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Endoscopic submucosal dissection in a patient with esophageal adenoid cystic carcinoma

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World Journal of Gastroenterology 2017年第45期23卷 8097-8103页

作者： Kenichi Yoshikawa Akiyoshi Kinoshita yuki hirose Keiko Shibata Takafumi Akasu Noriko Hagiwara Takeharu Yokota Nami Imai Akira Iwaku Go Kobayashi Hirohiko Kobayashi Nao Fushiya Hiroyuki Kijima Kazuhiko Koike Haruka Kaneyama Keiichi Ikeda Masayuki Saruta Division of Gastroenterology and Hepatology Internal MedicineJikei University Daisan Hospital Department of Endoscopy Jikei University Daisan Hospital Division of Gastroenterology and Hepatology Internal MedicineJikei University School of Medicine

We report the first use of endoscopic submucosal dissection(ESD) for the treatment of a patient with adenoid cystic carcinoma of the esophagus(EACC). An 82-year-old woman visited our hospital for evaluation of an esophageal submucosal tumor. Endoscopic examination showed a submucosal tumor in the middle third of the esophagus. The lesion partially stained with Lugol's solution,and narrow band imaging with magnification showed intrapapillary capillary loops with mild dilatation and a divergence of caliber in the center of the lesion. Endoscopic ultrasound imaging revealed a solid 8 mm × 4.2 mm tumor,primarily involving the second and third layers of the esophagus. A preoperative biopsy was non-diagnostic. ESD was performed to resect the lesion,an 8 mm submucosal tumor. Immunohistologically,tumor cells differentiating into ductal epithelium and myoepithelium were observed,and the tissue type was adenoid cystic carcinoma. There was no evidence of esophageal wall,vertical stump or horizontal margin invasion with p T1 b-SM2 staining(1800 μm from the muscularis mucosa). Further studies are needed to assess the use of ESD for the treatment of patients with EACC.

关键词： Adenoid cystic carcinoma of esophagus Endoscope Ultrasound Esophageal Tumor Endoscopic submucosal dissection

Recurrence of unilateral angioedema of the tongue:A case report

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世界临床病例杂志 2023年第27期11卷 6603-6612页

作者： yuki Matsuhisa Tsuneaki Kenzaka Hironori Shimizu Hideo hirose Tadao Gotoh Department of General Medicine Center for Community Medicine in North-Western Gifu Prefecture National Health Insurance Shirotori HospitalGujo 501-5122Japan Department of Pediatrics Center for Community Medicine in North-Western Gifu Prefecture National Health Insurance Shirotori HospitalGujo 501-5122Japan Department of Internal Medicine Hyogo Prefectural Tamba Medical CenterTamba 669-3495Japan Division of Community Medicine and Career Development Kobe University Graduate School of MedicineKobe 652-0032Japan

BACKGROUND Angioedema is a disorder characterized by edema of the face,lips,tongue,and extremities due to increased vascular *** of the tongue usually occurs bilaterally,and the incidence of unilateral angioedema of the tongue is *** study reports a rare case of unilateral angioedema of the tongue with no identifiable cause and repeated recurrence even after discontinuation of an angiotensin-converting enzyme *** SUMMARY The patient was a 65-year-old woman with pre-existing hypertension and hyperlipidemia and had been receiving 20 mg/d of *** was diagnosed with angioedema due to unilateral swelling of the *** airway obstruction was observed,and the symptoms improved following the administration of 0.3 mg of epinephrine intramuscularly and 125 mg of methylprednisolone *** lisinopril was discontinued,unilateral angioedema of the tongue continued to recur every 2-5 mo,with the symptoms improving following the administration of prednisolone and an *** oral administration of 500 mg of tranexamic acid after dinner prevented the recurrence of *** Careful monitoring and identification of the underlying mechanism play a crucial role in the treatment of angioedema.

关键词： Angioedema Tongue Unilateral Bradykinin Tranexamic acid Case report

Diurnal freeze/thaw cycles of the ground surface on the Tibetan Plateau

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Chinese Science Bulletin 2007年第1期52卷 136-139页

作者： YANG MeiXue YAO TanDong GOU XiaoHua hirose Nozomu FUJII Hide yuki HAO LiSheng D. F. LEVIA Key Laboratory of Cryosphere and Environment Cold and Arid Regions Environmental and Engineering Research Institute Chinese Academy of Sciences Lanzhou 730000 China Institute of Tibetan Plateau Research Chinese Academy of Sciences Beijing 100085 China Key Laboratory of Western China's Environment System MOE Lanzhou University Lanzhou 730000 China University of Tokyo Tokyo Japan Hengshui Meteorological Bureau Hengshui 053000 China Center for Climatic Research and Department of Geography University of Delaware DE 19716 USA

