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Removal of p-Nitrophenol Using Persulfate Activated by Biochars Prepared from Different Biomass Materials

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Chemical Research in Chinese Universities 2018年第1期34卷 39-43页

作者： shi Chenfei LI yumeng FENG Haiyao JIA Shumin XUE Ruijie LI Gang WANG Guoxiang School of Environment Nanjing Normal University Nanfing 210023 P. R. China Center for Test and Analysis Nanjing Normal University Nanjing 210023 P R. China

Three biochars from wheat straw（WSC）, chicken manure（CMC） and rice husk（RHC） were prepared as persulfate（PS） activators for p-nitropheol（PNP） removal. RHC exhibitted the best adsorption performance, followed by WSC and CIVIC, which was consistant with the surface area value. PS addition further promoted the PNP removal, indicating that a synergistic effect existed in the biochar/PS combined system. The composition and textual properties of biochar had a significant effect on the reactivity of activator and the function groups containing oxgygen or nitrogen might play important roles in the reaction. WSC could perform efficiently over a pH range from 4.4 to 10.4. The decrease in activation performance in cycle experiments was possiblely related to the loss of oxgygen-containing groups.

关键词： Persulfate Bioehar, p-Nitrophenol

基于指纹图谱和网络药理学的黄芩质量标志物预测研究

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世界中医药 2022年第8期17卷 1041-1046,1051页

作者：刘静李春霞何巧玉王誉程石玉梦刘二伟陈晓鹏天津中医药大学组分中药国家重点实验室天津301617

目的:基于中药质量标志物(Q-marker)的概念,建立高效液相色谱法(HPLC)指纹图谱,并测定2种成分的含量,同时应用网络药理学方法探讨2种成分的潜在作用靶点进行反向筛选,从而确定黄芩药材的质量标志物。方法:采用HPLC建立10批黄芩药材的指... 详细信息

目的:基于中药质量标志物(Q-marker)的概念,建立高效液相色谱法(HPLC)指纹图谱,并测定2种成分的含量,同时应用网络药理学方法探讨2种成分的潜在作用靶点进行反向筛选,从而确定黄芩药材的质量标志物。方法:采用HPLC建立10批黄芩药材的指纹图谱,并进行含量测定。结合网络药理学分析有效成分的对应靶点和途径并构建“活性成分-重要靶点-通路”,探究黄芩发挥药理作用特点,预测出潜在的Q-marker。结果:建立的黄芩药材指纹图谱共标定12个共有峰,指认2个成分并确定其含量。10批样品指纹图谱与对照图谱的相似度均大于0.970。“化合物-预测靶点”网络筛选出8个关键靶点,相关9条通路,涉及到癌症通路、炎症通路、免疫通路等。结论:本研究所建立的HPLC准确、可行,筛选出2种成分可作为潜在Q-marker,以网络药理学验证黄芩主成分相关的靶点作用机制,进一步确认黄芩中黄芩苷、汉黄芩苷作为Q-marker的可行性,为黄芩质量控制提供参考。

关键词：黄芩质量标志物高效液相色谱法指纹图谱含量测定黄芩苷汉黄芩苷网络药理学

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生物质基活性炭材料的制备技术研究进展

河南化工 2023年第11期40卷 1-4页

作者：位文祥史雨蒙李前娣鲁冰雪赵振新蔡文豪张庆志河南城建学院材料与化工学院河南平顶山467000

生物质材料作为一种可再生资源,制备出的活性炭具有更高的比表面积和更强的吸附性能。生物质基活性炭的制备一般需要经过炭化和活化。介绍了几种生物质基活性炭的炭化与活化工艺,并对不同工艺的优缺点进行了分析,最后对其未来的发展方... 详细信息

生物质材料作为一种可再生资源,制备出的活性炭具有更高的比表面积和更强的吸附性能。生物质基活性炭的制备一般需要经过炭化和活化。介绍了几种生物质基活性炭的炭化与活化工艺,并对不同工艺的优缺点进行了分析,最后对其未来的发展方向进行了展望。

