检索结果-南通市图书馆

Does the intracoronary pressure differ according to two types(diffuse or focal)of coronary spasm?

World Journal of Cardiology 2023年第1期15卷 1-12页

作者： Hiroki Teragawa Chikage Oshita yuko Uchimura Department of Cardiovascular Medicine JR Hiroshima HospitalHiroshima 732-0057Japan

BACKGROUND Several reports show that two types of coronary vasospasm(diffuse and focal spasm)are associated with the severity or prognosis of coronary spasm in patients with vasospastic angina(VSA).It is unclear whether intracoronary pressure differs between the two spasm *** To investigate such relationships using a pressure wire during the spasm provocation test(SPT)in patients with *** Eighty-seven patients with VSA(average age:67 years;50 men,37 women)underwent *** the SPT,a pressure wire was advanced into the distal portion of the right coronary artery and left anterior descending coronary artery,and the ratio of the intracoronary pressure to the aortic pressure(Pd/Pa)was continuously *** SPT was performed using acetylcholine(ACh),and the presence of coronary spasm was defined as the presence of>90%arterial narrowing in response to an ACh infusion,with the usual chest symptoms and/or ischemic ECG *** spasm was defined as total or subtotal spasm within one segment of the AHA classification,while diffuse spasm was defined as>90%spasm with two or more *** Among 87 patients,the frequencies of metabolic syndrome and having coronary atherosclerosis were higher in the focal group(n=33)than in the diffuse spasm group(n=54,P<0.05).In the vessel analyses,in these 134 spastic segments,diffuse and focal spasms were detected in 100 and 34 vessels,*** Pd/Pa at baseline was similar in both groups(diffuse:0.96±0.05,focal:0.95±0.05,P=0.35);however,the Pd/Pa during coronary spasm was lower in focal spastic vessels(0.66±0.20)than in diffuse spastic vessels(0.76±0.11,P<0.01),and the reduction in Pd/Pa during an SPT was also lower in focal spastic vessels(-0.29±0.20)than in diffuse spastic vessels(-0.18±0.11,P<0.01).The presence of focal spasm was a significant factor responsible for reduction in Pd/Pa during *** These findings suggest that focal spasm may be more severe than diffuse spasm,judging from the

关键词： Acetylcholine Intracoronary pressure Diffuse or focal spasm Vasospastic angina

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Investigation on Retention and Release Behaviors of Hydrogen and Helium in Vanadium Alloy

引用

Plasma Science and Technology 2005年第3期7卷 2835-2838页

作者：刘翔 Tsuyoshi Yamada Yuji Yamauchi yuko Hirohata Tomoaki Hino Nobuaki Noda Southwestern Institute of Physics Chengdu 610041 China Laboratory of Plasma Physics and Engineering Hokkaido UniversityKita-13 Nishi-8 Kita-ku Sapporo 060-8628 Japan National Institute for Fusion Science Toki-shi Gifu-ken 509-5202 Japan

Vanadium alloy is proposed as an attractive candidate for first wall and blanket structural material of fusion reactors. The retention and release behaviors of hydrogen and helium in vanadium alloy may be an important issue. In the present work, 1.7 keV deuterium and 5 keV helium ions are respectively implanted into V-4Cr-4Ti and V-4Ti at room temperature. The retention and release of deuterium and helium are measured with thermal desorption spectroscopy (TDS). When the helium ion fluence is larger than 3 × 1017 He/cm2, the retained helium saturates with a value of approximately 2.5 ×1017 He/cm2. However, when the ion fluence is 1×1019 D/cm2, the hydrogen saturation in vanadium alloy does not take place. Experimental results indicates that hydrogen and helium retention in vanadium alloy may lead to serious problems and special attention should be paid when it is applied to fusion reactors.

