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Insight into the role of ethylene glycol on thermodynamics and nucleation kinetics of dimethyl terephthalate in mixed solvent system

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Particuology 2024年第2期85卷 1-12页

作者： yujin Zhang Chunyan Shi Jing tang Li Liu Dongxia Yan Qing Zhou Xingmei Lu Songyan Jia College of Chemical Engineering Shenyang University of Chemical TechnologyShenyang110142China Bejing Key Laboratoryoflonic Liquids Clean Process CAS Key LaboratoryofGreen Process and EngineeringState Key Laboratoryof Multiphase Complex SystemsInstitute of Process EngineeringChinese Academy of SciencesBeijing100190China School of Chemistry and Chemical Engineering Qingdao UniversityQingdao266071China Henan Institute of Advanced Technology Zhengzhou UniversityZhengzhou450001China School of Chemical Engineering University of Chinese Academy of SciencesBeijing100049China

Dissolution and nucleation are two essential processes for industrial crystallization.This paper in-vestigates the effect of ethylene glycol addition on the crystallization behavior of dimethyl terephthalate(DMT)in solution.The DMT solubility in mixed solvent system(methanol-ethylene glycol)was deter-mined by isothermal satiation approach,and the solubility was associated using seven models.The model fitting results were consistent with the experimental values.Based on the results,the metastable zone width(MSZW)of DMT was detected by the polythermal approach;the modified Sangwal's theory was used to investigate the nucleation behavior,which can provide a new way of thought for better analysis of the crystallization behavior.The results demonstrated that MSZW was associated with various elements,such as cooling rate,saturation temperature and mass fraction of ethylene glycol.The addition of ethylene glycol slowed down the nucleation rate as shown by the broadening of MSZW.We derive the solid-liquid interface energy,the nucleation driving force,the critical nucleation size and the critical Gibbs free energy according to the classical nucleation theory.It is demonstrated that the nucleation driving force and the solid-liquid interface energy are dependent and jointly influence the MSZW.

关键词： Dissolution Nucleation Solubility Apparent thermodynamic parameters Metastable zone width Solid-liquid interface energy

Computer vision-aided bioprinting for bone research

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Bone Research 2022年第2期10卷 213-226页

作者： Changxi Liu Liqiang Wang Weijie Lu Jia Liu Chengliang Yang Chunhai Fan Qian Li yujin tang State Key Laboratory of Metal Matrix Composites School of Material Science and EngineeringShanghai Jiao Tong UniversityNo.800 Dongchuan RoadShanghai 200240China Affiliated Hospital of Youjiang Medical University for NationalitiesBaiseGuangxi 533000China School of Chemistry and Chemical Engineering National Center for Translational MedicineShanghai Jiao Tong UniversityShanghai 200240China

Bioprinting is an emerging additive manufacturing technology that has enormous potential in bone implantation and repair. The insufficient accuracy of the shape of bioprinted parts is a primary clinical barrier that prevents widespread utilization of bioprinting,especially for bone design with high-resolution requirements. During the last five years, the use of computer vision for process control has been widely practiced in the manufacturing field. Computer vision can improve the performance of bioprinting for bone research with respect to various aspects, including accuracy, resolution, and cell survival rate. Hence, computer vision plays a substantial role in addressing the current defect problem in bioprinting for bone research. In this review, recent advances in the application of computer vision in bioprinting for bone research are summarized and categorized into three groups based on different defect types: bone scaffold process control, deep learning, and cell viability models. The collection of printing parameters,data processing, and feedback of bioprinting information, which ultimately improves printing capabilities, are further discussed. We envision that computer vision may offer opportunities to accelerate bioprinting development and provide a new perception for bone research.

关键词： printing defect implantation

Double crosslinked biomimetic composite hydrogels containing topographical cues and WAY-316606 induce neural tissue regeneration and functional recovery after spinal cord injury

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Bioactive Materials 2023年第6期24卷 331-345页

