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A robust synthesis route of confined carbyne

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Nano Research 2024年第7期17卷 6274-6280页

作者： Yanghao feng Wendi Zhang Kunpeng Tang Yingzhi Chen Jiou Zhang Kecheng Cao Weili cui Lei Shi State Key Laboratory of Optoelectronic Materials and Technologies Nanotechnology Research CenterGuangdong Basic Research Center of Excellence for Functional Molecular EngineeringSchool of Materials Science and EngineeringSun Yat-sen UniversityGuangzhou 510275China School of Physical Science and Technology and Shanghai Key Laboratory of High-resolution Electron Microscopy Shanghai Tech UniversityShanghai 201210China

The unique mechanical,optical,and electrical properties of carbyne,a one-dimensional allotrope of carbon,make it a highly promising material for various *** has been demonstrated that carbon nanotubes(CNTs)can serve as an ideal host for the formation of confined carbyne(CC),with the yield being influenced by the quality of the carbon nanotubes for confinement and the carbon source for carbyne *** this study,a robust synthesis route of CC within CNTs is proposed.C70 was utilized as a precursor to provide an additional carbon source,based on its ability to supply more carbon atoms than C60 at the same filling ***-step transformation processes,including defect creation,were designed to enhance the yield of *** a result,the yield of CC was significantly increased for the C70 encapsulated single-walled CNTs by more than an order of magnitude than the empty counterparts,which also surpasses that of the double-walled CNTs,making it the most effective route for synthesizing *** findings highlight the importance of the additional carbon source and the optimal pathway for CC formation,offering valuable insights for the application of materials with high yield.

关键词： confined carbyne yield enhancement carbon nanotube C70 encapsulation defect introduction Raman spectroscopy

Hernandezine promotes cancer cell apoptosis and disrupts the lysosomal acidic environment and cathepsin D maturation

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Chinese Journal of Natural Medicines 2024年第5期22卷 387-401页

作者： feng Qianwen SUN Lu Muhammad Jibran Sualeh ZHAO Qingli ZHAO Songji cui Zhengguo INADERA Hidekuni Department of Public Health Graduate School of Medicine and Pharmaceutical SciencesUniversity of ToyamaToyama 930-8501Japan Department of Pediatric Cardiology Heart CenterGuangzhou Women and Children’s Medical CenterGuangzhou Medical UniversityGuangzhou 510000China Department of Basic Medical Sciences College of MedicineUniversity of SharjahSharjah 57545United Arab Emirates Department of Radiology Graduate School of Medicine and Pharmaceutical SciencesUniversity of ToyamaToyama 930-8501Japan Advanced Clinical Research Center Fukushima Global Medical Science CenterFukushima Medical UniversityFukushima CityFukushima 960-8074Japan Department of Environmental Health School of Medical SciencesUniversity of FukuiFukui 910-8580Japan

Hernandezine(Her),a bisbenzylisoquinoline alkaloid extracted from Thalictrum flavum,is recognized for its range of biological activities inherent to this herbal *** its notable properties,the anti-cancer effects of Her have remained largely *** this study,we elucidated that Her significantly induced cytotoxicity in cancer cells through the activation of apoptosis and necroptosis ***,Her triggered autophagosome formation by activating the AMPK and ATG5 conjugation systems,leading to LC3 *** findings revealed that Her caused damage to the mitochondrial membrane,with the damaged mitochondria undergoing mitophagy,as evidenced by the elevated expression of mitophagy ***,Her disrupted autophagic flux,demonstrated by the upregulation of p62 and accumulation of autolysosomes,as observed in the RFP-GFP-LC3 reporter ***,we determined that Her did not prevent the fusion of autophagosomes and ***,it inhibited the maturation of cathepsin D and increased lysosomal pH,indicating an impairment of lysosomal *** use of the early-stage autophagy inhibitor,3-methyladenine(3-MA),did not suppress LC3II,suggesting that Her also induces noncanonical autophagy in autophagosome *** application of Bafilomycin A1,an inhibitor of noncanonical autophagy,diminished the recruitment of ATG16L1 and the accumulation of LC3II by Her,thereby augmenting Her-induced cell *** observations imply that while autophagy initially plays a protective role,the disruption of the autophagic process by Her promotes programmed cell *** study provides the first evidence of Her’s dual role in inducing apoptosis and necroptosis while also initiating and subsequently impairing autophagy to promote apoptotic cell *** insights contribute to a deeper understanding of the mechanisms underlying programmed cell death,offering potential avenues for enhancing cancer prevention and therapeutic st

