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Extracellular vesicles-coupled miRNAs from oviduct and uterus modulate signaling pathways related to lipid metabolism and bovine early embryo development

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Journal of Animal Science and Biotechnology 2024年第4期15卷 1528-1549页

作者： Rosane Mazzarella Karina Canon‑Beltran yulia N.Cajas Meriem Hamdi Encina M.Gonzalez Juliano C.da Silveira Claudia L.v.Leal D.Rizos Department of Animal Reproduction INIA-CSICMadridSpain Department of Biochemistry and Molecular Biology Veterinary FacultyComplutense University of Madrid(UCM)MadridSpain Department Agrarian Production Technical University of MadridUPMMadridSpain Departamento de Ciencias Biologicas Universidad Tecnica Particular de LojaUTPLLojaEcuador Department of Anatomy and Embryology FV-UCMMadridSpain Department of veterinary Medicine FZEA-USPPirassunungaBrazil

Background Extracellular vesicles(Evs) present in oviductal(OF) and uterine fluid(UF) have been shown to enhance bovine embryo quality during in vitro culture by reducing lipid contents and modulating lipid metabolism-related genes(LMGs), while also influencing cell proliferation, suggesting their involvement on the regulation of different biological pathways. The regulation of signaling pathways related to cell differentiation, proliferation, and metabo-lism is crucial for early embryo development and can determine the success or failure of the pregnancy. Bioactive molecules within Evs in maternal reproductive fluids, such as micro RNAs(miRNAs), may contribute to this regulatory process as they modulate gene expression through post-transcriptional *** This study evaluated miRNA cargo in OF-Evs from the early luteal phase and UF-Evs from the mid-luteal phase, coinciding with embryo transit within oviduct and uterus in vivo, and its possible influence on LMGs and sign-aling pathways crucial for early embryo development. A total of 333 miRNAs were detected, with 11 exclusive to OF, 59 to UF, and 263 were common between both groups. From the 20 differentially expressed miRNAs, 19 up-regulated in UF-Evs(bta-miR-134, bta-miR-151-3p, bta-miR-155, bta-miR-188, bta-miR-181b, bta-miR-181d, bta-miR-224, bta-miR-23b-3p, bta-miR-24-3p, bta-miR-27a-3p, bta-miR-29a, bta-miR-324, bta-miR-326, bta-miR-345-3p, bta-miR-410, bta-miR-652, bta-miR-677, bta-miR-873 and bta-miR-708) and one(bta-miR-148b) in OF-Evs. These miRNAs were predicted to modulate several pathways such as Wnt, Hippo, MAPK, and lipid metabolism and degradation. Differ-ences in miRNAs found in OF-Evs from the early luteal phase and UF-Evs from mid-luteal phase may reflect differ-ent environments to meet the changing needs of the embryo. Additionally, miRNAs may be involved, particularly in the uterus, in the regulation of embryo lipid metabolism, immune system, and *** Our study su

关键词： Embryo-maternal interaction Epigenetic Exosomes Mammalian Preimplantation Reproductive fluids

Olefin Polymerization Behavior of Titanium(Iv) Complexes with Fluorinated and Non-fluorinated Aliphatic Phenoxyimine Ligands

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Chinese Journal of Polymer Science 2024年第1期42卷 52-62,I0007页

作者： vladislav A.Tuskaev Kasim F.Magomedov Svetlana Ch.Gagieva Dmitry A.Kurmaev yulia v.Nelyubina Evgenii K.Golubev Maria D.Evseeva viktor G.vasil'ev Galina G.Nikiforova Mikhail I.Buzin vyacheslav S.Bogdanov Boris M.Bulychev Department of Chemistry M.V.Lomonosov Moscow State UniversityMoscow 119992Russian Federation A.N.Nesmeyanov Institute of Organoelement Compounds Russian Academy of SciencesMoscow119991Russian Federation Enikolopov Institute of Synthetic Polymer Materials Russian Academy of SciencesMoscow 117393Russian Federation

