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An omega result for supremum norms of Hecke-eigenforms in the level aspect

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Science China Mathematics 2010年第1期53卷 223-242页

作者： lau yuk-kam Department of Mathematics The University of Hong KongPokfulam RoadHong KongChina

This note is to remark the large supremum norms of some Hecke-eigenforms of large squarefree levels and nebentypus of small conductors,based on the recent prominent progress by Soundararajan on the extreme central val... 详细信息

关键词： Hecke-eigenforms central values of L-functions

Coefficients of symmetric square L-functions

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Science China Mathematics 2010年第9期53卷 2317-2328页

作者： lau yuk-kam Department of Mathematics The University of Hong Kong

Let λsym2f(n) be the n-th coefficient in the Dirichlet series of the symmetric square L-function associated with a holomorphic primitive cusp form *** prove Ω± results for λsym2f(n) and evaluate the number of posi... 详细信息

关键词： Fourier coefficients of modular forms B-free numbers

Gut microbiota in cancer initiation,development and therapy

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Science China Life Sciences 2025年

作者： Ruyi Zhang Xiang Zhang Harry Cheuk Hay lau Jun Yu Institute of Digestive Disease and Department of Medicine and Therapeutics State Key Laboratory of Digestive DiseaseLi Ka Shing Institute of Health SciencesCUHK Shenzhen Research InstituteThe Chinese University of Hong Kong

Cancer has long been associated with genetic and environmental factors,but recent studies reveal the important role of gut microbiota in its initiation and *** 13%of cancers are linked to infectious agents,highlighting the need to identify the specific microorganisms *** microbiota can either promote or inhibit cancer growth by influencing oncogenic signaling pathways and altering immune *** can lead to cancer,while certain probiotics and their metabolites may help reestablish microecological balance and improve anti-tumor immune *** into targeted approaches that enhance therapy with probiotics is ***,the effects of probiotics in humans are complex and not yet fully ***,methods to counteract harmful bacteria are still in *** clinical trials also indicate that modifying gut microbiota may help manage side effects of cancer *** research is crucial to understand better how gut microbiota can be used to improve cancer prevention and treatment outcomes.

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Efficient photocatalytic reduction of CO2 to formate by a molecular noble metal-free system

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Science China Chemistry 2025年第1期 152-156页

作者： Lihua Zhang Lingjing Chen Huatian Shi Yue Wei Gui Chen Tai-Chu lau School of Environment and Civil Engineering Research Center for Eco-environmental Engineering Dongguan University of Technology Department of Chemistry and Institute of Molecular Functional Materials City University of Hong Kong

Reducing CO2to carbon-neutral solar fuels can not only alleviate the energy demand but also mitigate the greenhouse *** present,developing an efficient non-noble metal photo/electrocatalytic system for converting CO2to a specific product beyond CO is still a big ***,we report a new cobalt complex bearing 2,2′-bi-1,10-phenanthroline ligand that can photocatalytically reduce CO2to formate （HCOO-）.Turnover number （TON） for HCOO-up to 677 with 99%selectivity can be achieved using organic dyes purpurin as photosensitizer and 1,3-dimethyl-2-phenyl-2,3-dihydro-1H-benzo[d]imidazole （BIH） as sacrificial reductant in a CO2-saturated NMP/TEA （v/v,3:1） solution under visible light *** potential electrolysis at-1.41 V （***/Ag Cl） in the presence of 12 m M Et3NHBF4also produced HCOO-with Faradaic efficiency of 39%.Spectroscopic and electrochemical studies suggest that a[CoI-H]species is the key intermediate for CO2reduction.

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A ruptured recurrent small bowel gastrointestinal stromal tumour causing hemoperitoneum

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Frontiers of Medicine 2015年第1期9卷 108-111页

作者： Eric C.H. Lai kam Man Chung Stephanie H.Y. lau Wan Yee lau Faculty of Medicine The Chinese University of Hong Kong Shatin Hong Kong SAR China Dr. K.M. Chung's Clinic Rm 807 Hang Seng Tsimshatsui Building 18 Carnarvon Road Tsimshatsui Hong Kong SAR China Department of Surgery Pamela Youde Nethersole Eastern Hospital Hong Kong SAR China Department of Surgery Queen Elizabeth Hospital Hong Kong SAR China

Hemoperitoneum is a rare and potentially life-threatening complication of GIST. We reported a 54- year-old man who developed disseminated intra-abdominal recurrence from a previously resected gastrointestinal stromal tumour （GIST） of the small bowel, and the patient presented with hemoperitoneum. Emergent debulking surgery was performed. A high dose imatinib was prescribed. Despite the presence of residual disease, the patient was well clinically 8 months after the operation. Even though, there is no evidence to support the routine use of debulking surgery in the management of GIST. In our patient, disease progression after second line targeted therapy and the absence of alternative treatment options for spontaneous rupture and hemoperitoneum prompted us to treat the patient aggressively. Resection of the ruptured GIST was carried out for control of bleeding and to prevent recurrent bleeding in this patient with good surgical risks. During the treatment decision-making, the patient＇s general condition, the risk of surgery and the extent of dissemination were taken into consideration. In this patient who presented with spontaneous rupture of a small intestinal GIST, the novel use of targeted therapy and aggressive surgical treatment produced reasonably good survival outcome.

