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补骨舒筋汤联合正清风痛宁缓释片治疗肾阳亏虚型类风湿性关节炎临床研究

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新中医 2024年第16期56卷 62-65页

作者：杨俊涛罗玉雷陈叶海郭可东阳花园田氏医院脊柱外科浙江东阳322121 荆州市中医院骨科湖北荆州434000 温州医科大学浙江温州325035

目的:观察补骨舒筋汤联合正清风痛宁缓释片治疗肾阳亏虚型类风湿性关节炎的临床效果。方法:选取72例肾阳亏虚型类风湿性关节炎患者,按照随机数字表法分为研究组与对照组各36例。对照组采用来氟米特治疗,研究组采用补骨舒筋汤联合正清风... 详细信息

目的:观察补骨舒筋汤联合正清风痛宁缓释片治疗肾阳亏虚型类风湿性关节炎的临床效果。方法:选取72例肾阳亏虚型类风湿性关节炎患者,按照随机数字表法分为研究组与对照组各36例。对照组采用来氟米特治疗,研究组采用补骨舒筋汤联合正清风痛宁缓释片治疗。比较2组临床疗效、中医证候评分以及视觉模拟评分法(VAS)评分、晨僵时间与双手握力改善情况,以及血清类风湿因子(RF)、C-反应蛋白(CRP)和白细胞介素-6 (IL-6)水平。结果:研究组总有效率86.11%,对照组为63.89%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组关节压痛、晨僵畏寒、舌淡苔白等中医证候评分均较治疗前降低(P<0.05),且研究组各项中医证候评分均低于对照组(P<0.05)。治疗后,2组血清RF、CRP、IL-6水平均较治疗前降低(P<0.05),且研究组RF、CRP、IL-6水平均低于对照组(P<0.05)。治疗后,2组VAS评分、晨僵时间均较治疗前减少(P<0.05),双手握力较治疗前增加(P<0.05);且研究组VAS评分、晨僵时间少于对照组(P<0.05),双手握力大于对照组(P<0.05)。结论:补骨舒筋汤联合正清风痛宁缓释片治疗肾阳亏虚型类风湿性关节炎,能够显著缓解患者临床症状,改善关节功能,减轻炎症反应及RF损害。

关键词：类风湿性关节炎肾阳亏虚补骨舒筋汤正清风痛宁缓释片类风湿因子炎症因子

安徽省3市新生儿葡萄糖-6-磷酸脱氢酶缺乏症发生情况及基因突变分析

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安徽预防医学杂志 2024年第2期30卷 138-141页

作者：李辉李梅玲罗玉雷刘浩李明刚宋旺生邵子瑜合肥市妇女儿童保健中心安徽230001 阜阳市妇幼保健计划生育服务中心安徽236072 安庆市妇幼保健计划生育服务中心安徽246004 浙江博圣生物技术股份有限公司浙江杭州310012

目的了解安徽省3市新生儿葡萄糖-6-磷酸脱氢酶(G6PD)缺乏症的发生情况及基因突变特征。方法在安庆市、合肥市和阜阳市分别选取一部分分娩量较大的医疗机构,收集31 480例新生儿疾病筛查标本进行G6PD缺乏症筛查,对可疑样本进行基因检测... 详细信息

目的了解安徽省3市新生儿葡萄糖-6-磷酸脱氢酶(G6PD)缺乏症的发生情况及基因突变特征。方法在安庆市、合肥市和阜阳市分别选取一部分分娩量较大的医疗机构,收集31 480例新生儿疾病筛查标本进行G6PD缺乏症筛查,对可疑样本进行基因检测,采用SPSS 22.0软件分析安徽省3市G6PD缺乏症的检出率和基因突变位点分布情况。结果共检出男性半合子变异数28例,女性杂合子变异数29例,未发现女性纯合变异,安徽省3市G6PD缺乏症总体检出率为0.089%,基因突变携带率为0.18%。共发现7种突变类型,其中c. 95A>G、c. 1376G>T、c. 1388G>A和c. 1024C>T,这4个基因变异位点构成比达到82.4%。男性半合子变异组G6PD酶活性低于女性杂合子变异组(Z=-0.605,P<0.001)。结论安徽省3市G6PD缺乏症检出率较高,建议将其纳入新生儿遗传代谢病常规筛查病种。

