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Third-look endoscopy prevents delayed bleeding after endoscopic submucosal dissection under antithrombotic therapy

World Journal of Gastroenterology 2020年第41期26卷 6475-6487页

作者： Ryosuke Ikeda Kingo Hirasawa Chiko Sato yuichiro ozeki Atsushi Sawada Masafumi Nishio Takehide Fukuchi Ryosuke Kobayashi Makomo Makazu Masataka Taguri Shin Maeda Endoscopy Division Yokohama City University Medical CenterYokohama 232-0024Japan Endoscopy Division Yokohama Medical University Center HospitalYokohama 232-0024Japan Department of Data Science Yokohama City University School of Data ScienceYokohama 236-0004Japan Division of Gastroenterology Yokohama City University Graduate School of MedicineYokohama 236-0004Japan

BACKGROUND Postoperative delayed bleeding(PDB) after gastric endoscopic submucosal dissection(ESD) is the most common adverse event in patients receiving antithrombotics even with second-look endoscopy. Moreover, with the increasing prevalence of cardiovascular and cerebrovascular diseases in an aging population with associated lifestyle-related diseases, an increasing number of patients receive antithrombotics. Several attempts have been made to prevent PDB in aging population;however, a consensus has yet to be *** To examine the efficacy of third-look endoscopy(TLE) for PDB *** One hundred patients with early gastric neoplasms receiving antithrombotics were prospectively enrolled and subjected to ESD with TLE between February 2017 and July 2019. The primary endpoint was PDB rate, which was compared with our preset threshold. Furthermore, we divided the bleeding period into early-and late-onset PDB(E-PDB and L-PDB, respectively) and analyzed its rate. As a secondary analysis, we compared PDB rates with those of a historical control group, using propensity score matching, and calculated the PDB rates per antithrombotic agent use in each *** In total, 96 patients and 114 specimens were finally evaluated. The overall PDB rate was 7.9%(9/114) [90%CI: 4.7-13.1, P = 0.005], while the late-and early-onset PDB rates(L-PDB and E-PDB) were 5.3% [90%CI: 2.7-9.9, P < 0.0001] and 2.6% [90%CI: 1.1-6.4, P = 0.51], respectively. Propensity score matching generated 58 matched pairs for TLE and control groups. No differences were found in overall PDB incidence(10.3% vs 20.7%, P = 0.12), whereas L-PDB occurrence significantly differed(5.2% vs 17.2%, P = 0.04) between groups. Considering antithrombotics' use, the overall PDB rate was higher for direct oral anticoagulants and multiple antithrombotics in the control group, while L-PDB incidence was lower in the TLE group for these agents(8.7% vs 23.1% and 5.0% vs 29.4%, respectively).CONCLUSION TLE for g

关键词： Endoscopic submucosal dissection Postoperative delayed bleeding Third look endoscopy Antithrombotic agents Late phase bleeding Phase II

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Histopathological validation of magnifying endoscopy for diagnosis of mixed-histological-type early gastric cancer

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World Journal of Gastroenterology 2020年第36期26卷 5450-5462页

作者： yuichiro ozeki Kingo Hirasawa Ryosuke Kobayashi Chiko Sato Yoko Tateishi Atsushi Sawada Ryosuke Ikeda Masafumi Nishio Takehide Fukuchi Makomo Makazu Masataka Taguri Shin Maeda Division of Endoscopy Yokohama City University Medical CenterYokohama 232-0024Japan Department of Pathology Yokohama City University Graduate School of MedicineYokohama 236-0004Japan Department of Data Science Yokohama City University School of Data ScienceYokohama 236-0004Japan Department of Gastroenterology Yokohama City University Graduate School of MedicineYokohama 236-0004Japan

