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Post-treatment Process of Semi-solid Powder Rolling

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Acta Metallurgica Sinica(English Letters) 2015年第10期28卷 1305-1315页

作者： Xia Luo yun-zhong Liu Bin Wang National Engineering Research Center of Near-Net-Shape Forming for Metallic Materials South China University of Technology School of Materials Science and Engineering Southwest Petroleum University

Semi-solid powder rolling is a strip manufacturing process, which combines powder rolling with semi-solid rolling in one step to prepare high-performance metallic strips. A total of 7050 aluminum alloy strips were prepared by semi-solid powder rolling and then used to study the post-treatment process and evaluate qualities of post-treated *** post-treatment processes involving sintering, pre-sintering-cold deformation-sintering, and hot rolling were used to process the semi-solid powder rolled strips. The results show that both swelling of pores and densification occur during solid-state sintering while microhardness increases. The decrease in density is due to that the swelling of pores has a larger effect on the density change than that of densification. The relative density reaches 92.6% with the maximum microhardness of 300 HV after ＇＇pre-sintering-cold deformation-sintering＇＇ process. High microhardness is due to the ultrafine secondary particles uniformly distributed within the grains. The microhardness and relative density of a hot rolled strip are 176 HV and 99%, respectively, and the secondary particles disappear. Occurrence of recrystallization in these three post-treatment processes makes the grains finer.

关键词： Semi-solid powder rolling Post-treatment Sintering Hot rolling Pore swelling

Formation and adjustment of manned/unmanned combat aerial vehicle cooperative engagement system

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Journal of Systems Engineering and Electronics 2018年第4期29卷 756-767页

作者： zhong yun YAO Peiyang ZHANG Jieyong WAN Lujun Information and Navigation College Air Force Engineering University Air Traffic Control and Navigation College Air Force Engineering University

Manned combat aerial vehicles （MCAVs）, and un-manned combat aerial vehicles （UCAVs） together form a cooper-ative engagement system to carry out operational mission, whichwill be a new air engagement style in the near future. On the basisof analyzing the structure of the MCAV/UCAV cooperative engage-ment system, this paper divides the unique system into three hi-erarchical levels, respectively, i.e., mission level, task-cluster leveland task level. To solve the formation and adjustment problem ofthe latter two levels, three corresponding mathematical modelsare established. To solve these models, three algorithms calledquantum artificial bee colony （QABC） algorithm, greedy strategy（GS） and two-stage greedy strategy （TSGS） are proposed. Finally,a series of simulation experiments are designed to verify the effec-tiveness and superiority of the proposed algorithms.

关键词： manned combat aerial vehicle (MCAV) unmannedcombat aerial vehicle (UCAV) cooperative engagement system quantum artificial bee colony (QABC) greedy strategy (GS) two-stage greedy strategy (TSGS)

Intervention decision-making in MAV/UAV cooperative engagement based on human factors engineering

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Journal of Systems Engineering and Electronics 2018年第3期29卷 530-538页

作者： zhong yun YAO Peiyang WAN Lujun YANG Juan Information and Navigation College Air Force Engineering UniversityXi'an 710077China Air Traffic Control and Navigation College Air Force Engineering UniversityXi'an 710051China Unit 93010 of the PLA Shenyang 110015China

Aiming at the intervention decision-making problem in manned/unmanned aerial vehicle（MAV/UAV） cooperative engagement, this paper carries out a research on allocation strategy of emergency discretion based on human factors engineering（HFE）.Firstly, based on the brief review of research status of HFE, it gives structural description to emergency in the process of cooperative engagement and analyzes intervention of commanders. After that,constraint conditions of intervention decision-making of commanders based on HFE（IDMCBHFE） are given, and the mathematical model, which takes the overall efficiency value of handling emergencies as the objective function, is established. Then, through combining K-best and variable neighborhood search（VNS） algorithm, a K-best optimization variable neighborhood search mixed algorithm（KBOVNSMA） is designed to solve the model. Finally,through three groups of simulation experiments, effectiveness and superiority of the proposed algorithm are verified.

