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Cross-Modal Interaction and Integration Through Stimulus-Specific Adaptation in the Thalamic Reticular Nucleus of Rats

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Neuroscience Bulletin 2022年第7期38卷 785-795页

作者： yumei gong Yuying Zhai Xinyu Du Peirun Song Haoxuan Xu Qichen Zhang Xiongjie Yu Department of Neurology of the Second Affiliated Hospital of Zhejiang University School of MedicineInterdisciplinary Institute of Neuroscience and TechnologyCollege of Biomedical Engineering and Instrument ScienceZhejiang UniversityHangzhou 310029China Key Laboratory for Biomedical Engineering of Ministry of Education Zhejiang UniversityHangzhou 310027China Zhejiang Provincial Key Laboratory of Cardio-Cerebral Vascular Detection Technology and Medicinal Effectiveness Appraisal Zhejiang UniversityHangzhou 310027China

Stimulus-specific adaptation(SSA),defined as a decrease in responses to a common stimulus that only partially generalizes to other rare stimuli,is a widespread phenomenon in the brain that is believed to be related to novelty detection.Although cross-modal sensory processing is also a widespread phenomenon,the interaction between the two phenomena is not well understood.In this study,the thalamic reticular nucleus(TRN),which is regarded as a hub of the attentional system that contains multi-modal neurons,was investigated.The results showed that SSA existed in an interactive oddball stimulation,which mimics stimulation changes from one modality to another.In the bimodal integration,SSA to bimodal stimulation was stronger than to visual stimulation alone but similar to auditory stimulation alone,which indicated a limited integrative effect.Collectively,the present results provide evidence for independent cross-modal processing in bimodal TRN neurons.

关键词： Stimulus-specific adaptation Regularity:Novelty detection Thalamic reticular nucleus Crossmodal

General FIR Filter Design with Linear Phase in Passband by Water Cycle Algorithm

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Journal of Computer and Communications 2018年第11期6卷 326-331页

作者： Haijiang Hu Shaojing Song yumei gong College of Engineering Shanghai Polytechnic University Shanghai China

FIR filter is an important type of filter in the field of signal processing because of its inherent stability, simpler structure, and easier implementation on linear phase. WCA is used to solve FIR filter design with low magnitude error and linear phase in passband. This method uses WCA to optimize the filter coefficient based on the low magnitude errors in all frequency domains. Moreover, in the constraint conditions, the least group delay in passband is used for the optimization. The experiments testify this method has good performance on the passband error and group delay error in the passband. Therefore this method is an efficient algorithm for FIR filter optimization which can be used in the digital signal processing widely.

关键词： FIR WCA Linear Phase Optimization

基于CFD数值模拟的汽车中冷器流动均匀性研究

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小型内燃机与车辆技术 2024年第1期53卷 11-16页

作者：张辉王鹏超徐慧龚玉梅陈基岩台州职业技术学院汽车学院浙江台州318000 台州职业技术学院汽车关键零部件精益智造研究所浙江银轮机械股份有限公司

针对汽车中冷器内流道气体流动均匀性差的问题,提出了一种在中冷器气室安装导流板的中冷器结构优化方案。基于CFD数值模拟,对中冷器内部气体质量流量分布、速度场和压力场进行了分析,通过风洞试验验证了仿真模型的有效性。在此基础上,... 详细信息

针对汽车中冷器内流道气体流动均匀性差的问题,提出了一种在中冷器气室安装导流板的中冷器结构优化方案。基于CFD数值模拟,对中冷器内部气体质量流量分布、速度场和压力场进行了分析,通过风洞试验验证了仿真模型的有效性。在此基础上,研究了气室导流板对中冷器内流道气体流动均匀性的影响。研究结果表明:合理设置导流板,中冷器各散热管气体平均质量流量偏差由7.66%减小到3.20%,中冷器许用环境温度提高了0.84℃,气室压力损失减少了37.4%,改善了中冷器内流道气体流动均匀性,提高了散热性能,避免了芯体热应力集中,减少了可靠性失效风险。此中冷器结构优化方案可为中冷器流动均匀性研究提供参考。

关键词：中冷器流动均匀性气室导流板散热性能

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重型卡车散热器失效分析及优化研究

机械制造与自动化 2024年第1期53卷 55-60页

作者：张辉夏航王鹏超徐慧龚玉梅陈天锋台州职业技术学院汽车学院浙江台州318000 台州职业技术学院汽车关键零部件精益智造研究所浙江台州318000 浙江工业大学浙江杭州310014 浙江银轮机械股份有限公司浙江台州317200

针对重型卡车铝塑管带式散热器泄漏失效问题,根据疲劳失效机理分析,优化设计塑料水室、主板、散热管、侧板等散热器核心零件。利用有限元仿真进行耐压分析和热-结构耦合分析。仿真结果表明:在压力交变载荷和温度交变载荷作用下,散热器... 详细信息