A series of Ti(Ⅳ) dichloride and dialkoxide com plexes with phenoxyimine ligands containing fluorinated and nonfluorinated aliphatic imine fragments have been *** molecular structures of complexes 1 and 4 were established by single-crystal X-ray diffraction *** complexes adopt a distorted octahedral coordination structure around the titanium atom and two oxygen atoms are situated in trans position while two nitrogen atoms and two outgoing ligands(Cl or iPrO) are situated in cis *** of activators(MMAO-12 and combinations Et_nAICl_(3-n)+Bu_(2)Mg) and outgoing ligand(Cl or iPrO) nature on the catalytic activity and properties of the resulting polymers was *** Ti complexes,despite the nature of the outgoing ligands(Cl or iPrO) in the presence of Al/Mg activators,was found to display a high ethylene polymerization activity in the range 1600-3830 kg_(polymer)·mol_(Ti)^(-1)·h^(-1)·atm^(-1) with a viscosity average molecular weight(M_v) value in the range 1.1×10~6-7.1×10~6 Dalton(Da).The resulting UHMWPE can be processed by a solventless method into high-strength and high-modulus oriented *** rheological characteristics of a polymer melt have been *** absence of a cross-over point did not allow to compare the values of the molecular weight distribution of polymers obtained on fluorinated and non-fluorinated pre-catalysts,however,the estimation of the entanglement density is in good agreement with the mechanical characteristics of oriented film *** activation with methylalumoxane,the activity of the com plexes decreased very significantly;however,a polymer with a molecular weight of about 12 million Da was *** the process of ethylene/octene-1 copolymerization,fluorine-containing precatalysts showed a clear advantage over non-fluorinated analogues both in activity and in comonomer content.

关键词： FI catalysts Titanium(Iv) (Co)polymerization Al/Mg co-catalyst Ultra-high molecular weight polyethylene

Growth of Micropropagated Solanum tuberosum *** under Artificial Solar Spectrum and Different Mono-and Polychromatic LED Lights

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Horticultural Plant Journal 2022年第2期8卷 205-214页

作者： Olga v.Grishchenko Eugeny P.Subbotin Irina v.Gafitskaya yulia v.vereshchagina Elena v.Burkovskaya yulia A.Khrolenko valeria P.Grigorchuk Olga v.Nakonechnaya victor P.Bulgakov Yuri N.Kulchin Federal Scientific Center of the East Asia Terrestrial Biodiversity Far Eastern Branch of the Russian Academy of SciencesVladivostok 690022Russia Institute of Automation and Control Processes Far Eastern Branch of the Russian Academy of SciencesVladivostok 690041Russia

In agriculture,LED light sources have increasingly replaced the standard luminescent lamps and have acquired an important role in plant *** studied the effect of different light sources such as narrow-band LEDs(bright blue,blue,green,yellow,deep red,and red)and wide-band LEDs(cold white,white,warm white,full spectrum,and an artificial solar spectrum sun box constructed by us)on development of potato plantlets in *** luminescent lamps were used as a *** light intensity of 49μmol·m^(-2)·s^(-1)was provided in all light *** showed that the long-wave narrow-band light treatments were inapplicable for potato micropropagation,because plantlets were weak with small leaves,inhibited roots,and significantly elongated *** lights provided growth of shortened plantlets with large leaves,well-growing roots,and abundant green *** chlorophyll content was lower under blue and bright blue light and was at the same level in the remained *** differences in the stomatal apparatus development were observed depending on the light *** differences were not always reflected in the plantlet phenotype:e.g.,plantlets under blue and bright blue lights showed no differences in any characteristics except stomatal density and size of stomatal guard *** found no significant effect of blue light portion in the white lights and full spectrum on plantlet *** artificial solar spectrum sun box was the most suitable for potato micropropagation,because it supported the development of plantlets with good fitness,uniform internodes length,abundant roots and green mass accumulation.

关键词： Solanum tuberosum LED Artificial solar light Growth Micropropagation

Experimental and ab initio study of Ba_(2)Na_(3)(B_(3)O_(6))_(2)F stability in the pressure range of 0–10 GPa

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International Journal of Minerals,Metallurgy and Materials 2023年第9期30卷 1846-1854页

作者： Nursultan E.Sagatov Tatyana B.Bekker yulia G.vinogradova Alexey v.Davydov Ivan v.Podborodnikov Konstantin D.Litasov Sobolev Institute of Geology and Mineralogy Siberian Branch of Russian Academy of SciencesNovosibirsk 630090Russia Department of Geology and Geophysics Novosibirsk State UniversityNovosibirsk 630090Russia Research and Development Department Novosibirsk State University of ArchitectureDesign and Arts(NSUADA)Novosibirsk 630099Russia vereshchagin Institute for High Pressure Physics Russian Academy of SciencesTroitsk 108840Russia Fersman Mineralogical Museum Russian Academy of SciencesMoscow 119071Russia