关键词： deuterium helium vanadium alloy thermal desorption spectroscopy retention and release

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Vasospastic angina in women: Clinical backgrounds and prognoses of patients younger than and older than 60 years

引用

World Journal of Cardiology 2023年第4期15卷 154-164页

作者： Hiroki Teragawa Chikage Oshita yuko Uchimura Department of Cardiovascular Medicine JR Hiroshima HospitalHiroshima 732-0057Japan

BACKGROUND We frequently encounter cases of women with vasospastic angina(VSA).Additionally,some women with VSA are younger than 60 years ***,it is unknown whether the characteristics of VSA in women aged20%)detected using coronary angiography and focal spasms(coronary spasm within one segment of one coronary artery),and major cardiovascular adverse events(MACE)were assessed in both *** Smoking was more prevalent in Group Y than in Group O(P=0.04).FMD was similar in both groups(Group O:4.3%±3.2%,Group Y:4.5%±3.3%;P=0.75),whereas NID was higher in Group Y(20.5%±8.6%)than in Group O(13.6%±5.3%,P<0.01).Atherosclerosis was not detected in Group Y but was detected in Group O(61%,P<0.01).Focal spasms were less frequent in Group Y(12%)than in Group O(38%,P=0.04).The incidence of major adverse cardiac events did not differ between the two groups(P=0.40).CONCLUSIONWomen aged < 60 years with VSA have less atherosclerotic lesions and focal spasms. These characteristicsmay be affected by smoking habits and vascular smooth muscle dysfunction.

关键词： Acetylcholine Young female Smoking Vasospastic angina Vascular smooth muscle dysfunction

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Adrenocorticotropic hormone-secreting pancreatic neuroendocrine carcinoma with multiple organ infections and widespread thrombosis:A case report

引用

World Journal of Clinical Cases 2022年第17期10卷 5723-5731页

作者： Akihiro Yoshihara Kota Nishihama Chisa Inoue yuko Okano Kazuhito Eguchi Soichiro tanaka Kanako Maki Valeria Fridman D'Alessandro Atsuro Takeshita Taro Yasuma Mei Uemura Toshinari Suzuki Esteban C Gabazza Yutaka Yano Department of Diabetes and Endocrinology Japan Community Health care Organization Yokkaichi Hazu Medical CenterYokkaichi 510-0016MieJapan Department of Diabetes Metabolismand EndocrinologyMie UniversityTsu 514-8507MieJapan Department of Immunology Mie UniversityTsu 514-8507MieJapan Department of Immunology Faculty and Graduate School of MedicineMie UniversityTsu 514-8507MieJapan Department of Immunology and Department of Diabetes Metabolismand EndocrinologyMie UniversityTsu 514-8507MieJapan Department of Immunology Mie University School of MedicineMie UniversityTsu 514-8507MieJapan

BACKGROUND Ectopic adrenocorticotropic hormone(ACTH)-secreting neuroendocrine tumors are rare *** with ACTH-secreting pancreatic neuroendocrine carcinomas have a poor *** and coagulopathies have been reported as the cause of ***,detailed clinical descriptions of the morbid complications of ACTH-secreting neuroendocrine carcinomas have not been *** SUMMARY A 78-year-old Japanese woman consulted a medical center due to systemic edema and epigastric *** analysis revealed hypercortisolemia with increased ACTH secretion without diurnal variation in serum cortisol *** enhanced computed tomography(CT)scan revealed a 3-cm tumor in the pancreatic *** cytological material from endoscopic ultrasound-guided fine-needle aspiration was compatible with ACTHsecreting pancreatic neuroendocrine *** Ki-67 index was 40%.She was transferred to Mie University Hospital for surgical *** patient was diagnosed with urinary tract infection,cytomegalovirus hepatitis,esophageal candidiasis,pulmonary infiltrates suspicious for Pneumocystis carinii pneumonia,peripheral deep vein thrombosis,pulmonary embolism,and disseminated intravascular *** multiple organ infections and thromboses responded well to antimicrobial and anticoagulant *** studies disclosed a pancreatic tumor and a metastatic lesion in the liver,whereas somatostatin receptor scintigraphy showed negative findings,suggesting the primary and metastatic tumors were poorly differentiated.A CT scan before admission showed no metastatic liver lesion,suggesting that the pancreatic tumor was rapidly *** of surgery,antitumor chemotherapy was *** patient was transferred to another hospital to initiate ***,she died four months later due to the rapidly progressive *** ACTH-secreting pancreatic neuroendocrine neoplasm is a rare disease with a very poor ***

