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Mitophagy in acute central nervous system injuries:regulatory mechanisms and therapeutic potentials

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Neural Regeneration Research 2025年第9期20卷 2437-2453页

作者： Siyi Xu Junqiu jia Rui Mao Xiang Cao yun Xu Department of Neurology Nanjing Drum Tower HospitalClinical College of Jiangsu UniversityNanjingJiangsu ProvinceChina Department of Neurology Nanjing Drum Tower HospitalChinese Academy of Medical Science&Peking Union Medical CollegeNanjingJiangsu ProvinceChina Department of Neurology Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina State Key Laboratory of Pharmaceutical Biotechnology and Institute of Translational Medicine for Brain Critical Diseases Nanjing UniversityNanjingJiangsu ProvinceChina jiangsu Key Laboratory for Molecular Medicine Medical School of Nanjing UniversityNanjingJiangsu ProvinceChina Nanjing Neurology Medical Center NanjingJiangsu ProvinceChina

Acute central nervous system injuries,including ischemic stro ke,intracerebral hemorrhage,subarachnoid hemorrhage,traumatic brain injury,and spinal co rd injury,are a major global health *** optimal therapies and improving the long-term neurological functions of patients with acute central nervous system injuries are urgent *** are susceptible to damage after acute central nervous system injury,and this leads to the release of toxic levels of reactive oxygen species,which induce cell ***,a selective form of autophagy,is crucial in eliminating redundant or damaged mitochondria during these *** evidence has highlighted the significant role of mitophagy in acute central nervous system *** this review,we provide a comprehensive overview of the process,classification,and related mechanisms of *** also highlight the recent developments in research into the role of mitophagy in various acute central nervous system injuries and drug therapies that regulate *** the final section of this review,we emphasize the potential for treating these disorders by focusing on mitophagy and suggest future research paths in this area.

关键词： autophagy intracerebral hemorrhage ischemic stroke mitochondria mitochondrial biogenesis mitochondrial quality control mitophagy spinal cord injury subarachnoid hemorrhage traumatic brain injury

Physarum polycephalum-inspired adaptive optimization design of artificial microtubular networks

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Science China Chemistry 2025年

作者： Si-Min Zeng Di-Wei Zheng Ting Pan Xing-Lan Ding yun Zhang Chi-Hui Yang Si-xue Cheng Xian-Zheng Zhang Key Laboratory of Biomedical Polymers of Ministry of Education&Department of Chemistry Wuhan University

Natural biological microtubular networks have undergone adaptive evolutionary selection and may offer viable solutions to design challenges in artificial microtubular networks. The plasmodium of the slime mold Physarum polycephalum(P. polycephalum) extends continuously to form a protoplasmic microtubular network structure, directly connecting food *** simulations revealed that the formation of this adaptive P. polycephalum microtubular network could be captured by a mathematical algorithm. Inspired by the P. polycephalum microtubular networks, we propose an adaptive optimization design method for artificial microtubular networks. Specifically, we utilized hydrogels with biodegradable and tissue-adhesive properties to replicate the P. polycephalum microtubular networks via photomask. In Rhodamine B diffusion and glucosecatalyzed reaction experiments, we found that the P. polycephalum microtubular networks exhibited significantly enhanced efficiency compared to vascular and artificial networks. Furthermore, we demonstrated the potential for uric acid(UA) degradation of the hydrogels with a real P. polycephalum microtubular network loaded with urate oxidase(UOx) in a rodent model of hyperuricemia. And this network achieved more than double the effect of the artificial network. This underscores the potential of natural microtubular networks to replace artificial microtubular networks.

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中国钼深加工基础与国外的差别浅析

中国钼业 2016年第5期40卷 7-10页

作者：张惠贾云雪牛海涛锦州新华龙钼业股份有限公司技术中心辽宁锦州121007

本文分析了目前中国钼产业发展的状况、发展的瓶颈、急需解决的问题以及与国外先进企业的差别,并对未来中国钼产业的发展方向进行了简单的探讨。

关键词：中国钼产业发展状况发展趋势差别

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钠碱盐析结晶法生产亚硫酸钠工艺研究

中国钼业 2020年第2期44卷 49-51页

作者：张惠岳国海贾云雪谭刚辽宁新华龙大有钼业有限公司辽宁锦州121013

本文针对试生产过程中出现的问题,对钠碱盐析结晶法生产亚硫酸钠工艺进行理论分析。结果表明,每盐析结晶生产1 t亚硫酸钠,吸收塔中吸收反应会结晶析出0.157 t亚硫酸钠,中和反应会给系统带进0.995 t水;氧化副反应主要发生在三级吸收塔,... 详细信息

