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Chinese Journal of Structural Chemistry 2006年第8期25卷 919-922页

作者： DENG Yi-Fang KUANG Dai-Zhi ZHANG Chun-Hua CHEN Man-Sheng peng yun-Lin yang Ying-Qun LI Wei Department of Chemistry and Material Science Hengyang Normal University Hengyang 421008 China

The title complex [Zn（L）（phen）（CH3OH）] （L = C8H6BrO4NS, aminomethanesulfonic acid 5-bromo-salicylaldelyde schiff base; phen = 1,10-phenanthroline） has been synthesized and characterized by X-ray diffraction method. The crystal belongs to monoclinic, space group P21/c with a = 1.8712（3）, b = 1.38008（19）, c = 0.83685（12） nm, β = 97.791 （2）°, Mr = 569.72, V = 2.1411 （5） nm^3, Z= 4, Dc = 1.767 g/cm^3,μ = 3.151 mm^-1, F（000） = 1144, the final R = 0.0402 and wR = 0.0885. The central Zn（Ⅱ） is six-coordinated by one nitrogen and two oxygen atoms from the Schiff base, two nitrogen atoms from 1,10-phenanthroline and one oxygen from methanol to form a distorted octahedral coordination geometry.

关键词： zinc complex aminomethanesulfonic acid 5-bromo-salicylalddyde schiff base crystal structure thermal analysis

Characterization of gut microbial alterations in cynomolgus macaques during growth and maturation

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Zoological Research 2022年第2期43卷 176-179页

作者： yun-peng yang Yong Lu Pei-Jun Yu Qi-Ming Liu Chang-Shan Gao Xiao-Tong Zhang Qiang Sun Institute of Neuroscience CAS Key Laboratory of Primate NeurobiologyState Key Laboratory of NeuroscienceCAS Center for Excellence in Brain Science and Intelligence TechnologyChinese Academy of SciencesShanghai 200031China University of Chinese Academy of Sciences Beijing 100049China

Aging is closely related to physiology and disease development in *** microbiota varies with lifecycle and exerts profound influences on the *** investigate gut microbial alterations during growth and maturation,41 female cynomolgus monkeys(Macaca fascicularis)ranging in age from 1 month to 15 years were divided into four groups(infant,young,adult,and middle-aged).

关键词： alterations infant maturation

The Good Pain Management(GPM) Ward Program in China and its impact on Chinese cancer patients: the SYSUCC experience

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Chinese Journal of Cancer 2014年第7期33卷 323-329页

作者： yun-peng yang Yu-Xiang Ma Yan Huang Yuan-Yuan Zhao Fei Xu Ying Tian Ben-Yan Zou Rui-Zhen Gao Li Zhang State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Department of Medical Oncology Sun Yat-sen University Cancer Center

To improve cancer pain management, the Medical Oncology Department of Sun Yat-sen University Cancer Center(SYSUCC) launched the Good Pain Management(GPM) Ward Program, which has been recognized by the Chinese Ministry of Health and promoted throughout the nation. This retrospective case-control study was designed to evaluate the effectiveness of the program. Patients diagnosed with malignant solid tumors with bone metastasis were eligible. Patients who were admitted 6 months before the initiation of the GPM program were used as the control group, and patients admitted 6 months after the initiation of the program were used as the GPM group. The pain-reporting rate and pain management index(PMI) were calculated. The pain levels before and after pain management were compared. A total of 475 patients(244 in the control group and 231 in the GPM group) were analyzed. The pain-reporting rate of the GPM group was significantly higher than that of the control group(62.8% vs. 37.7%, P < 0.001). The PMI of the GPM group was significantly higher than that of the control group(0.083 vs.-0.261, P < 0.001). Therefore, the GPM Ward Program improved the pain management of cancer patients and provided experience for improving cancer pain management in the future.