作者： Xingchang Zhao Xianzhe Lu Kai Li Shiqiang Song Zhaohui Luo Chuanchuan Zheng Chengliang Yang Xiumei Wang Liqiang Wang yujin tang Chong Wang Jia Liu Department of Orthopaedics Affiliated Hospital of Youjiang Medical University for NationalitiesBaiseGuangxiChina Guangxi Key Laboratory of Basic and Translational Research of Bone and Joint Degenerative Diseases Guangxi Biomedical Materials Engineering Research Center for Bone and Joint Degenerative DiseasesBaiseGuangxiChina Academy of Orthopedics Guangdong ProvinceGuangdong Provincial Key Laboratory of Bone and Joint Degeneration DiseasesThe Third Affiliated Hospital of Southern Medical UniversityGuangzhouChina Youjiang Medical University for Nationalities BaiseGuangxiChina School of Mechanical Engineering Dongguan University of TechnologySongshan LakeDongguanGuangdongChina State Key Laboratory of New Ceramics and Fine Processing Key Laboratory of Advanced Materials of Ministry of EducationSchool of Materials Science and EngineeringTsinghua UniversityBeijingChina State Key Laboratory of Metal Matrix Composites School of Material Science and EngineeringShanghai Jiao Tong UniversityShanghaiChina

Spinal cord injury(SCI)is an overwhelming and incurable disabling condition,for which increasing forms of multifunctional biomaterials are being tested,but with limited progression.The promising material should be able to fill SCI-induced cavities and direct the growth of new neurons,with effective drug loading to improve the local micro-organism environment and promote neural tissue regeneration.In this study,a double crosslinked biomimetic composite hydrogel comprised of acellularized spinal cord matrix(ASCM)and gelatin-acrylated-β-cyclodextrin-polyethene glycol diacrylate(designated G-CD-PEGDA)hydrogel,loaded with WAY-316606 to activate canonical Wnt/β-catenin signaling,and reinforced by a bundle of three-dimensionally printed aligned polycaprolactone(PCL)microfibers,was constructed.The G-CD-PEGDA component endowed the composite hydrogel with a dynamic structure with a self-healing capability which enabled cell migration,while the ASCM component promoted neural cell affinity and proliferation.The diffusion of WAY-316606 could recruit endogenous neural stem cells and improve neuronal differentiation.The aligned PCL microfibers guided neurite elongation in the longitudinal direction.Animal behavior studies further showed that the composite hydrogel could significantly recover the motor function of rats after SCI.This study provides a proficient approach to produce a multifunctional system with desirable physiological,chemical,and topographical cues for treating patients with SCI.

关键词： Spinal cord injury 3D printing PCL oriented fibers WAY-316606 Wnt/β-catenin signaling

Effect of cytotoxic T-lymphocyte antigen-4,TNF-alpha polymorphisms on osteosarcoma: evidences from a meta-analysis

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Chinese Journal of Cancer Research 2013年第6期25卷 671-678页

作者： Jianwei Liu Junli Wang Weiping Jiang yujin tang Department of Osteology the Third Affiliated Hospital of Guangxi Medical University Center of Clinical Laboratory Affiliated Hospital of Youjiang Medical College for Nationalities Department of Osteology Affiliated Hospital of Youjiang Medical College for Nationalities

Objective： Previous studies have investigated the role of cytotoxic T-lymphocyte antigen-4 （CTLA-4） and tumor necrosis factor-alpha （TNF-a） in carcinogenesis of osteosarcoma, but their results were inconsistent. We aimed to clarify the associations between CTLA-4, TNF-a polymorphism and osteosarcoma risk by using meta-analysis. Methods： We searched relevant studies without language restriction in PubMed, EMbase, Cochrane Library, Google Scholar databases, Chinese National Knowledge Infrastructure （CNKI） and conference literature in humans published prior to March 2013. The strengths of the associations between genetic variants and osteosarcoma risk were estimated by odds ratio （OR） with 95% confidence interval （95% CI）. Results： A total of seven studies with 1,198 osteosarcoma patients and 1,493 controls were selected. Four studies were eligible for CTLA-4 （1,003 osteosarcoma and 1,162 controls）, and three studies for TNF-a （195 osteosarcoma and 331 controls）. Pooled results showed that rs231775 polymorphism of CTLA-4 was associated with osteosarcoma risk （GG vs. AA： OR=1.63, 95% CI=1.24-2.13; GG ＋ GA vs. AA： OR=1.56, 95% CI=1.21-2.01; AA ＋ GA vs. GG： OR=0.83, 95% CI=0.71-0.97; G vs. A： OR=1.21, 95% CI=1.08-1.36）. No significant heterogeneity was observed across the studies. No significant associations were found between rs5742909 polymorphism of CTLA-4 or rs1800629 polymorphism of TNF-a and osteosarcoma risk. Conclusions： These results suggest that the rs231775 polymorphism of CTLA-4 may play an important role in carcinogenesis of osteosarcoma.