关键词： Neuroendocrine tumors Cushing's syndrome Ectopic adrenocorticotropic hormone syndrome Pneumocystis pneumonia Pulmonary embolism Infections Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Sodium-glucose co-transporter-2 inhibitor-associated euglycemic diabetic ketoacidosis that prompted the diagnosis of fulminant type-1 diabetes:A case report

引用

World Journal of Clinical Cases 2021年第13期9卷 3163-3169页

作者： Taro Yasuma yuko Okano Soichiro tanaka Kota Nishihama Kazuhito Eguchi Chisa Inoue Kanako Maki Akihiro Uchida Mei Uemura Toshinari Suzuki Corina N D'Alessandro-Gabazza Esteban C Gabazza Yutaka Yano Department of Diabetes Metabolismand Endocrinology and ImmunologyMie UniversityTsu 514-8507Japan Department of Diabetes Metabolismand EndocrinologyMie UniversityTsu 514-8507Japan Department of Immunology Mie University School of MedicineMie UniversityTsu 514-8507Japan Department of Immunology Mie University Faculty and Graduate School of MedicineTsu 514-8507Japan Department of Diabetes Mie University Graduate School of MedicineTsu 514-8507Japan

Fulminant type 1 diabetes mellitus(FT1DM)is a subtype of type 1 diabetes mellitus characterized by an abrupt onset and a rapid and complete functional loss of isletβ*** is a very rare disease generally associated with ketoacidosis and the absence of circulating pancreatic islet-related *** ketoacidosis with normal blood glucose levels has been reported during sodiumglucose co-transporter 2(SGLT2)inhibitor *** SUMMARY The patient was a 43-year-old woman that consulted a medical practitioner for malaise,thirst,and *** analysis showed high blood glucose levels(428 mg/dL),a mild increase of hemoglobin A1c(6.6%),and increased ketone bodies in *** patient was diagnosed with type 2 diabetes *** patient was initially treated with insulin,which was subsequently changed to an oral SGLT2 *** to glutamic acid decarboxylase were *** days after receiving oral SGLT2 inhibitor,she consulted at Mie University Hospital,complaining of fatigue and *** analysis revealed diabetic ketoacidosis with almost normal blood glucose *** endogenous insulin secretion was markedly low,and the serum levels of islet-related autoantibodies were *** made the diagnosis of FT1DM with concurrent SGLT2 inhibitor-associated euglycemic diabetic *** patient's general condition improved after therapy with intravenous insulin and withdrawal of oral *** was discharged on day 14 with an indication of multiple daily insulin *** This patient is a rare case of FT1DM that developed SGLT2 inhibitor-associated diabetic ketoacidosis with almost normal blood glucose *** case report underscores the importance of considering the diagnosis of FT1DM in patients with negative circulating autoantibodies and a history of hyperglycemia that subsequently develop euglycemic diabetic ketoacidosis following treatment with a SGLT2 inhibitor.

关键词： Euglycemic diabetic ketoacidosis Sodium-glucose cotransporter 2 inhibitors Fulminant type 1 diabetes Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Comparison of imo and Humphrey field analyzer perimeters in glaucomatous eyes

引用

International Journal of Ophthalmology(English edition) 2021年第12期14卷 1882-1887页

作者： Yoshinori Nakai Kyoko Bessho yuko Shono Kaori Taoka Yoshihide Nakai Tokai Eye Clinic 399-Hadokoro-choTsu 514-0009Japan

AIM:To compare the imo perimeter,a new portable head-mounted perimeter unit that enables both eyes to be examined quickly and simultaneously,with the Humphrey field analyzer(HFA)perimeter to investigate correlations and their diagnostic ability in glaucomatous ***:The performance of the equipment in 128 glaucomatous eyes and 40 normal eyes were *** investigated the correlations of mean deviation,pattern standard deviation,visual field index,and the ***:Measurements of mean deviation(r=0.886,P<0.001),pattern standard deviation(r=0.814,P<0.001),and visual field index(r=0.871,P<0.001)in both perimeters were strongly and positively *** sensitivities in the imo perimeter were 80.5%for mean deviation,81.2%for pattern standard deviation,and 80.5%in visual field index;those in the HFA were 63.3%for mean deviation,74.5%for pattern standard deviation,and 80.5%for visual field *** perimeters demonstrated high diagnostic ***:The parameters by the imo and HFA in glaucomatous eyes show strong positive correlations with favorable sensitivity,specificity,and diagnostic ***,the difference between imo and HFA results increases with the increase in visual field disturbance.