关键词：癌症患者管理指数疼痛中国肿瘤防治中心对照组中山大学 PMI

Simulation of the Weakly Nonlinear Rayleigh–Taylor Instability in Spherical Geometry

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Chinese Physics Letters 2020年第5期37卷 73-76页

作者： yun-peng yang Jing Zhang Zhi-Yuan Li Li-Feng Wang Jun-Feng Wu Wen-Hua Ye Xian-Tu He School of Physics Peking UniversityBeijing 100871 Center for Applied Physics and Technology HEDPSPeking UniversityBeijing 100871 Institute of Applied Physics and Computational Mathematics Bejing 100094

The Rayleigh-Taylor instability at the weakly nonlinear(WN)stage in spherical geometry is studied by numerical *** mode coupling processes are *** results are consistent with the WN model based on parameter expansion,while higher order effects are found to be *** Legendre mode perturbation Pn(cos B),the nonlinear saturation amplitude(NSA)of the fundamental mode decreases with the mode number *** n is large,the spherical NSA is lower than the corresponding planar ***,for large n,the planar NSA can be recovered by applying Fourier transformation to the bubble/spike near the equator and calculating the NSA of the converted trigonometric harmonic.

关键词： planar spherical negligible

Interface Width Effect on the Weakly Nonlinear Rayleigh–Taylor Instability in Spherical Geometry

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Chinese Physics Letters 2020年第7期37卷 43-46页

作者： yun-peng yang Jing Zhang Zhi-Yuan Li Li-Feng Wang Jun-Feng Wu Wun-Hua Ye Xian-Tu He School of Physics Peking UniversityBeijing 100871China Center for Applied Physics and Technology HEDPSand College of EngineeringPeking UniversityBeijing 100871China Institute of Applied Physics and Computational Mathematics Beijing 100094China

Interface width effect on the spherical Rayleigh–Taylor instability in the weakly nonlinear regime is studied by numerical *** Legendre perturbation mode Pn with wave number Kn and interface half-width L,the commonly adopted empirical linear growth rate formulaγnem(L)=γn/√1+KnL is found to be sufficient in spherical *** the weakly nonlinear stage,the interface width affects the mode coupling *** development of the mode P2n is substantially influenced by the interface ***,the nonlinear saturation amplitude increases with the interface width.

关键词： interface nonlinear weakly

Versatile dopamine-functionalized hyaluronic acid-recombinant human collagen hydrogel promoting diabetic wound healing via inflammation control and vascularization tissue regeneration

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Bioactive Materials 2024年第5期35卷 330-345页

作者： Yong Wang Yuan Zhang yun-peng yang Ming-Yuan Jin Sha Huang Ze-Ming Zhuang Tao Zhang Li-Li Cao Xiao-Ying Lin Jun Chen Yong-Zhong Du Jian Chen Wei-Qiang Tan Department of Plastic Surgery Sir Run Run Shaw HospitalZhejiang University School of Medicine3 East Qingchun RoadHangzhou310016China Department of Ultrasound in Medicine The Fourth Affiliated HospitalZhejiang University School of MedicineYiwu322000China Institute of Pharmaceutics College of Pharmaceutical SciencesZhejiang University866 Yu-Hang-Tang RoadHangzhou310058China MOE Key Laboratory of Biosystems Homeostasis&Protection College of Life SciencesZhejiang UniversityHangzhou310058China

The management of chronic wounds in diabetes remains challenging due to the complexity of impaired wound healing,delayed healing,susceptibility to infection,and elevated risk of reopening,highlighting the need for effective chronic wound management with innovative approaches such as multifunctional ***,we have produced HA-DA@rhCol hydrogels consisting of dopamine-modified hyaluronic acid and recombinant human collagen type-III(rhCol)by oxidative coupling of the catechol group using the H_(2)O_(2)/HRP catalytic *** post-reactive hydrogel has a good porous structure,swelling rate,reasonable degradation,rheological and mechanical properties,and the catechol group and dopamine impart to the hydrogel tissue adhesiveness,antioxidant capacity,and excellent photothermal effects leading to superior in vitro antimicrobial *** addition,the ability of rhCol to confer hydrogels to promote angiogenesis and wound repair has also been *** and hemolysis tests demonstrated the good biocompatibility of the *** closure,collagen deposition and immunohistochemical examination confirmed the ability of the hydrogel to promote diabetic wound *** summary,the adhesive hemostatic antioxidative hydrogel with rhCol to promote wound healing in diabetic rat is an excellent chronic wound dressing.

