检索结果-南通市图书馆

Asian Journal of Andrology 2007年第2期9卷 199-205页

作者： yumi Miura Munekazu Naito Maira Ablake Hayato Terayama Shuang-Qin Yi Ning Qu Lin-Xian Cheng Shigeru Suna Fumihiko Jitsunari Masahiro Itoh Department of Anatomy Tokyo Medical University Tokyo 160-8402 Japan Department of Histology and Embryology Xin Jiang Medical University Xinjiang 830001 China Department of Hygiene and Public Health Faculty of Medicine Kagawa University Kagawa 761-0783 Japan

Aim： To determine the biochemical effect of di-（2-ethylhexyl） phthalate （DEHP） on testes, liver, kidneys and pancreas on day 10 in the process of degeneration of the seminiferous epithelium. Methods： Diets containing 2% DEHP were given to male Crlj：CDI（ICR） mice for 10 days. The dose of DEHP was 0.90±0.52 mg/mouse/day. Their testes, livers, kidneys and pancreata were examined for detection of mono-（2-ethylhexyl） phthalate （MEHP）, nitrogen oxides （NOx） produced by peroxidation of nitric oxide （NO） with free radicals, and lipid peroxidation induced by the chain reaction of free radicals. Results： Histological observation and serum analysis showed the presence of severe sperrnatogenic disturbance, Leydig cell dysfunction, liver dysfunction and dehydration. Unexpectedly, the concentration of MEHP in the testes was extremely low compared with that in the liver. However, the concentration of the NOx in the testes was as high as the hepatic concentration. Furthermore, free radical-induced lipid peroxidation was histochemically detected in the testes but not in the liver. Conclusion： The results indicate that DEHP-induced aspermatogenesis is caused by the high sensitivity of the testicular tissues to MEHP rather than the specific accumulation or uptake of circulating MEHP into the testes.

关键词： phthalatc nitrogen oxide free radical testis

Maintenance treatment with infliximab for ulcerative ileitis after intestinal transplantation: A case report

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World Journal of Clinical Cases 2021年第19期9卷 5270-5279页

作者： Takumi Fujimura Yohei Yamada Tomoshige Umeyama yumi Kudo Hiroki Kanamori Teizaburo Mori Takahiro Shimizu Mototoshi Kato Miho Kawaida Naoki Hosoe Yasushi Hasegawa Kentaro Matsubara Naoki Shimojima Masahiro Shinoda Hideaki Obara Makoto Naganuma Yuko Kitagawa Ken Hoshino Tatsuo Kuroda Department of Pediatric Surgery National Saitama HospitalWako ShiSaitama 351-0102Japan Department of Pediatric Surgery Keio University School of MedicineTokyo 160-8582Japan Department of Pathology Keio University School of MedicineTokyo 160-8582Japan Center for Diagnostic and Therapeutic Endoscopy Keio University School ofMedicineTokyo 160-8582Japan Department of Surgery Keio University School of MedicineTokyo 160-8582Japan Digestive Diseases Center International University of Health and WelfareMita HospitalTokyo 108-8329Japan Department of Gastroenterology and Hepatology Keio University School of MedicineTokyo 160-8582Japan

BACKGROUND Evidence has been published on the successful applications of the anti-tumor necrosis factor alpha antibody infliximab,such as induction therapy,salvage treatment for acute cellular rejection,and treatment for chronic ulcerative inflammation,in intestinal transplant ***,the optimal protocol for the effective use of infliximab remains largely undetermined due to scarcity of available clinical *** report a continuative application of infliximab as maintenance therapy for recurrent chronic ulcerative ileitis in a recipient of isolated intestinal transplantation(ITx).CASE SUMMARY The patient was a 11-year-old boy with intestinal motility disorder classified as a hypogenic type of intestinal *** patient underwent living-donor related intestinal *** immunosuppression regimen consisted of daclizumab,tacrolimus,and *** he did not show rejection while on tacrolimus monotherapy,routine screening endoscopy showed several ulcerative lesions in the distal end of the graft 2 years after the intestinal *** work up to evaluate the progression of anemia revealed stenosis with ulcerative inflammatory changes and multiple longitudinal ulcers in the *** the endoscopic findings suggested ulcerative lesions in Crohn’s disease,infliximab treatment was *** with infliximab and a small dose of oral prednisolone afforded successful withdrawal of total parenteral nutrition and maintenance of a well-functioning graft without infectious complications for 5 years since the administration of the first dose of *** Infliximab is effective as maintenance therapy for recurrent chronic ulcerative ileitis in an isolated ITx patient.