BACKGROUND The undifferentiated-type(UDT)component profoundly affects the clinical course of early gastric cancers(EGCs).However,an accurate preoperative diagnosis of the histological types is *** date,few studies have investigated whether the UDT component within mixed-histological-type(MT)EGCs can be recognized *** To clarify the histopathological characteristics of the endoscopically-resected MT EGCs for investigating whether the UDT component could be recognized *** This was a single-center retrospective ***,we attempted to clarify the histopathological characteristics of the endoscopically-resected MT EGCs with emphasis on the UDT *** examination investigated each lesion’s UDT component:(1)Whole mucosal layer occupation of the UDT component;(2)UDT component exposure to the surface of the mucosa;and(3)existence of a clear border between the differentiated-type and UDT ***,preoperative endoscopic images with magnifying endoscopy with narrowband imaging(ME-NBI)were examined to identify whether the endoscopic UDT component finding was recognizable within the area where it was present in the histopathological *** preoperative biopsy results and comparative relationships between endoscopic and histopathological findings were also *** In the histopathological examination,the whole mucosal layer occupation of the UDT component and exposure of the UDT component to the mucosal surface were observed in 67.3%(33/49)and 79.6%(39/49)of samples,respectively.A clear distinction of the border between the differentiated-type and UDT components could not be drawn in 65.3%(32/49)of MT *** the endoscopic examination,the preoperative endoscopic images showed that only 24.5%(12/49)of MT EGCs revealed the UDT component within the area where it was present *** UDT predominance was the single significant factor associated with the

关键词： Early gastric cancer Endoscopic submucosal dissection Mixed-histologicaltype Undifferentiated-type Narrow-band imaging

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Clinicopathological features of early gastric cancers arising in Helicobacter pylori uninfected patients

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World Journal of Gastroenterology 2020年第20期26卷 2618-2631页

作者： Chiko Sato Kingo Hirasawa Yoko Tateishi yuichiro ozeki Atsushi Sawada Ryosuke Ikeda Takehide Fukuchi Masafumi Nishio Ryosuke Kobayashi Makomo Makazu Hiroaki Kaneko Yoshiaki Inayama Shin Maeda Endoscopy Division Yokohama City University Medical CenterYokohama 232-0024Japan Department of Histopathology Yokohama City University Graduate School of MedicineYokohama 236-0004Japan Department of Gastroenterology Yokohama City University Graduate School of MedicineYokohama 236-0004Japan Division of Pathological Diagnosis Yokohama City University Medical CenterYokohama 232-0024Japan

BACKGROUND Persistent Helicobacter pylori(***)infection causes chronic inflammation,atrophy of the gastric mucosa,and a high risk of developing gastric *** recent years,awareness of eradication therapy has increased in *** *** infections decrease,the proportion of gastric cancers arising from *** uninfected gastric mucosa will *** emergence of gastric cancer arising in *** uninfected patients though rarely reported,is a concern to be addressed and needs elucidation of its clinicopathological *** To evaluate the clinicopathological features of early gastric cancer in *** *** A total of 2462 patients with 3375 instances of early gastric cancers that were treated by endoscopic submucosal dissection were enrolled in our study between May 2000 and September *** these,30 lesions in 30 patients were diagnosed as ***-uninfected gastric cancer(Hp UIGC).We defined a patient as ***-uninfected using the following three criteria:(1)The patient did not receive treatment for ***,which was determined by investigating medical recordsand conducting patient interviews;(2)Lack of endoscopic atrophy;and(3)The patient was negative for *** after being tested at least twice using various diagnostic methods,including serum ***-Ig G antibody,urease breath test,rapid urease test,and microscopic *** The frequency of Hp UIGC was 1.2%(30/2462)for the patients in our *** study included 19 males and 11 females with a mean age of 59 *** location of the stomach lesions was divided into three sections;upper third(U),middle third(M),lower third(L).Of the 30 lesions,15 were U,1 was M,and 14 were ***,17 lesions were protruded and flat elevated type(0-I,0-IIa,0-IIa+IIc),and 13 lesions were flat and depressed type(0-IIb,0-IIc).The median tumor diameter was 8 mm(range 2-98 mm).Histological analysis revealed that22 lesions(73.3%)were differentiated ***

