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Identification of shared and unique gene families associated with oral clefts

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International Journal of Oral Science 2017年第2期9卷 104-109页

作者： Noriko Funato Masataka nakamura Department of Signal Gene Regulation Research Center for Medical and Dental SciencesTokyo Medical and Dental University1-5-45 YushimaBunkyo-kuTokyoJapan

Oral clefts, the most frequent congenital birth defects in humans, are multifactorial disorders caused by genetic and environmental factors. Epidemiological studies point to different etiologies underlying the oral cleft phenotypes, cleft lip(CL),CL and/or palate(CL/P) and cleft palate(CP). More than 350 genes have syndromic and/or nonsyndromic oral cleft associations in humans. Although genes related to genetic disorders associated with oral cleft phenotypes are known, a gap between detecting these associations and interpretation of their biological importance has remained. Here, using a gene ontology analysis approach, we grouped these candidate genes on the basis of different functional categories to gain insight into the genetic etiology of oral clefts. We identified different genetic profiles and found correlations between the functions of gene products and oral cleft phenotypes. Our results indicate inherent differences in the genetic etiologies that underlie oral cleft phenotypes and support epidemiological evidence that genes associated with CL/P are both developmentally and genetically different from CP only, incomplete CP, and submucous CP. The epidemiological differences among cleft phenotypes may reflect differences in the underlying genetic causes. Understanding the different causative etiologies of oral clefts is important as it may lead to improvements in diagnosis, counseling, and prevention.

关键词： cleft palate epidemiology gene ontology mutations soft palate syndrome

TC10 as an essential molecule in axon regeneration through membrane supply and microtubule stabilization

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Neural Regeneration Research 2022年第1期17卷 87-88页

作者： Takeshi nakamura Shingo Koinuma Division of Cell Signaling Research Institute for Biomedical SciencesTokyo University of ScienceNodaJapan

Mammalian central nervous system(CNS)neurons lose axon regenerative ability as they *** failure to regenerate shows a clear contrast to a remarkable potential of axon growth during embryonic development and after an injury in the peripheral nervous system(PNS)(Hilton and Bradke,2017).The absence of regeneration in the mature CNS neurons is caused by an inhibitory influence of the environment of the injured axons and the deficit of intrinsic factors that enable regeneration in the PNS(He and Jin,2016).

关键词： stabilization enable axon

从诉讼法学的立场对实体法学的学术方法及其构造质疑

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河北法学 2024年第3期42卷 2-34页

作者： [日]中村宗雄冯祝恒(译) 张卫平(校) 早稻田大学东京清华大学法学院北京100084 烟台大学山东烟台264005

在现代法学之下,民事实体法学与诉讼法学虽然都取得了飞速发展,但直到现在两者之间也没有建立起充分的学术联系。实体法学现阶段仍然是从罗马法继受而来的潘德克顿法学的一元自足体系,其对已形成独立法律体系的诉讼法理论毫不关心。也因... 详细信息

在现代法学之下,民事实体法学与诉讼法学虽然都取得了飞速发展,但直到现在两者之间也没有建立起充分的学术联系。实体法学现阶段仍然是从罗马法继受而来的潘德克顿法学的一元自足体系,其对已形成独立法律体系的诉讼法理论毫不关心。也因此,实体法理论存在缺陷、曲解以及学术范围不当扩大等问题。这些问题的主要成因可细分为:其一,现代私法学舍弃了实体法作为裁判规范的一面,完全沦为了社会规范理论;其二,现代私法学以具有私法性质的“请求权”概念继承了actio理论,舍弃了其诉讼性质;其三,现代私法学没有将对私法关系产生影响的“裁判效力”纳入其理论;其四,实体法学者对通过诉讼进行“权利确定”缺乏明确的认识。法的世界由实体法与诉讼法组成,二者应当分别划分学术领域,在互补关系上相互融合,从而构成法学的整个体系。为此,应首先打破实体法学与诉讼法学的自足体系,一方面需要将实体法理论引入到诉讼法学领域,提倡“实体法与诉讼法并立二元观”的诉讼法学理论构造,另一方面也需要在实体法学中建立与诉讼法学相融合的理论构造。

