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Journal of Oceanology and Limnology 2021年第6期39卷 2295-2308页

作者： yujia yang Xiaoni LI Lina SUN Laboratory for Evolution and Development Institute of Evolution and Marine BiodiversityOcean University of ChinaQingdao 266003China CAS Key Laboratory of Marine Ecology and Environmental Sciences Institute of OceanologyChinese Academy of SciencesQingdao 266071China

Sea cucumbers are echinoderm species with a leathery skin and an elongated *** compounds,including saponins,have been previously isolated from sea *** majority of saponins derived from this organism typically belong to the triterpene glycosides,which exhibit various biological effects(e.g.,antifungal,cytotoxic,hemolytic,and cytostatic immunomodulatory activities).In the present study,30 saponin biosynthesis enzymes,namely 2 AACTs,2 FPSs,2 HMGSs,2 OSCs,1 SS,2 SEs,and 19 UGTs,were found in the genome of sea cucumber Apostichopus *** with upstream saponin biosynthesis enzymes(i.e.,AACTs,FPSs,HMGSs,OSCs,and SSs),the downstream saponin biosynthesis enzymes(SEs and UGTs)shared lower amino acid sequence similarity with the corresponding genes in other *** was proposed that the enzyme structures comprised bothα-helices andβ-***,only a low percentage ofβ-sheets were present in FPSs,OSCs,and *** saponin biosynthesis enzymes showed dynamic expression patterns during five critical developmental stages of ***(fertilized oocytes,blastula,gastrula,doliolaria,and penractula).The present study involved elucidation of putative saponin biosynthesis pathways in sea cucumber and provides a valuable platform for further investigation of saponin biosynthesis in echinoderms.

关键词： triterpene saponin biosynthesis sea cucumber enzyme expression development

间充质干细胞及其衍生细胞外囊泡靶向巨噬细胞干预自身免疫性疾病

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中国组织工程研究 2025年第31期29卷 6772-6781页

作者：姚兰宣王雪菲刘洋杨雨佳赵怡齐芳芳李颖辉河北医科大学口腔医学院河北省石家庄市050000 河北省口腔医学重点实验室河北省石家庄市050000 河北医科大学口腔医院牙体牙髓科河北省石家庄市050000 河北医科大学口腔医院正畸科河北省石家庄市050000

背景:巨噬细胞是机体固有免疫的重要组成部分,当机体内环境发生改变时巨噬细胞可以产生不同的极化表型,并发挥相应的炎性免疫作用。间充质干细胞能够分泌较多数量的细胞外囊泡到机体内环境中,具有细胞间信号传导及免疫调节功能。研究表... 详细信息

背景:巨噬细胞是机体固有免疫的重要组成部分,当机体内环境发生改变时巨噬细胞可以产生不同的极化表型,并发挥相应的炎性免疫作用。间充质干细胞能够分泌较多数量的细胞外囊泡到机体内环境中,具有细胞间信号传导及免疫调节功能。研究表明,间充质干细胞及间充质干细胞来源细胞外囊泡可以影响巨噬细胞M1/M2极化平衡,从而治疗机体免疫炎症性疾病。目的:探讨间充质干细胞及其来源细胞外囊泡通过调节巨噬细胞极化来干预自身免疫性疾病的信号机制,以及工程化细胞外囊泡在此领域的相关研究进展。方法:第一作者检索PubMed、中国知网等数据库自建库到2024年6月发表的相关文献,以“间充质干细胞,细胞外囊泡,外泌体,凋亡小体,凋亡囊泡,巨噬细胞极化,M1极化,M2极化,自身免疫性疾病,多发性硬化,类风湿性关节炎,系统性红斑狼疮,1型糖尿病,炎症性肠病,自身免疫性泪腺炎,工程化细胞外囊泡,工程化外泌体,药物递送”为中文检索词;以“macrophage polarization,M1 macrophage,M2 macrophage,autoimmune disease,type 1 diabetes,multiple sclerosis,rheumatoid arthritis,systemic lupus erythematosus,autoimmune dacryadenitis,inflammatory bowel disease,mesenchymal stem cells,extracellular vesicles,engineered extracellular vesicles,engineering exosomes,drug delivery”为英文检索词,阅读每篇文献的文题、摘要进行初筛,最终筛选出70篇文献进行归纳分析。结果与结论:①间充质干细胞可以通过释放或间接作用于功能性蛋白来调节M1/M2极化;②间充质干细胞可以通过作用于炎症小体调控巨噬细胞M2极化;③间充质干细胞可以与常用药物组合以增强药物疗效;④间充质干细胞受到炎性刺激后可以调控细胞外囊泡的释放影响巨噬细胞极化;⑤间充质干细胞来源细胞外囊泡可以通过PTEN、NOTCH、核因子κB、Toll样受体、PI3K/AKT等通路靶向巨噬细胞极化调节自身免疫性疾病;⑥工程化细胞外囊泡可以实现非侵入式靶向给药,延长药物半衰期,推动外泌体口服给药,减轻移植物异体反应,提高中草药生物利用度并攻克血脑屏障,开辟了一条药物递送新路径。