关键词： Intestinal transplantation Chronic ulcer Infliximab Crohn’s disease Tumor necrosis factor alpha Case report

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东京看她脸上这一抹嫣红

旅行者 2009年第6期 64-69页

作者： yumi 孙文婷(图) 蔡苗(图)

东京是多变且奇特的，但无论东京以怎样的形式展现在人们的面前，从不曾退去的，是那面颊上繁华而时尚的嫣红。

关键词：东京购物天堂城市化银座

Promoter Methylation of the CADM1 and 4.1BGenes Occurs Independently of the EGFRor the KRAS2 Mutation in Non-Small Cell Lung Cancer

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Journal of Cancer Therapy 2015年第3期6卷 273-285页

作者： Hiroyuki Kogai Shinji Kikuchi Takashi Obana yumi Tsuboi Tomoko Maruyama Mika Sakurai-Yageta Hisao Asamura Yae Kanai Yoshinori Murakami Division of Molecular Pathology Institute of Medical Science The University of Tokyo Tokyo Japan Division of Thoracic Surgery National Cancer Research Center Hospital Tokyo Japan Division of Pathology National Cancer Research Center Research Institute Tokyo Japan

Objective: Targeting mutated EGFR by EGFR-tyrosine kinase inhibitors (EGFR-TKI) is a potent approach to a subset of non-small cell lung cancer (NSCLC). However, the response to EGFR-TKI varies in individual cases even among tumors carrying the same?EGFR?mutation, suggesting the involvement of modifying factors. To characterize possible modifiers, we examined mutation state of the?EGFR?and the?KRAS?genes in Japanese NSCLC and compared them with the methylation state of lung tumor suppressors, the?CADM1 and?4.1B,?whose products have potentials to modify the functions of EGFR or KRAS. Materials and methods: A total of 103 Japanese NSCLC and 11 NSCLC cell lines were examined. Genomic DNA of exons 18–21 of the?EGFR?and exons 1 and 2 of the?KRAS?were amplified by polymerase chain reaction (PCR), followed by single-strand conformation polymorphism analysis and direct sequencing. Methylation status of gene promoters in NSCLC cells were examined by methylation-specific PCR. Results: Mutations of the?EGFR?and?KRAS?were detected mutually exclusively in 27 and 11 out of 103 NSCLC cases, respectively.?EGFR?mutations were observed exclusively in adenocarcinoma (27 of 69, 41%) and preferentially in tumors from female and non-smokers (p < 0.00001). Eight (30%) and 12 (44%) of 27 tumors carrying mutated?EGFR?and 4 (36%) and 8 (73%) of 11 tumors carrying mutated?KRAS?showed methylation of the?CADM1 and 4.1B, respectively.?EGFR-mutated tumors with methylation of either?CADM1 or 4.1B?showed more malignant features than those with unmethylated?CADM1 and 4.1B?(p < 0.05). Conclusion: Methylation state of the?CADM1 and?4.1B?are independent of the mutation status of the?EGFR?or?KRAS?but play roles in the malignant progression of NSCLC. Integration of epigenetic information would be useful for identifying possible modifiers to predict the response or recurrence of lung adenocarcinoma to the EGFR-TKI therapy.

关键词： Non-Small Cell Lung Cancer EGFR Mutation KRAS Mutation CADM1 Methylation 4.1B Methylation

“金”冬温暖巨献——上海喜乐蒂俱乐部年度聚会回顾

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宠物世界 2011年第2期 142-143页

作者： yumi Juju 咕嘟嘟 Marco

2006年,我们因喜乐蒂相识。2007年,因为喜乐蒂,我们建立了上海小喜群。2007年1 2月31日,我们举办了第一次活动……将近4年的时间,随着群内成员一天天"壮大",我相信,明年、后年、大后年,我们依然会相亲相爱地在一起!

