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Spinal cord injury regenerative therapy development:integration of design of experiments

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Neural Regeneration Research 2025年第9期20卷 2571-2573页

作者： yuji Okano Hideyuki Okano Yoshitaka Kase Division of CNS Regeneration and Drug Discovery International Center for Brain Science(ICBS)Fujita Health UniversityKutsukake-ChoToyoake-ShiAichiJapan Department of Extended Intelligence for Medicine The Ishii-Ishibashi LaboratoryKeio University School of MedicineShinanomachiShinjuku-KuTokyoJapan Keio University Regenerative Medicine Research Center Kawasaki-kuKawasaki-shiJapan

Spinal cord injury(SCI)can cause motor and sensory paralysis,and autonomic nervous system disorders including malfunction of urination and defecation,thereby significantly impairing the quality of *** continue to explo re new stem cell strategies for the treatment of paralysis by transpla nting human induced pluripotent stem cell-derived neural ste m/progenitor cells(hiPSCNS/PCs)into spinal cord injured tissues.

关键词： Spinal paralysis injury

Factors causing a relapse of major depressive disorders following successful electroconvulsive therapy:A retrospective cohort study

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World Journal of Psychiatry 2021年第10期11卷 841-853页

作者： Naoki Kurimoto Takahiko Inagaki Takashi aoki Hiroshi Kadotani Fujiki Kurimoto Kenichi Kuriyama Naoto Yamada yuji Ozeki Department of Psychiatry Shiga University of Medical ScienceOtsu 520-2192ShigaJapan Department of Psychiatry Shigasato HospitalOtsu 520-0006ShigaJapan Department of Psychiatry Biwako HospitalOtsu 520-0113ShigaJapan Department of Psychiatry Shiga Hachiman HospitalOmihachiman 523-8503ShigaJapan Department of Sleep and Behavioral Sciences Shiga University of Medical ScienceOtsu 520-2192ShigaJapan Department of Sleep-Wake Disorders National Institute of Mental HealthNational Center of Neurology and PsychiatryKodaira 187-8502TokyoJapan

BACKGROUND Electroconvulsive therapy(ECT)is used to treat major depressive disorder(MDD).Relapse is often observed even after successful ECT,followed by adequate pharmaceutical treatment for *** To investigate the diagnostic factors and treatment strategies associated with depression *** We analyzed the relationships between relapse,the diagnostic change from MDD to bipolar disorder(BP),and treatment after the initial *** performed a 3-year retrospective study of the prognoses of 85 patients of the Shiga University of Medical Science *** relative risk of relapse of depressive symptoms was calculated based on the diagnostic change from MDD to BP.A receiver operating characteristic(ROC)curve was generated to evaluate the predictive accuracy of diagnostic changes from MDD to BP based on the duration between the first course of ECT and the relapse of depressive *** Eighty-five patients initially diagnosed with MDD and successfully treated with ECT were enrolled in the *** with the MDD participants,more BP patients experienced relapses and required continuation and/or maintenance ECT to maintain remission(65.6%vs 15.1%,P<0.001;relative risk=4.35,95%CI:2.19-8.63,P<0.001).Twenty-nine patients experienced relapses during the three-year *** 21(72.4%,21/29)patients with relapse,the diagnosis was changed from MDD to *** duration from the first course of ECT to relapse was shorter for the BP patients than for the MDD patients(9.63±10.4 mo vs 3.38±3.77 mo,P=0.022);for most patients,the interval was less than one *** relative risk of depressive symptoms based on diagnostic changes was 4.35(95%confidence interval:2.19–8.63,P<0.001),and the area under the ROC curve for detecting diagnostic changes based on relapse duration was 0.756(95%CI:0.562-0.895,P=0.007).CONCLUSION It may be beneficial to suspect BP and change the treatment strategy from MDD to BP for patients experiencing an early relapse.