Both numerical and experimental studies of the stability and electronic properties of barium–sodium metaborate Ba_(2)Na_(3)(B_(3)O_(6))_(2)F(P63/m) at pressures up to 10 GPa have been carried out. Electronic-structure calculations with HSE06 hybrid functional showed that Ba_(2)Na_(3)(B_(3)O_(6))_(2)F has an indirect band gap of 6.289 ev. A numerical study revealed the decomposition of Ba_(2)Na_(3)(B_(3)O_(6))_(2)F into the BaB_(2)O_(4),Na BO_(2), and NaF phases above 3.4 GPa at 300 K. Subsequent high-pressure high-temperature experiments performed using ‘Discoverer-1500’DIA-type apparatus at pressures of 3 and 6 GPa and temperature of 1173 K confirmed the stability of Ba_(2)Na_(3)(B_(3)O_(6))_(2)F at 3 GPa and its decomposition into BaB_(2)O_(4), NaBO_(2), and NaF at 6 GPa, which was verified by energy-dispersive X-ray analysis and Raman spectroscopy. The observed Raman bands of the Ba_(2)Na_(3)(B_(3)O_(6))_(2)F phase were assigned by comparing the experimental and calculated spectra. The experimental Raman spectra of decomposition reaction products obtained at 6 GPa suggest the origin of a new high-pressure modification of barium metaborate BaB_(2)O_(4).

关键词： density functional theory phase stability borate high pressure Raman spectroscopy

Machine learning-driven synthesis of TiZrNbHfTaC_(5) high-entropy carbide

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npj Computational Materials 2023年第1期9卷 2293-2303页

作者： Alexander Ya.Pak vadim Sotskov Arina A.Gumovskaya Yuliya Z.vassilyeva Zhanar S.Bolatova yulia A.Kvashnina Gennady Ya.Mamontov Alexander v.Shapeev Alexander G.Kvashnin National Research Tomsk Polytechnic University 30 Lenin AvenueTomsk 634050Russia Skolkovo Institute of Science and Technology Skolkovo Innovation CenterBolshoi Blv.30Building 1Moscow 121205Russia Pirogov Russian National Research Medical University 1 Ostrovityanova St.Moscow 117997Russia

Synthesis of high-entropy carbides(HEC)requires high temperatures that can be provided by electric arc plasma ***,the formation temperature of a single-phase sample remains ***,under some temperatures multi-phase structures can *** this work,we developed an approach for a controllable synthesis of HEC TiZrNbHfTaC_(5) based on theoretical and experimental *** used Canonical Monte Carlo(CMC)simulations with the machine learning interatomic potentials to determine the temperature conditions for the formation of single-phase and multi-phase *** full agreement with the theory,the single-phase sample,produced with electric arc discharge,was observed at 2000 *** 1200 K,the sample decomposed into(Ti-Nb-Ta)C,and a mixture of(Zr-Hf-Ta)C,(Zr-Nb-Hf)C,(Zr-Nb)C,and(Zr-Ta)*** results demonstrate the conditions for the formation of HEC and we anticipate that our approach can pave the way towards targeted synthesis of multicomponent materials.

关键词： carbide materials

Intestinal microbiome changes in an infant with right atrial isomerism and recurrent necrotizing enterocolitis:A case report and review of literature

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World Journal of Clinical Cases 2022年第29期10卷 10583-10599页