关键词： manned/unmanned aerial vehicle(MAV/UAV) intervention decision-making human factors engineering structural description K-best algorithm variable neighborhood search algorithm

Influence of 6-shogaol potentiated on 5-fluorouracil treatment of liver cancer by promoting apoptosis and cell cycle arrest by regulating AKT/mTOR/MRP1 signalling

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Chinese Journal of Natural Medicines 2022年第5期20卷 352-363页

作者： ZHANG Yi QU Yong CHEN yun-zhong Pharmacy Faculty Hubei University of Chinese MedicineWuhan 430065China Department of Pharmacy CR&WISCO General HospitalWuhan 430000China

Currently, chemoresistance seriously attenuates the curative outcome of liver cancer. The purpose of our work was to investigate the influence of 6-shogaol on the inhibition of 5-fluorouracil (5-FU) in liver cancer. The cell viability of cancer cells was determined by MTT assay. Liver cancer cell apoptosis and the cell cycle were examined utilizing flow cytometry. Moreover, qRT–PCR and western blotting was used to analyse the mRNA and protein expression levels, respectively. Immunohistochemistry assays were used to examine multidrug resistance protein 1 (MRP1) expression in tumour tissues. In liver cancer cells, we found that 6-shogaol-5-FU combination treatment inhibited cell viability, facilitated G0/G1 cell cycle arrest, and accelerated apoptosis compared with 6-shogaol or 5-FU treatment alone. In cancer cells cotreated with 6-shogaol and 5-FU, AKT/mTOR pathway- and cell cycle-related protein expression levels were inhibited, and MRP1 expression was downregulated. AKT activation or MRP1 increase reversed the influence of combination treatment on liver cancer cell viability, apoptosis and cell cycle arrest. The inhibition of AKT activation to the anticancer effect of 6-shogaol-5-FU could be reversed by MRP1 silencing. Moreover, our results showed that 6-shogaol-5-FU combination treatment notably inhibited tumour growth in vivo. In summary, our data demonstrated that 6-shogaol contributed to the curative outcome of 5-FU in liver cancer by inhibiting the AKT/mTOR/MRP1 signalling pathway.

关键词： Liver cancer 6-Shogaol 5-Fluorouracil Multidrug resistance protein 1

Cellular reprogramming and hepatocellular carcinoma development

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World Journal of Gastroenterology 2013年第47期19卷 8850-8860页

作者： yun-Wen Zheng yun-zhong Nie Hideki Taniguchi Department of Regenerative Medicine Graduate School of MedicineYokohama City UniversityKanazawa-kuYokohamaKanagawa 236-0004Japan Jiangsu University Hospital Advanced Medical Research Center Yokohama City UniversityYokohamaKanagawa 236-0004Japan

Hepatocellular carcinoma(HCC)is one of the most common cancers,and is also the leading cause of death *** have shown that cellular reprogramming contributes to chemotherapy and/or radiotherapy resistance and the recurrence of *** this article,we summarize and discuss the latest findings in the area of cellular reprogramming in *** aberrant expression of transcription factors OCT4,KLF4,SOX2,c-MYC,NANOG,and LIN28 have been also observed,and the expression of these transcription factors is associated with unfavorable clinical outcomes in *** indicate that cellular reprogramming may play a critical role in the occurrence and recurrence of *** reports have shown that DNA methylation,miRNAs,tumor microenvironment,and signaling pathways can induce the expression of stemness transcription factors,which leads to cellular reprogramming in ***,studies indicate that therapies based on cellular reprogramming could revolutionize HCC ***,a novel therapeutic concept is discussed:reprogramming control therapy.A potential reprogramming control therapy method could be developed based on the reprogramming demonstrated in HCC studies and applied at two opposing levels:differentiation and *** increasing understanding and control of cellular programming should facilitate the exploitation of this novel therapeutic concept and its application in clinical HCC treatment,which may represent a promising strategy in the future that is not restricted to liver cancer.

关键词： Reprogramming Hepatocellular carcinomas Cancer stem cells Transcription factor Therapeutics

Colonic exclusion and combined therapy for refractory constipation

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World Journal of Gastroenterology 2006年第48期12卷 7864-7868页

作者： Hong-yun Peng Ai-zhong Xu Department of General Surgery The Second Affiliated Hospital Nanchang University Jiangxi Province China

AIM: To investigate the therapeutic effectiveness of colonic exclusion and combined therapy for refractory constipation. METHODS: Thirty-two patients with refractory constipation were randomly divided into treatment group (n = 14) and control group (n = 18). Fourteen patients in treatment group underwent colonic exclusion and end-to-side colorectal anastomosis. Eighteen patients in control group received subtotal colectomy and end-to- end colorectal anastomosis. The therapeutic effects of the operations were assessed by comparing the surgical time, incision length, volume of blood losses, hospital stay, recovery rate and complication incidence. All patients received long-term follow-up. RESULTS: All operations were successful and patients recovered fully after the operations. In comparison of treatment group and control group, the surgical time (h), incision length (cm), volume of blood losses (mL), hospital stay (d) were 87 ± 16 min vs 194 ± 23 min (t = 9.85), 10.4 ± 0.5 cm vs 21.2 ± 1.8 cm (t = 14.26), 79.5 ± 31.3 mL vs 286.3 ± 49.2 mL (t = 17.24), and 11.8 ± 2.4 d vs 18.6 ± 2.6 d (t = 6.91), respectively (P 0.05), 21.4% vs 33.3% (P = 0.73 > 0.05), respectively. CONCLUSION: Colonic exclusion has better therapeutic efficacy on refractory constipation. It has many advantages such as shorter surgical time, smaller incision, fewer blood losses and shorter hospital stay.

