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Frequency of IL-10-producing regulatory B cells associated with disease activity in thyroid-associated orbitopathy

International Journal of Ophthalmology(English edition) 2018年第9期11卷 1458-1462页

作者： yun-gang ding Guo Chen Qian Li Xiao-Feng Wen Lai Wei Hua-Sheng Yang State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangzhou 510060Guangdong ProvinceChina Qindao Ludong Eye Hospital Qingdao 266600Shandong ProvinceChina Ningxia Eye Hospital People's Hospital of Ningxia Hui Autonomous Regionthe First Clinical College of Northwest University for Nationalitiesthe Cooperative Teaching Hospital of North Minzu UniversityYinchuan 750001Ningxia Hui Autonomous RegionChina

AIM： To investigate the association between IL-10-producing regulatory B（B10） cells and the clinical features of thyroid-associated orbitopathy（TAO）. METHODS： A total of 30 patients with TAO were recruited at Zhongshan Ophthalmic Center from May 2015 to December 2015. Peripheral blood mononuclear cells（PBMCs） were separated from blood samples of 30 TAO patients and 16 healthy controls and stimulated with CD40 ligand and CpG for 48h. The frequency of IL-10＋ B cells was examined by flow cytometry and the correlation between the frequency of IL-10＋ B cells and clinical features of TAO was analyzed by SPSS. RESULTS： The frequency of IL-10＋ B cells among CD19＋ B cells in TAO patients was significantly lower than in healthy controls（TAO： 4.66%±1.88% vs healthy control： 6.82%±2.40%, P〈0.01）. The frequency of IL-10＋ B cells showed a positive correlation with disease activity of TAO measured by Clinical Activity Score（CAS）（r=0.50, P〈0.01）, and became higher in TAO patients with family history of Graves＇ disease（GD）（P=0.04）. CONCLUSION： The decrease of the frequency of IL-10＋ B cells in TAO patients indicates the deficiency of B10 cells in TAO, and the positive association with disease activity suggests its important role in TAO inflammation regulation.

关键词： thyroid-associated orbitopathy regulatory B cells interleukin-10 flow cytometry

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基于制剂原料物理特性的哮喘颗粒干法制粒工艺优选

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中草药 2017年第4期48卷 681-685页

作者：周恩丽康小东付娟吴云丁岗王振中萧伟江苏康缘药业股份有限公司江苏连云港222001 中药制药过程新技术国家重点实验室江苏连云港222001

目的利用粉体的物理性质,优选哮喘颗粒干法制粒工艺。方法通过考察哮喘颗粒制剂原料的休止角、压缩度、水分等物理特性,指导干法制粒处方筛选,以颗粒一次成型率、脆碎度和制粒过程质量评分为指标,采用L9(34)正交试验方法,同时采用基于... 详细信息

目的利用粉体的物理性质,优选哮喘颗粒干法制粒工艺。方法通过考察哮喘颗粒制剂原料的休止角、压缩度、水分等物理特性,指导干法制粒处方筛选,以颗粒一次成型率、脆碎度和制粒过程质量评分为指标,采用L9(34)正交试验方法,同时采用基于信息熵的评价方法优选哮喘颗粒干法制粒工艺参数。结果确定最佳辅料为糊精,最佳干法制粒工艺参数:轧轮压力为7 MPa,轧轮转速为10 r/min,送料速度为18 r/min。结论制剂原料的物理特性研究可指导制剂处方的筛选,制得颗粒成型性好,硬度适中,流动性好,优选的干法制粒工艺稳定合理。

关键词：哮喘颗粒物理特性辅料筛选干法制粒信息熵

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Prevalence of Helicobacter pylori infection in Chinese military personnel:A cross-sectional,multicenter-based study

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World Journal of Gastroenterology 2025年第3期31卷 42-49页