关键词： Cytotoxic T-lymphocyte antigen-4 （CTLA-4） tumor necrosis factor-alpha （TNF-a） osteosarcoma genetic polymorphism

鲁迅与章太炎传奇小说观之差异及其流衍——重审20世纪以来唐传奇文体的升格

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鲁迅研究月刊 2024年第4期 29-38页

作者：王瑜锦南通大学文学院 226019

清末章太炎提出“唐人始造意为巫蛊媟渎之言”,唐传奇背弃了汉代小说开创的街谈巷议、有益于政教的传统,当被视为变体,持类似观点的还有吴虞、朱希祖、浦江清等人。然而在西化小说观和文学观的冲击下,古典小说在20世纪以来逐渐失去了传... 详细信息

清末章太炎提出“唐人始造意为巫蛊媟渎之言”,唐传奇背弃了汉代小说开创的街谈巷议、有益于政教的传统,当被视为变体,持类似观点的还有吴虞、朱希祖、浦江清等人。然而在西化小说观和文学观的冲击下,古典小说在20世纪以来逐渐失去了传统底色,重“情”、尚“美”、提倡虚构等“现代因子”逐步成为小说的内在要义。在这一背景下,传奇小说的地位被不断抬升,鲁迅所提出的唐人“始有意为小说”的观点广泛传播并占据主流,章太炎等人的观点则逐渐隐没,成为边缘。

关键词：传奇小说观念章太炎鲁迅朱希祖浦江清

Cryogenic 3D printing of dual-delivery scaffolds for improved bone regeneration with enhanced vascularization

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Bioactive Materials 2021年第1期6卷 137-145页

作者： Chong Wang Jiahui Lai Kai Li Shaokui Zhu Bingheng Lu Jia Liu yujin tang Yen Wei School of Mechanical Engineering Dongguan University of TechnologySongshan LakeDongguanGuangdongPR China Department of Mechanical Engineering The University of Hong KongHong Kong SARPR China Department of Orthopedics The Third Affiliated Hospital of Southern Medical UniversityGuangzhouGuangdongPR China Department of Orthopaedics Affiliated Hospital of Youjiang Medical University for NationalitiesBaiseGuangxiPR China Department of Chemistry Tsinghua UniversityBeijingPR China

Three-dimensional(3D)printing has been increasingly employed to produce advanced bone tissue engineering scaffolds with biomimetic structures and matched mechanical strengths,in order to induce improved bone regeneration in defects with a critical size.Given that the successful bone regeneration requires both excellent osteogenesis and vascularization,endowing scaffolds with both strong bone forming ability and favorable angiogenic potential would be highly desirable to induce improved bone regeneration with required vascularization.In this investigation,customized bone tissue engineering scaffolds with balanced osteoconductivity/osteoinductivity were produced via cryogenic 3D printing ofβ-tricalcium phosphate and osteogenic peptide(OP)containing water/poly(lactic-co-glycolic acid)/dichloromethane emulsion inks.The fabricated scaffolds had a hierarchically porous structure and were mechanically comparable to human cancellous bone.Angiogenic peptide(AP)containing collagen I hydrogel was then coated on scaffold surface to further provide scaffolds with angiogenic capability.A sequential release with a quick AP release and a slow but sustained OP release was obtained for the scaffolds.Both rat endothelial cells(ECs)and rat bone marrow derived mesenchymal stem cells(MSCs)showed high viability on scaffolds.Improved in vitro migration and angiogenesis of ECs were obtained for scaffolds delivered with AP while enhanced osteogenic differentiation was observed in scaffolds containing OP.The in vivo results showed that,toward scaffolds containing both AP and OP,the quick release of AP induced obvious angiogenesis in vivo,while the sustained OP release significantly improved the new bone formation.This study provides a facile method to produce dual-delivery scaffolds to achieve multiple functions.