关键词：上海俱乐部公园宝贝长时间所有人比赛草坪回顾安全

Thoracic Endovascular Aortic Repair for Cardiopulmonary Arrest Due to Aortic Dissection

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Case Reports in Clinical Medicine 2021年第11期10卷 387-392页

作者： Yoshiro Kikuoka Naoki Fujimura Yu Michiura Tomohiro Kamagata yumi Tsuchiya Shiho Irino Motojiro Takebe Yoko Sugawara Satoshi Ohtsubo Kazuhiko Sekine Department of Emergency and Critical Care Medicine Tokyo Saiseikai Central Hospital Tokyo Japan Department of Cardiovascular Surgery Tokyo Saiseikai Central Hospital Tokyo Japan

Background and Aim: Reports on recovery from Stanford type A aortic dissection (TAAD) leading to cardiopulmonary arrest (CPA) are few. In retrograde TAAD (r-TAAD) cases, some authors reported the efficacy of thoracic endovascular aortic repair (TEVAR). However, only a few reports chose TEVAR for the treatment of r-TAAD resulting in cardiac arrest before hospital arrival. We report a case of r-TAAD presenting with cardiac arrest before hospital arrival not indicated for surgery but TEVAR as treatment. Case: A 65-year-old woman with a history of Marfan syndrome presented to the emergency department after a CPA. Sequential return of spontaneous circulation was achieved 27 min after CPA. Contrast-enhanced computed tomography showed retrograde r-TAAD with an entry tear to the false lumen in the thoracic descending aorta. Therefore, thoracic endovascular aortic repair (TEVAR) was performed with r-TAAD. Afterward, the clinical course was stabilized. This patient suggests that TEVAR is an effective option for the treatment of patients with hemodynamically unstable r-TAAD, even after CPA. Conclusion: TEVAR can lead to a successful recovery from cardiac arrest due to r-TAAD.

关键词： Acute Aortic Dissection Cardiac Tamponade Cardiopulmonary Arrest on Arrival Retrograde Stanford Type A Aortic Dissection r-TAAD Thoracic Endovascular Aortic Repair TEVAR

An Online mtDNA Tool for Identification of Neotropical Psittacid Species and Taxonomic Issues:A Study Case of the Amazona ochrocephala Complex

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Natural Resources 2014年第11期5卷 634-652页

作者： Anderson Vieira Chaves Rodrigo Octavio de Paiva Queiroz-Filho Fabiano Augusto Assuncao Silva Cristina yumi Miyaki Fabricio Rodrigues dos Santos Departamento de Biologia Geral Instituto de Ciencias Biologicas(ICB)Universidade Federal de Minas GeraisBelo HorizonteBrazil Policia Federal Belo HorizonteBrazil Departamento de Genetica e Biologia Evolutiva Instituto de BiocienciasUniversidade de Sao PauloSao PauloBrazil

Parrots are among the most popular pets in the world and they are also some of the most illegally traded, particularly in Brazil. Some computational tools were recently developed by researchers based on molecular databases for taxonomy support, forensic identification and conservation purposes. In this study, the DNA Surveillance platform was used to build an online database tool for molecular identification of Brazilian Psittacids using DNA sequences of six mitochondrial genes. To illustrate possible taxonomic issues of the online tool due to interspecific hybridization or unresolved taxonomy, we focused on Amazona aestiva that is considered as one of the most common parrots in Brazil, commonly bred as pets, and considered to be part of a species complex with Amazona ochrocephala from South America. We provide three curated sequence databases, which allow the species identification of individuals or tissue samples of birds of the Psittacidae family using mitochondrial DNA markers, and a comprehensive description of a taxonomic issue involving the A. ochrocephala complex. The results obtained corroborate previous studies suggesting that these species are not reciprocally monophyletic, due to either an ancient hybridization in central Brazil, or, they maybe just are morpho-varieties of the same species. Alternatively, if A. aestiva and A. ochrocephala were considered as sister species, the data could be interpreted either as a result of secondary contact or incipient speciation. Beyond the use of mtDNA for species identification, the high mtDNA haplotype diversity observed in A. aestiva indicates its potential use in discrimination of lineages that could be an important auxiliary tool to certify the captive origin of legally commercialized parrots.