本文针对试生产过程中出现的问题,对钠碱盐析结晶法生产亚硫酸钠工艺进行理论分析。结果表明,每盐析结晶生产1 t亚硫酸钠,吸收塔中吸收反应会结晶析出0.157 t亚硫酸钠,中和反应会给系统带进0.995 t水;氧化副反应主要发生在三级吸收塔,且温度越高,副反应程度越大。根据理论分析结果,采用一定的工艺改进后,使钠碱盐析结晶法实现了稳定工业化生产。

关键词：烟气脱硫盐析结晶亚硫酸钠理论分析

Role of nutrition in diabetes mellitus and infections

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World Journal of Clinical Cases 2025年第3期13卷 1-8页

作者： xue-Lu Yu Li-yun Zhou Xiao Huang Xin-Yue Li Ming-Ke Wang Ji-Shun Yang Naval Medical Center of PLA Naval Medical UniversityShanghai 200052China

In this editorial,we have commented on the article that has been published in the recent issue of World Journal of Clinical *** authors have described a case of unilateral thyroid cyst and have opined that the acute onset of infection may be linked to diabetes mellitus(DM).We have focused on the role of nutrition in the association between DM and *** with DM are at a high risk of infection,which could also be attributed to nutrition-related *** interventions for patients with diabetes are mainly based on a low-calorie diet,which can be achieved by adhering to a low-carbohydrate ***,dietary fiber supplementation is recommended to maintain the diversity of the gut ***,high-quality protein can prevent the increased risk of infection due to *** of vitamins C,vitamins A,vitamins D,and folic acid improves blood sugar control and facilitates immune *** deficiencies augment the risk of infection,but the relationship with diabetes is mostly U-shaped and a good intake should be maintained.

关键词： Diabetes mellitus Infection Macronutrients Vitamins Minerals

Separation of the ionospheric and thermospheric contributions in the data from the Triple Ionosophere Photo Meter onboard the Feng-yun 3E satellite

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Science China Earth Sciences 2025年第1期68卷 172-184页

作者： Fang jiaNG Tian MAO Jin-Song WANG Xiu-Qing HU Xiao-Xin ZHANG Liping FU Nan jia Tianfang WANG National Space Science Center Chinese Academy of Sciences Beijing Key Laboratory of Space Environment Exploration Key Laboratory of Environmental Space Situation Awareness Technology National Satellite Meteorological Center China Meteorological Administration

The Triple Ionosphere Photo Meter （TRIPM） is a far ultraviolet nadir-view photometer that is onboard the secondgeneration,polar-orbiting Chinese meteorological satellite Feng-yun 3E （FY-3E）,which was launched on July 5,*** has three channels,and each is used to measure different types of emissions:（1） 135.6 nm airglow produced by the recombination of the O+ions and electrons in the absence of sunlight （nighttime channel）;（2） 135.6 nm airglow from the OI when sunlight is present （daytime/dusk-dawn 135.6 nm channel）;and （3） Airglow in the N2LBH of the TRIPM （daytime/dusk-dawn N2LBH channel）.FY-3E is a satellite operating in the early morning ***,the data are mostly distributed on the dawndusk side or at times when the solar zenith angle is relatively *** this study,combined with simulation calculations,the data are *** further explore the application value of the data products,a model is used to separate the ionospheric radiative recombination contribution from the thermosphere photoelectron impact excitation contribution in the data from the daytime/dusk-dawn 135.6 nm *** approach not only improves the accuracy of O/N2derived from the 135.6 nm channel and N2LBH channel but also provides the ionospheric 135.6 nm radiance at the same time as the *** results show that the 135.6 nm radiance originating from the combination of O+and electrons extracted from the measurement data exhibits similar equatorial anomaly peak structure characteristics and seasonal variations as the corresponding GPS total electron content （TEC） *** the other hand,the separated 135.6 nm radiance generated from the thermosphere photoelectron collision excitation does not contain radiative recombination contributions;thus,the ionosphere influence is greatly avoided when the O/N2is obtained.

