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Chinese Journal of Chemical Engineering 2020年第12期28卷 2993-3001页

作者： Tomohito Kameda Kazuya Horikoshi Shogo Kumagai yuko saito Toshiaki Yoshioka Graduate School of Environmental Studies Tohoku University6-6-07 AobaAramakiAoba-kuSendai 980-8579Japan

In this paper,we propose that the urinary toxins from the wastewater be adsorbed on an adsorbent such as spherical activated carbon and the latter be regenerated by subjecting it to high temperatures to recycle activated carbon and also to recycle the water used in *** studied the adsorption of artificial waste dialysate,which is a mixed solution of urea,creatinine,and uric acid,and the separate solutions for each of these and found that their extents of adsorption onto the spherical activated carbon material were nearly *** amount of adsorption was approximately 1.4 mg·g^−1 for urea,18 mg·g^−1 for creatinine,and 20 mg·g^−1 for uric *** urea,creatinine,and uric acid adsorbed onto the spherical activated carbon decomposed on heat treatment at 500℃,and the adsorption capacity of the spherical activated carbon was *** study successfully demonstrated that the spherical activated carbon can be recycled in the waste dialysate treatment process.

关键词： Adsorption Dialysate Spherical activated carbon Recycling

Desorption of Cl^(-) from Mg-Al layered double hydroxide intercalated with Cl^(-) using CO_(2) gas and water

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Chinese Journal of Chemical Engineering 2021年第1期34卷 131-134页

作者： Tomohito Kameda Hiroki Uchida Shogo Kumagai yuko saito Keiichi Mizushina Ichirou Itou Tianye Han Toshiaki Yoshioka Graduate School of Environmental Studies Tohoku University6-6-07 AobaAramakiAoba-kuSendai 980-8579Japan Kurita Water Industries Ltd. Nakano Central Park East4-10-1 NakanoNakano-kuTokyo 164-0001Japan

Mg-Al layered double hydroxide intercalated with CO_(3)^(2-)(CO_(3)·Mg-Al LDH) is effective for treating HCl exhaust *** reacts with CO_(3)^(2-) in CO_(3)·Mg-Al LDH, resulting in the formation of Cl·Mg-Al *** propose that CO_(2) can be used for the desorption of Cl^(-)from Cl·Mg-Al LDH to regenerate CO_(3)·Mg-Al ***,we studied the desorption of a from CI-Mg-Al LDH by adding water to Cl·Mg-Al LDH and blowing CO_(2) into *** also analyzed the effects of temperature and water addition speed on the desorption of CI^(-)from Cl·Mg-Al *** results show that the added water adhered to CI·Mg-Al LDH and that CO_(2) in the gaseous phase was dissolved in this adhered water,thus generating CO_(3)^(2-).Therefore,anion exchange occurred between CO_(3)^(2-) and Cl^(-)in the Cl·Mg-Al LDH,thus desorbing Cl^(-).

关键词： Mg-Al layered double hydroxide CO_(2)gas Cl^(-)desorption Semi-dry method

Adsorption of urea, creatinine, and uric acid from three solution types using spherical activated carbon and its recyclability

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Desorption of Cl from Mg-Al layered double hydroxide intercalated with Cl using CO2 gas and water

中国化学工程学报（英文版） 2020年第12期

作者： Tomohito Kameda Kazuya Horikoshi Shogo Kumagai yuko saito Toshiaki Yoshioka

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Regeneration and Differentiation of Hamster Tracheal Epithelium Used Anti--Brdu Monoclonal Antibody After Mechanical Injury

中国化学工程学报（英文版） 2021年第1期

作者： Tomohito Kameda Hiroki Uchida Shogo Kumagai yuko saito Keiichi Mizushina Ichirou Itou Tianye Han Toshiaki Yoshioka

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中国医科大学学报 1991年第S2期20卷 15-20页

作者：王恩华 Masahiro saito Tsutomu WATANUKI Satsuki TAKAHASHI Sai WATANABE yuko DOI Department of Pathology China Medical University. Shenyang China First Department of Pathology Akita University School of Medicine. Japan

The ventral quadrant of the tracheal epithelium of the hamster,about one fourth of tracheal mucosa, was denuded by a venous needle *** stains were made with HE, PAS, and PAS-anti Brdu immunohis-tochemic technique. At the 0 h circumference cell number (CCN) was 927. *** 6 h post injured the viable cells changed in shapes and migrated from themargin to wound site. By 24 h the wound area was completely covered by a sin-gle layer of non-ciliated flattened cells, then an expotential increassing in cellregeneration occured in wound site by 48 h. The CCN had been restored to thelevel of control (1373), and the proliferative cell, composed of polygonal epi-dermoid metaplasia, 3～4 layers and reached a peak (338.8). The secretoryand ciliated cells appeared gradually from 72 h post injury, the epithelium re-stored to the normal epithelial architecture by one week post injury. In our pre-sent study either in control and non-injured epithelium or in all stages of woundsite about 70% of the Brdu positive cells contained small or confluent PAS posi-tive granules were observed. This fact indicated that secretory cells play a im-portant role in proliferation after mechanical injury and maintaining the normaltracheal pseudostratified epithelium.

