIMO 虚拟MIMO 能量有效性

Genome assembly of autotetraploid Actinidia arguta highlights adaptive evolution and enables dissection of important economic traits

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Plant Communications 2024年第6期5卷 173-192页

作者： Xue-Mei Lu Xiao-Fen Yu Guo-Qiang Li Ming-Hao Qu Huan Wang Chuang Liu Yu-Ping Man Xiao-Han Jiang Mu-Zi Li Jian Wang Qi-Qi Chen Rui Lei Cheng-Cheng Zhao yun-qiu zhou Zheng-Wang Jiang Zuo-zhou Li Shang Zheng Chang Dong Bai-Lin Wang Yan-Xiang Sun Hui-Qin Zhang Jie-Wei Li Quan-Hui Mo Ying Zhang Xin Lou Hai-Xu Peng Ya-Ting Yi He-Xin Wang Xiu-Jun Zhang Yi-Bo Wang Dan Wang Li Li Qiong Zhang Wen-Xia Wang Yongbo Liu Lei Gao Jin-Hu Wu Yan-Chang Wang CAS Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture Wuhan Botanical GardenChinese Academy of SciencesWuhanHubeiChina Key Laboratory of Western China’s Environmental Systems(Ministry of Education) College of Earth and Environmental SciencesLanzhou UniversityLanzhouGansuChina College of Life Sciences University of Chinese Academy of SciencesBeijingChina Wuhan Frasergen Bioinformatics Co. LtdWuhanHubeiChina Institute of Soil and Fertilizer Anhui Academy of Agricultural SciencesHefeiChina College of Agricultural Sciences Xichang UniversityXichangSichuanChina Department of Horticulture Heilongjiang Academy of Agricultural SciencesHarbinHeilongjiangChina College of Life Sciences Langfang Normal UniversityLangfangHebeiChina Institute of Horticulture Zhejiang Academy of Agricultural SciencesHangzhouZhejiangChina Guangxi Institute of Botany Chinese Academy of SciencesGuilinGuangxiChina Xi’an Botanical Garden of Shaanxi Province Institute of Botany of Shaanxi ProvinceXi’anShaanxiChina Institute of Modern Agricultural Research Dalian UniversityDalianLiaoningChina Bioinformatics Center College of Plant Science and TechnologyBeijing University of AgricultureBeijingChina College of Agriculture Eastern Liaoning UniversityDandongLiaoningChina Dalian Institute of Chemical Physics Chinese Academy of SciencesDalianLiaoningChina State Environmental Protection Key Laboratory of Regional Eco-process and Function Assessment Chinese Research Academy of Environmental SciencesBeijingChina Hubei Hongshan Laboratory WuhanHubeiChina The New Zealand Institute for Plant and Food Research Limited AucklandNew Zealand

Actinidia arguta,the most widely distributed Actinidia species and the second cultivated species in the genus,can be distinguished from the currently cultivated Actinidia chinensis on the basis of its small and smooth fruit,rapid softening,and excellent cold *** evolution of tetraploid Actinidia species and the genetic basis of their important agronomic traits are still ***,we generated a chromosome-scale genome assembly of an autotetraploid male *** *** genome assembly was 2.77 Gb in length with a contig N50 of 9.97 Mb and was anchored onto 116 *** and clustering of 101 geographically representative accessions showed that they could be divided into two geographic groups,Southern and Northern,which first diverged 12.9 million years *** underwent two prominent expansions and one demographic bottleneck from the midPleistocene climate transition to the late *** genomics studies using paleoclimate data enabled us to discern the evolution of the species’adaptation to different historical *** genes(AaCEL1,AaPME1,and AaDOF1)related to flesh softening were identified by multi-omics analysis,and their ability to accelerate flesh softening was verified through transient expression assays.A set of genes that characteristically regulate sexual dimorphism located on the sex chromosome(Chr3)or autosomal chromosomes showed biased expression during stamen or carpel *** chromosome-level assembly of the autotetraploid *** genome and the genes related to important agronomic traits will facilitate future functional genomics research and improvement of ***.

关键词： kiwiberry dioecism adaptive evolution paleoclimate GEA rapid softening

Kangfuxin solution alleviates esophageal stenosis after endoscopic submucosal dissection:A natural ingredient strategy

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World Journal of Gastroenterology 2025年第1期31卷 110-125页

作者： Xin zhou Dan Ma Yi-Xiang He Jing Jin Hong-Lian Wang yun-Feng Wang Fan Yang Jian-Qin Liu Jie Chen Zhi Li Department of Spleen and Stomach Diseases the Affiliated Traditional Chinese Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina The Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Digestive System Diseases of Luzhou City The Affiliated Traditional Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina Department of Gastroenterology Changhai HospitalNaval Medical UniversityShanghai 20082China Research Center of Integrated Chinese and Western Medicine The Affiliated Traditional Chinese Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina School of Integrated Traditional Chinese and Western Clinical Medicine North Sichuan Medical CollegeNanchong637100Sichuan ProvinceChina