作者： Han-Chen Min Chun-Yan Zhang Fang-Yu Wang Xiao-Hui Yu Shan-Hong Tang Hong-Wu Zhu Ya-gang Zhao Ji-Luo Liu Jian Wang Jing-Han Guo Xiao-Mei Zhang yun-Sheng Yang Chinese People’s Liberation Army Medical School Chinese People’s Liberation Army General HospitalBeijing 100853China Department of Gastroenterology and Hepatology The First Medical CenterChinese People’s Liberation Army General HospitalBeijing 100853China Sixth Healthcare Department The Second Medical CenterChinese People’s Liberation Army General HospitalBeijing 100853China Department of Gastroenterology The 940th Hospital of Joint Logistic Support Force of Chinese People’s Liberation ArmyLanzhou 730050Gansu ProvinceChina Department of Gastroenterology General Hospital of Western Theater CommandChengdu 610011Sichuan ProvinceChina Department of Gastroenterology General Hospital of Southern Theater CommandGuangzhou 510010Guangdong ProvinceChina Department of Epidemiology Naval Medical UniversityShanghai 200433China School of Medicine Nankai UniversityTianjin 300071China National Clinical Research Center for Geriatric Diseases Chinese People’s Liberation Army General HospitalBeijing 100853China

BACKGROUND Helicobacter pylori(***)infection is a prevalent disease encountered in military internal medicine and recognized as the main cause of dyspepsia,gastritis,and peptic ulcer,which are common diseases in military *** guidelines in China state all patients with evidence of active infection with *** are offered ***,the prevalence of *** infection and its regional distribution in the military population remain unclear,which hinders effective prevention and treatment *** the prevalence of *** infection in the military population will aid in the development of customized strategies to better manage this infectious *** To investigate the prevalence of *** infection in the Chinese military population in different geographic *** This multicenter,retrospective study included 22421 individuals from five tertiary hospitals located in north,east,southwest,and northwest cities of *** infection was identified using the urea breath test,which had been performed between January 2020 and December *** Of the 22421 military service members,7416(33.1%)were urea breath *** highest prevalence of *** was in the 30-39 years age group for military personnel,with an infection rate of 34.9%.The majority of infected subjects were younger than 40-years-old,accounting for 70.4%of the infected *** individuals serviced in Lanzhou and Chengdu showed a higher infection prevalence than those in Beijing,Nanjing,and Guangzhou,with prevalence rates of 44.3%,37.9%,29.0%,31.1%,and 32.3%,*** *** infection remains a common infectious disease among military personnel in China and has a relatively high prevalence rate in northwest China.

关键词： Helicobacter pylori Prevalence Military personnel Urea breath test Multicenter study

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Enhanced Crystallization Kinetics of PLLA by Ethoxycarbonyl Ionic Liquid Modified Graphene

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Chinese Journal of Polymer Science 2019年第3期37卷 243-252页

作者： Pei Xu Zhao-Pei Cui gang Ruan yun-Sheng ding Department of Polymer Science and Engineering School of Chemistry and Chemical Engineering and Anhui Key Laboratory of Advanced Functional Materials and Devices Hefei University of Technology

To investigate the performance of graphene(Gra) modified with ethoxycarbonyl ionic liquid(IL), chain mobility and crystallization kinetics of poly(L-lactic acid)(PLLA), a series of PLLA nanocomposites have been prepared using solution-cast *** can improve the dispersion of Gra in PLLA matrix and the samples containing IL have higher growth rate of PLLA spherulite than neat PLLA does. PLLA/IL/Gra and PLLA/2 Gra exhibit the same relaxation strength and time of αN relaxation that corresponds to the longest normal mode motion at 110-140 °C. PLLA/IL/Gra shows a faster crystallization rate than PLLA/2 Gra does, which might be attributed to the Gra-imidazolium cation interaction in IL modified Gra, the significant dispersion effect of IL at Gra surface, and the increase of nuclei density of PLLA/IL/Gra.

