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Chinese Journal of Structural Chemistry 2015年第6期34卷 871-878页

作者： ZONG Guang-Ning LI Feng-yun FAN Zhi-Jin MAO Wu-Tao SONG Hai-Bin CHEN Lai Zhu Yu-Jie XU Jing-hua SONG Yin-Qi WANG jia-Ran State Key Laboratory of Elemento-organic Chemistry Collaborative Innovation Center of Chemical Science and Engineering (Tianjin) Nankai University College of Chemistry and Pharmacy Engineering Nanyang Normal University

The title compound diethyl 2-（3,4-dichloroisothiazol-5-yl）-4-（trifluoromethyl）-4,5- dihydrothiazol-4-yl-3-methylbenzoate （C15H9C12F3N202S2, Mr = 441.26） was prepared from methyl 3,4-dichloroisothiazole-5-carboxylate as the starting material by four steps of reaction. Its structure was characterized by IR, 1H-NMR, 13C-NMR, EA and single-crystal X-ray diffraction. The crystal of the title compound belongs to the monoclinic system, space group P2dc with a = 8.8437（18）, b = 16.128（3）, c = 12.305（3） A, β = 91.68（3）°, V= 1754.4（6） A3, Z = 4, Dc = 1.671 g/cm3,μ（MoKa） = 0,71073 mm^-1, F（000） = 888, R = 0.0384 and wR = 0.0778. Weak π-π interactions occur between the isothiazole rings and phenyl rings of adjacent molecules to form a one-dimensional chain and stabilize the crystal structure. Bioassay indicates that the title compound has good activity against the fungi and TMV tested.

关键词： isothiazole 4,5-dihydrothiazole synthesis crystal structure biological activity

Event vertex and time reconstruction in large-volume liquid scintillator detectors

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Nuclear Science and Techniques 2021年第5期32卷 51-62页

作者： Zi-Yuan Li Yu-Mei Zhang Guo-Fu Cao Zi-Yan Deng Gui-Hong huang Wei-Dong Li Tao Lin Liang-jian Wen Miao Yu jia-Heng Zou Wu-Ming Luo Zheng-yun You School of Physics Sun Yat-Sen UniversityGuangzhou 510275China Sino-French Institute of Nuclear Engineering and Technology Sun Yat-Sen UniversityZhuhai 519082China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China School of Physics and Technology Wuhan UniversityWuhan 430072China

Large-volume liquid scintillator detectors with ultra-low background levels have been widely used to study neutrino physics and search for dark *** vertex and event time are not only useful for event selection but also essential for the reconstruction of event *** this study,four event vertex and event time reconstruction algorithms using charge and time information collected by photomultiplier tubes were analyzed *** effects of photomultiplier tube properties were also *** results indicate that the transit time spread is the main effect degrading the vertex reconstruction,while the effect of dark noise is *** addition,when the event is close to the detector boundary,the charge information provides better performance for vertex reconstruction than the time information.

关键词： JUNO Liquid scintillator detector Neutrino experiment Vertex reconstruction Time reconstruction

基于“三师共管”平台探讨910例2型糖尿病患者失眠、胃肠道症状与糖化血红蛋白的相关性

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北京中医药大学学报 2024年第7期47卷 989-997页

作者：李博袁琪王永发冯尤健王桂妙粘为东周艺胡天赤马思思贾丽燕张智海李津闫冰赵能江杨叔禹厦门大学附属第一医院厦门361001 厦门大学医学院中西医结合中心厦门市中医院晋江市中医院厦门市第五医院安溪县中医院南安市中医院

目的探讨2型糖尿病(T2DM)患者的失眠、胃肠道症状与糖化血红蛋白(HbA1c)的关系。方法纳入2022年1—12月于厦门大学附属第一医院、厦门市中医院、晋江市中医院等就诊的T2DM患者910例,采集患者的一般资料(性别、年龄、吸烟饮酒史、运动... 详细信息

