检索结果-南通市图书馆

China Ocean Engineering 2024年第2期38卷 297-312页

作者： ZHANG Yi CHEN Yue yun lai LIANG Xu Ocean College Zhejiang UniversityZhoushan 316000China Hainan Institute Zhejiang UniversitySanya 572000China

This paper aims to enhance the compression capacity of underwater cylindrical shells by adopting the corrugated sandwich structure of *** cuttlebone suffers uniaxial external compression,while underwater cylindrical shells are in a biaxial compressive stress *** suit the biaxial compressive stress state,a novel bidirectional corrugated sandwich structure is proposed to improve the bearing capacity of cylindrical *** static and buckling analysis for the sandwich shell and the unstiffened cylindrical shell with the same volume-weight ratio are studied by numerical *** is indicated that the proposed sandwich shell can effectively reduce the ratio between circumferential and axial stress from 2 to 1.25 and improve the critical buckling load by about 1.63 *** simulation shows that optimizing and adjusting the structural parameters could significantly improve the advantage of the sandwich ***,the hydrostatic pressure tests for shell models fabricated by 3D printing are carried *** to the experimental results,the overall failure position of the sandwich shell is at the center part of the sandwich *** has been found the average critical load of the proposed sandwich shell models exceeds two times that of the unstiffened shell ***,the proposed bio-inspired bidirectional corrugated sandwich structure can significantly enhance the pressure resistance capability of cylindrical shells.

关键词： bio-inspiration bidirectional corrugation sandwich shell external pressure buckling

THR-βAgonist for Nonalcoholic Steatohepatitis Treatment:Challenges of a Promising Drug

在线全文

学校读者我要写书评

暂无评论

Journal of Clinical and Translational Hepatology 2024年第8期12卷 755-757页

作者： feng Xue lai Wei School of Clinical Medicine Tsinghua UniversityBeijingChina Hepatopancreatobiliary Center Beijing Tsinghua Changgung HospitalTsinghua UniversityBeijingChina

*** incidence of nonalcoholic steatohepatitis(NASH)is ***,a thyroid hormone receptorβTHR-βagonist,has demonstrated a good safety profile in published phase 2 and phase 3 studies,meeting the *** and Drug Administration(FDA)-required histological endpoint for ***,on March 14,2024,resmetirom became the first drug to receive FDA approval for the treatment of NASH patients with fibrosis,marking a significant milestone in the field of ***,there are still some challenges in the clinical application of resmetirom.

关键词： THR hepatitis histological

Boosting rate performance of layered lithium-rich cathode materials by oxygen vacancy induced surface multicomponent integration

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2024年第5期92卷 250-262页

作者： Youyou Fang Yuefeng Su Jinyang Dong Jiayu Zhao Haoyu Wang yun Lu Bin Zhang Hua Yan feng Wu lai Chen Beijing Key Laboratory of Environmental Science and Engineering School of Material Science and EngineeringBeijing Institute of TechnologyBeijing 100081China Chongqing Innovation Center Beijing Institute of TechnologyChongqing 401120China Yibin Libode New Materials Co. Ltd.Yibin 64400SichuanChina School of Metallurgy and Environment Central South UniversityChangsha 410083HunanChina Engineering Research Center of the Ministry of Education for Advanced Battery Materials Central South UniversityChangsha 410083HunanChina

The rapid development of electric vehicles and portable energy storage systems demands improvements in the energy density and cost-effectiveness of lithium-ion batteries,a domain in which Lithium-rich layered cathode(LLO)materials inherently ***,these materials face practical challenges,such as low initial Coulombic efficiency,inferior cycle/rate performance,and voltage decline during cycling,which limit practical *** study introduces a surface multi-component integration strategy that incorporates oxygen vacancies into the pristine LLO material Li1.2Mn_(0.6)Ni_(0.2)O_(2).This process involves a brief citric acid treatment followed by calcination,aiming to explore rate-dependent degradation *** induced surface oxygen vacancies can reduce surface oxygen partial pressure and diminish the generation of O_(2)and other highly reactive oxygen species on the surface,thereby facilitating the activation of Li ions trapped in tetrahedral sites while overcoming transport ***,the formation of a spinel-like phase with 3D Li+diffusion channels significantly improves Li^(+)diffusion kinetics and stabilizes the surface *** optimally modified sample boasts a discharge capacity of 299.5 mA h g^(-1)at a 0.1 C and 251.6 mA h g^(-1)at a 1 C during the initial activation cycle,with an impressive capacity of 222.1 mA h g^(-1)at a 5 *** notably,it retained nearly 70%of its capacity after 300 cycles at this elevated *** straightforward,effective,and highly viable modification strategy provides a crucial resolution for overcoming challenges associated with LLO materials,making them more suitable for practical application.