作者： Aleksandra Kaplina Ekaterina Zaikova Artem Ivanov yulia volkova Tatiana Alkhova vladimir Nikiforov Alexander Latypov Marina Khavkina Tatiana Fedoseeva Tatiana Pervunina yulia Skorobogatova Svetlana volkova vladimir Ulyantsev Olga Kalinina Stanislav Sitkin Natalia Petrova Research Laboratory of Physiology and Diseases of Newborns Almazov National Medical Research CentreSt.Petersburg 197341Russia Research Laboratory of Autoimmune and Autoinflammatory Diseases Almazov National Medical Research CentreSt.Petersburg 197341Russia vladimir Ulyantsev International Laboratory of Computer TechnologiesITMO UniversitySt.Petersburg 197101Russia Department of Cardiovascular Surgery for Children Almazov National Medical Research CentreSt.Petersburg 197341Russia Department of Neonatal Physiology with an ICU Ward Almazov National Medical Research CentreSt.Petersburg 197341Russia Pediatric Cardiac Intensive Care Unit Almazov National Medical Research CentreSt.Petersburg 197341Russia Neonatal and Preterm Special Care Unit(2nd Stage Care) Almazov National Medical Research CentreSt.Petersburg 197341Russia Institute of Perinatology and Pediatrics Almazov National Medical Research CentreSt.Petersburg 197341Russia Express Laboratory of Perinatal Centre Almazov National Medical Research CentreSt.Petersburg 197341Russia Clinical Diagnostic Laboratory Almazov National Medical Research CentreSt.Petersburg 197341Russia Epigenetics and Metagenomics Group Institute of Perinatology and PediatricsAlmazov National Medical Research CentreSt.Petersburg 197341Russia Department of Internal Diseases Gastroenterology and DieteticsNorth-Western State Medical University named after I.I.MechnikovSt.Petersburg 191015Russia

BACKGROUND Necrotizing enterocolitis(NEC)is a multifactorial disease that predominantly affects premature *** dysbiosis plays a critical role in NEC pathogenesis in premature *** main risk factor for NEC in term infants is mesenteric hypoperfusion associated with ductaldependent congenital heart disease(CHD)that eventually leads to intestinal *** incidence of NEC in neonates with critical CHD is 6.8%-13%.However,the role of the intestinal microbiome in NEC pathogenesis in infants with ductal-dependent CHD remains *** SUMMARY A male term neonate with right atrial isomerism underwent modified Blalock-Taussig shunt placement on the 14^(th)day of life and had persistent mesenteric hypoperfusion after *** patient had episodes of NEC stageⅡA on the 1^(st)and 28^(th)days after cardiac *** microbial composition was analyzed before and after cardiac surgery by sequencing region v4 of the 16S rRNA *** surgery,species belonging to genera veillonella and Clostridia and class Gammaproteobacteria were detected,Bifidobacteriaceae showed a low *** first NEC episode was associated with postoperative hemodynamic instability,intestinal ischemiareperfusion injury during cardiopulmonary bypass,and a high abundance of Clostridium paraputrificum(Clostridium sensu stricto I)(56.1%).Antibacterial therapy after the first NEC episode resulted in increased abundance of Gammaproteobacteria,decreased abundance of Firmicutes,and low alpha *** changes in the microbial composition promoted the growth of Clostridium sensu strictoⅠ(72.0%)before the second NEC *** A high abundance of Clostridium sensu strictoⅠand mesenteric hypoperfusion may have contributed to NEC in the present case.

关键词： Necrotizing enterocolitis Congenital heart disease Ivemark syndrome Heterotaxy Right atrial isomerism Intestinal microbiome Case report

Waxes in asphaltenes of crude oils and wax deposits

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Petroleum Science 2016年第4期13卷 737-745页

作者： yulia M.Ganeeva Tatiana N.Yusupova Gennady v.Romanov A.E. Arbuzov Institute of Organic and Physical Chemistry Kazan Scientific Center Russian Academy of Sciences Institute of Geology and Petroleum Technologies Kazan (Volga region) Federal University

Composition and molecular mass distribution of n-alkanes in asphaltenes of crude oils of different ages and in wax deposits formed in the borehole equipment were studied. In asphaltenes, n-alkanes from C12 to C60 were detected. The high molecular weight paraffins in asphaltenes would form a crystalline phase with a melting point of 80–90 ℃. The peculiarities of the redistribution of high molecular paraffin hydrocarbons between oil and the corresponding wax deposit were detected. In the oils, the high molecular weight paraffinic hydrocarbons C50–C60were found, which were not practically detected in the corresponding wax deposits.

