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A preliminary study on rectal dose reduction associated with hyaluronic acid implantation in brachytherapy for prostate cancer

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Asian Journal of Urology 2024年第2期11卷 286-293页

作者： Tairo Kashihara yuka urago Hiroyuki Okamoto Mihiro Takemori Hiroki Nakayama Shohei Mikasa Tetsu Nakaichi Kotaro Iijima Takahito Chiba Junichi Kuwahara Satoshi Nakamura Weishan Chang Yoshiyuki Matsui Hiroshi Igaki Department of Radiation Oncology National Cancer Center Hospital5-1-1 TsukijiChuo-kuTokyoJapan Radiation Safety and Quality Assurance Division National Cancer Center Hospital5-1-1 TsukijiChuo-kuTokyoJapan Department of Radiological Sciences Graduate School of Human Health SciencesTokyo Metropolitan University7-2-10 Higashi-OguArakawa-kuTokyoJapan Department of Radiological Technology National Cancer Center Hospital5-1-1 TsukijiChuo-kuTokyoJapan Department of Urological Oncology National Cancer Center Hospital5-1-1 TsukijiChuo-kuTokyoJapan

Objectives: Hydrogel spacer (HS) was developed to reduce rectal toxicities caused by radiotherapy, but has been reported to cause major adverse events. Our institute has attempted to introduce a hyaluronic acid (HA) as an alternative spacer. This study aimed to compare rectal doses and geometric distributions between the HS and HA implantation in prostate ***: HS and HA were inserted in 20 and 18 patients undergoing high-dose brachytherapy, respectively. The rectum spacer volumes injected were 10 mL and 22 mL, respectively. In the treatment planning system, 13.5 Gy was administered with common catheter positions. The rectal dose indices were assessed between the spacer groups for dosimetry evaluation. Distances between the prostate and rectum and configurations of the spacers were ***: The mean doses irradiated to 0.1 and 2 mL of the rectum were 10.45 Gy and 6.71 Gy for HS, and 6.73 Gy and 4.90 Gy for HA (p<0.001). The mean minimum distances between the prostate and rectum were 1.23 cm and 1.79 cm for HS and HA, respectively (p<0.05). Geometrical configuration comparisons revealed that HA has a higher ability to expand the space than ***: The rectal dose reduction ability of HA is significantly greater than that of HS, suggesting its potential as a new spacer.

关键词： Brachytherapy Hyaluronicacid Hydrogel Prostaticneoplasm Radiotherapy

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Superconducting joints using reacted multifilament MgB_(2)wires:A technology toward cryogen-free MRI magnets

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Journal of Magnesium and Alloys 2024年第1期12卷 159-170页

作者： Dipak Patel Akiyoshi Matsumoto Hiroaki Kumakura yuka Hara Toru Hara Minoru Maeda Hao Liang Yusuke Yamauchi Seyong Choi Jung Ho Kim Md Shahriar A.Hossain School of Mechanical and Mining Engineering The University of QueenslandSt LuciaQueensland 4072Australia National Institute for Materials Science(NIMS) 1-2-1 SengenTsukubaIbaraki 305-0047Japan Department of Electrical Engineering and Kangwon High Magnetic Field Center Institute of Quantum Convergence TechnologyKangwon National UniversityGangwon 24341Republic of Korea Australian Institute for Bioengineering and Nanotechnology(AIBN) The University of QueenslandSt LuciaQueensland 4072Australia Department of Materials Process Engineering Graduate School of EngineeringNagoya UniversityNagoyaAichi 464-8603Japan Institute for Superconducting and Electronic Materials Australian Institute for Innovative MaterialsUniversity of WollongongNorth WollongongNew South Wales 2500Australia

The development of superconducting joining technology for reacted magnesium diboride(MgB_(2))conductors remains a critical challenge for the advancement of cryogen-free MgB_(2)-based magnets for magnetic resonance imaging(MRI).Herein,the fabrication of superconducting joints using reacted carbon-doped multifilament MgB_(2)wires for MRI magnets is *** achieve successful superconducting joints,the powder-in-mold method was employed,which involved tuning the filament protection mechanism,the powder compaction pressure,and the heat treatment *** fabricated joints demonstrated clear superconducting-to-normal transitions in self-field,with effective magnetic field screening up to 0.5 T at 20 *** evaluate the interface between one of the MgB_(2)filaments and the MgB_(2)bulk within the joint,serial sectioning was conducted for the first time in this type of superconducting *** serial sectioning revealed space formation at the interface,potentially caused by the volume shrinkage associated with the MgB_(2)formation or the combined effect of the volume shrinkage and the different thermal expansion coefficients of the MgB_(2)bulk,the filament,the mold,and the sealing *** findings are expected to be pivotal in developing MgB_(2)superconducting joining technology for MRI magnet applications through interface engineering.

