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MR imaging of cheek lesions of Kimura’s disease: Focusing on the signal abnormalities and the relationship with superficial musculoaponeurotic systems

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Modern Research in Inflammation 2013年第4期2卷 69-74页

作者： Ryutarou Ukisu yuichiro Kawahara Norihiro Hashizume Tamio Kushihashi Yoshinori Yamada Yoshiyuki Kadokura Department of Otolaryngology Showa University Northern Yokohama Hospital Yokohama Japan Department of Radiology Showa University Northern Yokohama Hospital Yokohama Japan

Background and Purpose: Kimura’s Disease (KD) is a rare benign chronic eosinophlic inflammatory disorder, characterized by angiolymphoid proliferation with peripheral eosinophilia and elevated serum immunoglobulin E. Most lesions occur in the head and neck regions. To the best of our knowledge, the relationship between subcutaneous cheek lesion of KD and the surrounding structures including superficial musculoaponeurotic systems (SMAS) has never been reported. The purpose of this study was to describe MR imaging findings of cheek subcutaneous lesion of KD and adjacent SMAS. Materials and Methods: Seven cheek subcutaneous lesions of 5 patients histopathologically proved KD were evaluated. We retrospectively evaluated the MR imaging findings of subcutaneous lesions for signal intensity in each imaging sequence, the border of the lesions, and appearance of SMAS. Results: All cheek lesions were displacing normal fat tissue. These lesions showed ill-defined border (7/7), slightly high signal intensity on T1-weighted images (7/7), and intermediate (1/7) or high signal intensity (6/7) on T2-weighted images. Cheek lesions were enhanced by intravenous injection of gadolinium to signal intensity close to that of fat tissue (3/4), and in one case, the avid enhancement of the mass was seen (1/4). All lesions attached to the outer surface of SMAS, however, only one out of 7 lesions distributed below the SMAS without tearing of the layers. SMAS below the lesion showed high signal intensity on T2-weighted images in two lesions (2/7). Conclusion: KD should be included in the differential diagnosis when a cheek mass presents with non-specific signal intensities and irregular border, which attaches to but does not interrupt SMAS on MR imaging.

关键词： Kimura’s Disease SMAS (Superficial Musculoaponeurotic Systems) MRI

Identification of CAR/RXR<i>α</i>Hetero-dimer Binding Sites in the Human Genome by a Modified Yeast One-Hybrid Assay

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Advances in Biological Chemistry 2015年第2期5卷 83-97页

作者： Kenta Hosoda yuichiro Kanno Masashi Sato Jun Inajima Yoshio Inouye Kazuyuki Yanai Department of Biomolecular Science Faculty of Science Toho University Chiba Japan Faculty of Pharmaceutical Sciences Toho University Chiba Japan

The constitutive androstane receptor (CAR) is a transcription factor that belongs to the nuclear receptor superfamily. CAR binds as a heterodimer with the retinoid X receptor α (RXRα) to CAR response elements (CAREs) and regulates the expression of various drug metabolizing enzymes and transporters. To identify CAR/RXRα binding sites in the human genome, we performed a modified yeast one-hybrid assay that enables rapid and efficient identification of genomic targets for DNA-binding proteins. DNA fragments were recovered from positive yeast colonies by PCR and sequenced. A motif enrichment analysis revealed that the most frequent motif was a direct repeat (DR) of RGKTCA-like core sequence spaced by 4 bp. Next, we predicted 149 putative CAR/RXRα binding sites from 414 unique clones, by searching for DRs, everted repeats (ERs) and inverted repeats (IRs) of the RGKTCA-like core motif. Based on gel mobility shift assays, the CAR/RXRα heterodimer could directly interact with the 108 predicted sequences, which included not only classical CAREs but also a wide variety of arrangements. Furthermore, we identified 17 regulatory polymorphisms on the CAR/RXRα-binding sites that may influence individual variation in the expression of CAR-regulated genes. These results provide insights into the molecular mechanisms underlying the physiological and pathological actions of CAR/RXRα het-erodimers.