关键词： Lithium-ion battery Layered lithium rich cathode Surface multicomponent integration Rate-dependent degradation and Li^(+) diffusion kinetics

Pretreatment and analysis techniques development of TKIs in biological samples for pharmacokinetic studies and therapeutic drug monitoring

在线全文

学校读者我要写书评

暂无评论

Journal of Pharmaceutical Analysis 2024年第4期14卷 439-459页

作者： Lan Chen Yuan Zhang Yi-Xin Zhang Wei-lai Wang De-Mei Sun Peng-yun Li Xue-Song feng Yue Tan School of Pharmacy China Medical UniversityShenyang110122China Institute of Pharmacology and Toxicology Institution National Engineering Research Center for Strategic DrugsBeijing100850China Department of Gastroenterology Shengjing Hospital of China Medical UniversityShenyang110022China

Tyrosine kinase inhibitors(TKIs)have emerged as the first-line small molecule drugs in many cancer therapies,exerting their effects by impeding aberrant cell growth and proliferation through the modulation of tyrosine kinase-mediated signaling ***,there exists a substantial inter-individual variability in the concentrations of certain TKIs and their metabolites,which may render patients with compromised immune function susceptible to diverse infections despite receiving theoretically efficacious anticancer treatments,alongside other potential side effects or adverse ***,an urgent need exists for an up-to-date review concerning the biological matrices relevant to bioanalysis and the sampling methods,clinical pharmacokinetics,and therapeutic drug monitoring of different *** paper provides a comprehensive overview of the advancements in pretreatment methods,such as protein precipitation(PPT),liquid-liquid extraction(LLE),solid-phase extraction(SPE),micro-SPE(μ-SPE),magnetic SPE(MSPE),and vortex-assisted dispersive SPE(VA-DSPE)achieved since *** also highlights the latest analysis techniques such as newly developed high performance liquid chromatography(HPLC)and high-resolution mass spectrometry(HRMS)methods,capillary electrophoresis(CE),gas chromatography(GC),supercritical fluid chromatography(SFC)procedures,surface plasmon resonance(SPR)assays as well as novel nanoprobes-based biosensing *** addition,a comparison is made between the advantages and disadvantages of different approaches while presenting critical challenges and prospects in pharmacokinetic studies and therapeutic drug monitoring.

关键词： TKIs Microextraction technique HRMS methods Pharmacokinetic studies Therapeutic drug monitoring

一种平衡抛射单兵反装甲武器发射装药低温发射安全性分析

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

兵工学报 2010年第4期31卷 429-433页

作者：贠来峰芮筱亭陈涛南京理工大学发射动力学研究所江苏南京210094 总装备部南京军事代表局江苏南京210024 南京理工大学力学实验中心江苏南京210094

发射膛炸的概率是评估武器使用安全性的重要性能指标。旨在研究某平衡抛射的单兵反装甲武器发射装药的发射安全性评估方法。分析了该武器系统的低温内弹道性能,建立了一种预测膛炸事故概率的方法,通过统计推断其低温最大膛压服从三参数W... 详细信息

发射膛炸的概率是评估武器使用安全性的重要性能指标。旨在研究某平衡抛射的单兵反装甲武器发射装药的发射安全性评估方法。分析了该武器系统的低温内弹道性能,建立了一种预测膛炸事故概率的方法,通过统计推断其低温最大膛压服从三参数Weibull分布,计算了其发射装药引起膛炸事故的概率。结果表明该武器发生膛炸概率较大,并通过改进消除了膛炸隐患。建立的膛炸概率预测方法可用于平衡抛射单兵反装甲武器、迫击炮、无坐力炮等武器的发射安全性分析。

关键词：概率论内弹道平衡抛射发射装药发射安全性 Weibull分布

在线全文

学校读者我要写书评

暂无评论

DCD格式在气固两相流计算中的应用

弹道学报 2009年第2期21卷 107-110页

作者：贠来峰芮筱亭陈涛南京理工大学动力工程学院南京210094 总装备部南京军事代表局南京210024

为将DCD格式推广到两相流动力学计算,通过对气固两相流动力学方程的适当变形,并处理为向量形式,实现了用DCD格式对气相和固相的统一计算,无须数值粘性和人工滤波.分别用DCD格式、Mac Cormack格式、TVD格式对密闭容器内的一维非定常气固... 详细信息

为将DCD格式推广到两相流动力学计算,通过对气固两相流动力学方程的适当变形,并处理为向量形式,实现了用DCD格式对气相和固相的统一计算,无须数值粘性和人工滤波.分别用DCD格式、Mac Cormack格式、TVD格式对密闭容器内的一维非定常气固两相流动进行了计算.计算结果表明,DCD格式计算精度高,使用方便.DCD格式能用于两相流动力学仿真,是一种很好的激波捕捉格式.

关键词：气固两相流差分格式 DCD格式流体力学内弹道学

在线全文

学校读者我要写书评

暂无评论

发射药破碎程度描述方法

弹道学报 2008年第2期20卷 99-102页

作者：陈涛芮筱亭贠来峰南京理工大学力学实验中心南京理工大学动力工程学院南京210094

利用动态活度定义推导了动态活度比,提出了用起始动态活度比描述发射药破碎程度的方法,研究了破碎发射药动态活度比数据处理方法.对几种不同形状、不同破碎程度发射药的起始动态活度比进行了计算.结果表明,起始动态活度比随发射药破碎... 详细信息

利用动态活度定义推导了动态活度比,提出了用起始动态活度比描述发射药破碎程度的方法,研究了破碎发射药动态活度比数据处理方法.对几种不同形状、不同破碎程度发射药的起始动态活度比进行了计算.结果表明,起始动态活度比随发射药破碎程度增加而增大,这与试验结果一致.