关键词： Mg B2 superconducting joint MgB_(2)conductor MRI applications Cryogen-free magnet Persistent-mode operation

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Identification of research gaps to improve care for healthy ageing:a scoping review

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Family Medicine and Community Health 2024年第4期12卷 9-16页

作者： Matteo Cesari Marco Canevelli Jotheeswaran Amuthavalli Thiyagarajan Soung-Eun Choi Polina Grushevska Saloni Kumar Muyan Chen Hyobum Jang yuka Sumi Anshu Banerjee Ageing and Health Unit Department of MaternalNewbornChild and Adolescent Health and AgeingWorld Health OrganizationGenevaSwitzerland Department of Neurobiology Care Sciences and SocietyStockholm UniversityStockholmSweden National Center for Disease Prevention and Health Promotion Italian National Institute of HealthRomeItaly Department of Human Neuroscience Sapienza UniversityRomeItaly Master in Health and International Development London School of EconomicsLondonUK Department of Maternal NewbornChild and Adolescent Health and AgeingWorld Health OrganizationGenevaSwitzerland

Objective Several research gaps affect the improvement of care for healthy *** identification is crucial to developing a specific research prioritisation agenda supporting progress at the micro(clinical),meso(service delivery)and macro(system)*** achieve this,a scoping review was carried out to describe the most significant gaps impeding the improvement of care for healthy *** A scoping review of the literature was conducted according to the Joanna Briggs Institute *** selected articles were analysed to identify topics or areas essential for improving care for healthy ageing but requiring further support from *** criteria Every type of scientific article,except for randomised controlled trials,was considered of potential interest without restrictions on publication date,type of publication and *** sources A systematic search(last search:6 December 2023)was conducted using PubMed,MEDLINE and *** Overall,1558 articles were retrieved from the *** these,310 were finally retained for this work.A total of 1195 research gaps were identified(average:3.85 per article)and clustered into the 13 primary areas:ageing,care approach,caregivers,health economics,health,interventions,policies,research,settings,training,technology,specific populations and understanding the older *** particular,research for improving the person-centred approach(n=38),better considering cultural diversities(n=27),implementing integrated care(n=25)and ensuring access to care(n=25)were the most prevalent priorities reported in the *** A wide range of factors spanning multiple disciplines,from clinical to policy levels,require special consideration,exploration and *** findings of this scoping review represent an essential step in identifying gaps for developing a research prioritisation agenda to improve care for healthy ageing.

关键词： policy service supporting

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Effect of Wearing a Maxillofacial Prosthesis on Masticatory Rhythm Improvement in Mandibulectomy Patients

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Health 2024年第7期16卷 717-729页

作者： Xuewei Han Mihoko Haraguchi yuka I. Sumita Marwa Ahmed Aboelez Noriyuki Wakabayashi Department of Advanced Prosthodontics Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University (TMDU) Tokyo Japan Department of Partial and Complete Denture School of Life Dentistry at Tokyo The Nippon Dental University Tokyo Japan Department of Prosthodontics Faculty of Dentistry Mansoura University Mansoura Egypt

Background: Recording jaw movement rhythms in patients with jaw defects is challenging using conventional tracking devices. However, masticatory rhythm is crucial for masticatory performance and nutritional intake. This study aimed to explore the impact of using a maxillofacial prosthesis to restore masticatory rhythm in mandibulectomy patients with a novel wearable device. Methods: Twelve patients who underwent mandibulectomy and were rehabilitated with maxillofacial prosthesis were recruited. Chewing rate, cycle durations, coefficient of variation of cycle durations (CV), changing times of skin morphology on the back of the ear pinna area (SM), and masticatory performance were measured during gum chewing without and with a denture using a wearable jaw movement rhythm tracking device. A paired t-test and the Pearson correlation coefficient were used for statistical analysis. Results: The chewing rate increased by 8.6 cycles/min with dentures (P P = 0.01). The CV and SM decreased with dentures (P = 0.004 and P = 0.01, respectively). Significant correlations were found between the CV and SM without dentures (P = 0.004). Conclusion: 1. Wearing maxillofacial prostheses can improve masticatory rhythm in patients who undergo mandibulectomy with Eichner B2 occlusal supports. 2. The wearable device is available for measuring masticatory rhythm in patients with jaw defects in clinics. 3. Changing times of the skin morphology on the back of the ear pinna indicate jaw movement stability through a simpler process than the coefficient of variation of cycle durations.