关键词：活性炭生物质材料炭化活化

奥西替尼二线治疗EGFR突变型晚期非小细胞肺癌的疗效观察

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临床肿瘤学杂志 2022年第3期27卷 221-226页

作者：施玥姜莹莹陈槿施雨萌陈芊颖田海霞陈诚史美琪沈波周国仁王晓华冯继锋南京医科大学附属肿瘤医院(江苏省肿瘤医院)江苏省肿瘤防治研究所肿瘤内科南京210009 中国药科大学基础药学理科基地 210009 南京医科大学附属肿瘤医院放疗科 210009

目的评价奥西替尼二线治疗表皮生长因子受体(EGFR)突变型晚期非小细胞肺癌(NSCLC)的疗效,对治疗前转移部位、耐药后进展部位与疗效间的关系进行探讨。方法收集2017年1月1日至2019年1月1日67例经1~2代EGFR-酪氨酸激酶抑制剂(EGFR-TKI)治... 详细信息

目的评价奥西替尼二线治疗表皮生长因子受体(EGFR)突变型晚期非小细胞肺癌(NSCLC)的疗效,对治疗前转移部位、耐药后进展部位与疗效间的关系进行探讨。方法收集2017年1月1日至2019年1月1日67例经1~2代EGFR-酪氨酸激酶抑制剂(EGFR-TKI)治疗和50例一线化疗后进展的晚期NSCLC患者。全组患者均存在EGFR外显子20 T790M突变阳性,均给予奥西替尼(80 mg口服,每天1次)治疗直至疾病进展或出现不可耐受的不良反应;分析总体及不同亚组间患者的疗效。结果截至2020年10月31日,117例奥西替尼受试者中有28例仍服用奥西替尼,用药最长时间达43.2个月;治疗后进展89例,其中45例死亡。全组中位无进展生存期(PFS)达15.2(95%CI:12.352~18.114)个月,中位总生存期(OS)未达。亚组分析显示,性别、一线治疗方案和治疗前转移病灶部位与PFS有关(P0.05),其中以骨转移为进展部位的患者死亡比例最高(75.0%),而肾上腺转移出现进展的患者中位PFS最短(7.1个月)。结论奥西替尼对EGFR突变阳性晚期NSCLC患者二线治疗表现出良好的疗效。一线治疗使用EGFR-TKI序贯奥西替尼比一线化疗序贯奥西替尼治疗的PFS更长,治疗前肺内与肺外均有转移者预后不良,进展部位对疗效的影响有限。

关键词：非小细胞肺癌奥西替尼表皮生长因子受体酪氨酸激酶抑制剂靶向治疗肿瘤转移

Functionalization of cellulose carbon dots with different elements(N,B and S)for mercury ion detection and anti-counterfeit applications

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Chinese Chemical Letters 2024年第7期35卷 355-359页

作者： Xiaoning Li Quanyu shi Meng Li Ningxin Song yumeng Xiao Huining Xiao Tony D.James Lei Feng Second Affiliated Hospital of Dalian Medical University Dalian 116023China Hebei Key Lab of Power Plant Flue Gas Multi-Pollutants Control Department of Environmental Science and EngineeringNorth China Electric Power UniversityBaoding 071003China Department of Chemical Engineering and Limerick Pulp&Paper Centre University of New Brunswick15 Dineen DriveFredericton NB E3B 5A3Canada Department of Chemistry University of BathBath BA27AYUnited Kingdom School of Chemistry and Chemical Engineering Henan Normal UniversityXinxiang 453007China

Mercury ion(Hg^(2+)),as one of the most toxic heavy metal ions,accumulates easily in the environment,which can generate potential hazards to the ecosystem and human *** effectively detect and remove Hg^(2+),we fabricated four types of carbon dots(CDs)using carboxymethyl nanocellulose as a carbon source doped with different elements using a hydrothermal *** the CDs exhibited a strong fluorescence emission,excitation-dependent emission and possessed good water ***,the four fluorescent CDs were used for Hg^(2+)recognition in aqueous solution,where the CDs-N exhibited better sensitivity and selectivity for Hg^(2+)detection,with a low limit of detection of 8.29×10^(-6)mol/*** was determined that the fluorescence quenching could be ascribed to a photoinduced charge-transfer processes between Hg^(2+)and the *** addition,the CDs-N were used as a smart invisible ink for anticounterfeiting,information encryption and ***,the CDs-N were immersed into a cellulose(CMC)-based hydrogel network to prepare fluorescent hydrogels capable of simultaneously detecting and adsorbing Hg^(2+).We anticipate that this research will open possibilities for a green method to synthesize fluorescent CDs for metal ion detection and fluorescent ink production.

