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Global research landscape of Peutz-Jeghers syndrome and successful endoscopic management of intestinal intussusception in patients with recurrent laparotomies

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World Journal of Gastrointestinal Surgery 2024年第8期16卷 2702-2718页

作者： qi Sun Xiao-Ying wang Guang-Jin Guo Lei wang Li-Min Meng yun-Fei Guo Tao Sun Shou-Bin Ning Department of Gastroenterology Air Force Medical CenterBeijing 100142China College of Life Science Northwest UniversityXi'an 710069Shaanxi ProvinceChina Clinical Medical Laboratory Air Force Medical CenterBeijing 100142China Department of Medical Imaging Air Force Medical CenterBeijing 100142China Department of Pathology Air Force Medical CenterBeijing 100142China

BACKGROUND Peutz-Jeghers syndrome(PJS)has brought significant physical,psychological and economic burdens on the patients and their families due to its early onset,diagnostic and therapeutic challenges and increased recurrence *** To explore the current research status and emerging hotspots of *** Studies on PJS published during 1994-2023 were gathered based on Web of Science Core ***,a case of PJS-induced intestinal intussusception,successfully treated with endoscopic methods despite three laparotomies,was *** bibliometric and visual analysis were conducted with VOSviewer,R and *** Altogether 1760 studies were identified,indicating a steady increase in the publication *** United States had the highest influence,whereas the University of Helsinki emerged as the leading institution,and Aaltonen LA from the University of Helsinki was the most prolific *** Research,Oncogene and Endoscopy were the top three journals based on *** burst direction analysis revealed that"cancer risk","management","surveillance"and"familial pancreatic cancer"were the potential hotspots for ***,"early detection","capsule endoscopy","clinical management","double-balloon endoscopy","familial pancreatic cancer"and"molecular genetic basis"were identified as the key clusters of co-cited *** polypectomy remained effective on resolving intestinal intussusception in patients who underwent three previous *** In the last three decades,global publications related to PJS show a steadily increasing trend in *** management is currently a research hotspot.

关键词： Peutz-Jeghers syndrome Endoscopy Management Cancer Microbiota Bibliometric

Effect of lanthanum on inclusions in non-oriented electrical steel slabs

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Journal of Iron and Steel Research International 2024年第7期31卷 1680-1691页

作者： qiang Ren Zhi-yuan Hu yun-xia Liu Wei-cheng Zhang Zi-qi Gao Li-feng Zhang School of Mechanical Engineering Yanshan UniversityQinhuangdao 066004HebeiChina School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China Research and Development Department Shougang Zhixin Qian'an Electromagnetic Material Co.Ltd.Qian'an 064400HebeiChina School of Mechanical and Materials Engineering North China University of TechnologyBeijing 100144China

The effect of lanthanum on the characteristics of inclusions in the slab of non-oriented electrical steels was investigated through industrial trials and thermodynamic *** number,size,and chemical composition of inclusions in the surface,one-quarter of thickness and the center of slabs with and without lanthanum addition were statistically analyzed using an automatic inclusion analysis *** the lanthanum-free slab,inclusions were predominately ***_(2)O_(3),MgO,and AlN as well as a small number of Al_(2)O_(3)-MgO-CaO and *** number densities of oxide inclusions and AlN decreased from the surface to the center of the slab,which was ascribed to the difference in cooling intensity during the continuous *** the steel with lanthanum addition,inclusions were modified into LaAlO_(3) and La_(2)O_(2)S and gradually transformed into dual-phase MgO-La_(2)S3 with an increasing distance from the slab surface due to the reaction between the lanthanum-containing inclusion and the steel *** uneven distribution of oxide inclusions along the thickness of the slab was eliminated in the lanthanum-bearing slab because the dissolved oxygen was remarkably decreased by ***-bearing inclusions were more likely to agglomerate AlN by inducing the heterogeneous nucleation of AlN on their surface,while small-size ***_(2)O_(3) inclusions hardly showed a coarsening effect on the size of AlN.

关键词： Lanthanum-Inclusion Non-oriented electrical steel Aluminum nitride Heterogenous nucleation

A Dynamic Covalent Bonding-based Nanoplatform for Intracellular Co-Delivery of Protein Drugs and Chemotherapeutics with Enhanced Anti-Cancer Effect

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Chinese Journal of Polymer Science 2024年第5期42卷 559-569,I0005页

作者： Sai-Nan Liu Jia-Hui Meng Li-yun Cui Hua Chen Lin-qi Shi Ru-Jiang Ma Key Laboratory of Functional Polymer Materials of Ministry of Education Institute of Polymer ChemistryTianjin Key Laboratory of Functional Polymer MaterialsState Key Laboratory of Medicinal Chemical BiologyFrontiers Science Center for New Organic MatterCollege of ChemistryNankai UniversityTianjin300071China Haihe Laboratory of Sustainable Chemical Transformations Tianjin300192China