关键词：间充质干细胞细胞外囊泡外泌体巨噬细胞极化 M1/M2极化自身免疫性疾病工程化细胞外囊泡

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SNR-adaptive deep joint source-channel coding scheme for image semantic transmission with convolutional block attention module

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The Journal of China Universities of Posts and Telecommunications 2024年第1期31卷 1-11页

作者： yang yujia Liu Yiming Zhang Wenjia Zhang Zhi State Key Laboratory of Networking and Switch Technology Beijing University of Posts and TelecommunicationsBeijing 100876China

With the development of deep learning(DL),joint source-channel coding(JSCC)solutions for end-to-end transmission have gained a lot of *** deep JSCC schemes support dynamically adjusting the rate according to different channel conditions during transmission,enhancing robustness in dynamic wireless ***,most of the existing adaptive JSCC schemes only consider different channel conditions,ignoring the different feature importance in the image processing and *** uniform compression of different features in the image may result in the compromise of critical image details,particularly in low signal-to-noise ratio(SNR)*** address the above issues,in this paper,a dual attention mechanism is introduced and an SNR-adaptive deep JSCC mechanism with a convolutional block attention module(CBAM)is proposed,in which matrix operations are applied to features in spatial and channel dimensions *** proposed solution concatenates the pooling feature with the SNR level and passes it sequentially through the channel attention network and spatial attention network to obtain the importance evaluation *** show that the proposed solution outperforms other baseline schemes in terms of peak SNR(PSNR)and structural similarity(SSIM),particularly in low SNR scenarios or when dealing with complex image content.

关键词： semantic communication joint source-channel coding image transmission

Lentiviral-mediated vascular endothelial growth factor 165 gene transfer into neural stem cells promotes proliferation

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Neural Regeneration Research 2011年第19期6卷 1457-1461页

作者： Shanshan Zhang Xiangrong Zheng Fei Yin Jielu Tan yujia yang Department of Pediatrics Xiangya Hospital Central South University Changsha 410008 Hunan Province China

We constructed a lentiviral vector carrying vascular endothelial growth factor 165, which was used to transfect neural stem cells. The transfection rate was approximately 50%, as determined by flow cytometry. Vascular... 详细信息

关键词： vascular endothelial growth factor 165 gene therapy lentivirus neural stem cells transfection

Thermally conductive MWCNTs/Fe_(3)O_(4)/Ti_(3)C_(2)T_(x) MXene multi-layer films for broadband electromagnetic interference shielding

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Journal of Materials Science & Technology 2022年第35期130卷 75-85页

作者： Heguang Liu Zhe Wang yujia yang Shaoqing Wu Chukai Wang Caiyin You Na Tian School of Materials Science and Engineering Xi’an University of TechnologyXi’an 710048China School of Materials Science and Engineering Henan University of Science and TechnologyLuoyang 471023China

The Ti_(3)C_(2)T_(x)MXene is thought to be a promising candidate for next-generation electromagnetic interference(EMI) shielding ***,its broadband shielding capability and thermal conduction performance are insufficient to meet the growing ***,we reported a layer-by-layer composite film composed of Ti_(3)C_(2)T_(x)MXene,multi-walled carbon nanotubes(MWCNTs),and Fe_(3)O_(4)*** from the architecture and the synergistic effect of components,the obtained composite film exhibited high comprehensive ***,the introduction of Fe_(3)O_(4)magnetic nanoparticles effectively reduced the impedance mismatch between the composite film and air and enhanced the magnetic loss of the composite *** layered structure prolonged the transmission path of electromagnetic waves inside the composite film and constructed a rich conductive network,causing interfacial polarization and ohmic *** results indicated that the composite film(52 μm) delivered a high EMI shielding effectiveness of 49 dB in the frequency range from X-band to ***,the MWCNTs layers in the composite films provided numerous heat transfer channels,reducing phonon scattering during heat transfer and resulting in a maximum thermal conductivity of 8.241 W/(m K).

