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The role of substantia nigra sonography in the differentiation of Parkinson’s disease and multiple system atrophy

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Translational Neurodegeneration 2018年第1期7卷 138-144页

作者： Hai-Yan Zhou Pei huang Qian Sun Juan-Juan Du Shi-Shuang Cui yun-yun hu Wei-Wei Zhan Ying Wang Qin Xiao Jun Liu Yu-Yan Tan Sheng-Di Chen Department of Neurology&Institute of Neurology Ruijin Hospital affiliated to Shanghai Jiao Tong University School of MedicineNo.197 Ruijin 2nd RoadShanghai 200025China Department of Ultrasonography Ruijin Hospital affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200025China

Background:The differential diagnosis of Parkinson’s disease(PD)and multiple system atrophy(MSA)remains a challenge,especially in the early ***,we assessed the value of transcranial sonography(TCS)to discriminate non-tremor dominant(non-TD)PD from MSA with predominant parkinsonism(MSA-P).Methods:Eighty-six MSA-P patients and 147 age and gender-matched non-TD PD patients who had appropriate temporal acoustic bone windows were included in this *** the patients were followed up for at least 2 years to confirm the initial *** with at least one substantia nigra(SN)echogenic size≥18 mm^(2) were classified as hyperechogenic,those with at least one SN echogenic size≥25 mm^(2) was defined as markedly ***:The frequency of SN hyperechogenicity in non-TD PD patients was significantly higher than that in MSA-P patients(74.1%vs.38.4%,p<0.001).SN hyperechogenicity discriminated non-TD PD from MSA-P with sensitivity of 74.1%,specificity of 61.6%,and positive predictive value of 76.8%.If marked SN hyperechogenicity was used as the cutoff value(≥25 mm^(2)),the sensitivity decreased to 46.3%,but the specificity and positive predictive value increased to 80.2 and 80.0%.Additionally,in those patients with SN hyperechogenicity,positive correlation between SN hyperechogenicity area and disease duration was found in non-TD PD rather than in MSA-P *** this context,among early-stage patients with disease duration≤3 years,the sensitivity,specificity and positive predictive value of SN hyperechogenicity further declined to 69.8%,52.2%,and 66.7%,***:TCS could help discriminate non-TD PD from MSA-P in a certain extent,but the limitation was also obvious with relatively low specificity,especially in the early stage.

关键词： Parkinson’s disease Multiple system atrophy Atypical parkinsonian disorders Transcranial sonography Substantia nigra Disease duration

Combination of olfactory test and substantia nigra transcranial sonopraphy in the differential diagnosis of Parkinson’s disease:a pilot study from China

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Translational Neurodegeneration 2012年第1期1卷 199-202页

作者： Wei Chen Yu-Yan Tan yun-yun hu Wei-Wei Zhan Li Wu Yue Lou Xi Wang Yi Zhou Pei huang Yuan Gao Qin Xiao Sheng-Di Chen Department of Neurology&Institute of Neurology Ruijin Hospital affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200025China Department of Ultrasound Ruijin Hospital affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200025China

Objectives:Both hyposmia and substania nigra(SN)hyperechogenicity on trascranial sonography(TCS)were risk markers for idiopathic Parkinson’s disease(PD),which was beneficial to the differential diagnosis of the ***,each of their single diagnostic value is often *** purpose of present study was to explore whether the combination of olfactory test and TCS of SN could enhance the differential diagnostic power in Chinese patients with ***:Thirty-seven patients with PD and twenty-six patients with essential tremor(ET)were evaluated on 16-item odor identification test from extended version of sniffin’sticks and TCS of *** frequency of hyposmia and SN hyperechogenicity in each group was *** sensitivity,specificity,positive predictive value(PPV)and negative predictive value(NPV)of the two clinical biomarkers were ***:The frequency of hyposmia in patients with PD was significantly higher than in patients with ET(62.2%VS.3.8%,P=0.000).The frequency of SN hyperechogenicity in patients with PD was significantly higher than in ET subjects(48.6%VS.15.4%,P=0.006).The combination of hyposmia and SN hyperechogenicity(if either one or both present)discriminated patients with PD from ET with a sensitivity of 78.4%and 29.7%,specificity of 80.8%and 100%,PPV of 85.3%and 100%,and NPV of 72.4%and 50.0%,***:Our preliminary data suggested that the combination of hyposmia and SN hyperechogenicity could improve the diagnostic potential for discriminating Chinese patients with PD from ET.