关键词： imo perimeter visual field diagnosis diagnostic validation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

High Preoperative Anxiety Level and the Risk of Intraoperative Hypothermia

引用

International Journal of Clinical Medicine 2012年第6期3卷 461-468页

作者： Noriyoshi tanaka yuko Ohno Megumi Hori Mai Utada Kenji Ito Toshiyasu Suzuki Department of Anesthesiology School of Medicine Tokai University Tokyo Japan Division of Health Science Graduate School of Medicine Osaka University Osaka Japan

Aim: The relationship between preoperative anxiety level and intraoperative hypothermia (<36℃) was investigated. Background: Core temperature often decreases during surgery, with an initial rapid decrease followed by a slower decrease for about 2 hours. Preoperative anxiety may influence perioperative physiological responses. The relationship between preoperative anxiety level and perioperative decrease in core temperature has not been studied closely. Design: A prospective observational study. Methods: This study enrolled 120 adult patients who underwent elective major abdominal surgery under combined epidural and general anesthesia. Tympanic membrane temperature was used to measure core temperature preoperatively and during the operation. The relationship between anxiety level according to the State-Trait Anxiety Inventory (STAI) and core temperature was examined using descriptive and multivariate risk analysis. Results: High anxiety level was found in 61 patients (51%), of which 26 (43%) developed hypothermia during the first hour and 40 (66%) developed hypothermia during the first 2 hours of anesthesia. After adjustment for covariates, patients with a high anxiety level were found to have a 2.17-fold higher risk of hypothermia during the first hour and a 1.77-fold higher risk of hypothermia during the first 2 hours than patients with a low/moderate anxiety level. Conclusions: The risk of hypothermia in the early phase of general anesthesia can be predicted by measurement of the preoperative anxiety level using the STAI. Relevance to Clinical Practice: Patients with a high anxiety level had a significantly higher risk of intraoperative hypothermia. Preoperative preventive nursing care programs should include anxiety management and thermal care.

关键词： Anxiety Hypothermia Perioperative Nursing Risk Factors State-Trait Anxiety Inventory

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Association of non-synonymous variants in WIPF3 and LIPA genes with ab- dominal aortic aneurysm： an autopsy study

引用

Journal of Geriatric Cardiology 2016年第12期13卷 960-967页

作者： yuko Maeda Noriko Sato Makiko Naka-Mieno Seijiro Mori Tomio Arai Masashi tanaka Masaaki Muramatsu Motoji Sawabe Department of Molecular Epidemiology Medical Research Institute Tokyo Medical and Dental University Tokyo Japan Department of Medical Informatics Center of Inormation Jichi Medical University Tochigi Japan Center for Promotion of Clinical Investigation Tokyo Metropolitan Geriatric Hospital Tokyo Japan Department of Pathology Tokyo Metropolitan Geriatric Hospital Tokyo Japan Research Teams for Geriatric Pathology Tokyo Metropolitan Institute of Gerontology Tokyo Japan Department of Genomics for Longevity and Health Tokyo Metropolitan Institute of Gerontology Tokyo Japan Department of Molecular Pathology Graduate School of Health Care Sciences Tokyo Medical and Dental University Tokyo Japan