关键词：葡萄糖-6-磷酸脱氢酶缺乏症新生儿基因突变多色探针溶解曲线法

自拟通窍祛瘀汤治疗外伤性气滞血瘀型脑内血肿51例

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湖南中医杂志 2024年第2期40卷 1-4,36页

作者：李茂坤陈铁军张维陈刚杜松州梅钢罗玉雷陈蓉荆州市中医医院湖北荆州434000 松滋市中医医院湖北松滋434200

目的:观察自拟通窍祛瘀汤治疗外伤性气滞血瘀型脑内血肿的临床疗效。方法:选取外伤性气滞血瘀型脑内血肿患者100例,将其随机分为治疗组(51例)和对照组(49例)。2组均予以基础治疗,对照组在基础治疗上加用西医常规治疗,治疗组在对照组基... 详细信息

目的:观察自拟通窍祛瘀汤治疗外伤性气滞血瘀型脑内血肿的临床疗效。方法:选取外伤性气滞血瘀型脑内血肿患者100例,将其随机分为治疗组(51例)和对照组(49例)。2组均予以基础治疗,对照组在基础治疗上加用西医常规治疗,治疗组在对照组基础上加用自拟通窍祛瘀汤口服治疗。治疗2周后观察2组中医证候疗效,治疗前、治疗1周后、治疗2周后观察2组血肿吸收、水肿吸收、神经功能缺失(NIHSS)评分、中医证候积分情况。结果:总有效率治疗组为94.11%(48/51),明显高于对照组的75.51%(37/49),2组比较,差异有统计学意义(P<0.05)。治疗后2组血肿体积、水肿体积、NIHSS评分、中医证候积分均较治疗前减少,且治疗组与对照组治疗后同时间节点比较,差异均有统计学意义(P<0.05或P<0.01)。结论:外伤性气滞血瘀型脑内血肿患者在常规治疗的基础上使用自拟通窍祛瘀汤治疗可以促进神经功能恢复,改善中医证候,促进血肿和水肿吸收。

关键词：脑内血肿外伤气滞血瘀型自拟通窍祛瘀汤

Efficacy and safety of Sancai powder in patients with type 2 diabetes mellitus: a randomized controlled trial

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Journal of Traditional Chinese Medicine 2016年第5期36卷 640-648页

作者： Guo Qiang Zhang Hengyao Li Mindian Zhao Ziyi luo Yunlin luo yulei Cao Wenzhai Zhao Huan Zhu Ranran Lei Xingxing Chen Huizhen Gan Huakui Zuo Zhihuang Chen Qi Shi Cuimei Zhang Xinli Guo Jian Zhong Sen Chen Qiu School of Clinical Medicine Chengdu University of Traditional Chinese Medicine Department of Endocrinology Ningxia Chinese Medicine Research Center Department of Cellular and Molecular Physiology Section of Comparative Medicine and Program in Integrative Cell Signaling and Neurobiology of Metabolism Yale University School of Medicine Department of Central Laboratory Teaching Hospital of Chengdu University of Traditional Chinese Medicine Department of Traditional Chinese Medicine Dujiangyan Traditional Chinese Medicine Hospital Diabetes Center The third Teaching Hospital of Chengdu University of Traditional Chinese Medicine Medical Department of Cardiology Zigong First People's Hospital Medical Department of Neurology Teaching Hospital of Chengdu University of Traditional Chinese Medicine Department of Endocrinology The First People's Hospital of Neijiang Department of Endocrinology The Central Hospital of Guangyuan Department of Endocrinology Zizhong County Hospital of Traditional Chinese Medicine Department of Endocrinology Hospital of traditional Chinese Medicine of Xichang Department of Endocrinology Liangshan Hospital of Integrated Traditional and Western Medicine Department of Endocrinology The Second People's Hospital of Leshan Medical Department of Infections Teaching Hospital of Chengdu University of Traditional Chinese Medicine Medical Department of Endocrinology Teaching Hospital of Chengdu University of Traditional Chinese Medicine

OBJECTIVE: To assess the efficacy and safety of Sancai powder in patients with type 2 diabetes mellitus(T2DM) inadequately controlled with single oral metformin in a randomized controlled trial(RCT).METHODS: A total of 132 patients with T2 DM were enrolled in the study, who only took metformin(500-1000 mg/day) for at least three months and with inadequate glycemic control(7.0% ≤ hemoglobin A1 c ≤ 9.0%) in the past three *** patients stopped taking metformin with lifestyle interventions for three weeks, and 105 patients qualified for the program. They were randomly divided into the Sancai powder group and the metformin group(1500 mg/day). The follow-up period was for 12 weeks. Comparisons of several variables were ***: No significant differences were found between the two groups in hemoglobin A1c(Hb A1c),fasting plasma glucose(FPG) and 2 h post-meal glucose(2h PG), although they had decreased significantly(P < 0.01). Homeostasis model assessment of beta cell function index was significantly improved in Sancai powder group(P < 0.01), and there were significant differences in the changes of homeostasis model assessment of insulin resistance and insulin sensitivity index in the two groups(P < 0.05). Sancai powder significantly reduced triglyceride level(P < 0.05), although there was no significant difference in the body weight and body mass index in the two ***: In this 12-week study, Sancai powder could significantly reduce hemoglobin A1 c,FPG and 2h PG levels, improved beta-cell function and insulin resistance of the T2 DM inadequately controlled with metformin.