关键词：实体法学诉讼法学学术方法学术构造学术联系

A NEW APPROACH AND ERROR ANALYSIS FOR RECONSTRUCTING THE SCATTERED WAVE BY THE POINT SOURCE METHOD

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Journal of Computational Mathematics 2007年第2期25卷 113-130页

作者： Jijun Liu Gen nakamura Roland Potthast Department of Mathematics Southeast University Nanjing 210096 China Department of Mathematics Graduate School of Science Hokkaido University Sapporo 060-0810 Japan Institute for Numerical and Applied Mathematics University of Gottingen Lotzestr 16-1837085 Gottingen Germany

Consider an inverse scattering problem by an obstacle D belong to R^2 with impedance boundary. We investigate the reconstruction of the scattered field u^s from its far field pattern u^∞ using the point source method. First, by applying the boundary integral equation method, we provide a new approach to the point-source method of Potthast by classical potential theory. This extends the range of the point source method from plane waves to scattering of arbitrary waves. Second, by analyzing the behavior of the Hankel function, we obtain an improved strategy for the choice of the regularizing parameter from which an improved convergence rate （compared to the result of [15]） is achieved for the reconstruc- tion of the scattered wave. Third, numerical implementations are given to test the validity and stability of the inversion method for the impedance obstacle.

关键词： Inverse scattering Regularization Error estimate Numerics

RECONSTRUCTION OF SCATTERED FIELD FROM FAR-FIELD BY REGULARIZATION

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Journal of Computational Mathematics 2004年第3期22卷 389-402页

作者： Ji-junLiu JinCheng G.nakamura DepartmentofMathematics SoutheastUniversityNanjing210096China DepartmentofMathematics FudanUniversityShanghai200433China DepartmentofMathematics HokkaidoUniversitySapporo060-0810Japan

In this paper, we consider an inverse scattering problem for an obstacle D R^2 with Robin boundary condition. By applying the point source, we give a regularizing method to recover the scattered field from the far-fie... 详细信息

关键词： Inverse scattering Numerics Point source Regularization

THE LOCAL WELL-POSEDNESS OF A CHEMOTAXIS-SHALLOW WATER SYSTEM WITH VACUUM

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Acta Mathematica Scientia 2021年第1期41卷 231-240页

作者： Jishan FAN Fucai LI Gen nakamura Department of Applied Mathematics Nanjing Forestry UniversityNanjing 210037China Department of Mathematics Nanjing UniversityNanjing 210093China Department of Mathematics Hokkaido UniversitySapporo 060-0810Japan

In this paper we prove the local well-posedness of strong solutions to a chemotaxisshallow water system with initial vacuum in a bounded domainΩ■R^(2)without the standard compatibility condition for the initial *** ... 详细信息

关键词： chemotaxis shallow water vacuum local well-posedness strong solution

Attenuation and Distortion of Compression Waves Propagating in Very Long Tube

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Journal of Thermal Science 2011年第1期20卷 53-57页

作者： Shinya nakamura Daisuke SASA Toshiyuki AOKI Graduate School of Engineering Sciences Kyushu UniversityKasugaFukuoka816-8580Japan

A lot of phenomena related to propagating various waves are seen when the high-speed train goes through the tunnel,the gas pipeline is broken due to an accident or the air brake of the wagon *** instance,a compression wave generated ahead of a high-speed train entering a tunnel propagates to the tunnel exit and spouts as a micro pressure wave,which causes an exploding *** order to estimate the magnitude correctly,the mechanism of the attenuation and distortion of a compression wave propagating along a very long tunnel must be understood and the experimental information on these phenomena is *** experimental investigation is carried out to clarify the attenuation and distortion of the propagating compression wave in a very long *** results show that the strength of a compression wave decreases with *** attenuation and distortion of compression waves are affected by the initial waveform of the compression wave and by the unsteady boundary layer induced by the propagating *** shape of a compression wave becomes different with the propagating distance;that is,a shock wave appears just head of a wavefront and an overshoot on pressure distribution is observed behind a shock wave due to the transition of the unsteady boundary layer.

关键词： Propagating Compression Wave Very Long Tube Micro-pressure Wave High-Speed Train