关键词： Masticatory Rhythm Jaw Movement Rhythm Tracking Device Maxillofacial Prosthesis Head and Neck Tumor Mandibulectomy

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Survey of international experts on research priorities to improve care for healthy ageing

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Family Medicine and Community Health 2024年第3期12卷 36-39页

作者： Matteo Cesari yuka Sumi Hyobum Jang Jotheeswaran Amuthavalli Thiyagarajan Yejin Lee Rachel Albone Marco Canevelli Monica R Perracini Andrew M Briggs Anshu Banerjee Department of Maternal NewbornChild and Adolescent Health and AgeingWorld Health OrganizationGenevaSwitzerland Department of Clinical Sciences and Community Health University of MilanMilanItaly Department of Human Neuroscience Universitàdegli Studi di Roma La SapienzaRomeItaly Department of Neurobiology Care Sciences and SocietyStockholm UniversityStockholmSweden National Center for Disease Prevention and Health Promotion Italian National Institute of HealthRomeItaly Master's and Doctoral Program in Physical Therapy Universidade Cidade de São PauloSão PauloBrazil Curtin School of Allied Health Curtin enAble InstituteCurtin UniversityPerthWAAustralia

INTRODUCTION The United Nations(UN)Decade of Healthy Ageing(2021–2030),coordinated by the World Health Organization(WHO),1 is a global collaborative initiative aimed at improving the lives of older people,their families and the communities.23 The Action Areas 3(ie,‘deliver person-centred,integrated care and primary health services responsive to older people’)and 4(ie,‘provide access to long-term care(LTC)for older people who need it’)of the Decade’s work programme focus on reorienting health and care systems to promote‘ageing in place’and the delivery of personalised interventions in a seamless continuum of care.

关键词： services ageing centre

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Emotion Measurement Using Biometric Signal

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Health 2024年第5期16卷 395-404页

作者： Yukina Miyagi Saori Gocho yuka Miyachi Chika Nakayama Shoshiro Okada Kenta Maruyama Taeyuki Oshima College of Pharmacy Kinjo Gakuin University Nagoya Japan Graduate School of Medicine Aichi Medical University Nagakute Japan Department of Pharmacy Nagoya Ekisaikai Hospital Nagoya Japan Department of Pharmacy Gifu University of Medical Science Kani Japan

In recent years, research on the estimation of human emotions has been active, and its application is expected in various fields. Biological reactions, such as electroencephalography (EEG) and root mean square successive difference (RMSSD), are indicators that are less influenced by individual arbitrariness. The present study used EEG and RMSSD signals to assess the emotions aroused by emotion-stimulating images in order to investigate whether various emotions are associated with characteristic biometric signal fluctuations. The participants underwent EEG and RMSSD while viewing emotionally stimulating images and answering the questionnaires. The emotions aroused by emotionally stimulating images were assessed by measuring the EEG signals and RMSSD values to determine whether different emotions are associated with characteristic biometric signal variations. Real-time emotion analysis software was used to identify the evoked emotions by describing them in the Circumplex Model of Affect based on the EEG signals and RMSSD values. Emotions other than happiness did not follow the Circumplex Model of Affect in this study. However, ventral attentional activity may have increased the RMSSD value for disgust as the β/θ value increased in right-sided brain waves. Therefore, the right-sided brain wave results are necessary when measuring disgust. Happiness can be assessed easily using the Circumplex Model of Affect for positive scene analysis. Improving the current analysis methods may facilitate the investigation of face-to-face communication in the future using biometric signals.

关键词： Biometric Signals Electroencephalogram Electrocardiogram Emotion Communication

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Symptomatic COVID-19 in University Students: A School-Wide Web-Based Questionnaire Survey during the Omicron Variant Outbreak

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Advances in Infectious Diseases 2024年第1期14卷 133-146页

作者： Mai Kitahara Hisami Sameshima Rie Tanuma Kumi Setoyama yuka Yamaguchi Akiyo Kamachi Satoko Nakamura Mayuko Sakuma Yoichi Kawaike Tamotsu Furuya Shinji Ijichi Health Service Center Kagoshima University Kagoshima Japan Center for Management of Information Technologies Kagoshima University Kagoshima Japan

Aim: To detect risk and preventive factors associated with the Omicron variant infection in university students, a combination of a web-based survey and multivariate logistic regression analysis was introduced as the front-line initiatives by the school health practitioners. Design: Questionnaire survey. Methods: The school-wide web-based questionnaire survey was conducted among our university students as a part of the annual health check-up in April, 2023. The positive outcome was confined to the first symptomatic COVID-19 onset during the Omicron variant outbreak. Results: In this self-administered survey, risk or protective associations were merely estimated statistically in university students (n = 5406). In measured factors, karaoke and club/group activities could maintain the statistical significance in adjusted odds ratios (ORs) as relative risk factors, and science course, measles/ rubella (MR) vaccination, and COVID-19 vaccination remained as relative protective factors in adjusted OR analyses. Club/group activities with member gathering and karaoke sing-along sessions in university students may frequently have WHO’s three Cs. These risk factors are still important topics for the infection control of COVID-19 in university students. Together with some recent reports from other researchers, the significant protective role of MR vaccine in our survey warrants further clinical investigation. If the breakthrough infection continuously constitutes the majority of infection, real data in test-negative case-control or web-based questionnaire design continue to be important for statistical analysis to determine the minimal requirement of our strategies which may be equivalent to or replace COVID-19 vaccines.