关键词： Waxes Asphaltenes Hydrocarbon composition Crude oil Wax deposit

Taxonomic Composition and Spatial Distribution of Meiofauna Community from a Sandy Intertidal Zone in Sishili Bay, Yellow Sea Coast (Northern China)

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Journal of Ocean University of China 2022年第5期21卷 1389-1401页

作者： PAvLYUK Olga N TREBUKHOvA yulia A SHCHERBAKOv Ilya A TARASOvA Tatiana S LUTAENKO Konstantin A CHEN Linlin SONG Bo LI Xiaojing LI Baoquan A.v.Zhirmunsky National Scientific Center of Marine Biology Far Eastern BranchRussian Academy of SciencesVladivostok 690041Russia Yantai Institute of Coastal Zone Research Chinese Academy of SciencesYantai 264003China

The meiofauna composition and trophic groups of the nematode communities have been studied at a sandy intertidal zone in Sishili Bay along the Yantai coast(Yellow Sea,China).Nematoda was dominant among the 11 groups of *** meiofaunal densities were low,ranging between 111±47 and 542±131 ind./10 cm^(2).Results obtained from the correlation analysis made it possible to determine several factors that influence species composition and ***,sediment granulometry significantly affected the *** highest abundance was found in fine-grained sediments(318.77±126 ind./10 cm^(2))com-pared to coarse-grained sediments(175±82 ind./10 cm2).Nematodes were predominant in all studied sites.A total of 70 species be-longing to 52 genera and 18 families were identified in the study *** was a significant difference in nematode abundance(ANOvA,F=2.38,Pvel of species diversity in sediments composed mainly of very-fine sands(>63μm),with dominant species belonging to the genus Bathylaimus,Ptycho-laimellus,Spirinia,and *** trophic groups were dominated by non-selective deposit feeders(40.7%)and epistrate feed-ers(41.29%).In contrast,the species composition in medium grain sands was characterized by a low species diversity index and a high Simpson dominance *** communities showed similar dominant species compositions belonging to a single genus Bathylaimus,Enoplolaimus,and Oncholaimus,and in terms of trophic structure-representatives of deposit feeders(46.15%),preda-tors,and omnivores(64.71%)*** divergence of meiofaunal community structures can be explained by abiotic factors such as sediment grain size,salinity,and organic carbon ***,sediment particle size can explain the diversity of nematodes at the level of in abundance,diversity indices,and trophic *** highest nematode density and diversity coincided with

关键词： meiofauna nematodes sandy intertidal zone sediment grain size Yellow Sea

Expansion of Juniperus sibirica *** a response to climate change and associated effect on mountain tundra vegetation in the Northern Urals

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Journal of Mountain Science 2020年第10期17卷 2339-2353页

作者： Andrey A.GRIGORIEv yulia v.SHALAUMOvA Olga v.EROKHINA Svetlana Yu.SOKOvNINA Elizaveta I.vATOLINA Martin WILMKING Institute of Plant and Animal Ecology UB RAS Laboratory of Geoinformation TechnologyEkaterinburgRussia Institute of Industrial Ecology UB RAS Laboratory of Mathematical Modeling in Ecology and MedicineEkaterinburgRussia Institute of Plant and Animal Ecology UB RAS Laboratory of Vegetation and Mycobiota BiodiversityEkaterinburgRussia Institute of Plant and Animal Ecology UB RAS Laboratory of Dynamics of Arctic EcosystemsLabytnangiRussia Department of Forest Taxation and Forest Management Institute of Forest and Nature ManagementUral state Forest Engineering UniversityEkaterinburgRussia Institute for Botany and Landscape Ecology Greifswald UniversityGreifswaldGermany

Shrub expansion into arctic and alpine tundra is one of the prominent vegetation changes currently *** studied the expansion of shrub vegetation into high elevation tundra in the Kvarkush Range of the Northern Ural mountains,*** structure analysis of the dominant shrub Juniperus sibirica *** to support ongoing upslope advance of shrubs,a process particularly active in the second half of the 20 th *** found a close connection between the expansion of shrub vegetation and the general change in climatic conditions of the cold season(months with mean airtemperature below 0°Сfrom November to March).In general,the greatest influence on the distribution of *** is exerted by the climate conditions of the beginning(November-January)and the end(March)of the cold *** increasing elevation,the correlation coefficients between the establishment of *** shrubs and the precipitation of the beginning of the cold season increased,and reached maximum values at the top elevation level of the study ***,the upwards shift of *** into typical mountain tundra does not lead to changes in the ecological structure of vegetation at this stage,but simply a decrease in the area of mountain tundra.

关键词： Juniperus sibirica Expansion Tundra vegetation Plant communities Climate changes Northern Ural mountains