关键词： Hernandezine Apoptosis Mitophagy Autophagic flux Lysosome Noncanonical autophagy

Construction of cytomegalovirus promoter-driven gene expression system in Laodelphax striatellus

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Insect Science 2024年第3期31卷 720-732页

作者： Xiaohui Cheng Wan Zhao Guohua Liang Hong Lu Yumei Fu Yiming Li feng cui State Key Laboratory of Integrated Management of Pest Insects and Rodents Insttute of ZoologyChinese Academy of SciencesBejingChina University of Chinese Academy of Sciences BejingChina School of Life Sciences Hebei UniversityBaodingHebei China Key Laboratory of Animal Ecology and Conservation Biology Institute of ZoologyChinese Academy of SciencesBejingChina Institute of Wetland Ecology&Clone Ecologyl Zhejiang Provincial Key Laboratory of Plant Evolutionary Ecology and Conservation Taizhou UniversityTaizhouZhejiangChina

The small brown planthopper(SBPH,Laodelphax striatellus)is a significant rice pest,responsible for transmitting rice stripe virus(RSV)in a persistent and propagative *** is one of the most detrimental rice viruses,causing rice stripe disease,which results in considerable loss of rice grain *** RNA interference and gene knockout techniques have enabled gene downregulation in SBPH,no system currently exists for the overexpression of endogenous or exogenous ***,the development of a protein expression system for SBPH is imperative to serve as a technical foundation for pest control and gene function *** study aimed to construct an expression vector using the promoter of the constitutive-expressed tubulin gene of SBPH,and promoter of human cytomegalovirus(CMV).Fluorescence experiments demonstrated that both tubulin and CMV promoter could drive green fluorescent protein(GFP)expression in SBPH,and could also facilitate the expression of a nucleocapsid protein(NP)-GFP fusion protein containing viral NP with comparable *** expression vector optimization,we have identified that the 3 tandem CMV promoters display a significantly higher promoter activity compared with both the 2 tandem CMV promoters and the single CMV *** addition,the incorporation of Star polycation nanoparticles significantly enhanced the expression efficiency in *** results provide a promising technical platform for investigating gene functions in SBPH.

关键词： cytomegalovirus promoter gene expression system nanoparticle small brown planthopper

Electrochemical chemoselective thiocarbamylation of late-stage Tyr-containing drugs and peptides

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Science China Chemistry 2024年第10期67卷 3382-3388页

作者： Wan-Jie Wei Xin-Yu Wang Hai-Tao Tang Fei-Hu cui yun-Qi Wu Ying-Ming Pan State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources(Ministry of Education of China)Collaborative Innovation Center for Guangxi Ethnic MedicineSchool of Chemistry and Pharmaceutical SciencesGuangxi Normal UniversityGuilin 541004China

The synthesis and modification of peptides occupy a unique position in the field of drug development,and the functionalization of amino acids is a valuable strategy as an alternative to peptide ***,the development of tyrosine(Tyr)as a target amino acid is a major challenge in the field of ***,we report an electrochemical radical coupling reaction of labeling tyrosine-containing active drugs and peptides with thiocarbamate derivatives for the first *** tri-component,onepot reaction can be performed smoothly under simple,gentle,and clean electrochemical conditions and is suitable for the functionalization of various Tyr-containing drug molecular derivatives and peptides.

关键词： tyrosine electrochemical radical coupling chemical modification peptides

Lightweight Intrusion Detection Using Reservoir Computing

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Computers, Materials & Continua 2024年第1期78卷 1345-1361页

作者： Jiarui Deng Wuqiang Shen Yihua feng Guosheng Lu Guiquan Shen Lei cui Shanxiang Lyu Joint Laboratory on Cyberspace Security China Southern Power GridGuangzhou510080China College of Cyber Security Jinan UniversityGuangzhou510632China Guangdong Power Grid Company Limited Guangzhou510663China School of Computer Science and Technology Guangdong University of TechnologyGuangzhou510006China China Southern Power Grid Extra High Voltage Transmission CompanyGuangzhouChina

