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TRAVELING WAVES IN A SIRH MODEL WITH SPATIO-TEMPORAL DELAY AND NONLOCAL DISPERSAL

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Acta Mathematica Scientia 2022年第2期42卷 715-736页

作者： Lu YANG yun-Rui YANG Xue song School of Mathematics and Physics Lanzhou Jiaotong UniversityLanzhou 730070China

This paper deals mainly with the existence and asymptotic behavior of traveling waves in a SIRH model with spatio-temporal delay and nonlocal dispersal based on Schauder’s fixed-point theorem and analysis techniques,which generalize the results of nonlocal SIRH models without relapse and *** particular,the difficulty of obtaining the asymptotic behavior of traveling waves for the appearance of spatio-temporal delay is overcome by the use of integral techniques and analysis ***,the more general nonexistence result of traveling waves is also included.

关键词： Nonlocal dispersal spatio-temporal delay traveling waves

Translocator protein ligand, YL-IPA08, attenuates lipopolysaccharide-induced depression-like behavior by promoting neural regeneration

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Neural Regeneration Research 2018年第11期13卷 1937-1944页

作者： Xiao-Ying Zhang Li-ming Zhang Wei-Dong mi yun-Feng Li Anesthesia and Operation Center Chinese PLA General Hospital Beijing China State Key Laboratory of Toxicology and Medical Countermeasures Beijing China

Translocator protein has received attention for its involvement in the pathogenesis of depression. This study assessed the effects of the new translocator protein ligand, YL-IPA08, on alleviating inflammation-induced depression-like behavior in mice and investigated its mechanism of action. mice were intracerebroventricularly injected with 1, 10, 100 or 1000 ng lipopolysaccharide. The tail-suspension test and the forced swimming test confirmed that 100 ng lipopolysaccharide induced depression-like behavior. A mouse model was then established by intraventricular injection of 100 ng lipopolysaccharide. On days 16-24 after model establishment, mice were intragastrically administered 3 mg/kg YL-IPA08 daily. Immunohistochemistry was used to determine BrdU and NeuN expression in the hippocampus. YL-IPA08 effectively reversed the depression-like behavior of lipopolysaccharide-treated mice, restored body mass, increased the number of BrdU-positive cells, and the number and proportion of BrdU and NeuN double-positive cells. These findings indicate that YL-IPA08 can attenuate lipopolysaccharide-induced depression-like behavior in mice by promoting the formation of hippocampal neurons.

关键词： nerve regeneration YL-IPA08 hippocampus dentate gyrus lipopolysaccharide neuroinflammation depression translocator protein neural regeneration

Quantum Solitary Wave Solutions in a Ferromagnetic Chain with Nearest-and Next-Nearest-Neighbor Interaction

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Communications in Theoretical Physics 2008年第11期50卷 1177-1180页

作者： LI De-Jun WANG Xiao-yun mi Xian-Wu KUE Jing Department of Physics Jishou University Jishou 416000 China Department of Physics Xiangtan University Xiangtan 411105 China

The quantum solitary wave solutions in a one-dimensional ferromagnetic chain is investigated by using theHartree-Fock approach and the multiple-scale *** is shown that quantum solitary wave solutions can exist in aferromagnetic system with nearest-and next-nearest-neighbor exchange interaction,and at the certain value of the firstBrillouin zone,the solitary wave solution of the Hartree wave function becomes the intrinsic localized mode.

关键词： Hartree-Fock approach multiple-scale method quantum solitary wave solution

α_(2) phase precipitation behavior and tensile properties at room temperature and 650℃ in an(α+β) titanium alloy

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Rare Metals 2021年第11期40卷 3261-3268页

作者： Wen-Jing Zhang Xiao-yun song song-Xiao Hui Wen-Jun Ye Yang Yu Yan-Feng Li State Key Laboratory of Nonferrous Metals and Processes GRIMAT Engineering Institute Co.Ltd.Beijing 100088China

The microstructure,room temperature and 650℃ tensile properties of an(α+β) titanium alloy were investigated after aging over a temperature range of 600-750℃ following solution *** results exhibit that both aging temperature and aging time influence the precipitation behavior of α_(2) phase,and the size ofα_(2) phase affects the tensile *** growth speed ofα_(2) phase gets quicker with the aging temperature increasing under the same aging *** a given aging temperature,the size of α_(2) phase gets larger when prolonging the aging *** are significant improvements in yield and ultimate tensile strength at room temperature and 650 ℃ after aging at 600℃ for 2 h,but these values decrease with the size of α_(2) phase *** is found that α_(2) phase,less than 7 nm,does not impair the roomtemperature ***,when the size of α_(2) phase grows up from 7 to 15 nm,ductility decreases *** 650 ℃ tensile process,with the particle size increasing from 3 to 15 nm,the interaction between moving dislocations and coherent particles changes from cutting mechanism to bypass mechanism.