针对重型卡车铝塑管带式散热器泄漏失效问题,根据疲劳失效机理分析,优化设计塑料水室、主板、散热管、侧板等散热器核心零件。利用有限元仿真进行耐压分析和热-结构耦合分析。仿真结果表明:在压力交变载荷和温度交变载荷作用下,散热器各组成零件的最大变形量和最大应力值分布点与实际失效区域吻合,验证了有限元模型和仿真分析的准确性,对比材料疲劳寿命曲线,优化后散热器的应变、应力值小于设计安全值。对散热器样件进行压力脉冲试验和冷热循环试验,结果满足主机厂设计要求。

关键词：铝塑管带式散热器疲劳失效有限元分析压力脉冲冷热循环

Single-cell transcriptomic analysis reveals transcript enrichment in oxidative phosphorylation,fluid sheer stress,and inflammatory pathways in obesity-related glomerulopathy

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Genes & Diseases 2024年第4期11卷 314-326页

作者： Yinyin Chen Yushun gong Jia Zou Guoli Li Fan Zhang Yiya Yang yumei Liang Wenni Dai Liyu He Hengcheng Lu Department of Nephrology Hunan Provincial People's HospitalThe First Affliated Hospital of Hunan Normal UniversityHunan Clinical Research Center for Chronic Kidney DiseaseChangshaHunan 410000China Department of Nephrology The Second Xiangya Hospital of Central South UniversityHunan Key Laboratory of Kidney Disease and Blood PurificationChangshaHunan 410011China Cardiovascular Research Institute of Jiangxi Province Jiangxi Provincial People's HospitalThe First Affiliated Hospital of Nanchang Medical CollegeNanchangJiangxi 330006China

Obesity-related glomerulopathy(ORG)is an independent risk factor for chronic kid-ney disease and even progression to end-stage renal disease.Efforts have been undertaken to elucidate the mechanisms underlying the development of ORG and substantial advances have been made in the treatment of ORG,but relatively little is known about cell-specific changes in gene expression.To define the transcriptomic landscape at single-cell resolution,we analyzed kidney samples from four patients with ORG and three obese control subjects without kidney disease using single-cell RNA sequencing.We report for the first time that immune cells,including T cells and B cells,are decreased in ORG patients.Further analysis indicated that SPP1 was significantly up-regulated in T cells and B cells.This gene is related to inflammation and cell proliferation.Analysis of differential gene expression in glomerular cells(endothelial cells,mesangial cells,and podocytes)showed that these cell types were mainly enriched in genes related to oxidative phosphorylation,cell adhesion,thermogenesis,and inflammatory pathways(PI3K-Akt signaling,MAPK signaling).Furthermore,we found that the podocytes of ORG patients were enriched in genes related to the fluid shear stress pathway.Moreover,an evaluation of cell-cell communications revealed that there were interactions between glomerular parietal epithelial cells and other cells in ORG patients,with major interactions between parietal epithelial cells and podocytes.Altogether,our identification of molecular events,cell types,and differentially expressed genes may facilitate the development of new preventive or therapeutic approaches for ORG.

关键词： Fluid shear stress Inflammation Obesity-related glomerulopathy Oxidative phosphorylation Single-cell RNA seq

Study on Online Teaching of High Frequency Circuit under COVID-19 Epidemic

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Study on Online Teaching of High Frequency Circuit under COV...

作者： Haijiang Hu Shaojing Song Yu Chai yumei gong College of Engineering Shanghai Polytechnic University

Most schools close their campus for the safety of students and teachers under COVID-19 epidemic. Online teaching is used in most schools and universities widely in spring term 2020. This paper studies on the online teaching method and results in online teaching of high frequency circuit, which is useful for online teaching of electronic engineering. In the online class, we use the discussion as the main method instead of the lecture. Students study the course contents before class. Most students are satisfied with the online teaching method. This online teaching method should be applied in other courses teaching in online university education.

关键词： Online Teaching High Frequency Circuit Electronic Engineering Simulation COVID-19

来源： cnki会议评论

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抗菌聚酰胺纤维的研究进展

化工新型材料 2023年第3期51卷 68-72页

作者：朱旭宫玉梅何欣欣郝新敏大连工业大学纺织与材料工程学院大连116034 优纤科技(丹东)有限公司丹东118303 总后勤部军需装备研究所北京100010

聚酰胺(PA)材料强度高,耐磨性好,主要应用于机械、化工、医疗等工业中制造零件以及用于军用织物。但如今单一的聚酰胺产品不足以满足产业发展的需求,需要赋予聚酰胺特殊的功能。聚酰胺纤维的功能化有助于提升纤维产品的价值以及在产业... 详细信息