关键词： Far ultraviolet 135.6 nm emission intensity Photoelectron impact excitation Radiative recombination excitation

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Improvement of Mechanical Properties of Wood-Plastic Composite Floors Based on the Optimum Structural Design

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Acta Mechanica Solida Sinica 2016年第4期29卷 444-454页

作者： Yang Zhang Ping xue yun Ding Mingyin jia jianchen Cai Xiaoming Jin College of Mechanical and Electrical Engineering Beijing University of Chemical Technology College of Mechanical Engineering Quzhou University

A study is carried out on the structural design of wood-plastic composite floors. The geometric parameters of the cavities, the structure, and the means to optimize the performance of these light boards are investigated. Various structural parameters of the boards, such as size, shape, and the pattern of cavities are also studied. The optimal structure can be determined by calculation and analysis of the strength, stiffness, weight and cost of the material. A finite element model for the mechanical analysis of wood-plastic composite floors is established; and the results are used to verify the strength criteria under bending deformation, which is the most common loading condition of flooring board.

关键词： wood plastic composite cavities flooring board optimal structure the finite element model

Pharmacological targeting cGAS/STING/NF-κB axis by tryptanthrin induces microglia polarization toward M2 phenotype and promotes functional recovery in a mouse model of spinal cord injury

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Neural Regeneration Research 2025年第11期20卷 3287-3301页

作者： Ziwei Fan Mengxian jia jian Zhou Zhoule Zhu Yumin Wu Xiaowu Lin Yiming Qian jiashu Lian Xin Hua jianhong Dong Zheyu Fang Yuqing Liu Sibing Chen Xiumin xue Juanqing Yue Minyu Zhu Ying Wang Zhihui Huang Honglin Teng Department of Orthopedics(Spine Surgery) the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina School of Pharmacy Hangzhou Normal UniversityHangzhouZhejiang ProvinceChina Department of Neurology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina Department of Pathology Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhouZhejiang ProvinceChina Department of Clinical Research Center Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhouZhejiang ProvinceChina

The M1/M2 phenotypic shift of microglia after spinal cord injury plays an important role in the regulation of neuroinflammation during the secondary injury phase of spinal cord *** of shifting microglia polarization from M1(neurotoxic and proinflammatory type)to M2(neuroprotective and anti-inflammatory type)after spinal cord injury appears to be *** possesses an anti-inflammatory biological ***,its roles and the underlying molecular mechanisms in spinal cord injury remain *** this study,we found that tryptanthrin inhibited microglia-derived inflammation by promoting polarization to the M2 phenotype in *** promoted M2 polarization through inactivating the cGAS/STING/NF-κB ***,we found that targeting the cGAS/STING/NF-κB pathway with tryptanthrin shifted microglia from the M1 to M2 phenotype after spinal cord injury,inhibited neuronal loss,and promoted tissue repair and functional recovery in a mouse model of spinal cord ***,using a conditional co-culture system,we found that microglia treated with tryptanthrin suppressed endoplasmic reticulum stress-related neuronal *** together,these results suggest that by targeting the cGAS/STING/NF-κB axis,tryptanthrin attenuates microglia-derived neuroinflammation and promotes functional recovery after spinal cord injury through shifting microglia polarization to the M2 phenotype.

关键词： cGAS/STING functional recovery microglia neuroinflammation neuroprotection nuclear factor-κB polarization spinal cord injury tryptanthrin

A New Feistel-Type White-Box Encryption Scheme

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Journal of Computer Science & Technology 2017年第2期32卷 386-395页

作者： Ting-Ting Lin xue-jia Lai Wei-jia xue Yin jia Cryptography and Information Security Laboratory Department of Computer Science Shanghai Jiao Tong University Shanghai 200240 China Irdeto Canada Ottawa Ontario K2K3G5 Canada

The white-box attack is a new attack context in which it is assumed that cryptographic software is implemented on an un-trusted platform and all the implementation details are controlled by the attackers. So far, almost all white-box solutions have been broken. In this study, we propose a white-box encryption scheme that is not a variant of obfuscating existing ciphers but a completely new solution. The new scheme is based on the unbalanced Feistel network as well as the ASASASA （where ＂A＂ means affine, and ＂S＂ means substitution） structure. It has an optional input block size and is suitable for saving space compared with other solutions because the space requirement grows slowly （linearly） with the growth of block size. Moreover, our scheme not only has huge white-box diversity and white-box ambiguity but also has a particular construction to bypass public white-box cryptanalysis techniques, including attacks aimed at white-box variants of existing ciphers and attacks specific to the ASASASA structure. More precisely, we present a definition of white-box security with regard to equivalent key, and prove that our scheme satisfies such security requirement.

关键词： white-box equivalent key Feistel network cryptography ASASASA