目的探讨2型糖尿病(T2DM)患者的失眠、胃肠道症状与糖化血红蛋白(HbA1c)的关系。方法纳入2022年1—12月于厦门大学附属第一医院、厦门市中医院、晋江市中医院等就诊的T2DM患者910例,采集患者的一般资料(性别、年龄、吸烟饮酒史、运动情况、病程、治疗方式和并发症数量),HbA1c,阿森斯失眠量表(AIS)评分和胃肠道症状评定量表(GSRS)评分等信息,根据HbA1c控制是否达标分为2组,比较睡眠及胃肠道症状差异,并对差异与HbA1c水平进行相关性分析,同时根据上述采集信息对HbA1c控制不达标进行危险因素分析。结果 HbA1c控制达标组的AIS评分与GSRS评分均低于控制未达标组(P<0.01);37.0%的T2DM患者伴有失眠,失眠组的HbA1c水平高于非失眠组(10.00%±2.38%、8.26%±1.73%,P<0.01);57.5%的T2DM患者伴有胃肠道症状,伴有胃肠道症状组的HbA1c水平高于不伴有胃肠道症状组(9.26%±2.23%、8.43%±1.98%,P<0.01);26.3%的T2DM患者同时伴有失眠及胃肠道症状,伴失眠及胃肠道症状组的HbA1c水平高于不伴有失眠及胃肠道症状组(10.18%±2.44%、8.45%±1.86%,P<0.01);睡眠质量、胃肠功能与HbA1c水平存在显著相关性(P<0.01);年龄、GSRS评分、AIS评分、失眠合并胃肠道等指标是预测HbA1c≥6.5%的独立危险因素(P<0.01),同时伴有失眠合并胃肠道症状,是HbA1c控制不达标的最强风险因素,当两者伴随出现时,血糖控制的风险可能相应升高约5倍。结论失眠和胃肠道症状是T2DM患者的常见伴随疾病,两者呈现交叉串扰关系,并且与血糖控制不佳合并出现、互为因果、叠加放大。

关键词： 2型糖尿病失眠胃肠道症状糖化血红蛋白 “三师共管”平台

Repeated exposure to moxa-burning smoke: its acute and chronic toxicities in rats

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Journal of Traditional Chinese Medicine 2018年第1期38卷 67-75页

作者： Han Li Liu Changxi Liu Ping hu Hai Yang jia Cai Hong Lim Minyee Zhu Maoxiang Pan Xiujie huang jian Cui Yingxue Lao Lixing Zhao Baixiao Shool of Chinese medicine Beijing University of Chinese Medicine Healthcare Management Center Beijing Electric Power Hospital Department of Acupunture Beijing Hospital of Acupuncture and Moxibustion Shool of Acupuncture-Moxibustion and Tuina Beijing University of Chinese Medicine Department of Traditional Chinese Medicine Chongqing Yubei District Hospital of Traditional Chinese Medicine Institute of Radiation Medicine China Academy of Military Medical Science Department of Acupunture Beijing Dong Fang Hospital Department of Acupunture Beijing Hospital of Traditional Chinese Medicine School of Chinese Medicine The University of Hong Kong

OBJECTIVE： To assess toxicities of the air in Chinese medicine clinics polluted by moxa-burning smoke due to moxibustion-derived burning products （MBP）. METHODS： Both acute and chronic toxicity studies were conducted. For the acute toxicity study, five groups of Wistar rats （n = 16/group, male： female = 1 ： 1） were exposed to five different concentrations （95%, 90%, 85%, 80% and 75%, respectively） of MBP for 2 h. For the chronic toxicity study, another three groups of male rats （n = 21/group） were ex- posed to MBP in three concentrations （10%, 40% and 70%, respectively） and one control group ex- posed to clean air 20 min/d for 144 d. Routine ex- aminations were performed and analyzed by analy- sis of variance and dose-response relationship. RESULTS： In the acute toxicity study, the number of dead rats in the 95%, 90%, 85%, 80% and 75% groups were 16, 13, 7, 6 LDS0 of 86.274% after or and 3, respectively, with during the 2 h exposure. In the chronic toxicity study, MBP exposure induced a decline in activity of the rats. Rats in the 10% group showed no signs of toxicity, while those in the 40% MBP group showed toxicity effects on the body weights （P 〈 0.05） and lung. Rats in the 70% MBP group also presented with reversible damage in the blood coagulation system （P 〈 0.05）. CONCLUSION： Exposure to 10% MBP, which is equivalent to 27.45 mg/m^3 was under the critical threshold for male rats＇safety. Exposure to MBP above that limit induced lung damage. MBP in clinics need to be reduced to a safe level with enhanced ventilation.