关键词： Constitutive Androstane Receptor Retinoid X Receptor Transcription SNP Polymorphism Nuclear Receptor

Impact of laparoscopic liver resection on bleeding complications in patients receiving antithrombotics

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World Journal of Gastrointestinal Endoscopy 2017年第8期9卷 396-404页

作者： Takahisa Fujikawa Hiroshi Kawamoto yuichiro Kawamura Norio Emoto Yusuke Sakamoto Akira Tanaka Department of Surgery Kokura Memorial HospitalFukuoka 802-8555Japan

To assess the impact of laparoscopic liver resection (LLR) on surgical blood loss (SBL), especially in patients with antithrombotics for thromboembolic risks. METHODSConsecutive 258 patients receiving liver resection at our institution between 2010 and 2016 were retrospectively reviewed. Preoperative antithrombotic therapy (ATT; antiplatelets and/or anticoagulation) was regularly used in 100 patients (ATT group, 38.8%) whereas not used in 158 (non-ATT group, 61.2%). Our perioperative management of high thromboembolic risk patients included maintenance of preoperative aspirin monotherapy for patients with antiplatelet therapy and bridging heparin for patients with anticoagulation. In both ATT and non-ATT groups, outcome variables of patients undergoing LLR were compared with those of patients receiving open liver resection (OLR), and the independent risk factors for increased SBL were determined by multivariate analysis. RESULTSThis series included 77 LLR and 181 OLR. There were 3 thromboembolic events (1.2%) in a whole cohort, whereas increased SBL (≥ 500 mL) and postoperative bleeding complications (BCs) occurred in 66 patients (25.6%) and 8 (3.1%), respectively. Both in the ATT and non-ATT groups, LLR was significantly related to reduced SBL and low incidence of BCs, although LLR was less performed as anatomical resection. Multivariate analysis showed that anatomical liver resection was the most significant risk factor for increased SBL [risk ratio (RR) = 6.54, P < 0.001] in the whole cohort, and LLR also had the significant negative impact (RR = 1/10.0, P < 0.001). The same effects of anatomical resection (RR = 15.77, P < 0.001) and LLR (RR = 1/5.88, P = 0.019) were observed when analyzing the patients in the ATT group. CONCLUSIONLLR using the two-surgeon technique is feasible and safely performed even in the ATT-burdened patients with thromboembolic risks. Independent from the extent of liver resection, LLR is significantly associated with reduced SBL, both in t

关键词： Laparoscopic liver resection Two-surgeon technique Antithrombotic therapy Increased surgical blood loss Bleeding complication

Hyperglycemia is a significant prognostic factor of hepatocellular carcinoma after curative therapy

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World Journal of Gastroenterology 2013年第2期19卷 249-257页

作者： Takanori Hosokawa Masayuki Kurosaki Kaoru Tsuchiya Shuya Matsuda Masaru Muraoka yuichiro Suzuki Nobuharu Tamaki Yutaka Yasui Toru Nakata Takashi Nishimura Shoko Suzuki Ken Ueda Hiroyuki Nakanishi Jun Itakura Yuka Takahashi Namiki Izumi Division of Gastroenterology and Hepatology Musashino Red Cross HospitalTokyo 180-8610Japan