关键词： Multi-layer film Ti_(3)C_(2)T_(x)MXene EMI shielding Thermal conduction

Theoretical investigations on the growth of graphene by oxygenassisted chemical vapor deposition

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Nano Research 2024年第6期17卷 4645-4650页

作者： Xiaoli Sun Chaojie Yu yujia yang Zhihao Li Jianjian Shi Wanjian Yin Zhongfan Liu Beijing Graphene Institute(BGI) Beijing 100095China School of Physics and Electronics Shandong Normal UniversityJinan 250014China College of Energy Soochow Institute for Energy and Materials InnovationsLight Industry Institute of Electrochemical Power SourcesSUDA-BGI Collaborative Innovation CenterSoochow UniversitySuzhou 215006China School of Electronic Engineering Chengdu Technological UniversityChengdu 611730China Center for Nanochemistry Beijing National Laboratory for Molecular SciencesCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China

Recently,graphene has drawn considerable attention in the field of electronics,owing to its favorable conductivity and high carrier *** to the industrialization of graphene is its high-quality microfabrication via chemical vapor ***,many problems remain in its preparation,such as the not fully understood cracking mechanism of the carbon source,the mechanism of its substrate oxidation,and insufficient defect repair *** help close this capability gap,this study leverages density functional theory to explore the role of O in graphene *** effects of Cu substrate oxidation on carbon source cracking,nucleation barriers,crystal nucleus growth,and defect repairs are *** was found to reduce energy change during dehydrogenation,rendering the process ***,the adsorbed O in graphene or its Cu substrate can promote defect repair and edge growth.

关键词： density functional theory oxygen-assisted graphene growth chemical vapor deposition Cu substrate

Response of the sensorimotor cortex of cerebral palsy rats receiving transplantation of vascular endothelial growth factor 165-transfected neural stem cells

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Neural Regeneration Research 2014年第19期9卷 1763-1769页

作者： Jielu Tan Xiangrong Zheng Shanshan Zhang yujia yang Xia Wang Xiaohe Yu Le Zhong Department of Pediatrics Xiangya HospitalCentral South University

Neural stem cells are characterized by the ability to differentiate and stably express exogenous ge- nes. Vascular endothelial growth factor plays a role in protecting local blood vessels and neurons of newborn rats with hypoxic-ischemic encephalopathy. Transplantation of vascular endothelial growth factor-transfected neural stem cells may be neuroprotective in rats with cerebral palsy. In this study, 7-day-old Sprague-Dawley rats were divided into five groups：（1） sham operation （control）, （2） cerebral palsy model alone or with （3） phosphate-buffered saline, （4） vascular en- dothelial growth factor 165 ＋ neural stem cells, or （5） neural stem cells alone. The cerebral palsy model was established by ligating the left common carotid artery followed by exposure to hypox- ia. Phosphate-buffered saline, vascular endothelial growth factor ＋ neural stem cells, and neural stem cells alone were administered into the sensorimotor cortex using the stereotaxic instrument and microsyringe. After transplantation, the radial-arm water maze test and holding test were performed. Immunohistochemistry for vascular endothelial growth factor and histology using hematoxylin-eosin were performed on cerebral cortex. Results revealed that the number of vas- cular endothelial growth factor-positive cells in cerebral palsy rats transplanted with vascular endothelial growth factor-transfected neural stem cells was increased, the time for finding water and the finding repetitions were reduced, the holding time was prolonged, and the degree of cell degeneration or necrosis was reduced. These findings indicate that the transplantation of vascu- lar endothelial growth factor-transfected neural stem cells alleviates brain damage and cognitive deficits, and is neuroprotective in neonatal rats with hypoxia ischemic-mediated cerebral palsy.

关键词： nerve regeneration vascular endothelial growth factor neural stem cells cerebral palsy animal model transplantation neuroprotection NSFC grant neural regeneration

A Proposal for Enhancing the Bond between Shanghai and Hong Kong:Two Peaks of Financial Exploration

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China Forex 2024年第3期 48-51页

作者： HE Haifeng yang yujia Guotai Junan Securities China Financial Policy Report Tsinghua University PBC School of Finance

The Resolutionof the Central Committee of the Communist Party of China on Further Deepening Reform Comprehensively to Advance Chinese Modernization(hereinafter referred to as"Resolution"),which was adopted at the third plenary session of the 2oth Central Committee of the Communist Party of China,highlighted the need to move faster to build Shanghai into an international financial center and to work to consolidate and enhance the status of China's Hong Kong(hereinafter referred to as Hong Kong)as an international financial,shipping,and *** Central Financial Work Conference underlined the need to accelerate the building of a nation with a strong financial sector,advocating for equal emphasis on"bringing in"and"going global",and steadily expanding institutional opening up in the financial *** the opening ceremony of the study session on promoting high-quality financial development,attended by provincial and ministerial-level leading officials.