聚酰胺(PA)材料强度高,耐磨性好,主要应用于机械、化工、医疗等工业中制造零件以及用于军用织物。但如今单一的聚酰胺产品不足以满足产业发展的需求,需要赋予聚酰胺特殊的功能。聚酰胺纤维的功能化有助于提升纤维产品的价值以及在产业化方面的应用,以聚酰胺纤维改性的基础理论为出发点,重点讨论了近年来无机抗菌剂、有机抗菌剂、天然抗菌剂等改性聚酰胺(PA)纤维的研究现状,并对抗菌功能性聚酰胺纤维未来的研究重点和发展进行了展望。

关键词：聚酰胺纤维复合材料功能化抗菌纤维

中国中老年人群甘油三酯葡萄糖指数-腰围身高比与认知障碍关联的队列研究

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中华流行病学杂志 2024年第6期45卷 802-808页

作者：侯丁淳魏玥孙玉梅裴丽君陈功北京大学人口研究所北京100871 北京大学护理学院北京100191 北京大学中国老龄事业发展研究中心北京100871

目的分析中老年人中甘油三酯葡萄糖指数(TyG)-腰围身高比(WHtR)(TyG-WHtR)与认知障碍的关联。方法应用中国健康与养老追踪调查数据,以2011年和2015年的8946名中老年人为基线人群,构建队列数据库。应用Cox比例风险回归模型估计中老年人基... 详细信息

目的分析中老年人中甘油三酯葡萄糖指数(TyG)-腰围身高比(WHtR)(TyG-WHtR)与认知障碍的关联。方法应用中国健康与养老追踪调查数据,以2011年和2015年的8946名中老年人为基线人群,构建队列数据库。应用Cox比例风险回归模型估计中老年人基线TyG-WHtR不同水平与认知障碍风险的关联,并分别进行年龄和性别分层分析。结果8946名研究对象平均随访7.08人年,认知障碍发病密度为21.15/1000人年。与TyG-WHtR的Q1水平相比,其Q3和Q4水平分别使认知障碍风险增加32%(HR=1.32,95%CI:1.09~1.60)和47%(HR=1.47,95%CI:1.14~1.91)。趋势检验显示,认知障碍风险随TyG-WHtR水平升高而增加,且存在剂量-反应关系(P=0.001)。分层分析显示,45~59岁人群中,与TyG-WHtR的Q1水平相比,其Q3水平使认知障碍风险增加34%(HR=1.34,95%CI:1.02~1.78);≥60岁人群中,相比于TyG-WHtR的Q1水平,其Q3和Q4水平分别使认知障碍风险增加31%(HR=1.31,95%CI:1.01~1.72)和63%(HR=1.63,95%CI:1.15~2.31);男性中,TyG-WHtR水平与认知障碍风险无统计学关联(P>0.05);女性中,相比于TyG-WHtR的Q1水平,其Q4水平使认知障碍风险增加76%(HR=1.76,95%CI:1.26~2.46)。结论中老年人中较高的TyG-WHtR水平可增加认知障碍风险,且存在年龄、性别差异,早期的心血管健康管理和科学合理的体重管理对预防认知障碍具有重要意义。

关键词：认知障碍甘油三酯葡萄糖指数-腰围身高比队列研究中老年人

生物基聚酰胺56分子质量及其Mark-Houwink方程参数的测定

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纺织学报 2022年第7期43卷 36-40页

作者：王莉娟宫玉梅李晓妍王迎郝新敏樊丽君大连工业大学纺织与材料工程学院辽宁大连116034 军事科学院系统工程研究院军需工程技术研究所北京100010 优纤科技(丹东)有限公司辽宁丹东118303

为了使研究者能够快速对合成的生物基聚酰胺56(PA56)分子质量做出评价,通过对一系列生物基PA56样品分子质量和溶液流动性的测定,计算生物基PA56的Mark-Houwink方程分子质量参数K和α。分别以90%甲酸(FA)和六氟异丙醇(HFIP)为溶剂溶解生... 详细信息

为了使研究者能够快速对合成的生物基聚酰胺56(PA56)分子质量做出评价,通过对一系列生物基PA56样品分子质量和溶液流动性的测定,计算生物基PA56的Mark-Houwink方程分子质量参数K和α。分别以90%甲酸(FA)和六氟异丙醇(HFIP)为溶剂溶解生物基PA56,测定其稀溶液在25℃时的特性黏度。结果表明:在与PA56能形成强氢键的溶剂FA中,使用其比浓黏度极限值作为特性黏度数值是合理的,而在能与PA56形成较弱氢键的溶剂HFIP中,其比浓黏度和比浓对数黏度极限值交于一点,该点即为特性黏度;通过Mark-Houwink方程计算得到生物基PA56在FA中的分子质量参数α为0.77,K为7.088×10^(-3) cm^(3)/g,在HFIP中α为0.90,K为2.140×10^(-3) cm^(3)/g。

关键词：生物基聚酰胺56 Mark-Houwink方程参数六氟异丙醇甲酸特性黏度