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Targeted gene sequencing and bioinformatics analysis of patients with gallbladder neuroendocrine carcinoma:A case report

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 239-251页

作者： yun-Chuan yang Zhi-Tao Chen Da-Long Wan Hui Tang Mu-Lin Liu Department of Medical College Jinan UniversityGuangzhou 510000Guangdong ProvinceChina Department of General Surgery The First Affiliated Hospital of Bengbu Medical UniversityBengbu 233000Anhui ProvinceChina Department of Hepatobiliary Surgery Shulan(Hangzhou)Hospital Affiliated to Zhejiang Shuren University Shulan International Medical CollegeHangzhou 310022Zhejiang ProvinceChina Department of Hepatobiliary and Pancreatic Surgery The First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310003Zhejiang ProvinceChina Department of Pathology The First Affiliated Hospital of Medical School of Zhejiang UniversityHangzhou 310000Zhejiang ProvinceChina

BACKGROUND Gallbladder neuroendocrine carcinoma(NEC)represents a subtype of gallbladder malignancies characterized by a low incidence,aggressive nature,and poor *** its clinical severity,the genetic alterations,mechanisms,and signaling pathways underlying gallbladder NEC remain *** SUMMARY This case study presents a rare instance of primary gallbladder NEC in a 73-year-old female patient,who underwent a radical cholecystectomy with hepatic hilar lymphadenectomy and resection of liver segments IV-B and *** gene sequencing and bioinformatics analysis tools,including STRING,GeneMANIA,Metascape,TRRUST,Sangerbox,cBioPortal and GSCA,were used to analyze the biological functions and features of mutated genes in gallbladder *** mutations(APC,ARID2,IFNA6,KEAP1,RB1,SMAD4,TP53,BTK,GATA1,GNAS,and PRDM3)were identified,and the tumor mutation burden was determined to be 9.52 muts/Mb via targeted gene sequencing.A protein-protein interaction network showed significant interactions among the twelve mutated *** Ontology and Kyoto Encyclopedia of Genes and Genomes analyses were used to assess mutation functions and *** results revealed 40 tumor-related pathways.A key regulatory factor for gallbladder NEC-related genes was identified,and its biological functions and features were compared with those of gallbladder *** Gallbladder NEC requires standardized *** with other gallbladder carcinomas revealed clinical phenotypes,molecular alterations,functional characteristics,and enriched pathways.

关键词： Gallbladder neuroendocrine carcinoma Targeted-gene sequencing Bioinformatics analysis case report Immunocytochemistry Case report

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Prevalence of Helicobacter pylori infection in Chinese military personnel:A cross-sectional,multicenter-based study

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World Journal of Gastroenterology 2025年第3期31卷 42-49页

作者： Han-Chen Min Chun-Yan Zhang Fang-Yu Wang Xiao-Hui Yu Shan-Hong Tang Hong-Wu Zhu Ya-Gang Zhao Ji-Luo Liu Jian Wang Jing-Han Guo Xiao-Mei Zhang yun-Sheng yang Chinese People’s Liberation Army Medical School Chinese People’s Liberation Army General HospitalBeijing 100853China Department of Gastroenterology and Hepatology The First Medical CenterChinese People’s Liberation Army General HospitalBeijing 100853China Sixth Healthcare Department The Second Medical CenterChinese People’s Liberation Army General HospitalBeijing 100853China Department of Gastroenterology The 940th Hospital of Joint Logistic Support Force of Chinese People’s Liberation ArmyLanzhou 730050Gansu ProvinceChina Department of Gastroenterology General Hospital of Western Theater CommandChengdu 610011Sichuan ProvinceChina Department of Gastroenterology General Hospital of Southern Theater CommandGuangzhou 510010Guangdong ProvinceChina Department of Epidemiology Naval Medical UniversityShanghai 200433China School of Medicine Nankai UniversityTianjin 300071China National Clinical Research Center for Geriatric Diseases Chinese People’s Liberation Army General HospitalBeijing 100853China