The blockchain-empowered Internet of Vehicles(IoV)enables various services and achieves data security and privacy,significantly advancing modern vehicle ***,the increased frequency of data transmission and complex network connections among nodes also make them more susceptible to adversarial *** a result,an efficient intrusion detection system(IDS)becomes crucial for securing the IoV *** IDSs based on convolutional neural networks(CNN)often suffer from high training time and storage *** this paper,we propose a lightweight IDS solution to protect IoV against both intra-vehicle and external *** approach achieves superior performance,as demonstrated by key metrics such as accuracy and ***,our method achieves accuracy rates ranging from 99.08% to 100% on the Car-Hacking dataset,with a remarkably short training time.

关键词： Echo state network intrusion detection system Internet of Vehicles reservoir computing

Artemordins A-S, Cadinane-Type Sesquiterpenoid Dimers from Artemisia ordosica and Their Antihepatoma Activities

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Chinese Journal of Chemistry 2024年第13期42卷 1493-1508页

作者： Yuan Wang Tian-Ze Li yun-Bao Ma Chang-An Geng Yong-cui Wang Ji-Jun Chen State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunmingYunnan 650201China University of Chinese Academy of Sciences Beijing 100049China

Nineteen new cadinane-involving sesquiterpenoid dimers,artemordins A-S(1-—19),together with 13 known SDs(20-32)were isolated from Artemisia *** structures and absolute configurations were established by comprehensive spectral analyses,X-ray single crystal diffraction,theoretical ECD,and NMR ***,artemordins A-F(1—6)were the first examples of two cadinane units constructed by unprecedented C-3−C-15′or C-3−C-13′single bond with an oxido-rearranged 6/5/6/6 fused ring system;artemordins G-K(7-11)were biogenetically connected by[4+2]cycloaddition reaction and artemordins G-J(7-10)possessed a novel 5/6/6/6/6/6/5-heptacyclic fused ring *** L-S(12-19)were formed by esterification,which involved three different types of *** assay suggested that the most active compounds,artemordins B and H(2 and 8),exhibited inhibitory activities on three hepatoma cell lines with IC50 values of 26.9 and 25.1μmol/L(HepG2),29.5 and 18.3μmol/L(Huh7),19.7 and 15.7μmol/L(SK-Hep-1).

关键词： Artemisia ordosica Artemordins A-s Cadinane-type sesquiterpenoid dimers Antihepatoma activities Terpenoids Natural products Cytotoxicity

银杏内酯B对小鼠胚胎着床过程中滋养层和蜕膜组织超微结构的影响

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生殖与避孕 2012年第10期32卷 656-661页

作者：刁英崔风云遵义医学院第一附属医院生殖中心遵义563003

目的:观察银杏内酯B(GB)抗小鼠胚胎着床的组织形态学与超微结构变化特征。方法:将25只未经产成年雌性昆明小鼠随机分成5组,每组5只,于妊娠第2日右侧子宫角注射不同剂量的GB(2 mg/kg、4 mg/kg、6 mg/kg、8 mg/kg、10 mg/kg)作为实验侧,... 详细信息

目的:观察银杏内酯B(GB)抗小鼠胚胎着床的组织形态学与超微结构变化特征。方法:将25只未经产成年雌性昆明小鼠随机分成5组,每组5只,于妊娠第2日右侧子宫角注射不同剂量的GB(2 mg/kg、4 mg/kg、6 mg/kg、8 mg/kg、10 mg/kg)作为实验侧,左侧子宫角注射等量的生理盐水作为阴性对照侧。另取3只孕鼠不作任何处理,作为空白对照组。于妊娠第8日处死小鼠,取子宫组织,观察GB对滋养层细胞和子宫蜕膜细胞组织形态学和超微结构的影响。结果:妊娠第8日,实验侧小鼠胚胎发育不良,子宫壁充血,胚胎总数显著少于阴性对照侧。光镜下观察到实验侧蜕膜相对较薄、绒毛间隙有白细胞浸润、巨细胞结构松散,并有部分蜕膜细胞发生变性和坏死;电镜下观察到实验侧滋养层细胞胞质电子密度减低、出现小空泡、核形态发生改变、蜕膜细胞胞质内溶酶体增多、线粒体发生肿胀,而且随着GB剂量增大(≥8 mg/kg),滋养细胞胞质出现大量溶酶体、核固缩、碎裂,蜕膜细胞胞质亦出现大量溶酶体、核固缩、碎裂,并出现核膜溶解。结论:GB可造成绒毛滋养细胞及蜕膜细胞超微结构的改变,破坏胚胎赖以生存与发育的内环境,从而干扰胚胎着床。

