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Anti-breast cancer effect of quercetin nanoparticles based on MOFs for chemo-phototherapy and heat shock proteins inhibition

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Nano Research 2025年第1期18卷 545-558页

作者： Rongyue Zhu Shilang Liao Mengru Cai Dongge Yin Tingting Fu Jing Liu yuji Du Jiahui Kong Rongrong Chang Jian Ni Xingbin Yin Beijing University of Chinese Medicine Fangshan DistrictBeijing 102488China

Phototherapy, including photodynamic therapy(PDT) and photothermal therapy (PTT), is a promisingmethod of tumor treatment, which has the advantages ofstrong specificity and small side effects. However, PDT willaggravate the hypoxic environment in tumor cells, and PTTwill lead to heat-resistant reaction, both of which will make theorganism quickly produce heat shock proteins (HSPs) toprotect itself, thus seriously hindering the therapeuticefficiency of phototherapy. As a natural HSPs inhibitor,quercetin (QR) provides a feasible way to solve this ***, a kind of metal organic framework (MOF), Fe-TCPP(FT), was used as a delivery material and photosensitizer tobuild a chemo-phototherapy platform, and QR was used as achemotherapy drug and HSPs inhibitor. On this basis, the nanoparticles (NPs) were modified with PEG-CPP30 (a cellpenetratingpeptide that specifically recognizes human breast cancer MCF-7 cells), which showed excellent targetingcapacity and biocompatibility. The combination of chemotherapy and phototherapy significantly improved the anti-cancereffect. At the same time, NPs also showed prominent anti-HSPs effect. The effective connection of the two played acomplementary role in the process of tumor treatment, which provided a new strategy for the accurate and efficienttreatment of tumors in the future.

关键词： quercetin Fe-metal organic frameworks(MOFs) phototherapy anti-cancer heat shock proteins inhibition

New paradigms in regenerative engineering:Emerging role of extracellular vesicles paired with instructive biomaterials

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BIOCELL 2022年第6期46卷 1445-1451页

作者： W.BENTON SWANSON yuji MISHINA Department of Biologic and Materials Science&Prosthodontics School of DentistryUniversity of MichiganAnn ArborMI48109USA

Mesenchymal stem cells(MSCs)have long been regarded as critical components of regenerative medicine strategies,given their multipotency and persistence in a variety of ***,the specific role of MSCs in mediating regenerative outcomes has been attributed(in part)to secreted factors from transplanted cells,namely extracellular *** viewpoint manuscript highlights the promise of cell-derived extracellular vesicles as agents of regeneration,enhanced by synergy with appropriate biomaterials *** vesicles are a potentially interesting regenerative tool to enhance the synergy between MSCs and *** a result,we believe these technologies will improve patient outcomes through efficient therapeutic strategies resulting in predictable patient outcomes.

关键词： Biomaterials Extracellular vesicles Mesenchymal stem cells Regenerative medicine Tissue engineering

General Solutions of a Higher Order Impulsive Fractional Differential Equation Involving the Riemann-Liouville Fractional Derivatives

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Journal of Mathematical Research with Applications 2020年第2期40卷 140-164页

作者： yuji LIU Department of Mathematics Guangdong University of Finance and Economics

We give general solutions(the explicit solutions) of a class of multi-term impulsive fractional differential equations involving the Riemann-Liouville fractional derivatives. This paper contributes within the domain of impulsive fractional differential equations. The author strongly believes that the article will highly be appreciated by the researchers working in the field of fractional calculus and on fractional differential models.

关键词： higher order fractional differential equation piecewise continuous solution RiemannLiouville fractional derivative impulse effect

DESIGN OF A SOFTWARE AGENT FOR BUSINESS GAMING SIMULATION

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Journal of Systems Science and Systems Engineering 2006年第1期15卷 83-94页

作者： yuji SHINODA Mina RYOKE Takao TERANO Yoshiteru NAKAMORI School of Knowledge Science Japan Advanced Institute of Science and Technology 1-1 Asahidai Nomi Ishikawa 923-1292 Japan Graduate School of Business Sciences University of Tsukuba Tokyo 3-29-1 Otsuka Bunkyo Tokyo 112-0012 Japan Dept. Computational Intelligence and Systems Science Tokyo Institute of Technology 4259 Nagatsuda-cho Midori-ku Yokohama 226-8503 Japan

This paper introduces a software agent as a virtual player of the business game called Bakery Game. The business game is a tool to understand business and management principles through experience in a virtual world. In order to construct software agents for the gaming simulation, which is able to participate in a game and become human players' worthy rival, we combine a simple model that considers the property of Bakery Game with a strategy adjustment model. The agent has so-called strategy parameters that are updated through the experience. The agent changes his strategy depending on particular situation. The agent participates in the game that is regenerated from log data in various situations.