关键词： Cryogenic 3D printing Dual-delivery Osteogenesis Angiogenesis Bone regeneration

Damping of aluminum-matrix composite reinforced by carbon nanotube:Multiscale modeling and characteristics

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Science China(Technological Sciences) 2023年第4期66卷 1062-1074页

作者： WANG Fei LI Li tang HaiShan WANG XueLin HU yujin State Key Laboratory of Digital Manufacturing Equipment and Technology School of Mechanical Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074China

It is a crucial requirement for structure-damping materials to attain both stiffness and damping;unfortunately,the two properties are usually mutually exclusive.This study interestingly demonstrates that introducing Ni atoms into the interface of carbon nanotube(CNT)reinforced aluminum-matrix composites can defeat the conflict of stiffness versus damping.This originates from the gradient variation of the modulus and energy dissipation in the effective interfacial zone.The rule of mixture is modified by taking the interface contribution into account,and a gradient damping model is proposed to account for the contribution of the interface energy dissipation.Molecular dynamics simulations confirm that the proposed multiscale modulus and damping models can describe the elastic modulus and damping behavior of the composites with different volume fractions and different diameters of CNTS.The gradient interface slip caused by the lattice mismatches and misfit dislocations between Ni-coated CNT and aluminum is one of the pathways for achieving unprecedented levels of the product of stiffness and damping.

关键词： molecular dynamics interfacial dissipation elastic modulus damping loss modulus

基于多头自注意力机制和对抗训练的实体关系联合抽取

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成都理工大学学报（自然科学版） 2024年第3期51卷 513-521页

作者：甘雨金李红军唐小川王子怡甘晨灼胡正浩成都理工大学计算机与网络安全学院(示范性软件学院) 成都610059

实体关系联合抽取是构建知识图谱的重要阶段,旨在抽取文本中存在语义关系的实体对。针对已有的实体关系联合抽取方法在抽取过程中存在的冗余关系预测、实体关系重叠以及上下文潜在语义信息捕捉不足的问题,提出联合多头自注意力机制和对... 详细信息

实体关系联合抽取是构建知识图谱的重要阶段,旨在抽取文本中存在语义关系的实体对。针对已有的实体关系联合抽取方法在抽取过程中存在的冗余关系预测、实体关系重叠以及上下文潜在语义信息捕捉不足的问题,提出联合多头自注意力机制和对抗训练的方法进行实体关系的抽取。该方法利用多头自注意力机制捕获潜在语义特征,以提升模型对上下文语义信息的感知能力;将对抗训练引入模型的训练阶段,以增强模型的泛化能力和鲁棒性。实验结果表明:与现有主流模型对比,提出的模型在NYT和WebNLG两个公共数据集上都取得了更优的F 1值,在处理实体关系重叠问题以及不定数量三元组抽取上都能保持稳定的性能表现,验证了模型的有效性。

关键词：实体关系联合抽取对抗训练多头自注意力知识图谱

光谱预处理小波基函数的选择对结合FIBS技术和机器学习的铝合金识别精确度影响研究

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激光杂志 2024年第6期45卷 88-93页

作者：于海龙高宇瑾谢云双杨硕汤宇轩高勋林景全长春理工大学物理学院长春130022 长春理工大学中山研究院广东中山528400

随着经济不断发展,工业建筑领域产生了大量的废弃铝合金材料,对废弃铝合金材料分类回收可以提升废弃资源的利用效率,缓解能源紧张。选取了工业领域常用的五种型号的铝合金,开展了等离子体丝诱导击穿光谱(FIBS)光谱预处理小波变换基函数... 详细信息

随着经济不断发展,工业建筑领域产生了大量的废弃铝合金材料,对废弃铝合金材料分类回收可以提升废弃资源的利用效率,缓解能源紧张。选取了工业领域常用的五种型号的铝合金,开展了等离子体丝诱导击穿光谱(FIBS)光谱预处理小波变换基函数对铝合金分类识别精度的影响的研究。分别采用bior2.2、bior2.4和bior2.6正交小波基函数对铝合金的FIBS光谱进行预处理,结合线性判别分析(LDA)、网格搜索优化的支持向量机(GSSVM)和反向传播神经网络(BPNN)实现了铝合金型号的快速分类识别。结果表明bior2.2、bior2.4和bior2.6正交小波基函数结合LDA-GSSVM实现铝合金型号的平均识别准确率为90%、100%和76.67%,结合LDA-BPNN实现铝合金型号的平均识别准确率为96.67%、100%和90%,因此选择合适的正交小波基函数对FIBS光谱预处理,对于提高铝合金型号识别准确率有较大作用。

关键词： FIBS 正交小波基函数线性判别分析分类识别铝合金材料