关键词： Parkinson’s disease Hyposmia Transcranial sonography

Establishment of a cell-based assay system for hepatitis C virus serine protease and its primary applications

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World Journal of Gastroenterology 2003年第11期9卷 2474-2479页

作者： Hong-Xia Mao Shui-yun Lan yun-Wen hu Li Xiang Zheng-Hong Yuan, Key Laboratory of Medical Molecular Virology, Shanghai Medical College, Fudan University, Shanghai 200032, China Key Laboratory of Medical Molecular Virology Shanghai Medical College Fudan University Shanghai 200032 China.

AIM: To establish an efficient, sensitive, cell-based assay system for NS3 serine protease in an effort to study further the property of hepatitis C virus (HCV) and develop new antiviral ***: We constructed pCI-neo-NS3/4A-SEAP chimeric plasmid, in which the secreted alkaline phosphatase (SEAP) was fused in-frame to the downstream of NS4A/4B cleavage site. The protease activity of NS3 was reflected by the activity of SEAP in the culture media of transient or stable expression cells. Stably expressing cell lines were obtained by G418 selection. Pefabloc SC, a potent irreversible serine protease inhibitor, was used to treat the stably expressing cell lines to assess the system for screening NS3 inhibitors. To compare the activity of serine proteases from 1b and 1a, two chimeric clones were constructed and introduced into both transient and stable expression ***: The SEAP activity in the culture media could be detected in both transient and stable expression systems,and was apparently decreased after Pefabloc SC *** both transient and stable systems, NS3/4A-SEAP chimeric gene from HCV genotype 1b produced higher SEAP activity in the culture media than that from ***: The cell-based system is efficient and sensitive enough for detection and comparison of NS3 protease activity, and screening of anti-NS3 inhibitors. The functional difference between NS3/4A from 1a and 1b subtypes revealed by this system provides a clue for further investigations.

关键词：丙型肝炎病毒丝氨酸蛋白酶抗滤过性病原体 NS3蛋白酶细胞基础分析系统

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数字地球与中国GIS发展战略的思考

石家庄师范专科学校学报 2004年第6期6卷 47-51页

作者：刘芸芸胡文亮河北师范大学资源与环境科学学院河北石家庄050016

数字地球就是应用3S技术对地球信息的全方位、多维的、多分辨率的描述与表达,更新及时,获取方便.面对数字地球的发展,我国应抓住机遇,积极应对挑战,通过数字地球战略的实施,推动中国经济的跨世纪发展,保障国家安全与国际和平,促进信息... 详细信息

数字地球就是应用3S技术对地球信息的全方位、多维的、多分辨率的描述与表达,更新及时,获取方便.面对数字地球的发展,我国应抓住机遇,积极应对挑战,通过数字地球战略的实施,推动中国经济的跨世纪发展,保障国家安全与国际和平,促进信息科学技术、环境科学技术和地球科学的发展.

关键词：数字地球中国 GIS 地理信息系统

Some Remarks on Teichmüller Spaces and Modular Groups

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Acta Mathematica Sinica,English Series 2009年第8期25卷 1289-1296页

作者： yun hu Department of Mathematics Soochow University Suzhou 215006 P. R. China

We study the fixed point sets of subgroups of modular groups acting on Teichmiiller spaces.

关键词： Teichmiiller space modular group allowable mapping

Multi-time Collaborative Restoration for Integrated Electrical-gas Distribution Systems Based on Rolling Optimization

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CSEE Journal of Power and Energy Systems 2024年第2期10卷 660-671页

作者： Jingyang yun Zheng Yan yun Zhou Peichao Zhang Weidong hu Key Laboratory of Control of Power Transmission and Conversion of Ministry of Education Department of Electrical EngineeringShanghai Jiao Tong University

This paper proposes a multi-time collaborative restoration model for integrated electricity-gas distribution sys-tems(IEGDSs)considering multiple resources after extreme weather *** on the linearized power flow constraints of the unbalanced electrical distribution system(EDS)and gas distribution system(GDS),this problem can be formulated as a mixed-integer linear programming(MILP)*** improve the efficiency and veracity of the solution,a rolling optimiza-tion based two-stage method is developed with the first stage solved by a linear approximation model,and the second stage solved by real-time updated rolling *** solving the MILP problem using rolling optimization,the proposed model and solution method achieve efficient and reliable collaborative restoration of IEGDS considering multiple resources and unbal-anced operation characteristics of *** effectiveness of the proposed model and method is validated by using an IEGDS made of a 37-bus unbalanced EDS and 11-node *** Terms-Electricity-gas system,mix-integer linear programming,power system restoration.