关键词： trachea Brdu regeneration differentiation

Surveillance using trimodal imaging endoscopy after endoscopic submucosal dissection for superficial gastric neoplasia

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World Journal of Gastroenterology 2014年第43期20卷 16311-16317页

作者： Hiroyuki Imaeda Naoki Hosoe Kazuhiro Kashiwagi Yosuke Ida Rieko Nakamura Hidekazu Suzuki Yoshimasa saito Naohisa Yahagi Yasushi Iwao yuko Kitagawa Toshifumi Hibi Haruhiko Ogata Takanori Kanai Department of General Internal Medicine Saitama Medical UniversitySaitama 350-0495Japan Center for Diagnostic and Therapeutic Endoscopy School of MedicineKeio UniversityTokyo 108-8345Japan Division of Gastroenterology Department of Internal MedicineSchool of MedicineKeio UniversityTokyo 108-8345Japan Cancer Center School of MedicineKeio UniversityTokyo 108-8345Japan Center for Preventive Medicine School of MedicineKeio UniversityTokyo 108-8345Japan Department of Surgery School of MedicineKeio UniversityTokyo 108-8345Japan

AIM: To evaluate the effectiveness of trimodal imaging endoscopy (TME) to detect another lesion after endoscopic submucosal dissection (ESD) for superficial gastric neoplasia (SGN).

关键词： Autofluorescence imaging Endoscopic submucosal dissection Superficial gastric neoplasia

Relationship between Social Capital and Cognitive Functions among Community-Based Elderly

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Advances in Alzheimer's Disease 2017年第2期6卷 45-51页

作者： Sayuri Takechi Kimio Yoshimura yuko Oguma Yoshinobu saito Masaru Mimura Department of Neuropsychiatry Keio University School of Medicine Tokyo Japan Department of Health Policy and Management Keio University School of Medicine Tokyo Japan Graduate School of Health Management Keio University Fujisawa Japan Sports Medicine Research Center Keio University Yokohama Japan

The concept of social capital encompasses all relationships and networks among people in a local community or society as a whole. It has been found to be associated with the health and daily living status of people. Furthermore, an association between social capital and cognitive functions among the elderly has been suggested in recent years. However, the number of such reports is very few. Hence, the present study aims to evaluate the relationship between social capital and cognitive functions among the elderly living in a local community in Japan. A questionnaire survey was administered to 192 elderly individuals belonging to 10 neighborhood elderly groups. A regression analysis was conducted to determine the relationship between cognitive functions and the level of engagement with the local community, after adjusting for age, gender, and symptoms of depression. Valid responses were collected from 145 participants (mean age: 75.3 years). An analysis of the data concerning the level of engagement with the local community revealed a significant difference in the cognitive function scores between the group of people who indicated that they had someone they could consult (n = 69) and the group that indicated they had no one to consult (n = 76) (regression coefficient: -0.61, p = 0.0038, 95% confidence interval: -1.02 to -0.20). This result indicates the existence of a significant correlation between social capital and cognitive functions of the elderly living in a local community. In future studies, we need to investigate the same with a larger number of participants from a wider geographical area, and by incorporating more indicators for a comprehensive evaluation of social capital.

关键词： Social Capital Cognitive Functions Elderly Community

Pancreatic hyperechogenicity associated with hypoadiponectinemia and insulin resistance: A Japanese population study

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World Journal of Hepatology 2016年第33期8卷 1452-1458页

作者： Naohiko Makino Nakao Shirahata Teiichiro Honda Yoshiaki Ando Akiko Matsuda Yushi Ikeda Miho Ito yuko Nishise Takafumi saito Yoshiyuki Ueno Sumio Kawata Department of Gastroenterology Faculty of MedicineYamagata University Department of Internal Medicine Hyogo Prefectural Nishinomiya Hospital

AIMTo examine the relationship between pancreatic hyperechogenicity and risk factors for metabolic syndrome. METHODSA general population-based survey of lifestyle-related diseases was conducted from 2005 to 2006 in Japan. The study involved 551 participants older than 40 year of age. Data for 472 non-diabetic adults were included in the analysis. The measures included the demographic factors, blood parameters, results of a 75 g oral glucose tolerance test, and abdominal ultrasonography. The echogenicity of the pancreas and liver was compared, and then the subjects were separated into two groups: cases with pancreatic hyperechogenicity (n = 208) and cases without (controls, n = 264). The differences between both groups were compared using an unpaired t-test or Fisher’s exact test. Multiple logistic regression analysis was used to determine the relationship between the pancreatic hyperechogenicity and clinical and biochemical parameters. RESULTSSubjects with pancreatic hyperechogenicity had decreased serum adiponectin concentration compared to control subjects [8.9 (6.5, 12.8) vs 11.1 (7.8, 15.9), P P CONCLUSIONPancreatic hyperechogenicity is independently associated with increased BMI, insulin resistance, and hypoadiponectinemia in the general population.