关键词： Hyaluronic acid hydrogel Recombinant human collagen Antioxidant and anti-inflammation Antibacterial Diabetic wound

Multiple oncogenic mutations related to targeted therapy in nasopharyngeal carcinoma

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Chinese Journal of Cancer 2015年第4期34卷 177-183页

作者： Jian-Wei Zhang Tao Qin Shao-Dong Hong Jing Zhang Wen-Feng Fang Yuan-Yuan Zhao yun-peng yang Cong Xue Yan Huang Hong-Yuan Zhao Yu-Xiang Ma Zhi-Huang Hu Pei-Yu Huang Li Zhang Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Department of Medical Oncology Sun Yat-sen University Cancer Center Department of Nasopharyngeal Carcinoma Sun Yat-sen University Cancer Center

Introduction:An increasing number of targeted drugs have been tested for the treatment of nasopharyngeal carcinoma(NPC).However,targeted therapy-related oncogenic mutations have not been fully *** study aimed to detect targeted therapy-related oncogenic mutations in NPC and to determine which targeted therapy might be potentially effective in treating ***:By using the SNaPshot assay,a rapid detection method,19 mutation hotspots in 6 targeted therapy-related oncogenes were examined in 70 NPC *** associations between oncogenic mutations and clinicopathologic factors were ***:Among 70 patients,12(17.1%) had mutations in 5 oncogenes:7(10.0%) had v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog(KIT) mutation,2(2.8%) had epidermal growth factor receptor(EGFR) mutation,1(1.4%) had phosphatidylinositol-4,5-bisphosphate 3-kinase,catalytic subunit alpha(PIK3CA) mutation,1(1.4%) had Kirsten rat sarcoma viral oncogene homolog(KRAS) mutation,and 1(1.4%) had simultaneous EGFR and v-Raf murine sarcoma viral oncogene homolog B1(BRAF) *** significant differences were observed between oncogenic mutations and clinicopathologic ***,these oncogenic mutations were not associated with tumor recurrence or ***:Oncogenic mutations are present in NPC *** efficacy of targeted drugs on patients with the related oncogenic mutations requires further validation.

关键词：基因突变靶向治疗鼻咽癌致癌表皮生长因子受体快速检测方法原癌基因同源基因

一种基于社交影响力和平均场理论的信息传播动力学模型

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物理学报 2017年第3期66卷 227-239页

作者：肖云鹏李松阳刘宴兵重庆邮电大学网络与信息安全技术重庆市工程实验室重庆400065

在线社会网络中,信息传播蕴含着复杂的动力学成因.本文将传染病模型与社交影响力要素相结合,并针对影响力度量中主要研究静态网络拓扑结构、忽略个体行为特征的问题,提出一种基于动态节点行为和用户影响力的信息传播动力学模型,旨在量... 详细信息

在线社会网络中,信息传播蕴含着复杂的动力学成因.本文将传染病模型与社交影响力要素相结合,并针对影响力度量中主要研究静态网络拓扑结构、忽略个体行为特征的问题,提出一种基于动态节点行为和用户影响力的信息传播动力学模型,旨在量化影响力强度,为研究信息扩散过程中不同用户群体状态转变提供理论依据.首先,在网络拓扑结构和用户行为两方面,提取个人记忆和用户交互两个表征,分析影响力形成的内因和外因两个动力学成因,并基于多元线性回归模型,提出一种度量用户社会影响力的方法.其次,在传统传染病SIR(susceptible-infected-recovered)模型基础上,结合信息扩散与传染病蔓延相似的传播机理,综合考虑信息传播的多源并发性和双向性,引入影响力因子,利用平均场理论改进得到一种基于用户影响力的信息传播模型.实验表明,该模型能有效地解释在线社会网络中信息传播的动力学原因,感知社会网络中信息传播演化态势.