关键词： Early gastric cancer Helicobacter pylori Un-infection Negative Clinicopathological features Endoscopic submucosal dissection Mucins Phenotype

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A single atom photocatalyst co-doped with potassium and gallium for enhancing photocatalytic hydrogen peroxide synthesis

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Nano Research 2024年第8期17卷 7027-7038页

作者： Wenan Cai yuichiro Tanaka Xing Zhu Teruhisa Ohno Department of Applied Chemistry Faculty of EngineeringKyushu Institute of TechnologyKitakyushu 804-8550Japan College of Bioresources Chemical and Materials Engineering Shaanxi University of Science&TechnologyXi’an 710021China

Polymer carbon nitride(PCN)is widely used in ***,pristine PCN has disadvantages such as insufficient visible light absorption and low photogenerated carrier separation efficiency that greatly limited the photocatalytic *** a non-toxic metal,gallium has the potential to solve the defects of *** ions coordinated with nitrogen in carbon nitride to form Ga-N active sites and improved the photocatalytic *** doped potassium ions form a transmission channel for charge redistribution and transfer between adjacent layers,which is beneficial for better separation of photoexcited *** this study,a series of PCN co-doped with gallium and potassium(Ga-K-PCN)were *** experimental results indicated photocatalytic generation of hydrogen peroxide proceeds through the 2e−oxygen reduction reaction ***,Nyquist plots and photocurrent results further proved that the presence of Ga-N sites and potassium ion doping could significantly improve the separation/transfer of intra-planar and interlayer charge carriers and thus enhance photocatalytic *** Ga10-K3-PCN photocatalysts promoted yield of H_(2)O_(2),with reactivity at 28.2μmol/(g·h)and solar-to-chemical conversion efficiency at 0.64%,surpassed that of a typical photo-catalyst based on PCN(0.18%).

关键词： photocatalysis gallium oxygen reduction reaction H_(2)O_(2) production

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Pulmonary artery diameter ratio as a prognostic indicator of congenital diaphragmatic hernia

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World Journal of Pediatric Surgery 2024年第1期7卷 20-25页

作者： yuichiro Miyake Hiroyuki Koga Shuko Nojiri Shunsuke Yamada Takanori Ochi Go Miyano Geoffrey J Lane Atsuyuki Yamataka Tadaharu Okazaki Department of Pediatric General and Urogenital Surgery Juntendo University School of MedicineBunkyo-kuTokyoJapan Department of Medical Technology Innovation Center Juntendo UniversityBunkyo-ku TokyoJapan Department of Pediatric Surgery Juntendo University Urayasu HospitalUrayasuChibaJapan

Background Following on from an earlier study published in 2008 about left pulmonary artery(LPA)flow measured on serial echocardiography being strongly prognostic in left-sided congenital diaphragmatic hernia(CDH)and the ratio of LPA to right pulmonary artery(RPA)diameters being a simple and reliable indicator for commencing nitric oxide(NO)therapy,the ratio of LPA:RPA diameters(PA ratio orPAR)was hypothesized to possibly reflect cardiopulmonary stresses accompanying CDH *** Subjects with isolated left-sided CDH treated between 2007 and 2020 at a single pediatric surgical center were recruited and classified according to *** obtained retrospectively for subject demographics,clinical course,LPA/RPA diameters,and PAR were compared between survivors and *** value of PAR for optimizing the prognostic value of PA diameter data in CDH were analyzed with receiver operating characteristic(ROC)curve *** Of 65 subjects,there were 54 survivors(82.3%)and 11 non-survivors(17.7%);7 of 11 non-survivors died before surgical repair could be *** PAR for survivors(0.851±0.152)was significantly higher than for non-survivors(0.672±0.108)(p=0.0003).Mean PAR for non-survivors was not affected by surgical *** of survivors were:LPA≥2 mm(n=52 of 54;mean PAR=0.866±0.146)and RPA≥3mm(n=46 of 54;mean PAR=0.857±0.152).Non-survivors with similar LPA and RPA diameters to survivors had significantly lower mean *** curve cut-off for PAR was *** with high PAR(≥0.762)required high-frequency oscillatory ventilation/NO less than subjects with low PAR(<0.762)(p=0.0244 and p=0.0485,respectively)and subjects with high PAR stabilized significantly earlier than subjects with low PAR(1.71±0.68 days vs 3.20±0.87 days)(p<0.0001).Conclusions PAR would appear to be strongly correlated with clinical outcome in CDH and be useful for planning management of cardiopulmonary instability in CDH.