关键词： Smoke Moxibustion Environmental exposure Toxicity tests

Reverse effect of curcumin on CDDP-induced drug-resistance via Keap1/p62-Nrf2 signaling in A549/CDDP cell

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Asian Pacific Journal of Tropical Medicine 2017年第12期10卷 1190-1196页

作者： Jie Shen Ya-Juan Chen Yuan-Wei jia Wen-Ying Zhao Guang-Hai Chen Ding-Feng Liu yun-Yu Chen Chao Zhang Xiao-Ping Liu Anhui Provincial Center for Drug Clinical Evaluation Yijishan HospitalWannan Medical CollegeWuhuAnhui 241001China Pharmacy School Wannan Medical CollegeWuhuAnhui 241002China Department of Clinical Pharmacy Yijishan HospitalWannan Medical CollegeWuhuAnhui 241001China Anhui Provincial Engineering Research Center for Polysaccharides Drugs Wannan Medical CollegeWuhuAnhui 241001China oncology department yijishan hospital wannan medical college

Objective: To assess the effect of curcumin on CDDP-induced drug resistance and explore the underlying molecular mechanism through Nrf2 system and autophagy ***: A drug-resistant cell model was established by exposing A549/CDDP cell to2 μg/mL CDDP. A549/CDDP cell was treated with 20 μg/mL CDDP and 10 μM curcumin. The cell viability and apoptosis level, the signals of Keap1/P62-Nrf2 and autophagy pathway were ***: CDDP induction promoted drug-resistant phenotype in A549/CDDP cell and activated autophagy as well as Nrf2 signals in A549/CDDP cell. Meanwhile, curcumin combination attenuated autophagy and Nrf2 activation induced by CDDP, and reversed the drug-resistant phenotype. Notably, curcumin combination augmented Keap1 transcription. Furthermore, Keap1 ablation with short hairpin RNAs hampered the efficacy of curcumin, suggesting Keap1 played a crucial role on reversal effect of ***: The present findings demonstrate that CDDP promotes abnormal activation of Nrf2 pathway and autophagy, leading to drug resistance of A549/CDDP *** attenuates this process and combat drug-resistance through its potent activation on Keap1 transcription, which is essential for interplay between oxidative stress induced Nrf2 activation and autophagy/apoptosis switch.

关键词： Curcumin Drug-resistance Keap1 Nrf2 Autophagy

西北某市交通枢纽周围大气PM_(2.5)中多环芳烃污染特征和来源解析及人群健康风险评估

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环境与健康杂志 2024年第8期41卷 692-697页

作者：胡芸迪田栋戚发秋杜小红王心巧韩晓杰陈楠宁夏医科大学公共卫生与管理学院宁夏银川750000 宁夏环境因素与慢性病控制重点实验室西藏自治区人民政府驻成都办事处医院宁东能源化工基地公共卫生中心

目的分析西北某市交通枢纽周围空气不同季节的PM_(2.5)中多环芳烃污染特征、来源,并对人群健康风险进行评估。方法于2021年不同季节连续采样7 d,检测PM_(2.5)中16种多环芳烃单体浓度,采用特征组分比值法对PAHs进行溯源,并使用美国环境... 详细信息