Background Abdominal aortic aneurysm （AAA） is a multifactorial disease with strong genetic components. Various genetic loci have been associated with clinical AAA, but few studies have investigated pathological AAA, an intermediate phenotype of the disease. Methods We examined 2263 consecutive autopsies of older Japanese subjects from a study on geriatric diseases in Japanese individuals （The JG-SNP study）. The presence of AAA was determined with a pathological diagnosis during autopsy. Single nucleotide variants （SNVs） associated with AAA were determined with an Illumina HumanExome Beadchip array. Logistic regression analyses were performed to determine ge- netic associations. Age, gender, and other risk factors of AAA were analyzed as covariates. Results 118 subjects with AAA and 2145 sub- jects without AAA were analyzed in a case-control setting. No variants reached significance after applying the Bonferroni correction （P 〈 2.05×10^-6）. The strongest associations were found with rs3750092 （p.E321G, OR： 0.36, 95% CI： 0.24-0.56, P = 6.09 ×10^-6）, a variant in the WAS/WASL interacting protein family 3 （WIPF3）, and with rs1051338 （p.T16P, OR： 2.50, 95% CI： 1.70-3.66, P = 2.79 ×10^-6） and rs2246942 （intronic, OR： 2.32, 95% CI： 1.58-3.41, P = 1.61 ×10^-5）, variants in the lysosomal acid lipase A （LIPA）. LIPA is essential for macrophage cholesterol metabolism. Immunohistological analyses of WIPF3 protein in AAA samples from three subjects revealed that WIPF3 was expressed in macrophages ofatheromatous plaques. Conclusions This study suggests that WIPF3 and LIPA, both of which are expressed in the macrophages are involved in pathological AAA. These results should be regarded as hypothesis-generating; thus, replication study is warranted.

关键词： Abdominal aortic aneurysm Lysosomal acid lipase A WAS/WASL interactingproteinfamily 3

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Development of cancer-initiating cells and immortalized cells with genomic instability

引用

World Journal of Stem Cells 2015年第2期7卷 483-489页

作者： Ken-ichi Yoshioka yuko Atsumi Hitoshi Nakagama Hirobumi Teraoka Division of Carcinogenesis and Cancer Prevention National Cancer Center Research Institute Department of Pathological Biochemistry Medical Research InstituteTokyo Medical and Dental University

Cancers that develop after middle age usually exhibit genomic instability and multiple mutations. This is in direct contrast to pediatric tumors that usually develop as a result of specific chromosomal translocations andepigenetic aberrations. The development of genomic instability is associated with mutations that contribute to cellular immortalization and transformation. Cancer occurs when cancer-initiating cells(CICs), also called cancer stem cells, develop as a result of these mutations. In this paper, we explore how CICs develop as a result of genomic instability, including looking at which cancer suppression mechanisms are abrogated. A recent in vitro study revealed the existence of a CIC induction pathway in differentiating stem cells. Under aberrant differentiation conditions, cells become senescent and develop genomic instabilities that lead to the development of CICs. The resulting CICs contain a mutation in the alternative reading frame of CDKN2A(ARF)/p53 module, i.e., in either ARF or p53. We summarize recently established knowledge of CIC development and cellular immortality, explore the role of the ARF/p53 module in protecting cells from transformation, and describe a risk factor for genomic destabilization that increases during the process of normal cell growth and differentiation and is associated with the downregulation of histone H2 AX to levels representative of growth arrest in normal cells.

关键词： ARF/p53 module Cancer stem cells Cancerinitiatingcells Differentiation Genomic instability H2AX

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Does laparoscopic resection for colorectal cancer liver metastasis have a long-term oncologic advantage?

引用

Hepatobiliary Surgery and Nutrition 2021年第2期10卷 246-248页

作者： Yasushi Hasegawa Minoru Kitago Yuta Abe yuko Kitagawa Department of Surgery Keio University School of MedicineTokyoJapan

The long-term advantages of laparoscopic liver resection(LLR)over open liver resection(OLR)for colorectal cancer liver metastasis(CLM)have not been *** et al.(1)recently published an interesting article in the Annals of Surgery,titled“Survival Advantage of Laparoscopic Versus Open Resection for Colorectal Liver Metastases:A Meta-analysis of Individual Patient Data from Randomized Trials and Propensity-score Matched Studies.”The authors performed a meta-analysis of individual participant data from two randomized trials and thirteen propensity score-matched studies that compared long-term outcomes between patients undergoing LLR and OLR for CLM.A total of 1,275 patients who underwent LLR and 1,873 patients who underwent OLR were *** found that LLR was associated with a lower risk of death and concluded that LLR had a long-term survival benefit compared to OLR.

关键词： metastasis Surgery liver

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：