关键词： Electroconvulsive therapy Major depressive disorder Bipolar disorder Antidepressant Prognosis Relapse

Deep carbon recycling viewed from global plate tectonics

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National Science Review 2024年第6期11卷 37-55页

作者： Maoliang Zhang Sheng Xu yuji Sano School of Earth System Science Tianjin University Marine Core Research Institute Kochi University Atmosphere and Ocean Research Institute The University of Tokyo

Plate tectonics plays an essential role in the redistribution of life-essential volatile elements between Earth's interior and surface, whereby our planet has been well tuned to maintain enduring habitability over much of its history. Here we present an overview of deep carbon recycling in the regime of modern plate tectonics,with a special focus on convergent plate margins for assessing global carbon mass balance. The up-to-date flux compilation implies an approximate balance between deep carbon outflux and subduction carbon influx within uncertainty but remarkably limited return of carbon to convecting mantle. If correct, carbon would gradually accumulate in the lithosphere over time by（i） massive subsurface carbon storage occurring primarily in continental lithosphere from convergent margins to continental interior and（ii） persistent surface carbon sinks to seafloors sustained by high-flux deep CO2emissions to the atmosphere. Further assessment of global carbon mass balance requires updates on fluxes of subduction-driven carbon recycling paths and reduction in uncertainty of deep carbon outflux. From a global plate tectonics point of view, we particularly emphasize that continental reworking is an important mechanism for remobilizing geologically sequestered carbon in continental crust and sub-continental lithospheric mantle. In light of recent advances,future research is suggested to focus on a better understanding of the reservoirs, fluxes, mechanisms, and climatic effects of deep carbon recycling following an integrated methodology of observation, experiment,and numerical modeling, with the aim of decoding the self-regulating Earth system and its habitability from the deep carbon recycling perspective.

关键词： deep carbon recycling convergent plate margins subduction continental reworking global carbon mass balance

Topology optimization of supporting structure for seismic response reduction of an arch

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Science China(Technological Sciences) 2016年第6期59卷 852-861页

作者： MIYAZU yuji OHSAKI Makoto TSUDA Seita Department of Architecture Hiroshima University Department of Architecture and Architectural Engineering Kyoto University Department of Design and Technology Okayama Prefectural University

A flexible supporting structure that reduces seismic response of an arch is proposed. Topology and cross-sectional areas of the supporting structure modeled as a truss structure are optimized through two steps of static and dynamic optimization problems. In the first step, a flexible supporting structure that has diagonal displacement at the top under horizontal load is obtained by solving static optimization problems. Then, in the second step, the cross-sectional area of the flexible member is optimized to minimize the seismic response acceleration of the arch evaluated by the complete quadratic combination(CQC) method. Time-history seismic response analysis is carried out to show that the response in the normal direction of the roof successfully decreases due to flexibility of the supporting structure; in addition, installing passive energy dissipation devices into the flexible supporting structure is very effective in reducing the tangential response of the arch.

关键词： topology optimization arch supporting structure truss nonlinear programming problem CQC method

Acute renal failure associated with acute non-fulminant hepatitis B

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World Journal of Hepatology 2013年第2期5卷 82-85页

作者： Tomoya Kishi yuji Ikeda Tsuyoshi Takashima Shuichi Rikitake Motoaki Miyazono Shigehisa aoki Takanobu Sakemi Toshihiko Mizuta Kazuma Fujimoto Department of Internal Medicine Saga University Faculty of MedicineSaga 849-8501Japan Department of Pathology and Biodefense Center for ResearchSaga University Faculty of MedicineSaga 849-8501Japan Development in Higher Education Saga University Faculty of MedicineSaga 849-8501Japan

A 38-year-old female presenting with a high fever of 39 ℃ developed severe liver dysfunction and acute renal failure(ARF).In tests for a hepatitis associated virus,an Immunoglobulin M-anti-hepatitis B virus core antibody was the only positive ***,the progression of ARF coincided with the pole period of liver damage and all the other assumed causes for the ARF were ***,this case was diagnosed as ARF caused by acute hepatitis *** associated with non-fulminant hepatitis has been infrequently reported,usually in association with acute hepatitis *** case is considered to be an extremely rare and interesting case.

关键词： Acute hepatitis B Acute renal failure Nonfulminant hepatitis Acute tubular necrosis Hyperimmune response

Water Management for Improvement of Rice Yield,Appearance Quality and Palatability with High Temperature During Ripening Period

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Rice science 2021年第4期28卷 409-416,I0038页

作者： yuji Matsue Katsuya Takasaki Jun Abe Global Innovation Center Kyushu UniversityMinami-kuFukuoka 815-8540Japan AGL Co LtdAsoKumamoto 869-2225Japan Faculty of Agriculture Tokai UniversityHigashi-kuKumamoto 862-8652Japan

To clarify the optimal water management in large-scale fields under high temperatures at the ripening period,effective water managements during this period for improvement of yield,appearance quality and palatability were *** with intermittent irrigation and flooded irrigation,the soil temperature with saturated irrigation remained low throughout the day,and the decrease rate of the bleeding rate of hills was the *** results suggested that the saturated irrigation maintained root *** the three irrigation types,the number of spikelets per m2 and 1000-grain weight were similar,however,saturated irrigation resulted in significantly higher rice yield due to improvement in the percentage of ripened *** saturated irrigation produced a high percentage of perfect rice grains and thicker brown rice grain,furthermore,the palatability of cooked rice was excellent because protein content and hardness/adhesion ratio were both ***,under high-temperature ripening conditions,soil temperature was lowered and root activity was maintained when applying saturated irrigation after heading *** results indicated that saturated irrigation is an effective countermeasure against high-temperature ripening damage.