目的分析西北某市交通枢纽周围空气不同季节的PM_(2.5)中多环芳烃污染特征、来源,并对人群健康风险进行评估。方法于2021年不同季节连续采样7 d,检测PM_(2.5)中16种多环芳烃单体浓度,采用特征组分比值法对PAHs进行溯源,并使用美国环境保护署推荐的当量法评估各单体对人群造成的终身致癌健康风险。结果不同采样点多环芳烃浓度差异无统计学意义(P>0.05);同一采样点不同季节的多环芳烃浓度差异有统计学意义(P<0.05),表现为冬季浓度明显高于其他季节。两个采样点周围大气PM_(2.5)中的多环芳烃受交通源和燃煤燃烧的复合影响,对人群健康的影响随着年龄的增加而升高,秋冬季更易受到多环芳烃的影响。结论本次调查的采样点PAHs污染水平较高,主要源于交通源和燃煤燃烧的复合污染影响。暴露人群的健康风险随年龄而升高,且秋冬季更易受到多环芳烃的影响。

关键词：交通枢纽多环芳烃来源解析人群健康风险细颗粒物

Identification of novel genes associated with duck OASL in response to influenza A virus

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Journal of Integrative Agriculture 2019年第7期18卷 1451-1459页

作者： WANG Xiao-xue LU Chang RONG En-guang hu jia-xiang XING Yan-ling LIU Zheng-yu GAO Chu-ze LIU Jin-hua huANG Yin-hua State Key Laboratory of Agrobiotechnology China Agricultural UniversityBeijing 100193P.R. China Key Laboratory of Animal Epidemiology and Zoonosis Ministry of Agriculture/College of Veterinary MedicineChina Agricultural UniversityBeijing 100193P.R.China

2′-5′-Oligoadenylate synthetase like protein(OASL) plays a key role in response to viral infections through selectively activating the OAS/RNase L or OASL/RIG-I signaling *** classic pathway of OASL is well-known,its regulated genes or co-actors are largely *** study the possible molecular mechanism of duck OASL(dOASL),we performed RNA-sequencing(RNA-seq) and immunoprecipitation and mass spectrometry(IP-MS) at the level of mRNA and protein,*** RNA-seq,we used DF1 cell lines(DF1 dO ASL+/+,DF1 cO ASL–/–,and DF1) with or without the CK/0513 H5 N1 virus(A/chicken/huabei/0513/2007) infection.1 737 differentially expressed genes(DEGs) were identified as candidate target genes regulated by *** Ontology(GO),Kyoto Encyclopedia of Genes and Genomes(KEGG) analysis and Weighted Correlation Network Analysis(WGCNA) were *** identified one important yellow co-expression module correlated with antiviral immune *** this module,Ankyrin repeat and FYVE domain containing 1(ANKFY1),harboring a BTB domain similar to the methyl CpG-binding protein 1(MBD1) which bound to OASL in human,was regulated by *** protein level,133 host proteins were ***,ANKFY1 was one of them binding to dOASL *** phylogenomic and chromosomal syntenic analysis demonstrated MBD1 was absent in birds,while mammals *** is suggested that OASL-ANKFY1 interaction might act as a compensatory mechanism to regulate gene expression in *** findings will provide a useful resource for the molecular mechanism research of dOASL.

关键词： duck OASL ANKFY1 compensatory mechanism influenza A virus

工艺参数对双相不锈钢瞬间液相连接组织结构和等温凝固的影响

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中南大学学报（自然科学版） 2012年第10期43卷 3814-3819页

作者：袁新建罗军李佳 KANG Chung-yun 重庆大学材料科学与工程学院重庆400044 釜山国立大学材料工学部韩国釜山609735

采用3种非晶态镍合金作中间层,对双相不锈钢进行瞬间液相连接试验研究。试验结果表明:采用MBF-30作中间层在1 060℃和300 s进行连接时,等温凝固完成,连接中间区以γ-Ni相为主,BN出现在基体与中间层的界面处。但是,MBF-35作中间层在1 06... 详细信息