BACKGROUND Esophageal stricture ranks among the most significant complications following endoscopic submucosal dissection(ESD).Excessive fibrotic repair is a typical pathological feature leading to stenosis after *** To examine the effectiveness and underlying mechanism of Kangfuxin solution(KFX)in mitigating excessive fibrotic repair of the esophagus *** Pigs received KFX at 0.74 mL/kg/d for 21 days after esophageal full circumferential *** examinations occurred on days 7 and 21 *** vitro,recombinant transforming growth factor(TGF)-β1(5 ng/mL)induced a fibrotic microenvironment in primary esophageal fibroblasts(pEsF).After 24 hours of KFX treatment(at 1.5%,1%,and 0.5%),expression ofα-smooth muscle actin-2(ACTA2),fibronectin(FN),and type collagen I was *** signaling was analyzed,including TGF-β1,Smad2/3,and phosphor-smad2/3(p-Smad2/3).RESULTS Compared to the Control group,the groups treated with KFX and prednisolone exhibited reduced esophageal stenosis,lower weight loss rates,and improved food tolerance 21 d after *** treatment,Masson staining revealed thinner and less dense collagen fibers in the submucosal ***,the expression of fibrotic effector molecules was notably ***,KFX downregulated the transduction levels of fibrotic functional molecules such as TGF-β1,Smad2/3,and p-Smad2/*** vitro,pEsF exposed to TGF-β1-induced fibrotic microenvironment displayed increased fibrotic activity,which was reversed by KFX treatment,leading to reduced activation of ACTA2,FN,and collagen *** 1.5%KFX treatment group showed decreased expression of p-Smad 2/3 in TGF-β1-activated *** KFX showed promise as a therapeutic option for post-full circumferential esophageal ESD strictures,potentially by suppressing fibroblast fibrotic activity through modulation of the TGF-β1/Smads signaling pathway.

关键词： Kangfuxin solution Natural component Endoscopic submucosal dissection Esophagus stricture Fibrosis

IEEE 802.15.4中信道利用率的分析与改进

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计算机工程 2014年第4期40卷 103-107页

作者：孙启钱汉望刘建坡邱云周中国科学院上海微系统与信息技术研究所上海200050

在分析IEEE 802.15.4网络中为时延敏感应用提供的保护时隙(GTS)分配策略后,指出GTS分配中信道利用率低等不足。为此,对IEEE 802.15.4中的GTS进行改进。将GTS时隙再次划分为微时隙,与标准GTS申请命令不同,节点无须指定所需的GTS长度,而... 详细信息

在分析IEEE 802.15.4网络中为时延敏感应用提供的保护时隙(GTS)分配策略后,指出GTS分配中信道利用率低等不足。为此,对IEEE 802.15.4中的GTS进行改进。将GTS时隙再次划分为微时隙,与标准GTS申请命令不同,节点无须指定所需的GTS长度,而是提供需要发送的数据数量和数据长度,通过协调节点来决定所分配的GTS长度。仿真实验结果表明,改进后协议能提高信道利用率和网络吞吐量。

关键词： IEEE 802 15 4标准无线传感器网络介质访问控制保护时隙信道利用率

基于RTS/CTS协议的协同中继网络功率分配研究

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系统仿真学报 2009年第11期21卷 3394-3397页

作者：丁盛邱云周王营冠刘海涛中科院上海微系统与信息技术研究所无线传感网与通信重点实验室上海200050

针对使用分布式线性弥散码的放大转发协同中继网络,提出一种基于MAC层请求发送/允许发送协议的分布式功率分配方案。此方案不需要处理中心集中处理后反馈信息,信源和各中继节点可以计算自己的优化发射功率,简单易实现。还从降低系统中... 详细信息

针对使用分布式线性弥散码的放大转发协同中继网络,提出一种基于MAC层请求发送/允许发送协议的分布式功率分配方案。此方案不需要处理中心集中处理后反馈信息,信源和各中继节点可以计算自己的优化发射功率,简单易实现。还从降低系统中断概率的角度给出了基于中继信道强度的瓶颈效应和调和平均值的两种发射功率分配算法。仿真结果表明,相比较传统的等功率分配,提出的方案充分体现了分布式线性弥散码的分集增益,不仅降低系统的中断概率,还大大改善了接收端的误码率性能,有很强的实用性。

关键词：功率分配线性弥散码请求发送/允许发送协议协同分集

基于STBC与V-BALST的虚拟MIMO方案研究

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电子技术应用 2008年第5期34卷 104-107页

作者：邱云周丁盛严凯王营冠刘海涛中科院上海微系统与信息技术研究所上海200050

提出了一种比较不同编码速率的方法,并使用此方法分析了不同节点下基于V-BLAST和STBC两种虚拟MIMO方案的性能,得出了虚拟MIMO方案选择的一些结论。采用理论分析与Mento Carlo仿真相结合的方法,仿真结果为虚拟MIMO方案选择提供了理论依据... 详细信息

提出了一种比较不同编码速率的方法,并使用此方法分析了不同节点下基于V-BLAST和STBC两种虚拟MIMO方案的性能,得出了虚拟MIMO方案选择的一些结论。采用理论分析与Mento Carlo仿真相结合的方法,仿真结果为虚拟MIMO方案选择提供了理论依据,这对加速无线传感网的发展与应用无疑有重要意义。

关键词：虚拟MIMO STBC V—BLAST 每比特信噪比