关键词： Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Coronavirus Disease 2019 (COVID-19) Omicron Variant Risk Behaviors Protective Factors

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Differences in dinucleotide frequencies of thermophilic genes encoding water soluble and membrane proteins

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2011年第6期12卷 419-427页

作者： Hiroshi NAKASHIMA yuka KURODA Department of Clinical Laboratory Science Graduate Course of Medical Science and TechnologySchool of Health SciencesKanazawa University

The occurrence frequencies of the dinucleotides of genes of three thermophilic and three mesophilic species from both archaea and eubacteria were investigated in this study. The genes encoding water soluble proteins were rich in the dinucleotides of purine dimers, whereas the genes encoding membrane proteins were rich in pyrimidine dimers. The dinucleotides of purine dimers are the counterparts of pyrimidine dimers in a double-stranded DNA. The purine/pyrimidine dimers were favored in the thermophiles but not in the mesophiles, based on comparisons of observed and expected frequencies. This finding is in agreement with our previous study which showed that purine/pyrimidine dimers are positive factors that increase the thermal stability of DNA. The dinucleotides AA, AG, and GA are components of the codons of charged residues of Glu, Asp, Lys, and Arg, and the dinucleotides TT, CT, and TC are components of the codons of hydrophobic residues of Leu, Ile, and Phe. This is consistent with the suitabilities of the different amino acid residues for water soluble and membrane proteins. Our analysis provides a picture of how thermophilic species produce water soluble and membrane proteins with distinctive characters: the genes encoding water soluble proteins use DNA sequences rich in purine dimers, and the genes encoding membrane proteins use DNA sequences rich in pyrimidine dimers on the opposite strand.

关键词： Water soluble and membrane proteins Purine/pyrimidine dimers Thermophilic and mesophilic species Dinucleotide frequencies

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An experimental investigation of transient cavitation control on a hydrofoil using hemispherical vortex generators

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Journal of Hydrodynamics 2021年第6期33卷 1139-1147页

作者： Ebrahim Kadivar Takaho Ochiai yuka Iga Ould el Moctar Ship Technology Ocean Engineering and Transport SystemsUniversity of Duisburg-EssenDuisburgGermany Institute of Fluid Scienece Tohoku UniversitySendaiJapan

Unsteady cavitation causes noise,damage,and performance decline in the marine engineering and fluid machinery ***,finding a method to control the cavitation and its destructive effects is important for the industrial *** this work,we proposed a passive method to control the unsteady behavior of transient cavitation at the medium Reynolds *** this aim,we performed an experimental study using a high-speed camera to analyze the effects of hemispherical vortex generators(VGs)on the cavitation dynamics around a hydrofoil *** addition,the pressure pulsations induced by the collapse of the cavity structures in the wake region of the hydrofoil were captured with a pressure transducer mounted on the wall downstream of the *** results showed that the instability behaviors of the cavity structures on the hydrofoil were mitigated using the proposed cavitation passive control *** addition,the pressure pulsations in the wake region of the hydrofoil were reduced *** can be concluded that the suppression of cavitation instabilities can improve the operating life and reliability of the marine and hydraulic systems.

关键词： Hydrodynamic cavitation cavitation passive control hemispherical vortex generators pressure pulsations high speed observation

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Optimization of fuel consumption and NO_(x) emission for mild HEV via hierarchical model predictive control

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Control Theory and Technology 2022年第2期20卷 221-234页

作者： yuka Umezawa Ken Yamauchi Hiroki Seto Toshiro Imamura Toru Namerikawa Graduate School of Science and Technology Keio University3-14-1 HiyoshiKohoku-ku.YokohamaKanagawa 223-8522Japan Isuzu Advanced Engineering Center Ltd 8 TsuchidanaFujisawa.Kanagawa 252-0881.Japan

In this paper,we consider the fuel economy optimization problem for a mild hybrid electric vehicle(HEV)using hierarchical model predictive *** the proposed algorithm,two problems are addressed:eco-driving and torque *** the eco-driving problem,vehicle speed was *** the reduction in fuel consumption and NOx emissions,the torque required to follow the target speed was ***,in the torque distribution problem,the distribution between the engine and motor torques were *** this phase,engine characteristics were *** problems differ in terms of time scales;therefore,a hierarchical model predictive control is ***,the numerical simulation results demonstrated the efficacy of this research.

关键词： Mild HEV Energy management Model predictive control Hierarchical control

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