关键词： Ionic liquid Graphene PLLA Crystallization Dielectric behavior

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A Novel Serially Concatenated GMSK System for Satellite Communications

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Chinese Journal of Electronics 2021年第2期30卷 390-396页

作者： HUANG yun LIU gang YANG Yinan ding Xingwen CHANG Hongyu School of Telecommunications Engineering Xidian University Beijing Research Institute of Telemetry

A novel serially concatenated GMSK system is proposed for satellite communications subject to low SNR, limited power and spectrum resources. First, we design a Nonrecursive continuous-phase encoder(NRCPE)based GMSK based on the Rimoldi’s decomposition. Then,a corresponding pilot-aided quasi-coherent demodulation algorithm is developed, whose basic principle is that a modified BCJR-based detection performs on the received signals with initial and ending trellisstates being determined using the very limited pilot overhead. Finally,we choose proper modulation parameters for the NRCPE based Gaussian minimum shift keying GMSK signaling according to the trade-offs between the power and spectral efficiency. The simulation results show that the LDPC coded GMSK system using the proposed algorithm can achieve excellent performance and can also work well in the presence of the large Doppler shifts and some burst errors.

关键词： Doppler shift Nonrecursive continuous-phase encoder channel estimation satellite communication modified BCJR-based detection performs corresponding pilot-aided quasicoherent demodulation algorithm concatenated codes novel serially concatenated GMSK system parity check codes minimum shift keying NRCPE satellite communications demodulation

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Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

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Neural Regeneration Research 2025年第3期20卷 845-857页

作者： Lin-Yan Huang Yi-De Zhang Jie Chen Hai-Di Fan Wan Wang Bin Wang Ju-yun Ma Peng-Peng Li Hai-Wei Pu Xin-Yian Guo Jian-gang Shen Su-Hua Qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin

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Activin A receptor type 1C single nucleotide polymorphisms associated with esophageal squamous cell carcinoma risk in Chinese population

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 39-51页

作者： Si-yun Lin Hou Huang Jin-Jie Yu Feng Su Tian Jiang Shao-Yuan Zhang Lu Lv Tao Long Hui-Wen Pan Jun-Qing Qi Qiang Zhou Wei-Feng Tang Guo-Wen ding Li-Ming Wang Li-Jie Tan Jun Yin Department of Thoracic Surgery Zhongshan Hospital Affiliated to Fudan UniversityShanghai 200032China Shanghai Key Laboratory of Clinical Geriatric Medicine Huadong Hospital Affiliated to Fudan UniversityShanghai 200040China Department of Cardiothoracic Surgery The Affiliated People's Hospital of Jiangsu UniversityZhenjiang 212002Jiangsu ProvinceChina Department of Thoracic Surgery Sichuan Cancer Hospital&InstituteChengdu 610042Sichuan ProvinceChina Department of Cardiothoracic Surgery Nanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNanjing 210000Jiangsu ProvinceChina Department of Respiratory and Critical Care Medicine Shanghai Xuhui Central HospitalShanghai 200032China

BACKGROUND Transforming growth factor-β(TGF-β)superfamily plays an important role in tumor progression and *** A receptor type 1C(ACVR1C)is a TGF-βtype I receptor that is involved in tumorigenesis through binding to dif-ferent *** To evaluate the correlation between single nucleotide polymorphisms(SNPs)of ACVR1C and susceptibility to esophageal squamous cell carcinoma(ESCC)in Chinese Han *** In this hospital-based cohort study,1043 ESCC patients and 1143 healthy controls were *** SNPs(rs4664229,rs4556933,rs77886248,rs77263459,rs6734630)of ACVR1C were assessed by the ligation detection reaction ***-Weinberg equilibrium test,genetic model analysis,stratified analysis,linkage disequi-librium test,and haplotype analysis were *** Participants carrying ACVR1C rs4556933 GA mutant had significantly decreased risk of ESCC,and those with rs77886248 TA mutant were related with higher risk,especially in older male *** the haplotype analysis,ACVR1C Trs4664229Ars4556933Trs77886248Crs77263459Ars6734630 increased risk of ESCC,while Trs4664229Grs4556933Trs77886248Crs77263459Ars6734630 was associated with lower susceptibility to *** ACVR1C rs4556933 and rs77886248 SNPs were associated with the susceptibility to ESCC,which could provide a potential target for early diagnosis and treatment of ESCC in Chinese Han population.