关键词： Carbon dots Functional groups Hg^(2+)detection Mechanism Anti-counterfeiting

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混合果汁发酵饮料的研制

农产品加工 2024年第8期 5-9页

作者：王付转史雨梦魏培培王奥雪管若彤王孟姑罗宇王喜凤河南工业大学生物工程学院河南郑州450001

以梨、苹果和葡萄为主要原料,研究复合乳酸菌发酵果汁生产工艺。首先确定护色条件和水果组合,再确定乳酸菌种类,然后用正交试验设计对发酵工艺进行优化,最后进行口味调配和组织稳定性的研究。结果表明,护色剂用0.4 g/100 mL抗坏血酸,苹... 详细信息

以梨、苹果和葡萄为主要原料,研究复合乳酸菌发酵果汁生产工艺。首先确定护色条件和水果组合,再确定乳酸菌种类,然后用正交试验设计对发酵工艺进行优化,最后进行口味调配和组织稳定性的研究。结果表明,护色剂用0.4 g/100 mL抗坏血酸,苹果∶梨∶葡萄∶水配比为1∶2∶1∶5,保加利亚乳杆菌、嗜热链球菌和乳双歧杆菌为最适菌种组合,最佳发酵工艺条件为接种量1%,发酵温度35℃,发酵时间48 h,初始pH值6.5,蜂蜜添加量1.0%,白砂糖添加量1.5%,羧甲基纤维素钠(CMC-Na)、海藻酸钠、黄原胶添加量各0.04%进行口味和组织状态调配。制得的发酵果汁风味宜人,具有较好的营养和保健功能。

关键词：混合果汁乳酸菌发酵饮料发酵工艺感官评价

An Efficient Probe for Bacterial Nitroreductase Imaging and Detection Based on NanoLuc-Furimazine Bioluminescent Pair

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Chinese Journal of Chemistry 2024年第12期42卷 1373-1380页

作者： Ximeng shi yumeng Wang Jiaoyang Yu Yating Yang Zecheng Jin Hanghang Wang Dalei Wu Wei Chen Jianming Guo Yinan Zhang Jiangsu Key LaboratoryforFunctional Substances of Chinese Medicine School of PharmacyNanjing Universityof Chinese MedicineNanjingJiangsu210023China Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization School of PharmacyNanjing University of ChineseMedicineNanjingJiangsu210023China Clinical Research Center the Second Hospital of NanjingAffiliated Hospital to Nanjing University of Chinese MedicineNanjingJiangsu210003China Key Laboratory of Resources Biology and Biotechnology in Western China Ministry of EducationCollege of Life SciencesNorthwestUniversityXi'anShaanxi710069China Helmholtz International Lab State Key Laboratoryof Microbial TechnologyShandong UniversityQingdaoShandong 266237China

Comprehensive SummaryThe detection of critical endogenous species, such as bacteria in microenvironments in the body, requires better imaging tools for visualization and monitoring of biological events. Bioluminescence imaging is the most popular strategy for obtaining real-time in living cells and organisms. Herein, we introduced a nitroaryl group on the C-3 position and a hydroxy group at the C-6 phenyl ring on furimazine to report the first bioluminescent probe (7) based on NanoLuc-furimazine bioluminescent pair for the detection of nitroreductase in bacteria. The probe, which possessed up to 560-fold intensity increase with a low detection limit of 16 ng/mL of nitroreductase, has the most efficient uncage efficiency in comparison with other bioluminescent congeners, thus enabling highly selective and sensitive visualization of NTR activity in a panel of clinical priority pathogens. Additionally, imaging of the recombinant strain as well as the NTR from mouse feces indicated the potential of this probe in the application of different mouse disease models.