BACKGROUND Helicobacter pylori(***)infection is a prevalent disease encountered in military internal medicine and recognized as the main cause of dyspepsia,gastritis,and peptic ulcer,which are common diseases in military *** guidelines in China state all patients with evidence of active infection with *** are offered ***,the prevalence of *** infection and its regional distribution in the military population remain unclear,which hinders effective prevention and treatment *** the prevalence of *** infection in the military population will aid in the development of customized strategies to better manage this infectious *** To investigate the prevalence of *** infection in the Chinese military population in different geographic *** This multicenter,retrospective study included 22421 individuals from five tertiary hospitals located in north,east,southwest,and northwest cities of *** infection was identified using the urea breath test,which had been performed between January 2020 and December *** Of the 22421 military service members,7416(33.1%)were urea breath *** highest prevalence of *** was in the 30-39 years age group for military personnel,with an infection rate of 34.9%.The majority of infected subjects were younger than 40-years-old,accounting for 70.4%of the infected *** individuals serviced in Lanzhou and Chengdu showed a higher infection prevalence than those in Beijing,Nanjing,and Guangzhou,with prevalence rates of 44.3%,37.9%,29.0%,31.1%,and 32.3%,*** *** infection remains a common infectious disease among military personnel in China and has a relatively high prevalence rate in northwest China.

关键词： Helicobacter pylori Prevalence Military personnel Urea breath test Multicenter study

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Gradient Estimates for the Equation Δu+cu^(-α)=0 on Riemannian Manifolds

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Acta Mathematica Sinica,English Series 2010年第6期26卷 1177-1182页

作者： yun Yan yang Department of Mathematics Information School Renmin University of China Beijing 100872 P. R. China

Let （M, g） be a complete non-compact Riemannian manifold without boundary. In this paper, we give the gradient estimates on positive solutions to the following elliptic equation with singular nonlinearity：△u（x）＋cu^-a=0 in M,where a 〉 0, c are two real constants. When c 〈 0 and M is a bounded smooth domain in R^n, the above equation is known as the thin film equation, which describes a steady state of the thin film （see Guo-Wei [Manuscripta Math., 120, 193-209 （2006）]）. The results in this paper can be viewed as an supplement of that of J. Li [J. Funct. Anal., 100, 233-256 （1991）], where the nonlinearity is the positive power of u.

关键词： positive solution gradient estimate thin film equation

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Invariant hypersurface flows in centro-affine geometry

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Science China Mathematics 2021年第8期64卷 1715-1734页

作者： yun yang Changzheng Qu Department of Mathematics Northeastern UniversityShenyang 110819China School of Mathematics and Statistics Ningbo UniversityNingbo 315211China

In this paper,the invariant geometric flows for hypersurfaces in centro-affine geometry are *** first present evolution equations of the centro-affine invariants corresponding to the geometric *** on these fundamental evolution equations,we show that the centro-affine heat flow for hypersurfaces is equivalent to a system of ordinary differential equations,which can be solved ***,the centro-affine invariant normal flows for hypersurfaces are investigated,and two specific flows are provided to illustrate the behaviour of the flows.

关键词： invariant geometric flow centro-affine geometry heat flow normal flow centro-affine invariant

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IRES-mediated cap-independent translation,a path leading to hidden proteome

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Journal of Molecular Cell Biology 2019年第10期11卷 911-919页

作者： yun yang Zefeng Wang CAS Key Laboratory of Computational Biology Biomedical Big Data CenterCAS-MPG Partner Institute for Computational BiologyShanghai Institute of Nutrition and HealthChinese Academy of SciencesShanghai 200031China University of Chinese Academy of Sciences Chinese Academy of SciencesShanghai 200031China CAS Center for Excellence in Molecular Cell Science Chinese Academy of SciencesShanghai 200031China

Most eukaryotic mRNAs are translated in a cap-dependent fashion;however,under stress conditions,the cap-independent translation driven by internal ribosomal entry sites(IRESs)can serve as an alternative mechanism for protein *** IRESs have been discovered from viral or cellular mRNAs to promote ribosome assembly and initiate translation by recruiting different trons-acting *** the mechanisms of translation initiation driven by viral IRESs are relatively well understood,the existence of cellular IRESs is still under debate due to the limitations of translation reporter systems used to assay IRES activities.A recent screen identified>1000 putative IRESs from viral and human mRNAs,expanding the scope and mechanism for capindependent ***,a large number of circular RNAs lacking free ends were identified in eukaryotic cells,many of which are found to be translated through *** findings suggest that IRESs may play a previously unappreciated role in driving translation of the new type of mRNA,implying a hidden proteome produced from cap-independent translation.