关键词： appearance quality root activity high-temperature ripening damage palatability saturated irrigation soil temperature water management rice yield intermittent irrigation flooded irrigation

Synergistic effects of anti-angiogenesis and immune checkpoint blockade-a new era of systemic chemotherapy for hepatocellular carcinoma

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Hepatobiliary & Pancreatic Diseases International 2021年第5期20卷 493-495页

作者： yuji Eso Hiroshi Seno Department of Gastroenterology and Hepatology Graduate School of MedicineKyoto UniversityKyotoJapan

Tumor growth requires oxygen and nutrient supplementation through angiogenesis from preexisting vascular beds. Hepatocellular carcinoma(HCC) is a hyper-vascularized tumor with a predominant arterial blood flow. Therefore, targeting angiogenesis is essential for treating HCC. Currently approved molecular-targeted agents(MTAs) for HCC affect angiogenic pathways.

关键词： angiogenesis arterial chemotherapy

Forecasting Daily Electric Load by Applying Artificial Neural Network with Fourier Transformation and Principal Component Analysis Technique

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Journal of the Operations Research Society of China 2020年第4期8卷 655-667页

作者： yuji Matsuo Tatsuo Oyama National Graduate Institute for Policy Studies Tokyo 106-0032Japan

In this paper,we propose a hybrid forecasting model(HFM)for the short-term electric load forecasting using artificial neural network(ANN),discrete Fourier transformation(DFT)and principal component analysis(PCA)techniques in order to attain higher prediction ***,we estimate Fourier coefficients by the DFT for predicting the next-day load curve with an ANN and obtain approximate load curves by applying the inverse discrete Fourier *** curves,together with other input variables,are given to the ANN to predict the next-day hourly load ***,we predict PCA scores to obtain approximate load curves in the first step,which are then given to the ANN again in the second *** DFT and PCA models use input variables such as calendrical and meteorological data as well as past electric *** those models for forecasting hourly electric load in the metropolitan area of Japan for January and May in 2018,we train our models using historical data since January *** forecast results show that the HFM consisting of“ANN with DFT”and“ANN with PCA”predicts next-day hourly loads more accurately than the conventional three-layered ANN *** corresponding mean average absolute errors show 2.7%for ANN with DFT,2.6%for ANN with PCA and 3.0%for the conventional ANN *** also find that in May,when electric demand is smaller with smaller fluctuations,forecasting errors are much smaller than January for all the ***,we can conclude that the HFM would contribute to attaining significantly higher forecasting accuracy.

关键词： Artificial neural network Discrete Fourier transformation Electric load forecasting Hybrid forecasting model Load curve Principal component analysis

Parallelization and sustainability of distributed genetic algorithms on many-core processors

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International Journal of Intelligent Computing and Cybernetics 2014年第1期7卷 2-23页

作者： yuji Sato Mikiko Sato Faculty of Computer and Information Sciences Hosei UniversityTokyoJapan Graduate School of Engineering Tokyo University of Agriculture and TechnologyTokyoJapan

Purpose–The purpose of this paper is to propose a fault-tolerant technology for increasing the durability of application programs when evolutionary computation is performed by fast parallel processing on many-core processors such as graphics processing units(GPUs)and multi-core processors(MCPs).Design/methodology/approach–For distributed genetic algorithm(GA)models,the paper proposes a method where an island’s ID number is added to the header of data transferred by this island for use in fault ***–The paper has shown that the processing time of the proposed idea is practically negligible in applications and also shown that an optimal solution can be obtained even with a single stuck-at fault or a transient fault,and that increasing the number of parallel threads makes the system less susceptible to ***/value–The study described in this paper is a new approach to increase the sustainability of application program using distributed GA on GPUs and MCPs.

关键词： Evolutionary computation Genetic algorithms Fault identification Many-core processors Parallelization