关键词： Nitroreductase NanoLuc-furimazine Biosensors Analytical methods Luminescence Imaging agents

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工业共生网络的复杂性度量及案例分析

清华大学学报（自然科学版） 2008年第9期48卷 1441-1444页

作者：宋雨萌石磊清华大学环境科学与工程系国家环境保护生态工业重点实验室北京100084

以物质/能量关联所刻画的工业共生网络是否具有复杂性特征是工业生态学领域值得探讨的重要问题。运用网络复杂性度量方法,以丹麦Kalundborg和河南省巩义市为案例,分析了区域工业共生网络的复杂性特征。分析结果表明:Kalundborg系统不体... 详细信息

以物质/能量关联所刻画的工业共生网络是否具有复杂性特征是工业生态学领域值得探讨的重要问题。运用网络复杂性度量方法,以丹麦Kalundborg和河南省巩义市为案例,分析了区域工业共生网络的复杂性特征。分析结果表明:Kalundborg系统不体现复杂性,而巩义市系统则体现复杂性;与真实世界中很多复杂网络的度量结果相一致,巩义市工业共生系统体现出小世界性和无标度性,且高度数节点出现几率高于普通复杂网络;根据度量指标测算结果,巩义市工业共生系统与某些神经网络、代谢网络和生态链网具有相似性。

关键词：工业共生网络网络复杂性复杂网络

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Suboptimal reporting of randomized controlled trials on non-pharmacological therapies in Chinese medicine

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Frontiers of Medicine 2024年第5期18卷 798-813页

作者： Xuan Zhang Han Li Hanzhi Tan Nana Wang Chung Wah Cheng Juan Wang Dongni shi Lin Zhang yumeng Liu Yao Wang Shufeng Luo Yaxin Lin Lihan Hu Xuanqi Zhang Ji Li Fei Han Ping Wang Aiping Lyu Zhaoxiang Bian Chinese EQUATOR Centre Hong Kong Baptist UniversityHong Kong 999077China Vincent V.C.Woo Chinese Medicine Clinical Research Institute Hong Kong Baptist UniversityHong Kong 999077China Centre for Chinese Herbal Medicine Drug Development School of Chinese MedicineHong Kong Baptist UniversityHong Kong 999077China School of Chinese Medicine Hong Kong Baptist UniversityHong Kong 999077China Tianjin University of Traditional Chinese Medicine Tianjin 300193China Department of Pediatrics Guang’anmen HospitalChina Academy of Chinese Medical SciencesBeijing 100053China Xiyuan Hospital China Academy of Chinese Medical SciencesBeijing 100091China

With the successive release of the CONSORT extensions for acupuncture,moxibustion,cupping,and Tuina/massage,this review aims to assess the reporting characteristics and quality of randomized controlled trials(RCTs)based on these specific guidelines.A comprehensive review was conducted by searching multiple databases,including Embase,Ovid MEDLINE(R),All EBM Reviews,AMED,CNKI,VIP Chinese Medical Journal Database,and Wanfang Data,for publications from January 1 to December 31,*** reviewers independently evaluated the eligibility of the records,extracted predetermined information,and assessed the reporting based on the STRICTA,STRICTOM,STRICTOC,and STRICTOTM *** the included 387 studies(acupuncture,213;Tuina/massage,85;moxibustion,73;cupping,16),the overall reporting compliance averaged 56.0%,with acupuncture leading at 62.6%,followed by cupping(60.2%),moxibustion(53.1%),and Tuina/massage(47.9%).About half of the evaluated items showed poor reporting(compliance rate<65%).Notably,international journals demonstrated significantly higher reporting quality than Chinese journals(P<0.05).Although acupuncture trials had relatively higher compliance rates,deficiencies persist in reporting non-pharmacological therapies of Chinese medicine,particularly in areas like treatment environment details and provider background information.

关键词： CONSORT Chinese medicine reporting guideline STRICTA STRICTOM STRICTOC STRICTOTM