关键词：信息传播传播动力学社交影响力平均场理论

Computational Analysis for Residue-Specific CDK2-Inhibitor Bindings

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Chinese Journal of Chemical Physics 2019年第1期32卷 134-142,I0003页

作者： yun-peng yang Li-ping He Jing-xiao Bao Yi-fei Qi John Z. H. Zhang School of Chemistry and Molecular Engineering East China Normal University Shanghai 200062 China NYU-ECNU Center for Computational Chemistry at NYU Shanghai Shanghai 200062 China Department of Chemistry New York University NY NY 10003 USA

Cyclin-dependent kinase 2 (CDK2) is a key macromolecule in cell cycle regulation. In cancer cells, CDK2 is often overexpressed and its inhibition is an effective therapy of many cancers including breast carcinomas, leukemia, and lymphomas. Quantitative characterization of the interactions between CDK2 and its inhibitors at atomic level may provide a deep understanding of protein-inhibitor interactions and clues for more effective drug discovery. In this study, we have used the computational alanine scanning approach in combination with an efficient interaction entropy method to study the microscopic mechanism of binding between CDK2 and its 13 inhibitors. The total binding free energy from the method shows a correlation of 0.76?0.83 with the experimental values. The free energy component reveals two binding mode in the 13 complexes, namely van der Waals dominant, and electrostatic dominant. Decomposition of the total energy to per-residue contribution allows us to identify five hydrophobic residues as hot spots during the binding. Residues that are responsible for determining the strength of the binding were also analyzed.

关键词： CDK2 MD simulation Inhibitor Hot-spot residue Binding free energy

CaH2-promoted activity of Ni-carbonate interface for CO2 methanation

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Journal of Energy Chemistry 2025年第1期100卷 522-532页

作者： Jin-peng Wang Guo-Cui Mao Hui-Lin Jiang Bao-Xia Dong yun-Lei Teng School of Chemistry and Chemical Engineering Yangzhou University

Transition metal-carbonate interfaces often act as active sites in heterogeneous catalytic *** interface between transition metal and metal carbonate exhibits a dynamic equilibrium during the CO2hydrogenation reaction,involving surface carbonate hydrogenation and ***,there have been few reports on engineering the activity of the interface between transition metal and alkaline earth metal carbonate for catalytic *** work demonstrated that the incorporation of CaH2in Ni/CaCO3enhances the CO2methanation activity of the *** CO2conversion for Ni/CaH2-CaCO3reached 68.5%at 400°C,which was much higher than that of the Ni/CaCO3（31.6%） and Ni/CaH2-CaO （42.4%） ***,the Ni/CaH2-CaCO3catalysts remained stable during the stability test for 24 h at 400°C and 8 *** research revealed that CaH2played a crucial role in promoting the activity of the Ni-carbonate interface for ***2could modify the electronic structure of Ni and tune the structural properties of CaCO3to generate medium basic sites （OH groups）,which are favorable for the activation of H2and ***-situ Fourier transform infrared spectroscopy （FTIR） analysis combined with density functional theory calculations demonstrated that CO2activation occurs at the hydroxyl group （OH） on the CaH2-modified Ni-carbonate surface,leading to the formation of CO3H****,our study has confirmed that CO2methanation over the Ni/CaH2-CaCO3catalysts proceeds via the formate pathway.

关键词： Metal hydride Ni catalysts Carbonate Metal-carbonate interface