采用3种非晶态镍合金作中间层,对双相不锈钢进行瞬间液相连接试验研究。试验结果表明:采用MBF-30作中间层在1 060℃和300 s进行连接时,等温凝固完成,连接中间区以γ-Ni相为主,BN出现在基体与中间层的界面处。但是,MBF-35作中间层在1 060℃和300 s进行连接时,等温凝固未能完成,连接中心部含有Ni3Si;采用MBF-50作中间层在1175℃和300 s进行连接时,BN和(Cr,Ni)3Si相出现在连接中间区,等温凝固仍未能完成(等温凝固完成时间大于14400 s),而采用溶质分布模型计算结果仅为71 s。微观结构及等温凝固的差异归因于在较高温度下存在Si,N和Cr等合金元素并在连接中心处富集。

关键词：双相不锈钢镍基非晶合金瞬间液相连接工艺参数组织结构差异等温凝固差异

An intelligent method for contact fatigue reliability analysis of spur gear under EHL

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Journal of Central South University 2015年第9期22卷 3389-3396页

作者：胡贇刘少军常继华张建阁 School of Mechanical and Electrical Engineering Central South University State Key Laboratory for High Performance Complex Manufacturing (Central South University)

To complete the contact fatigue reliability analysis of spur gear under elastohydrodynamic lubrication(EHL) efficiently and accurately, an intelligent method is proposed. Oil film pressure is approximated using quadratic polynomial with intercrossing term and then mapped into the Hertz contact zone. Considering the randomness of the EHL, material properties and fatigue strength correction factors, the probabilistic reliability analysis model is established using artificial neural network(ANN). Genetic algorithm(GA) is employed to search the minimum reliability index and the design point by introducing an adjusting factor in penalty function. Reliability sensitivity analysis is completed based on the advanced first order second moment(AFOSM). Numerical example shows that the established probabilistic reliability analysis model could correctly reflect the effect of EHL on contact fatigue of spur gear, and the proposed intelligent method has an excellent global search capability as well as a highly efficient computing performance compared with the traditional Monte Carlo method(MCM).

关键词： reliability contact fatigue spur gear artificial neural network(ANN) genetic algorithm(GA) elastohydrodynamic lubrication(EHL)

Inversion of time-domain airborne EM data with IP effect based on Pearson correlation constraints

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Applied Geophysics 2020年第4期17卷 589-600页

作者： Man Kai-Feng Yin Chang-Chun Liu yun-He Ren Xiu-Yan Sun Si-Yuan Miao jia-jia Xiong Bin College of Geo-Exploration Sciences and Technology Jilin UniversityChangchun 130026China China Aero Geophysical Survey and Remote Sensing Center for Natural Resources Beijing 100083China China Geological Equipment Research Institute co. LtdBeijing 100120China College of Earth Sciences Guilin University of TechnologyGuilin 541006China

Due to the induced polarization(IP)eff ect,the sign reversal often occurs in timedomain airborne electromagnetic(AEM)*** inversions that do not consider IP eff ect cannot recover the true umderground electrical *** view of the fact that there are many parameters of airborne induced polarization data in time domain,and the sensitivity diff erence between parameters is large,which brings challenges to the stability and accuracy of the *** this paper,we propose an inversion mehtod for time-domain AEM data with IP effect based on the Pearson correlation *** method uses the Pearson correlation coeffi cient in statistics to characterize the correlation between the resistivity and the chargeability and constructs the Pearson correlation constraints for inverting the objective function to reduce the non uniqueness of *** verify the eff ectiveness of this method,we perform both Occam’s inversion and Pearson correlation constrained inversion on the synthetic *** experiments show that the Pearson correlation constrained inverison is more accurate and stable than the Occam’s ***,we carried out the inversion to a survey dataset with and without IP eff *** results show that the data misfit and the continuity of the inverted section are greatly improved when the IP eff ect is considered.

关键词： Time-domain AEM induced polarization effect forward modeling inversion Pearson correlation constraints