关键词： gastrointestinal stromal tumour hemoperitoneum small bowel GIST small bowel neoplasm imatinib

A monolithic InP/SOI platform for integrated photonics

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Light(Science & Applications) 2021年第11期10卷 2143-2152页

作者： Zhao Yan Yu Han Liying Lin Ying Xue Chao Ma Wai Kit Ng kam Sing Wong Kei May lau Department of Electronic and Computer Engineering Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongChina Department of Physics and William Mong Institute of Nano Science and Technology Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongChina

The deployment of photonic integrated circuits(PICs)necessitates an integration platform that is scalable,high-throughput,cost-effective,and *** we present a monolithic InP on SOI platform to synergize the advantages of two mainstream photonic integration platforms:Si photonics and InP *** monolithic InP/SOI platform is realized through the selective growth of both InP sub-micron wires and large dimension InP membranes on industry-standard(001)-oriented silicon-on-insulator(SOI)*** epitaxial InP is in-plane,dislocation-free,site-controlled,intimately positioned with the Si device layer,and placed right on top of the buried oxide layer to form“InP-on-insulator”.These attributes allow for the realization of various photonic functionalities using the epitaxial InP,with efficient light interfacing between the III-V devices and the Si-based *** exemplify the potential of this InP/SOI platform for integrated photonics through the demonstration of lasers with different cavity designs including subwavelength wires,square cavities,and *** results here mark a critical step forward towards fully-integrated Si-based PICs.

关键词： SOI monolithic integration

Metal removal studied by a laboratory scale immobilized microalgal reactor

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Journal of Environmental Sciences 1998年第4期10卷 91-95页

作者： Arthur lau yuk Shan Wong Zhang Tong Nora F.Y.Tam Research Center/Biology Department Hong Kong University of Science and TechnologyClearwater RoadKowloonH.K. CEDRC Beijing 100028China Department of Biology and Chemistry City University of Hong KongKowloonH.K.

A laboratory scale algal column reactor packed with 75 ml alginate algal beads was used to treat 30 mg/L Cu and Ni with a HRT of 30 minutes. At the end of loading 4L metal solution, over 97% of Cu and 91% of Ni were removed from the wastewater with a final residual of 1.76 mg/L Cu and 8.8 mg/L Ni. Up flow was preferred to down flow in maintaining a constant flow rate and hence HRT. Amount of metal recovered during regeneration depended on concentration and nature of regenerant used. Dilute acid was a better regenerant than calcium in terms of metal recovered (90%) and volume needed for regeneration. The consistency in the metal removal performance by the algal column over 10 metal treatment and regeneration cycles suggested that the algal beads can treat Cu or Ni bearing wastewater over 400 times its own volume.

关键词： immobilized microalgal reactor industrial wastewater treatment metal.

Pretreatment neutrophil-to-lymphocyte ratio predicts worse survival outcomes and advanced tumor staging in patients undergoing radical cystectomy for bladder cancer

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Asian Journal of Urology 2017年第4期4卷 239-246页

作者： Yu Guang Tan Ernest Eu Weber lau kam On Hong Hong Huang Department of Urology Singapore General HospitalSingapore

Objective:To determine the role of neutrophil-to-lymphocyte ratio(NLR)in prognosticating survival outcomes in patients with advanced/metastatic urothelial bladder ***:We retrospectively reviewed 84 patients undergoing radical cystectomy(RC)for UCB from January 2002 to June *** was computed(median:5 days)prior to *** patients received neoadjuvant *** was analyzed as a continuous variable and a cut-off point of 2.7 was obtained,with a statistical receiver operating characteristics of *** curves,multivariate Cox proportional hazard and logistics regression models were used to predict NLR association with survival ***:The median follow-up period was 30.1 months(range:3.2e161.7)owing to high recurrence rate and subsequent mortalities,compared to the median 64.7 months in patients alive at the end of study ***2.7 was associated with worse survival outcomes(5-year disease-specific survival:22%vs 58%,p Z 0.017,95%CI:1.193e6.009;5-year overall survival:23%vs 60%,p Z 0.008,95%CI:1.322e6.147).Furthermore,on multivariate analyses,higher NLR was independently associated with higher recurrence rate(p Z 0.007,HR Z6.999,95%CI:1.712e28.606),higher T staging(p Z 0.021,HR Z 3.479,95%CI:1.212e9.990)and lymph node involvement(p Z 0.009,HR Z 4.534,95%CI:1.465e14.034).

关键词： Bladder cancer Neutrophil-tolymphocyte ratio Radical cystectomy Bladder carcinoma

Prostate specific antigen bounce after intensity-modulated radiation therapy in an Asian population

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Asian Journal of Urology 2016年第2期3卷 59-63页

作者： Yu Guang Tan Weber lau kam On Hong Hong Huang Terence Tan Wee Kiat Department of Urology Singapore General HospitalSingapore Department of Radiotherapy National Cancer Centre SingaporeSingapore

Objective:Serum prostate specific antigen(PSA)is commonly used to evaluate treatment response after definitive radiation therapy(RT).However,PSA levels can temporarily rise without a clear reason,termed“PSA bounce”,and often engender great anxiety for both patients and *** present study aimed to determine the prevalence and factors that predict“PSA bounce”after intensity-modulated radiation therapy(IMRT),and the relevance to biochemical failure and cancer recurrence in an Asian ***:We retrospectively reviewed 206 patients who received IMRT for prostate cancer from 2004 to 2012 in the National Cancer Centre *** patients were followed up with regular PSA *** defined“PSA bounce”as a rise of 0.1 ng/mL,followed by two consecutive *** with biochemical failure(PSA nadir t 2 ng/mL)were further evaluated for cancer ***:Sixty-one patients(29.6%)experienced“PSA bounce”,at a median time of 16 months and lasted for 12 *** remained the most consistent predictor of the incidence,duration and extent of“PSA bounce”.Other contributory factors included baseline PSA,Gleason score and PSA *** therapy and prostate volume did not affect this *** patients(7.8%)developed biochemical recurrence,at median time of 32 months,of which 11 were confirmed to have metastatic *** median follow-up time was 71 months.

关键词： Prostate specific antigen Prostate specific antigen bounce Prostate cancer Intensity modulated radiation therapy