关键词： Gaming simulation strategy searching agent based simulation

Unsupervised calibration for noninvasive glucose-monitoring devices using mid-infrared spectroscopy

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Journal of Innovative Optical Health Sciences 2018年第6期11卷 87-96页

作者： Ryosuke Kasahara Saiko Kino Shunsuke Soyama yuji Matsuura Ricoh Institute of Information and Communication Technology Research and Development Division Ricoh Company 2-7-1 IzumiEbina 243-0460Japan Graduate School of Engineering Tohoku University 6-6-05 AobaSendai 980-8579Japan Graduate School of Biomedical Engineering Tohoku University 6-6-05 AobaSendai 980-8579Japan

Noninvasive,glucose-monitoring technologies using infrared spectroscopy that have been studied typically require a calibration process that involves blood collection,which renders the methods somewhat *** develop a truly noninvasive,glucose-monitoring technique using midinfrared spectroscopy that does not require blood collection for calibration by applying domain adaptation(DA)using deep neural networks to train a model that associates blood glucose concentration with mid-infrared spectral data without requiring a training dataset labeled with invasive blood sample *** realizing DA,the distribution of unlabeled spectral data for calibration is considered through adversarial update during training networks for regression to blood glucose *** calibration improved the correlation coeffcient between the true blood glucose concentrations and predicted blood glucose concentrations from 0.38 to *** result indicates that this calibration technique improves prediction accuracy for mid-infrared glucose measurements without any invasively acquired data.

关键词： Noninvasive glucose monitoring calibration mid-infrared spectroscopy domain adaptation neural network

Function of terahertz spectra in monitoring the decomposing process of biological macromolecules and in investigating the causes of photoinhibition

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Science China(Life Sciences) 2017年第3期60卷 307-312页

作者： Yuangang Qu Shuai Zhang yuji Lian Tingyun Kuang College of Life Sciences Linyi University Key Laboratory of Photobiology Institute of Botany Chinese Academy of Sciences

Chlorophyll α and β-carotene play an important role in harvesting light energy, which is used to drive photosynthesis in plants. In this study, terahertz(THz) and visible range spectra of chlorophyll α and β-carotene and their changes under light treatment were investigated. The results show that the all THz transmission and absorption spectra of chlorophyll α and β-carotene changed upon light treatment, with the maximum changes at 15 min of illumination indicating the greatest changes of the collective vibrational mode of chlorophyll α and β-carotene. The absorption spectra of chlorophyll α in the visible light region decreased upon light treatment, signifying the degradation of chlorophyll a molecules. It can be inferred from these results that the THz spectra are very sensitive in monitoring the changes of the collective vibrational mode, despite the absence of changes in molecular configuration. The THz spectra can therefore be used to monitor the decomposing process of biological macromolecules; however, visible absorption spectra can only be used to monitor the breakdown extent of biological macromolecules.

关键词： chlorophyll α β-carotene light terahertz spectra

Optimization of immunotherapy for patients with hepatobiliary cancer

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Hepatobiliary Surgery and Nutrition 2021年第5期10卷 717-719页

作者： yuji Eso Hiroshi Seno Department of Gastroenterology and Hepatology Graduate School of MedicineKyoto UniversityKyotoJapan

Immunotherapy with immune checkpoint inhibitors(ICIs)has been shown its benefit for patients with various types of cancers(1,2).Sahara et *** reported the utilization of immunotherapy in the United States among patients with hepatobiliary cancer in Hepatobiliary Surgery and Nutrition(3).In recent years,immunotherapy has become an increasingly popular choice for cancer *** practice,however,the choice is biased not only by the progression of the tumor stage,but also by patients'socioeconomic *** other words,the choice of immunotherapy has not been sufficiently optimized.

关键词： patients immunotherapy Surgery

Air-Fuel Ratio Controls for Clean Gasoline Engines

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Air-Fuel Ratio Controls for Clean Gasoline Engines

Synchrotron radiation studies of the orientation of thin silicon phthalocyanine dichloride film on HOPG substrate

第三十届中国控制会议

作者： yuji YASUI Honda R＆D CO. Ltd.4630 ShimotakanezawaHaga-machiHaga-gunTochigi321-3393 Japan

ISBN: (纸本)9781457706776

＜正＞The mainstream of low emission technology for gasoline engines is an accurate air-fuel ratio *** air-fuel ratio control maintains air-fuel ratio of combustion gas at the suitable target value to maximize emission conversion efficiency of three-way *** model based controls have been applied to air-fuel ratio controls in order to meet strict emission legislations in the *** this paper,modeling methods and control algorithms for air-fuel ratio controls will be introduced.

关键词： Adaptive control Sliding mode control Air-fuel ratio Gasoline engine

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Chinese Physics C 2008年第9期32卷 769-772页

作者：邓居智陈荣 SEKIGUCHI Tetsuhiro BABA yuji HIRAO Norie HONDA Mitsunori Key Laboratory of Nuclear Resources and Environment (East China Institute of Technology) Ministry of Education Synchrotron Radiation Research Center Japan Atomic Energy Agency

Thin silicon phthalocyanine dichloride films on HOPG were prepared and the sample was heated in the vacuum with laser. The thickness of the thin sample on HOPG was checked by X-ray photoemission spectroscopy. The orientation of the molecules in respect to the substrate plane was investigated by measuring the silicon K-edge near edge X-ray absorption fine structure （NEXAFS）. In the NEXAFS spectra of the thin sample, two clear peaks which were assigned to Is → σ^＊Si-N and 1s→ σ^＊Si-Cl appeared around 1847.2 eV and 1843.1 eV respectively. The intensities of the resonance peaks showed strong polarization dependence. A quantitative analysis of the polarization dependence revealed that the Si-N bond tended to lie down while the Si-Cl bond was out of the molecular plane.

关键词： near edge X-ray absorption fine structure (NEXAFS) orientation silicon phthalocyanine dichloride polarization dependence