关键词：银杏内酯B 着床滋养层蜕膜

Understanding the Thermal Impedance of Silicone Rubber/Hexagonal Boron Nitride Composites as Thermal Interface Materials

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Chinese Journal of Polymer Science 2024年第3期42卷 352-363,I0008页

作者： Yuan Ji Shi-Da Han Hong Wu Shao-yun Guo feng-Shun Zhang Jian-Hui Qiu The State Key Laboratory of Polymer Materials Engineering Sichuan Provincial Engineering Laboratory of Plastic/Rubber Complex Processing TechnologyPolymer Research InstituteSichuan UniversityChengdu 610065China Institute of Chemical Materials China Academy of Engineering PhysicsMianyang 621900China Department of Mechanical Engineering Faculty of Systems Science and TechnologyAkita Prefectural UniversityAkita 015-0055Japan

Silicone rubber(SR) composites are most widely used as thermal interface materials(TIMs) for electronics heat dissipation. Thermal impedance as the main bottleneck limiting the performance of TIMs is usually neglected. Herein, the thermal impedance of SR composites loaded with different levels of hexagonal boron nitride(h-BN) as TIMs was elaborated for the first time by the ASTM D 5470 standard test and finite element analysis. It was found that elastic modulus and surface roughness of SR composites increased with the increase of h-BN content, indicating that the conformity was reduced. When the assembly pressure was 0.69 MPa, there existed an optimal h-BN content at which the contact resistance was minimum(0.39 K·cm^(2)·W^(-1)). Although the decreased bond line thickness(BLT) by increasing the assembly pressure was beneficial to reduce the thermal impedance, the proper assembly pressure should be selected to prevent the warpage of the contact surfaces and the increase in contact resistance, according to the compression properties of the SR composites. This study provides valuable insights into fabrication of high-performance TIMs for modern electronic device applications.

关键词： Thermal interface materials Hexagonal boron nitride Thermal impedance Surfaces

Endowing low fatigue for elastocaloric effect by refined hierarchical microcomposite in additive manufactured NiTiCuCo alloy

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International Journal of Extreme Manufacturing 2024年第4期6卷 307-322页

作者： Bo feng Helong Liu Ying Yang Hui Shen Yang Ren Yinong Liu Lishan cui Bingmin Huang Shijie Hao College of New Energy and Materials China University of PetroleumBeijing 102249People's Republic of China College of Chemical Engineering and Environment China University of PetroleumBeijing 102249People's Republic of China Department of Physics City University of Hong Kong83 Tat Chee AvenueKowloonHong Kong Special Administrative Region of ChinaPeople's Republic of China Department of Mechanical Engineering The University of Western AustraliaPerthWA 6009Australia Jiangsu Smart Advanced Material Tech Co. LtdXuzhou 221000People's Republic of China

NiTiCu-based shape memory alloys have been considered as ideal materials for solid-state refrigeration due to their superb cycling stability for elastocaloric ***,the embrittlement and deterioration caused by secondary phase and coarse grains restrict their applications,and it is still challenging since the geometric components are ***,bulk NiTiCuCo parts with excellent forming quality were fabricated by laser powder bed fusion(LPBF)*** as-fabricated alloy exhibits refined three-phases hierarchical microcomposite formed based on the rapid cooling mode of LPBF,composed of intricate dendritic Ti2Ni–NiTi composite and nano Ti2Cu embedded inside the *** configuration endows far superior elastocaloric stability compared to the as-cast *** low fatigue stems from the strong elastic coupling between the interphases with reversible martensite transformation,revealed by in-situ synchrotron high-energy x-ray *** fabrication of NiTiCuCo alloy via LPBF fills the bill of complex geometric structures for elastocaloric NiTiCu *** understanding of interphase micro-coupling could provide the guide for designing LPBF fabricated shape memory-based composites,enabling their applications for special demands on other functionalities.

关键词： NiTiCuCo shape memoryalloy microcomposite high-energyx-raydiffraction laser powderbedfusion