关键词： Amazona aestiva Illegal Trade of Birds Psittaciformes Phylogeography DNA-Surveillance

Improvement of Scalp Condition and Quality of Life through Proper Skin Care of Dry Scalp

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Journal of Cosmetics, Dermatological Sciences and Applications 2014年第4期4卷 284-292页

作者： Mika Oshima Maiko Sogawa Hiroshi Matsunaka yumi Murakami yumiko Saya Takashi Sugita Yoshihiro Matsudate Nozomi Fukui Kazutoshi Murao Yoshiaki Kubo Department of Dermatology Institute of Health Biosciences The University of Tokushima Graduate School Tokushima Japan Tokiwa Pharmaceutical Co. Ltd. Tokyo Japan Department of Microbiology Meiji Pharmaceutical University Tokyo Japan

Introduction: Appropriate skin care for dry scalp includes treatment for dandruff and itchiness. However, little is known about the appropriate washing methods for subjects with dry scalp. Me- thods: A scalp moisturizing lotion was used for 8 weeks on 30 outpatients at the Tokushima University Hospital who had dry scalp. All subjects were given the same hair shampoo/conditioner and instructions on how to wash their hair. Scalp symptoms were observed before and after the testing period. Indigenous bacteria were collected from the scalp for quantitative assessment. A survey was conducted to assess the quality of life (QOL). Results: All scalp condition items (dryness, scales and desquamation, itchiness, excoriation, and erythema) improved significantly after the testing period;the levels of Malassezia and bacterial colonization also decreased significantly. The QOL evaluation indicated significant improvements in “symptoms”, “emotions”, and “global” measures. A correlation was found between the extent of dryness at the start of the test and the level of Malassezia colonization, as well as QOL scores. Conclusion: Using a scalp moisturizing lo- tion, washing hair with a shampoo and conditioner that cause low irritation levels, and using a hair washing method that avoids irritation led to improvement in scalp condition, QOL, and pa- tient satisfaction.

关键词： Atopic Dermatitis Seborrheic Dermatitis Moisturizer Malassezia Bacteria qPCR

High-Sensitivity Ozone Sensing Using 280 nm Deep Ultraviolet Light-Emitting Diode for Detection of Natural Hazard Ozone

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Journal of Environmental Protection 2012年第8期3卷 695-699页

作者： Yoshinobu Aoyagi Misaichi Takeuchi Kaoru Yoshida Masahito Kurouchi Tsutomu Araki Yasushi Nanishi Hiroyasi Sugano yumi Ahiko Hirotaka Nakamura Hikari Tec 4Miura-ori Lab. 1687 kanamori Machida Tokyo Japan Miura-ori Lab. 1687 kanamori Machida Tokyo Japan Ritsumeikan University Faculty of Engineering Science 1-1-1 Noji-higashi Shiga Japan Ritsumeikan University Global Innovation Research Organization Tokyo Metropolitan Industrial Technology Research Institute 3-13-10 Nishigaoka Kitaku Tokyo Japan

Recently ozone is one of natural hazards which comes from cars, industry using ozone for sterilization of organic and inorganic materials and for water purification. So, ozone sensing becomes very important, and convenient and accurate ozone sensor is required. A new high sensitivity ozone sensing system using an deep ultra-violet light emitting diode (DUV-LED) operated at the wavelength of 280 nm has been successfully constructed. The fabrication of diode operated at 280 nm is much easier than that of DUV-LED operated at Hg lamp wavelength of 254 nm. The system is compact and possible to sense the ozone concentration less than 0.1 ppm with an accuracy of 0.5% easily with low power DUV-LED of around 200 micro Watts operated at 280 nm without any data processing circuit.

关键词： Ozone Sensing Deep Ultra Violet Light Emitting Diode DUV-LED High Sensitivity Long Life Compact