关键词： Activin A receptor type 1C Single nucleotide polymorphisms Esophageal squamous cell carcinoma Genetic susceptibility Hospital-based cohort study

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Periodontal Ligament Stem Cells Reverse the High Glucose Level-Induced Inflammatory State of Macrophages

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Biomedical and Environmental Sciences 2022年第7期35卷 674-679页

作者： LIU yun Xia ding Xiao Ling TANG Shuai CUI Shu Yue LIU Jia Jia ding gang School of Stomatology Weifang Medical UniversityWeifang 261053ShandongChina Clinical Competency Training Center Weifang Medical UniversityWeifang 261053ShandongChina

Periodontitis is a chronic infectious disease characterized by plaque biofilm as its main pathogenic factor;its clinical manifestations include gingival inflammation,alveolar bone resorption,attachment loss,and periodontal pocket formation,all of which eventually lead to tooth loss and seriously affect the quality of life of patients[1].This illness has a close relationship with blood sugar levels in patients with diabetes and is one of the most important complications of diabetes[2].Macrophages are an important part of host immune responses and exhibit powerful functions of identifying,phagocytizing,and removing bacteria;macrophage polarization is involved in the pathogenesis of periodontitis[3].

关键词： inflammation removing eventually

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Stability Analysis of Systems With Time-varying Delay via a Novel Lyapunov Functional

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IEEE/CAA Journal of Automatica Sinica 2019年第4期6卷 1068-1073页

作者： yun Chen gang Chen the School of Electrical and Information Engineering Hunan University of TechnologyZhuzhou 412007 the Key Laboratory for Electric Drive Control and Intelligent Equipment of Hunan Province Zhuzhou 412007China

This paper investigates the stability problem for time-varying delay *** obtain a larger delay bound,this paper uses the second-order canonical Bessel-Legendre(BL)***,using four couples of integral terms in the augmented Lyapunov-Krasovskii function(LKF)to enhance the relationship between integral functionals and other ***,unlike the construction of the traditional LKF,a novel augmented LKF is constructed with two new delayproduct-type terms,which adds more state information and leads to less conservative ***,two numerical examples are provided to demonstrate the effectiveness and the significant improvement of the proposed stability criteria.

关键词： Integral inequality Lyapunov theorem stability time-delay systems

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Smoothness-oriented path optimization for robotic milling processes

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Science China(Technological Sciences) 2020年第9期63卷 1751-1763页

作者： PENG JingFu ding Ye ZHANG gang ding Han State Key Laboratory of Mechanical System and Vibration Shanghai Jiao Tong UniversityShanghai200240China HUST-Wuxi Research Institute Wuxi214174China

Industrial robots are increasingly used for five-axis machining operations, where the rotation of the end effector along the toolaxis direction is functionally redundant. This functional redundancy should be carefully resolved when planning the robot path according to the tool path generated by a computer-aided manufacturing(CAM) system. Improper planning of the redundancy may cause drastic variations of the joint motions, which could significantly decrease the machining efficiency as well as the machining accuracy. To tackle this problem, this paper presents a new optimization-based methodology to globally resolve the functional redundancy for the robotic milling process. Firstly, a global performance index concerning the smoothness of the robot path at the joint acceleration level is proposed. By minimizing the smoothness performance index while considering the avoidance of joint limits and the singularity and the constraint of the stiffness performance, the resolution of the redundancy is formulated as a constrained optimization problem. To efficiently solve the problem, the sequential linearization programming method is employed to improve the initial solution provided by the conventional graph-based method. Then, simulations for a given tool path are presented. Compared with the graph-based method, the proposed method can generate a smoother robot path in which a significant reduction of the magnitude of the maximum joint acceleration is obtained, resulting in a smoother tool-tip feedrate profile. Finally, the experiment on the robotic milling system is also presented. The results show that the optimized robot path of the proposed method obtains better surface quality and higher machining efficiency, which verifies the effectiveness of the proposed method.

关键词： robot milling functional redundancy path optimization smoothness sequential linear programming

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