关键词：内弹道膛炸动态活度起始动态活度比

Cr-catalyzed allylic C(sp^(3))–H addition to aldehydes enabled by photoinduced ligand-to-metal charge transfer

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2024年第5期67卷 1589-1595页

作者： Xianrong Zeng feng-Hua Zhang Runchen lai Xiaoyu Lin Zhaobin Wang Key Laboratory of Precise Synthesis of Functional Molecules of Zhejiang Province Department of ChemistrySchool of Science and Research Center for Industries of the FutureWestlake UniversityHangzhou 310030China Institute of Natural Sciences Westlake Institute for Advanced StudyHangzhou 310024China Key Laboratory of Precise Synthesis of Functional Molecules of Zhejiang Province Instrumentation and Service Center for Molecular SciencesWestlake UniversityHangzhou 310024China

Photoinduced ligand-to-metal charge transfer(LMCT) has emerged as an effective strategy for synthesizing organic molecules in a sustainable manner. However, the majority of existing reports on selective C(sp^(3))–H bond functionalization via photoinduced LMCT focus on the use of late transition metals or rare-earth metals for radical additions or cross-couplings. In contrast, the utilization of photoinduced LMCT with 3d early transition metals poses a significant challenge. Herein, we describe an unprecedented approach to allylic C(sp^(3))–H addition to aldehydes, employing chromium(Cr) complexes as catalysts through visible-light-induced LMCT. By investigating the reaction pathway through various mechanistic studies, including radical trapping, kinetic isotope effect(KIE) analysis, and transient absorption spectroscopy, valuable insights have been gained. The proposed mechanism suggests the intermediacy of bromine radicals through homolysis of the Cr–Br bond. Notably, this protocol expands our understanding of the photochemical properties of earth-abundant Cr complexes.

关键词： Cr catalysis photoinduced ligand-to-metal charge transfer hydrogen-atom transfer carbonyl addition

在线全文

学校读者我要写书评

暂无评论

平衡抛射武器内弹道性能研究

南京理工大学学报 2009年第2期33卷 258-261,271页

作者：贠来峰芮筱亭冯可华南京理工大学动力工程学院江苏南京210094 总装南京军代局弹药处江苏南京210024 国营925厂江苏盱眙211722

该文研究了某平衡抛射武器发射药厚度对其初速或然误差、最大膛压等内弹道性能的影响。采用所建立的平衡抛射武器内弹道模型计算了该武器系统的内弹道性能,进行了内弹道性能试验,计算结果与试验吻合较好。采用Monte Carlo模拟,计算了不... 详细信息

该文研究了某平衡抛射武器发射药厚度对其初速或然误差、最大膛压等内弹道性能的影响。采用所建立的平衡抛射武器内弹道模型计算了该武器系统的内弹道性能,进行了内弹道性能试验,计算结果与试验吻合较好。采用Monte Carlo模拟,计算了不同厚度发射药的弹丸初速及其或然误差和最大膛压。研究表明,在保持弹丸平均初速不变的条件下,发射药厚度对内弹道性能及其稳定性有明显影响。建立了发射药厚度与内弹道性能参数间的定量关系,为改进该武器系统的内弹道设计提供了帮助。

关键词：内弹道平衡抛射单兵武器发射药

Precise determination of the pole position of the exotic Z_(c)(3900)

在线全文

学校读者我要写书评

暂无评论

Science China(Physics,Mechanics & Astronomy) 2024年第9期67卷 84-90页

作者： yun-Hua Chen Meng-Lin Du feng-Kun Guo School of Mathematics and Physics University of Science and Technology BeijingBeijing 100083China School of Physics University of Electronic Science and Technology of ChinaChengdu 611731China CAS Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China Peng Huanwu Collaborative Center for Research and Education Beihang UniversityBeijing 100191China

We perform a unified description of the experimental data of the π^(+)π^(-)and J/ψπ^(±)invariant mass spectra for e^(+)e^(-)→J/ψπ^(+)π^(-)and the D^(0)D^(*-)mass spectrum for e^(+)e^(-)→D^(0)D^(*-)π^(+)at e^(+)e^(-)center-of-mass energies 4.23 and 4.26 *** analysis takes into account open-charm meson loops that contain triangle singularities,the J/ψπ-DD^(*)coupled-channel interaction respecting unitarity,and the strong ππ-KK final state interaction using dispersion *** analysis leads to a precise determination of the Z_(c)(3900)pole with the pole mass and width(3880.7±1.7_(stat)±22.4_(syst))MeV and(35.9±1.4_(stat)±15.3_(syst))MeV,respectively,and hints at that the DD^(*)molecular and non-molecular components are of similar importance in the Z_(c)(3900)formation.

关键词： exotic hadrons dispersion relations final state interaction triangle singularity