关键词： Financial bringing faster

The targeting expression of the vascular endothelial growth factor gene in endothelial cells regulated by ***-1

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Science China(Life Sciences) 2008年第11期51卷 959-965页

作者： ZHENG XiangRong, ZHANG ShangShang, yang yujia, WANG Xia, ZHONG Le & YU XiaoHe Department of Pediatrics, Xiangya Hospital, Central South University, Changsha 410008, China Department of Pediatrics Xiangya Hospital Central South University Changsha China

The success of gene therapy depends largely on the efficacy of gene delivery vector systems that can deliver genes to target organs or cells selectively and efficiently with minimal toxicity. Here, we show that by using the ***-1 regulatory element, we were able to restrict expression of the transgene of vascular endothelial growth factor (VEGF) to endothelial cells exclusively in hypoxic conditions. Eukaryotic expression vectors such as ***-1, pcDNA3.1-VEGF+Pa, pcDNA3.1-ppET-1+ EGF+Pa, and ***-1+VEGF+Pa were constructed by using a series of nuclear molecule handling methods like PCR, enzyme digestion. The recombinant vectors were transfected into HUVEC cells and HL7702 cells by the lipofectin method. GFP expression was observed with a fluorescence microscope to validate the specificity of expression in endothelial cells under the regulation of ***-1 element. Cobalt chloride (final concentration 100 μmol/L) was added to the medium to mimic hypoxia in vitro. After transfection of vectors, the expression of VEGF mRNA was detected by RT-PCR, and the expression of VEGF was detected by Western blotting and ELISA methods under normoxia and hypoxia, respectively. The cell proliferation rate was detected by the MTT test. The ex- pression of GFP revealed that the exterior gene was transcripted effectively in endothelial cells regu- lated by the ***-1 element, while the expression of GFP was very weak in nonendothelial cells. The results of RT-PCR, Western blotting and ELISA showed that VEGF gene expression in the ***-1+VEGF+Pa group and in the pcDNA3.1-ppET-1+VEGF+Pa group was higher in hypoxia than it was in normoxia (P<0.05). The MTT test showed that the proliferation rate of HUVEC transfected with HPVA under hypoxia exceeded that of the control group. We conclude that the ***-1 element was expressed specifically in endothelial cells, and can increase the expression of VEGF in hypoxia and stimulate proliferation of

关键词： hypoxia-responsive element human preproendothelin-1 promoter vascular endothelial growth factor endothelial cells

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水热处理异丙醇铝及其煅烧产物的显微结构

硅酸盐学报 2014年第12期42卷 1554-1559页

作者：刘超王晶杨雨佳大连交通大学辽宁省无机超细粉体制备及应用重点实验室辽宁大连116028

以异丙醇铝为原料,经水热处理获得菱形片状薄水铝石。利用X射线衍射、Fourier变换红外光谱和透射电子显微镜研究了水热温度及煅烧温度对产物相结构及微观形貌的影响。结果表明,随水热处理温度的提高,产物由结晶性能较差的拟薄水铝石向... 详细信息

以异丙醇铝为原料,经水热处理获得菱形片状薄水铝石。利用X射线衍射、Fourier变换红外光谱和透射电子显微镜研究了水热温度及煅烧温度对产物相结构及微观形貌的影响。结果表明,随水热处理温度的提高,产物由结晶性能较差的拟薄水铝石向结晶性良好的薄水铝石相转变,表明水热处理提高了产物晶体结构的对称性,使其非对称伸缩受到限制,而对称性伸缩得到增强。未经水热处理的产物呈褶皱的纳米薄片交联在一起的无规则团聚结构,经水热处理的产物逐渐向规则的菱形片状形貌转变,随水热处理温度升高,片状产物的厚度增大。水热处理影响煅烧产物的热稳定,随水热处理温度提高,α-Al2O3出现的温度提高,表明煅烧过程中中间相的热稳定性得到提高,同时α-Al2O3出现是在θ-Al2O3相晶格中发生层错产生的。

关键词：薄水铝石水热处理异丙醇铝结晶化 α-氧化铝