关键词： Electricity-gas system mix-integer linear programming power system restoration

Isomorphisms of fiber spaces over Teichmüller spaces

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Science China Mathematics 2006年第7期49卷 877-892页

作者： hu yun SHEN Yuliang Department of Mathematics Suzhou University Suzhou 215006 China Department of Mathematics Suzhou University Suzhou 215006 China

We will be mainly concerned with some important fiber spaces over Teichmuller spaces, including the Bers fiber space and Teichmuller curve, establishing an isomorphism theorem between 'punctured' Teichmuller curves an... 详细信息

关键词： Teichmuller space Bers fiber space 'punctured' fiber space Teichmuller curve 'punctured' Teichmuller curve biholomorphic isomorphism.

基于CNN和Transformer交叉教学的半监督医学图像分割

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陕西科技大学学报 2025年第1期43卷 185-192页

作者：杨云胡雯青杨虹吴亚男陕西科技大学电子信息与人工智能学院陕西西安710021 西安富德医疗电子有限公司陕西西安710075 西安计量技术研究院陕西西安710199

由于医学图像分割领域缺乏高质量的标注数据,半监督学习方法在医学图像语义分割任务中受到高度重视.为了充分利用卷积神经网络(Convolutional Neural Network,CNN)和Transformer在半监督学习中的优势,本文提出一种基于CNN与Transformer... 详细信息

由于医学图像分割领域缺乏高质量的标注数据,半监督学习方法在医学图像语义分割任务中受到高度重视.为了充分利用卷积神经网络(Convolutional Neural Network,CNN)和Transformer在半监督学习中的优势,本文提出一种基于CNN与Transformer交叉教学的半监督医学图像分割方法.该方法将经典的深度协同训练从一致性正则化简化为交叉教学,利用循环伪标签方案使两个网络的预测差异转换为无监督损失,以鼓励两个网络具有一致的低熵预测.所提方法在ISIC 2018数据集上进行实验,在采用20%的标注比例时,Dice系数和Jaccard系数分别达到87.25%和79.17%,相比于监督U-Net++的训练结果分别提升了2.89%和3.53%,并且优于目前主流的半监督学习方法,验证了所提方法在半监督医学图像分割上的有效性和泛化性.

关键词：半监督学习图像语义分割交叉教学循环伪标签

Aldo-Keto reductase 1C3 reduces myocardial cell damage after acute myocardial infarction by activating the Kelch-like ECH-associated protein 1-nuclear factor erythroid 2-related factor 2-antioxidant response element pathway to inhibit ferroptosis

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Journal of Geriatric Cardiology 2024年第9期21卷 899-912页

作者： Wang MIAO yun-Zhao hu Department of Cardiology Shunde HospitalSouthern Medical Universitythe First People’s Hospital of ShundeFoshanChina The Second School of Clinical Medicine Southern Medical UniversityGuangzhouChina

Background Acute myocardial infarction(AMI)is a high-risk cardiovascular condition associated with increased cellular damage and oxidative ***-Keto Reductase 1C3(AKR1C3)is a stress-regulating ***,its specific role and mechanisms regarding AMI remain *** We assessed cardiac function through echocardiography;tissue damage was evaluated using Hematoxylin and Eosin(HE)and Masson trichrome ***1C3 expression levels were measured through Reverse transcription-quantitative polymerase chain reaction and western *** cell viability using Cell Counting Kit-8 and lactate dehydrogenase(LDH)*** extent of ferroptosis was determined by measuring the levels of Fe2+,boron-dipyrromethane(BODIPY)and malondialdehyde(MDA),the glutathione/glutathione disulfide(GSH/GSSG)ratio,and the expression of Glutathione Peroxidase 4(GPX4)and Solute carrier 7A11(SLC7A11).Kelch-like ECH-associated protein 1-Nuclear factor erythroid 2-related factor 2-Antioxidant response element(Keap1-Nrf2-ARE)pathway activation was analyzed through western ***2 was inhibited with ML385and activated with(R)-Sulforaphane to investigate the Keap1-Nrf2-ARE *** The rats in the AMI group displayed reduced heart function,more tissue damage,and lower AKR1C3 expression compared to the Sham ***,hypoxia-treated H9C2 cells showed reduced viability,and decreased AKR1C3 *** AKR1C3 in H9C2 cells enhanced *** down AKR1C3 exhibited the opposite *** the inhibitors tested,Ferrostatin-1 most effectively restored cell viability in hypoxia-treated H9C2 ***,H9C2 cells subjected to hypoxia suggested Keap1-Nrf2-ARE pathway *** AKR1C3 reduced ferroptosis and activated the Keap1-Nrf2-ARE pathway in hypoxia-treated cells,knocking down AKR1C3 exhibited the opposite *** experiments using ML385 in hypoxia-treated H9C2 cells with overexpressed AKR1C3 showed decreased viabil

关键词： damage Antioxidant myocardial