Efficient intracellular delivery of protein drugs is critical for protein *** combination of protein drugs with chemotherapeutics represents a promising strategy in enhancing anti-cancer ***,co-delivery systems for efficient delivery of these two kinds of drugs are still lacking because of their different ***,we show a well-designed delivery system based on dynamic covalent bond for efficient intracellular co-delivery of ribonuclease A(RNase A)and doxorubicin(DOX).Two polymers,PEG-b-P(Asp-co-AspDA)and PAE-b-P(Asp-co-AspPBA),and two 2-acetylphenylboronic acid(2-APBA)-functionalized drugs,2-APBA-RNase A and 2-APBA-DOX,self-assemble into mixed-shell nanoparticles(RNase A/DOX@MNPs)via dynamic phenylboronic acid(PBA)-catechol bond between PBA and dopamine(DA)*** PBA-catechol bond endows the nanoparticles with high stability and excellent stimulus-responsive drug release *** the slight acidic environment at tumor tissue,RNase A/DOX@MNPs are positively charged,promoting their *** cellular uptake into endosome,further protonation of PAE chains leads to the rupture of endosomes because of the proton sponge effect and the cleavage of PBA-catechol bond promotes the release of two *** cytoplasm,the high level of GSH removed the modification of 2-APBA on *** restored RNase A and DOX show a synergistic and enhanced antic-cancer *** system may be a promising platform for intracellular co-delivery of protein drugs and chemotherapeutics.

关键词： Drug co-delivery Combination therapy Dynamic covalent bond

Probing the Affinity of Coronavirus with Contact Surfaces in Simulated Body Fluids

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Environment & Health 2024年第5期2卷 269-277页

作者： Yarong qi Xun Guan yun Shen Xitong Liu Department of Civil&Environmental Engineering The George Washington UniversityWashingtonD.C.20052United States Department of Environmental Science Policyand ManagementUniversity of CaliforniaBerkeleyCalifornia 94720United States

Transmission of viral pathogens has raised serious public health concerns,but the affinity and strength of viruses adhering to hightouch surfaces are not *** systematically investigated the propensities of a coronavirus,Murine hepatitis virus A59(MHV),adhering onto and releasing from four representative contact surfaces,silica,stainless steel,cellulose,and polystyrene,in simulated saliva and urine using quartz crystal microbalance with dissipation monitoring(QCM-D).We also quantified the interactions between MHV and contact surfaces using atomic force microscopy(AFM).Both initial adhesion rates and saturated adhesion mass of MHV were higher in urine buffer than in saliva buffer,which is attributed to the higher repulsions between the virus and surfaces in the presence of *** maximum adhesion mass of MHV follows the order of stainless steel>silica>cellulose≈polystyrene in both urine and saliva *** steel and silica are surfaces with likely higher risks of virus contamination due to their highest maximum adhesion mass in both urine and saliva buffers and lower virus release percentages upon water *** results of this study will provide insights into risk assessment and control of pathogens associated with contact surfaces.

关键词： Coronavirus Contact surfaces Silica Stainless steel Cellulose Polystyrene Fomite transmission

Universal paradigm of ternary metacomposites with tunable epsilon-negative and epsilon-near-zero response for perfect electromagnetic shielding

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Rare Metals 2024年第2期43卷 796-809页

作者： yun-Peng Qu yun-Lei Zhou Yang Luo Yao Liu Jun-Fei Ding Yan-Li Chen Xiu Gong Jing-Liang Yang qiong Peng Xiao-Si qi College of Physics Guizhou UniversityGuiyang550025China Hangzhou Institute of Technology Xidian UniversityHangzhou311231China Department of Materials ETH Zurich8093ZurichSwitzerland Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials(Ministry of Education) Shandong UniversityJinan250061China

CaCu_(3)Ti_(4)O_(12)(CCTO)ceramic nanocomposites incorporating graphene–carbon black(GRCB)fillers were fabricated by spark plasma sintering *** percolative effects of conductive GRCB fillers on dielectric response of GRCB/CCTO ternary metacomposites were systematically *** weakly real permittivity(ε′)-negative response(ε′~−1×10^(2))was achieved which originated from weakly low-frequency plasmonic state of free carriers within constructed GRCB *** enhancing three-dimensional GRCB network,the plasma frequency of metacomposites increased while the damping factor ***,theε′-negative values of metacomposites were tuned from−10^(2) to−10^(4) orders of magnitude andε′-near-zero(ENZ)frequencies from~142 to~340 MHz which substantially benefited from the moderate carrier concentration of GRCB dual *** Drude model and equivalent circuit models were adopted to demonstrate dielectric and electrical *** obtained metacomposites show strong EM shielding effect along with enhanced plasmonic oscillation and even better achieving perfect EM shielding effect in ENZ *** work achieves the tunableε′-negative andε′-near-zero response and more importantly clarifies its regulation mechanism in ceramic-based ternary metacomposites,which opens up the possibility of designing high-performance EM shielding materials based on metacomposites.