关键词： Aging treatment α_(2)phase Tensile properties Interaction mechanism

Brain-derived neurotrophic factor in Alzheimer’s disease and its pharmaceutical potential

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Translational Neurodegeneration 2022年第1期11卷 883-916页

作者： Lina Gao yun Zhang Keenan Sterling Weihong song Shandong Collaborative Innovation Center for Diagnosis Treatment and Behavioral Interventions of Mental DisordersInstitute of Mental HealthCollege of PharmacyJining Medical UniversityJining 272067ShandongChina Townsend Family Laboratories Department of PsychiatryThe University of British Columbia2255 Wesbrook MallVancouverBC V6T 1Z3Canada National Clinical Research Center for Geriatric Disorders Xuanwu HospitalCapital Medical UniversityBeijing 100053China Institute of Aging Key Laboratory of Alzheimer’s Disease of Zhejiang ProvinceSchool of Mental Health and The Affiliated Kangning HospitalWenzhou Medical UniversityWenzhou 325000ZhejiangChina Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)Wenzhou 325001ZhejiangChina.

Synaptic abnormalities are a cardinal feature of Alzheimer’s disease(AD)that are known to arise as the disease progresses.A growing body of evidence suggests that pathological alterations to neuronal circuits and synapses may provide a mechanistic link between amyloidβ(Aβ)and tau pathology and thus may serve as an obligatory relay of the cognitive impairment in ***-derived neurotrophic factors(BDNFs)play an important role in maintaining synaptic plasticity in learning and *** AD as a synaptic disorder,BDNF has attracted increasing attention as a potential diagnostic biomarker and a therapeutical molecule for *** depletion of BDNF has been linked with Aβaccumulation,tau phosphorylation,neuroinflammation and neuronal apoptosis,the exact mechanisms underlying the effect of impaired BDNF signaling on AD are still ***,we present an overview of how BDNF genomic structure is connected to factors that regulate BDNF *** then discuss the role of BDNF in AD and the potential of BDNF-targeting therapeutics for AD.

关键词： Brain-derived neurotrophic factor Alzheimer’s disease Amyloidβprotein Tau protein Neuroinflammation Neuronal apoptosis

Magnetization of Coupled Ultrathin Ferromagnetic Films

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Communications in Theoretical Physics 2002年第7期38卷 107-112页

作者： WANG Huai-Yu ZHOU yun-song WANG Chong-Yu Department of Physics Tsinghua University Beijing 100084 China Department of Physics Capital Normal University Beijing 100037 China Department of Physics Tsinghua University Beijing 100084 China

The magnetization of coupled ferromagnetic films is calculated by Green's function method. The coupling can either be ferromagnetic or antiferromagnetic. For the latter case, a concept of pseudo-spin is suggested to make calculation possible. A pseudo-spin is actually an anti-spin with its properties being analogue to other known anti particles such as a hole. The decreasing of Curie point as the coupling strength decays is computed. It is noted that with the same strength, antiferromagnetic coupling has higher Curie point than ferromagnetic coupling.

关键词： magnetization, pseudo-spin, coupled ferromagnetic films

Use of bionic inspired surfaces for aerodynamic drag reduction on motor vehicle body panels

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2011年第7期12卷 543-551页

作者： Xiao-wen song Guo-geng ZHANG yun WANG Shu-gen HU Department of Mechanical Engineering Zhejiang University Hangzhou 310027 China

Inspired by the successful applications of biological non-smoothness,we introduced bionic non-smooth surfaces as appendices into vehicle body design,aiming to further reduce aerodynamic *** size range of the non-smooth units with pits and grooves was determined according to our analysis with the mechanisms underlying non-smooth unit mediated aerodynamic drag *** bionic non-smooth units reported here were designed to adapt the structure of a given vehicle body from the point of boundary layer control that reduces the burst and the loss of turbulent kinetic *** engine cover lid and vehicle body cap were individually treated with the non-smooth units,and the treated vehicles were subjected to aerodynamic drag coefficient simulation tests using the computational fluid dynamics(CFD) analysis *** simulation results showed that,in comparison with smooth surfaces,properly designed non-smooth surfaces can have greater effects on drag *** mechanism underlying drag reduction mediated by non-smooth surfaces was revealed by further analyses,in which the effects of non-smooth and smooth surfaces were directly compared.