关键词： Diabetes Mellitus Type 2 Sancai powder Metformin Treatment outcome Randomized controlled trial

Unlocking the potential of thin-film composite reverse osmosis membrane performance:Insights from mass transfer modeling

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Chinese Chemical Letters 2024年第5期35卷 66-76页

作者： Kexin Yuan yulei Liu Haoran Feng Yi Liu Jun Cheng Beiyang luo Qinglian Wu Xinyu Zhang Ying Wang Xian Bao Wanqian Guo Jun Ma State Key Laboratory of Urban Water Resource and Environment School of EnvironmentHarbin Institute of TechnologyHarbin 150090China College of Architecture and Environment Sichuan UniversityChengdu 610065China School of Municipal and Environmental Engineering Shandong Jianzhu UniversityJi’nan 250101China College of Water Conservancy and Hydropower Engineering Sichuan Agricultural UniversityYaan 625014China

Thin-film composite(TFC)reverse osmosis(RO)membranes have attracted considerable attention in water treatment and desalination processes due to their specific separation ***,the trade-off effect between water flux and salt rejection poses huge challenges to further improvement in TFC RO membrane *** research works have been dedicated to optimizing membrane fabrication and modification for addressing this *** the meantime,several reviews summarized these ***,the existing reviews seldom analyzed these methods from a theoretical perspective and thus failed to offer effective optimization directions for the RO process from the root *** this review,we first propose a mass transfer model to facilitate a better understanding of the entire process of how water and solute permeate through RO membranes in detail,namely the migration process outside the membrane,the dissolution process on the membrane surface,and the diffusion process within the ***,the water and salt mass transfer behaviors obtained from model deduction are comprehensively analyzed to provide potential guidelines for alleviating the trade-off effect between water flux and salt rejection in the RO ***,inspired by the theoretical analysis and the accurate identification of existing bottlenecks,several promising strategies for both regulating RO membranes and optimizing operational conditions are proposed to further exploit the potential of RO membrane *** review is expected to guide the development of high-performance RO membranes from a mass transfer theory standpoint.

关键词： Reverse osmosis Mass transfer model Trade-off effect Membrane performance Optimization strategies

A multi-center epidemiologic study of vitamin D status among adults in south-west China

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A multi-center epidemiologic study of vitamin D status among...

基于接力排水的强夯法在滨海回填区地基处理中的试验研究

第二届中国临床分子诊断大会

作者： Lin Li Jing Li Haijun Li yulei luo Yuheng Cheng Chunbao Xie Chengjie Ji Liangmin Chuan Zhibin Wang Xiaolan Guo Jinbo Liu Li Jiang Department of Laboratory Medicine Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital Panzhihua Central Hospital Guangyuan Central Hospital People's Hospital of Aba Tibetan and Qiang Autonomous Prefecture Affiliated Hospital of North Sichuan Medical College The Affiliated Hospital of Southwest Medical University

＜正＞Introduction Vitamin D plays a vital role in calcium and phosphorus metabolism,and bone *** main vitamin D metabolites are cholecalciferol（vitamin D3,naturally occurring in humans and animals）and ergocalciferol（vitamin D2,naturally occurring in plants）.Both forms follow the same metabolic pathway in the human ***

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水文地质工程地质 2022年第1期49卷 117-125页

作者：张军舰李鹏殷坤宇罗玉磊郭幔岩土科技股份有限公司浙江杭州311401 青岛市勘察测绘研究院山东青岛266032 青岛岩土基础工程公司山东青岛266032 中交一航局第二工程有限公司山东青岛266071 青岛滨海勘察测绘有限公司山东青岛266071

本文对山东半岛海岸带滨海杂填土、饱和粉细砂、淤泥质土等特殊复杂地层地基处理方法进行了研究。以经济高效的强夯法为基础,提出复杂地层整体排水概念,设计了浅层、深层竖向排水和水平排水的接力排水系统,并进行了现场试验研究。监测... 详细信息