关键词： Metacomposites Ceramic matrix composites Negative permittivity Epsilon-near-zero Electromagnetic shielding

Prognostic Nutritional Index Associates with the Severity of Silicosis:A Study from a Tertiary Class A Prevention and Treatment Institute for Occupational Diseases in China

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Biomedical and Environmental Sciences 2024年第1期37卷 122-126页

作者： HE La Gu LIANG yun Lai YANG Lu qi YUAN Hua Min Medical laboratory Department Hunan Prevention and Treatment Institute for Occupational DiseasesChangsha 410000HunanChina Laboratory Medicine Department Xiangya HospitalCentral South UniversityChangsha 410013HunanChina

Pneumoconiosis is a group of heterogeneous fibrotic lung diseases caused by inorganic mineral dust and includes coal workers’pneumoconiosis and *** involves diffuse or nodular interstitial pulmonary fibrosis caused by exposure to asbestos or silica *** is thought to have the highest number of silicosis cases,with 6,000 new cases reported annually^([1]).Currently,the clinical diagnosis and monitoring of silicosis relies mainly on a history of occupational exposure and radiological abnormalities^([2]).Therefore,determining further indicators is crucial to reflect the severity of silicosis.

关键词： diagnosis lung diseases

Achieving high power factor in GaSb with intrinsically high mobility via Ge doping

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Rare Metals 2024年第10期43卷 5435-5441页

作者： Yan-Ci Yan Guo-Wei wang qi-Hong Xiong Xu Lu Peng Chen Wei Zou Deng-Feng Li Hong Wu yun Zhou Xiao-Yuan Zhou School of Science Chongqing University of Posts and Telecommunications College of Physics Chongqing University College of Ocean Science and Engineering Shanghai Maritime University

The thermoelectric power factor is as crucial as their overall thermoelectric ***-based compounds are deemed to achieve high power factor owing to their intrinsically high mobility compared to classical thermoelectric ***,the carrier concentration of pristine GaSb is considerably lower than the optimum value,which hinders its ability to attain high electrical *** this paper,we present the investigations on the thermoelectric performance of p-type *** experimental results reveal that Ge doping can effectively tune the carrier concentration.

关键词： Carrier concentration

Deep Underground Earthquake Observation:Small to Moderate Earthquakes and Microearthquakes Identification

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Journal of Earth Science 2024年第5期35卷 1789-1794页

作者： Chang Chen Wentao Wan yun wang Jingsong Liu Hongyi Li qiangqiang Miao Yongsheng He Juan qi Chao wang MWMC Research Group School of Geophysics and Information TechnologyChina University of GeosciencesBeijing 10083China State Kay Laboratory of Geological Processes and Mineral Resources China University of GeosciencesBeijing 10083China Institute of Engineering Protection Engineering Research Institute of Academy of Military SciencesLuoyang 471000China College of Electrical and Information Engineering Anhui University of Science and TechnologyHuainan 232001China Institute of Geochemistry.ChineseAcademy of Sciences Guivang 550081.China

0 INTRODUCTION Small to moderate earthquakes and microearthquakes occur widely and numerously(Luo,2010),which contributes to the research of focal mechanism,faults and deep geodynamics(Li et al.,2023;Yi et al.,2020;Mori,1991).It is of great significance for the focal mechanism solution of main shock and the distribution of coseismic activities(Meng et al.,2022;Zhang et al.,2021).

关键词： Earthquake earthquakes seismic

Plant Stem Cell Informatics Database(PSCIdb):A comprehensive computational platform for identifying and analyzing genes related to plant stem cells

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Plant Communications 2024年第5期5卷 100-103页

作者： Xiao Wu Yubo Yuan Siyuan Zhou Zewen wang Hongxiang Li Wanping Wu Zhijie Lei Siyao Liu Kaijie qi Hao Yin yun Zhou Shaoling Zhang Sanya Institute of Nanjing Agricultural University State Key Laboratory of Crop Genetics&Germplasm Enhancement and UtilizationNanjing Agricultural UniversityNanjing 210095China Department of Botany and Plant Pathology Purdue UniversityWest LafayetteIN 47907USA Purdue Center for Plant Biology Purdue UniversityWest LafayetteIN 47907USA

Dear Editor,Stem cells in the meristems of land plants share conserved functions,remaining undifferentiated while continually dividing and producing daughter cells that eventually differentiate into various new organs(Meyerowitz,1997;Heidstra and Sabatini,2014).Stem cell activity is therefore essential for sustaining plant growth and development,determining yield and biomass production,and dictating the diversity of body formation and plant architecture across species(Meyerowitz,1997;Heidstra and Sabatini,2014;Harrison,2017;Kitagawa and Jackson,2019).

关键词： Informatics eventually dividing