关键词： hernia congenital diameters

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Relationship between nutritional therapy and beneficial bacteria ratio in severe disease

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Journal of Acute Disease 2024年第1期13卷 26-30页

作者： Kento Nakayama Hiroyuki Koami yuichiro Sakamoto Advanced Emergency Care Center Saga University HospitalSaga 849-0851Japan

Objective:To evaluate relationship between changes in the beneficial bacteria in intensive care unit(ICU)patients and nutritional therapy ***:Ten patients aged≥18 years admitted to the ICU between January and December 2020,were *** enteral nutrition was defined as early achievement of target calorie intake through enteral *** ratio of beneficial bacteria at the first and second bowel movements after each patient’s admission was calculated and the patients were classified into the increase or decrease *** all patients,five each were in the increase and decrease *** investigated patient background,changes in sequential organ failure assessment(SOFA)and acute physiology and chronic health evaluation(APACHE)Ⅱscores,nutritional doses or methods,and clinical ***:No relationship was found between changes in the ratio of beneficial bacteria and changes in SOFA/APACHEⅡscores at the time of *** rate of good enteral nutrition was significantly higher in the increase group than in the decrease group(4/5 vs.0/5,P=0.01).Conclusions:An increase in beneficial bacteria may be significantly related to the early establishment of enteral *** the future,accumulating cases may make it possible to establish a new nutritional strategy for critically ill patients from an intestinal microbiota perspective.

关键词： Beneficial bacteria Enteral nutrition Parenteral nutrition Intensive care unit Good enteral nutrition Severe disease Nutritional therapy

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Quality assessment of volunteered geographic information for outdoor activities:an analysis of OpenStreetMap data for names of peaks in Japan

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Geo-Spatial Information Science 2023年第3期26卷 333-345页

作者： Jun Yamashita Toshikazu Seto Nobusuke Iwasaki yuichiro Nishimura Faculty of Social and Cultural Studies Kyushu UniversityFukuokaJapan Faculty of Letters Komazawa UniversityTokyoJapan Sciences NAROInstitute for Agro-EnvironmentalTsukubaJapan Faculty of Letters Nara Women’s UniversityNaraJapan

Geographical studies of outdoor activities have increased in recent years with the rise in popularity of these activities worldwide,including in *** geographic information(VGI)is a key tool for organizing outdoor activities as it offers a means to determine the locational information and names of *** evaluate the quality of VGI,geospatial data generated by land survey agencies and other VGI are often utilized as reference ***,since these reference data may not be available,other methods are necessary to assure the quality of *** this study,we examined five trust indicators based on the inherent characteristics of VGI through an empirical case *** used mountain names extracted from OpenStreetMap in Japan as data because there were almost no other VGI in the *** a result,we isolated three trust indicators,namely versions,users,and tag corrections,to examine the thematic accuracy of VGI because these were the only statistically significant ***,we found that the prediction rate of thematic accuracy was very *** improve thematic accuracy,this study recommends using the most accurate versions,applying correctly given tags,and considering the motivations and characteristics of the VGI contributors.