本文对山东半岛海岸带滨海杂填土、饱和粉细砂、淤泥质土等特殊复杂地层地基处理方法进行了研究。以经济高效的强夯法为基础,提出复杂地层整体排水概念,设计了浅层、深层竖向排水和水平排水的接力排水系统,并进行了现场试验研究。监测数据表明,强夯荷载作用下,接力排水系统整体协同排水,可快速排出各个地层中地下水、消散超孔隙水压力。7 h左右可基本消除强夯引起的地下水上升及孔隙水压力消散。持续降水,地表沉降为上部土体厚度的0.7%~2.0%。强夯动力荷载作用下,表层土体压缩为上部土体厚度的8.7%~10.9%。埋深3~7 m土体沉降约为土体厚度的5‰、3‰,埋深7~10 m土体沉降为土体厚度的2‰。检测数据表明,在强夯有效影响深度内地基处理效果明显,土体工程性状改善明显。表层承载力及变形模量满足设计要求,4 m以下淤泥承载力平均值略低于设计要求,下部淤泥质土计算平均固结度为77%。夯后1个月监测数据表明,地表沉降量在25 mm以内,已逐步趋于稳定,分层沉降、孔隙水压力数值整体稳定略有下降。

关键词：滨海回填区复杂地层接力排水强夯井点降水塑料排水板

MHC150移动式多用途港口起重机电气设计

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起重运输机械 2024年第6期 53-58页

作者：罗佩玉施宇雷上海振华重工(集团)股份有限公司上海200125

为实现港口码头移动式多功能起重机的技术应用和发展,文中叙述了MHC150移动式港口起重机的主体机构、工作原理、供电电源选型、主机构变频驱动系统选型、PLC通讯系统、抓斗/吊钩/吊具作业模式的电气控制系统、液压系统与电气通讯接口等... 详细信息

为实现港口码头移动式多功能起重机的技术应用和发展,文中叙述了MHC150移动式港口起重机的主体机构、工作原理、供电电源选型、主机构变频驱动系统选型、PLC通讯系统、抓斗/吊钩/吊具作业模式的电气控制系统、液压系统与电气通讯接口等的设计。该起重机实现了抓斗、吊钩、吊具集装箱的多种组合装卸功能,在起重机投资、适应性、维修费用和附属设施等方面比中小型岸边集装箱起重机和门座起重机具有更好的经济性和应用市场前景,可作为其替代产品。

关键词：移动式港口起重机吊具电气控制选型设计

外源褪黑素对干旱胁迫下园林小菊生长及生理的影响

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甘肃农业大学学报 2024年第1期59卷 211-218页

作者：罗艳虎淘淘高晓芬赵钰磊张黎严瑞宁夏大学葡萄酒与园艺学院宁夏银川750021

【目的】探究外源褪黑素(Melatonin,MT)对干旱胁迫下园林小菊的缓解作用及适宜浓度,为干旱和半干旱地区种植园林小菊提供理论支持和参考价值。【方法】以园林小菊绚秋凝红为试材,使用20%PEG作为干旱胁迫渗透剂,通过叶面喷施不同浓度MT(5... 详细信息

【目的】探究外源褪黑素(Melatonin,MT)对干旱胁迫下园林小菊的缓解作用及适宜浓度,为干旱和半干旱地区种植园林小菊提供理论支持和参考价值。【方法】以园林小菊绚秋凝红为试材,使用20%PEG作为干旱胁迫渗透剂,通过叶面喷施不同浓度MT(50、100、150、200μmol/L),研究MT对干旱胁迫下园林小菊幼苗生长及生理指标的影响。【结果】干旱胁迫条件下,外源喷施100μmol/L MT可有效缓解干旱胁迫对园林小菊幼苗造成的伤害。园林小菊幼苗叶绿素含量、叶片相对含水量较PEG处理分别增加37.4%、69.1%,相对电导率(REC)和丙二醛含量(MDA)分别降低55.7%和42.8%,过氧化氢(H_(2)O_(2))增加75.0%,脯氨酸(Pro)增加60.6%,超氧化物歧化酶(SOD)、过氧化物歧化酶(POD)、过氧化氢酶(CAT)活性分别是PEG处理的1.9倍、2倍、3.2倍。通过主成分分析结果可知,外源MT对园林小菊叶绿素含量、叶片相对含水量和地上部鲜质量产生较大影响。【结论】外源喷施100μmol/L MT能够有效缓解干旱胁迫对园林小菊绚秋凝红所造成的伤害,提高扦插幼苗的耐旱性。

关键词：园林小菊外源褪黑素 PEG干旱胁迫生理指标

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