关键词： Computational fluid dynamics(CFD) Bionics Non-smooth surface Aerodynamic drag reduction Vehicle body

The role of inflammasomes in human diseases and their potential as therapeutic targets

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Signal Transduction and Targeted Therapy 2024年第2期9卷 479-508页

作者： Jing Yao Keenan Sterling Zhe Wang yun Zhang Weihong song The National Clinical Research Center for Geriatric Disease Xuanwu HospitalCapital Medical UniversityBeijing 100053China Townsend Family Laboratories Department of PsychiatryBrain Research CenterThe University of British Columbia2255 Wesbrook MallVancouverBC V6T 1Z3Canada Key Laboratory of Neurodegenerative Diseases Ministry of EducationBeijingP.R.China Zhejiang Clinical Research Center for Mental Disorders Key Laboratory of Alzheimer’s Disease of Zhejiang ProvinceSchool of Mental Health and The Affiliated Kangning HospitalInstitute of AgingWenzhou Medical UniversityWenzhouZhejiang 325000China Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)WenzhouZhejiang 325000China

Inflammasomes are large protein complexes that play a major role in sensing inflammatory signals and triggering the innate immune *** inflammasome complex has three major components:an upstream sensor molecule that is connected to a downstream effector protein such as caspase-1 through the adapter protein *** formation typically occurs in response to infectious agents or cellular *** active inflammasome then triggers caspase-1 activation,followed by the secretion of pro-inflammatory cytokines and pyroptotic cell *** inflammasome activation and activity contribute to the development of diabetes,cancer,and several cardiovascular and neurodegenerative *** a result,recent research has increasingly focused on investigating the mechanisms that regulate inflammasome assembly and activation,as well as the potential of targeting inflammasomes to treat various *** clinical trials are currently underway to evaluate the therapeutic potential of several distinct inflammasome-targeting ***,understanding how different inflammasomes contribute to disease pathology may have significant implications for developing novel therapeutic *** this article,we provide a summary of the biological and pathological roles of inflammasomes in health and *** also highlight key evidence that suggests targeting inflammasomes could be a novel strategy for developing new disease-modifying therapies that may be effective in several conditions.

关键词： inflam therapeutic potential

Modeling turbulent heat fluxes over Arctic sea ice using a maximum-entropy-production approach

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Advances in Climate Change Research 2021年第4期12卷 517-526页

作者： ZHANG Yi-ming song mi-Rong DONG Chang-ming LIU Ji-Ping School of Marine Science Nanjing University of Information Science and TechnologyNanjing210044China LASG Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing100029China Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) Zhuhai519000China Department of Atmospheric and Environmental Sciences University at AlbanyState University of New YorkAlbanyNY12222USA

Recently,an algorithm of surface turbulent heat fluxes over snow/sea ice has been developed based on the theory of maximum entropy production(MEP),which is fundamentally different from the bulk flux algorithm(BF)that has been used in sea ice models for a few *** this study,we first assess how well the MEP algorithm captures the observed variations of turbulent heat fluxes over Arctic sea *** is found that the calculated heat fluxes by the MEP method are in good agreement with in-situ observations after considering the absorption of incoming radiation in a snow/ice surface layer with infinitesimal *** then investigate the effects of two different schemes(MEP ***)in the sea ice model of CICE6 on simulated turbulent heat fluxes and sea ice processes in the Arctic *** results show that the two different schemes give quite different representations of seasonal variations of heat fluxes,particularly for sensible heat fluxes in *** heat fluxes simulated by the MEP produce weak cooling effect on the ice surface in summer,whereas the BF generates a warming *** a result,compared to the BF,the MEP leads to a reduced seasonal cycle of Arctic sea ice mass flux by modulating snow-to-ice conversion,basal ice growth,surface ice melt and basal ice melt.

关键词： Sea ice modeling Turbulent heat fluxes Maximum-entropy-production Mass flux