关键词： Outdoor activities volunteered geographic information(VGI) OpenStreetMap(OSM) data quality assessment trust integrated usage

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IDENTIFICATION OF STIFFNESS COEFFICIENTS OF LAMINATED COMPOSITE PLATES

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中国有色金属学会会刊：英文版 1997年第3期7卷 46-50页

作者： Wang, XC Shen, XP yuichiro, M Xu, BY N CHINA UNIV TECHNOL BEIJING 100041PEOPLES R CHINA TSING HUA UNIV DEPT MECH ENGNBEIJING 100084PEOPLES R CHINA IBARAKI UNIV DEPT ENGNHITACHIIBARAKI 316JAPAN

ＩＤＥＮＴＩＦＩＣＡＴＩＯＮＯＦＳＴＩＦＦＮＥＳＳＣＯＥＦＦＩＣＩＥＮＴＳＯＦＬＡＭＩＮＡＴＥＤＣＯＭＰＯＳＩＴＥＰＬＡＴＥＳ①ＷａｎｇＸｉａｏｃｈｕｎ，ＳｈｅｎＸｉｎｐｕ，ＭａｓｕｄａＹｕｉｃｈｉｒｏ，ＸｕＢｉｎｇ... 详细信息

ＩＤＥＮＴＩＦＩＣＡＴＩＯＮＯＦＳＴＩＦＦＮＥＳＳＣＯＥＦＦＩＣＩＥＮＴＳＯＦＬＡＭＩＮＡＴＥＤＣＯＭＰＯＳＩＴＥＰＬＡＴＥＳ①ＷａｎｇＸｉａｏｃｈｕｎ，ＳｈｅｎＸｉｎｐｕ，ＭａｓｕｄａＹｕｉｃｈｉｒｏ，ＸｕＢｉｎｇｙｅＮｏｒｔｈＣｈｉｎａＵｎｉｖｅ...

关键词： inverse analysis composite laminated plate stiffness coefficient

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Investigation of Surge Behavior in a Micro Centrifugal Compressor

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Journal of Thermal Science 2006年第2期15卷 97-102页

作者： Shimpei MIZUKI yuichiro ASAGA Yushi ONO Hoshio TSUJITA Department of Mechanical Engineering Hosei University 3-7-2Kajino-choKoganei-shiTokyo Mitsubishi Heavy Industries Ltd. 1-1 Akunoura-machi Nagasaki-shi Nagasaki Department of Mechanical Engineering Hosei University 3-7-2 Kajino-cho Koganei-shi Tokyo

This paper reports the experimental and theoretical study of the surge occurred in prototyping an ultra micro centrifugal compressor. As the first step, the 10 times size model of an ultra micro centrifugal compressor having the 40 mm outer diameter was designed and manufactured. The detailed experimental investigations for the transient behavior of surge with several different values of B parameter were carded out. The experimental results during the surge were compared with those obtained by the non-linear lumped parameter theory in order to validate the effectiveness of the theoretical surge model for the micro centrifugal compressor. As a result, the quite different behavior of the surge appeared for the different values of B both in the experiment and in the analysis.

关键词： micro centrifugal compressor surge lumped parameter model

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Surge Control of a Centrifugal Compression System by Using a Bouncing Ball

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Journal of Thermal Science 2008年第2期17卷 141-146页

作者： yuichiro Asaga Shimpei Mizuki Hoshio Tsujita Shinsuke Ohta Department of Mechanical Engineering Faculty of EngineeringHosei University Mitsubishi Heavy Industries Ltd.

The purpose of this study is to suppress the fluctuations of surge by a simple passive control method. A bouncing ball system with different weight of the balls was tested. As a result, the bouncing ball system suppressed mild surge without the deterioration of the performance characteristics, and moved the initiation point of surge toward the lower flow rate when the steel ball of 15mm outer diameter was used. The present system was effective to suppress the surge and to widen the stable operating range of a centrifugal compressor when the ball was chosen appropriately.

关键词： centrifugal compressor surge passive control bouncing ball

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