关键词： Constipation Colonic exclusion Subtotalcolectomy Quality of life Follow-up

Effects of methyl-CD and humic acid on hydrolytic degradation of the herbicide diclofop-methyl

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Journal of Environmental Sciences 2005年第1期17卷 67-71页

作者： CAIXi-yun WENYue-zhong zhongTian-xiang LIUWei-ping InstituteofEnvironmentScience ZhejiangUniversityHangzhou310029China

Hydrolytic degradation of the herbicide diclofop methyl was investigated in the multi pH deionized water, natural aquatic systems and soil suspensions. Resulting data indicated that the herbicide was stable in the acidic and nearly neutral solutions for at least 15 d. The herbicide diclofop methyl rapidly dissipated in the natural aquatic systems and soil suspensions with half lives less than 4 d. Methyl CD(partially methylated β cyclodextrin) improved its hydrolytic degradation in the pH 8 deionized water and natural aquatic systems while humic acid inhibited its hydrolytic degradation at the same conditions. But dissolved organic matter in the natural aquatic systems and soil suspensions increased its hydrolysis. Two catalysis mechanisms were introduced to describe the effects of cyclodextrin and organic matter on its hydrolytic metabolism. Though inorganic ions maybe improved its hydrolysis reaction in the natural aquatic systems, Fe 2+ and Cu 2+ did not form complexes with the herbicide and had poor influences on its hydrolytic degradation whether cyclodextrin was added or not.

关键词： diclofop-methyl methyl-CD organic matter humic acid hydrolysis

Optimized Selection Method of Air Combat Course of Action under Stochastic Uncertainty

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Journal of Systems Science and Systems Engineering 2024年第4期33卷 494-518页

作者： yun zhong Jieyong Zhang Peng Sun Lujun Wan Kepeng Wang Information and Navigation College Air Force Engineering UniversityXi’an710077China Equipment Management and Unmanned Aerial Vehicle Engineering College Air Force Engineering UniversityXi’an710051China Air Traffic Control and Navigation College Air Force Engineering UniversityXi’an710051China Unit 94040 of PLA Korla841000China

Aiming at the design problem of aviation swarm combat course of action(COA),considering the influence of stochastic parameters in the causal relationship model and optimization problem model,according to the dynamic influence net(DIN)theory,stochastic simulation technique,feedforward neural network(FNN)function approximation technique and multi-objective artificial fish school algorithm(MOAFSA),this paper proposed a COA optimized method based on DIN and multi-objective stochastic chance constraint optimization for aviation swarm ***,on the basis of establishing the overall framework of the model and defining the elements of causal relationship modeling,the static and dynamic causal relationship modeling and optimization problem modeling were carried out ***,the probability propagation mechanism of DIN was established,which mainly included two aspects,i.e.,the overall process and the specific ***,input and output data were generated based on stochastic *** to these data,FNN was adopted for function approximation,and MOAFSA was adopted for iterative ***,the rationality of the model,and the effectiveness and superiority of the algorithm were verified through multiple sets of simulation cases.

关键词： Stochastic uncertainty aviation swarm stochastic simulation course of action feedforward neural network multi-objective artificial fish school algorithm

Process and properties of electroless Ni-W-B amorphous electrical resistance film

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中国有色金属学会会刊：英文版 2004年第Z1期14卷 144-146页

作者： ZHU Xiao-yun GUO zhong-cheng XU Rui-dong The Centre of New Materials and Surface Engineering Research and Development Kunming University of Science and Technology Kunming 650093 China The Centre of New Materials and Surface Engineering Research and DevelopmentKunming University of Science and Technology Kunming 650093 China The Centre of New Materials and Surface Engineering Research and DevelopmentKunming University of Science and Technology Kunming 650093 China

The process and properties of electroless plating Ni-W-B alloy have been studied. The results show that the deposits containing W and B are obtained, and the deposition rate of the bath is increased with increase of W content when a certain amount of sodium tungstate solution is added in the Ni-B bath. The Ni-W-B alloy is amorphous as deposition and its resistivity increases directly with the increase of W content in the coating, but decreases gradually with increasing the deposit thickness. XRD and SEM show that the distributions of W and B in the Ni-W-B alloy film are very uniform and dispersed without any segregation.

关键词： electroless Ni-W-B alloy electrical resistance film properties