关键词： Pancreatic hyperechogenicity Metabolic syndrome Obesity Adiponectin The Takahata study

Metabolomic Screening Applied to Rice FOX Arabidopsis Lines Leads to the Identification of a Gene-Changing Nitrogen Metabolism

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Molecular Plant 2010年第1期3卷 125-142页

作者： Doris Albinsky Miyako Kusano Mieko Higuchi Naomi Hayashi Makoto Kobayashi Atsushi Fukushima Masaki Mori Takanari Ichikawa Keiko Matsui Hirofumi Kuroda Yoko Horii yuko Tsumoto Hitoshi Sakakibara Hirohiko Hirochika Minami Matsui Kazuki saito RIKEN Plant Science Center Tsurumi-ku Yokohama 230-0045 Japan National Institute of Agrobiological Sciences Tsukuba 305-8602 Japan Graduate School of Pharmaceutical Sciences Chiba University Inage-ku Chiba 263-8522 Japan

Plant metabolomics developed as a powerful tool to examine gene functions and to gain deeper insight into the physiology of the plant cell. In this study, we screened Arabidopsis lines overexpressing rice full-length （FL） cDNAs （rice FOX Arabidopsis lines） using a gas chromatography-time-of-flight mass spectrometry （GC-TOF/MS）-based technique to identify rice genes that caused metabolic changes. This screening system allows fast and reliable identification of candi- date lines showing altered metabolite profiles. We performed metabolomic and transcriptomic analysis of a rice FOX Ara- bidopsis line that harbored the FL cDNA of the rice ortholog of the Lateral Organ Boundaries （LOB） Domain （LBD）/ Asymmetric Leaves2-1ike （ASL） gene of Arabidopsis, At-LBD37/ASL39. The investigated rice FOX Arabidopsis line showed prominent changes in the levels of metabolites related to nitrogen metabolism. The transcriptomic data as well as the results from the metabolite analysis of the Arabidopsis At-LBD37/ASL39-overexpressor plants were consistent with these findings. Furthermore, the metabolomic and transcriptomic analysis of the Os-LBD37/ASL39-overexpressing rice plants indicated that Os-LBD37/ASL39 is associated with processes related to nitrogen metabolism in rice. Thus, the combination of a metabolomics-based screening method and a gain-of-function approach is useful for rapid characterization of novel genes in both Arabidopsis and rice.

关键词： Metabolite profiling GC-TOF/MS rice FOX Arabidopsis lines transcript profiling LBD37/ASL39 nitrogenmetabolism.

Differentiation of embryonic stem cells into insulin-producing cells promoted by Nkx2.2 gene transfer

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World Journal of Gastroenterology 2005年第27期11卷 4161-4166页

作者： Akira Shiroi Shigehiko Ueda Yukiteru Ouji Ko saito Kei Moriya yuko Sugie Hiroshi Fukui Shigeaki Ishizaka Masahide Yoshikawa Division of Developmental Biology Department of Gastroenterology and Hepatology

AIM： To investigate the ability of a genetically altered embryonic stem （ES） cell line to generate insulin-producing cells in vitro following transfer of the Nkx2.2 ***： Hamster Nkx2.2 genes were transferred into mouse ES cells. Parental and Nkx2.2-transfected ES cells were initiated toward differentiation in embryoid body （EB） culture for 5 d and the resulting EBs were transferred to an attached culture system. Dithizone （DTZ）, a zincchelating agent known to selectively stain pancreatic beta cells, was used to detect insulin-producing *** outgrowths were incubated in DTZ solution （final concentration, 100μg/mL） for 15 rain before being examined microscopically. Gene expression of the endocrine pancreatic markers was also analyzed by RT-PCR. In addition, insulin production was determined immunohistochemically and its secretion was examined using an ***： DTZ-stained cellular clusters appeared after approximately 14 d in the culture of Nkx2.2-transfected ES cells （Nkx-ES cells）, which was as much as 2 wk earlier, than those in the culture of parental ES cells （wt-ES）. The frequency of DTZ-positive cells among total cultured cells on day 28 accounted for approximately 1.0% and 0.1% of the Nkx-ES- and wt-ES-derived EB outgrowths, respectively. The DTZ-positive cellular clusters were found to be immunoreactive to insulin, while the gene expressions of pancreatic-duodenal homeobox 1 （PDX1）, proinsulin 1 and proinsulin 2 were observed in the cultures that contained DTZ-positive cellular *** secretion was also confirmed by ELISA, whereas glucose-dependent secretion was not ***： Nkx2.2-transfected ES cells showed an ability to differentiate into insulin-producing cells.

关键词： Animals Cell Differentiation Cell Line Cricetinae Gene Transfer Techniques Homeodomain Proteins Insulin Islets of Langerhans Mice Mice, Inbred Strains Stem Cells Transcription Factors