关键词： IRES ITAF translation bicistronic system circular RNA

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Changes of Air–sea Coupling in the North Atlantic over the 20th Century

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Advances in Atmospheric Sciences 2015年第4期32卷 445-456页

作者： yang yun WU Lixin Physical Oceanography Laboratory Ocean University of China

Changes of air–sea coupling in the North Atlantic Ocean over the 20 th century are investigated using reanalysis data,climate model simulations, and observational data. It is found that the ocean-to-atmosphere feedback over the North Atlantic is significantly intensified in the second half of the 20 th century. This coupled feedback is characterized by the association between the summer North Atlantic Horseshoe（NAH） SST anomalies and the following winter North Atlantic Oscillation（NAO）. The intensification is likely associated with the enhancement of the North Atlantic storm tracks as well as the NAH SST anomalies. Our study also reveals that most IPCC AR4 climate models fail to capture the observed NAO/NAH coupled feedback.

关键词： air–sea coupling climate change North Atlantic Ocean 20th Century

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Biological functions and applications of circRNAs—next generation of RNA-based therapy

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Journal of Molecular Cell Biology 2023年第5期15卷 1-6页

作者： Meiling Sun yun yang Research and Development Department Shanghai CirCode Biomedicine Co.LtdShanghaiChina

Introduction Circular RNAs(circRNAs)are a unique class of single-stranded RNA molecules that are covalently closed and lack 5 and 3 *** were first discovered in eukaryotic cells>30 years ago,but technical limitations hindered the characterization of circRNAs until the *** advances in high-throughput RNA sequencing(RNA-seq),coupled with circRNA enrichment using RNase R treatment and new bioinformatic tools,have led to the discovery of a large number of circRNAs in various eukaryotic organisms,including mammals,insects.

关键词： limitations therapy circRNA

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Trudinger–Moser Inequalities on a Closed Riemann Surface with a Symmetric Conical Metric

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Acta Mathematica Sinica,English Series 2024年第9期40卷 2263-2284页

作者： Yu FANG yun Yan yang College of Teacher Education Quzhou UniversityQuzhou 324003P.R.China Department of Mathematics Renmin University of ChinaBeijing 100872P.R.China

This is a continuation of our previous work(*** ***.,20,1295–1324,2020).Let(Σ,g)be a closed Riemann surface,where the metric g has conical singularities at finite *** G is a group whose elements are isometries acting on(Σ,g).Trudinger–Moser inequalities involving G are established via the method of blow-up analysis,and the corresponding extremals are also *** extends previous results of Chen(***.,1990),Iula–Manicini(Nonlinear Anal.,2017),and the authors(2020).

关键词： Trudinger-Moser inequality blow-up analysis conical singularity

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A Note on the ASCLT for Triangular Arrays of Random Variables with an Extension to U-statistics

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Acta Mathematica Sinica,English Series 2012年第9期28卷 1907-1916页

作者： Yong ZHANG Xiao yun yang College of Mathematics Jilin University

In this paper, we obtain an almost sure central limit theorem for products of independent sums of positive random variables. An extension of the result gives an ASCLT for the U-statistics.

关键词： Almost sure central limit theorem triangular arrays products of sums U-statistics

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Self-Consistent Kinetic Modeling of Electron Distribution Function in a Low-Pressure Inductively Coupled Plasma

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Chinese Physics Letters 1996年第6期13卷 447-450页

作者： yang yun WU Han-ming Institute of Mechanics Chinese Academy of SciencesBeijing 100080

Based upon the spatially inhomogeneous Boltzmann equation in two-term approximation coupled with electromagnetic and fluid model analysis for the recently developed inductively coupled plasma sources,a self-consistent electron kinetic model is *** electron distribution function,spatial distributions of the electron density and ionization rate are calculated and discussed.

关键词： Electron inhomogeneous spatially

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