The exchange of energy and water between the lithosphere and atmosphere mainly takes place at the ground surface. Therefore, freeze/thaw condition at the ground surface is an important factor in ex- amining the interactions between the land surface and atmosphere. Based on the observation data obtained by CEOP/CAMP-Tibet, the diurnal freeze/thaw cycles of the ground surface near Naqu, central Tibetan Plateau was preliminarily analyzed. The results show that the surface layer was completely frozen for approximately one month. However, the time that the ground surface experienced diurnal freeze/thaw cycles was about 6 months. The high frequency of freeze/thaw cycles at the ground surface significantly influences water and energy exchanges between ground and atmosphere over half a year. The interaction processes between the ground and atmosphere under different soil conditions (such as complete thaw, complete freeze and diurnal freeze/thaw cycles) are issues worthy of further examina- tion.

关键词：西藏高原地貌冻结层解冻层

Effects of hyaluronan oligosaccharides on apoptosis ofhuman gingival fibroblasts

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Open Journal of Stomatology 2013年第1期3卷 19-24页

作者： yuki Tanne Kotaro Tanimoto Satoru Okuma Ryo Kunimatsu Naoto hirose Tomomi Mitsuyoshi Kazuo Tanne Department of Orthodontics Applied Life Sciences Hiroshima University Institute of Biomedical & Health Sciences Hiroshima Japan

An?increased?content?of?low?molecular?weight (LMW)- HA?was?found?in?human?gingiva?during?the?initial phase of?periodontitis. A?number?of?functions?have?been?described?for LMW-HA?in?inflammatory?processes.?It?is?also?demonstrated?that?LMWHA?induces?apoptosis?in?chondrocytes?and?tumor?cells,?however, effects of?LMWHA on the apoptosis?of?gingival?fibroblasts?(GFs) remain?unclear. The?purpose?of?this?study?was?to?investigate?the effects?of HA?oligosaccharides?(HAoligo) on?the apoptosis of GFs. GFs were?isolated?from?palatal?gingival?tissues around?the upper?first?premolars of eight youth?(6 -10?years?old)?and eight adult?(26 -35?years?old) subjects.?Cultured?GFs?were?subjected?to?the?analyses,?ELISA?for?cell?proliferation,?quantitative real?time-PCR?for?gene?expression?of?Bcl-2,?and?caspase-3?assay?for?apoptotic potency. Proliferative?activity?of?cultured?GFs was increased?

关键词： Hyaluronan Oligosaccharide Apoptosis Caspase-3

Longitudinal changes in the height and location of bone bridge from autogenous iliac bone graft in patients with cleft lip and palate

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Open Journal of Stomatology 2013年第1期3卷 58-62页

作者： Kotaro Tanimoto yuki Tanne Keisuke Sumi Naoto hirose Nobuhiko Kawai Eiji Tanaka Kazuo Tanne Department of Orthodontics Applied Life Sciences Hiroshima University Institute of Biomedical & Health Sciences Hiroshima Japan University of Tokushima Graduate School of Oral Sciences Tokushima Japan

Background: Secondary alveolar bone graft has been widely used for the closure of maxillary bone defects in patients with cleft lip and palate (CLP). However, the log-term stability of grafted bone in detail remains unclear. Purpose: To evaluate the nature of longitudinal changes in the grafted bone from autogenous iliac bone in patients with CLP for more than 2 years after the surgery. Methods and Subjects: The subjects were 124 CLP patients treated with iliac bone graft in Hiroshima University Hospital from 1997 to 2007. The height and location of the bone bridge was evaluated radiographically before and after surgery. Results: 1) Bone graft was performed at a mean age of 12.5 (±4.2) years old. The canines on the cleft side were not erupted at the surgery in 60.0%. All canines erupted except for the congenital missing and impacted ones (11.3%) within 2 years after bone graft;2) The height of the bone bridge was more than 11 mm in 71.8% of all patients 1 month after surgery. In addition, the location of bone bridge in 66.1% of all patients were clinically satisfactory. However, these rates decreased time-dependently owing to bone resorption after the bone graft. Conclusions: In conclusion, it is shown that autogenous bone graft produce a sufficient bone bridge in the jaw cleft area by the long-term evaluation of the changes in height and location of bone bridge, although some amount of time-dependent bone resorption is inevitable.

关键词： Bone Bridge Bone Graft Canine Eruption Cleft Lip and Palate