AIM:To evaluate whether metabolic factors are related to distant recurrence of hepatocellular carcinoma(HCC) and survival after curative ***:This retrospective study included 344 patients whose HCC was treated curatively by radiofrequency ablation(RFA) *** mean age was 67.6 years and the mean observation period was 4.04 *** etiological background of liver disease was hepatitis B virus infection in 30,hepatitis C virus infection in 278,excessive alcohol drinking in 9,and other in 27 *** Child-Pugh classification grade was A(n = 307) or B(n = 37).The number of HCC nodules was one in 260,two in 61,and three in 23 *** surveillance of HCC recurrence after curative therapy with RFA,patients were radiologically evaluated every 3 *** associated with distant recurrence of HCC or survival were ***:Inadequate maintenance of blood glucose in diabetic patients was associated with higher incidence of distant *** 1-,2-,and 3-year recurrence rates were significantly higher in diabetic patients with inadequate maintenance of blood glucose compared with the others:50.6% vs 26.8%,83.5% vs 54.4%,and 93.8% vs 73.0%,respectively(P = 0.0001).Inadequate maintenance of blood glucose was an independent predictor of distant recurrence [adjusted relative risk 1.97(95%CI,1.33-2.91),(P = 0.0007)] after adjustment for other risk factors,such as number of HCC nodules [2.03(95%CI,1.51-2.73),P < 0.0001] and initial level of serum alpha fetoprotein(AFP) [1.43(95%CI,1.04-1.97),P = 0.028].Obesity was not an independent predictor of *** incidence of distant recurrence did not differ between diabetic patients with adequate maintenance of blood glucose and non-diabetic *** 232 patients who had HCC recurrence,138 had a second *** 1-,2-,and 3-year rates of second recurrence were significantly higher in diabetic patients with inadequate maintenance of blood glucose than in the others:9.0% vs 5.9%,53.1

关键词： Hyperglycemia Hepatocellular carcinoma Recurrence Radio frequency ablation Survival

High-speed playback of spatiotemporal division multiplexing holographic 3D video stored in a solid-state drive using a digital micromirror device

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Chinese Optics Letters 2021年第9期19卷 121-126页

作者： Kohei Suzuki Minori Tao Yuki Maeda Hirotaka Nakayama Ren Noguchi Minoru Oikawa yuichiro Mori Takashi Kakue Tomoyoshi Shimobaba Tomoyoshi Ito Naoki Takada Graduate School of Integrated Arts and Sciences Kochi UniversityKochi 780-8520Japan Faculty of Science Kochi UniversityKochi 780-8520Japan National Astronomical Observatory of Japan Tokyo 181-8588Japan Research and Education Faculty Kochi UniversityKochi 780-8520Japan Graduate School of Engineering Chiba UniversityChiba 263-8522Japan

We propose a high-speed playback method for the spatiotemporal division multiplexing electroholographic three-dimensional(3D)video stored in a solid-state drive(SSD)using a digital micromirror *** spatiotemporal division multiplexing electroholography prevents deterioration in the reconstructed 3D video from a 3D object comprising many object *** the proposed method,the stored data is remarkably reduced using the packing technique,and the computer-generated holograms are played back at high ***,we successfully reconstructed a clear 3D video of a 3D object comprising approximately 1,100,000 points at 60 frames per second by reducing the reading time of the stored data from an SSD.

关键词： spatiotemporal division multiplexing electroholography digital micromirror device computer-generated hologram high-speed playback

Antimicrobial therapy using sulfamethoxazole trimethoprim for Kawasaki disease patients unresponsive to intravenous immunoglobulin

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Open Journal of Pediatrics 2011年第3期1卷 27-29页

作者： Satoru Nagata yuichiro Yamashiro Makoto Fujimori Yukihide Chiba Yoshikazu Ohtsuka Toshiaki Shimizu 不详

Our previous study suggested that the production of superantigens and heat-shock protein 60 by small intestinal bacteria might play a role in Kawasaki disease (KD). We demonstrated that they were all resistant to commonly used antibiotics, except for sulamethoxazole trimethoprim (SMX-TMP). We used SMX-TMP for 7 cases of KD that were unresponsive to intravenous immunoglobulin (IVIG) and studied the antipyretic potency of this treatment. In 6 out of the 7 cases, we demonstrated that antipyretic potency was observed without side effects within 2 days of the initial administration. Antimicrobial therapy using SMX-TMP might represent a novel strategy for cases of KD that are unresponsive to IVIG.

关键词： Antimicrobial Therapy Intravenous Immunoglobulin Resistance Kawasaki Disease Sulfamethoxazole Trimethoprim

Multilocular Thymic Cysts with Follicular Hyperplasia: Report of a Case

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Open Journal of Thoracic Surgery 2013年第4期3卷 111-113页

作者： Yoshinobu Ichiki yuichiro Kajiwara Takayuki Hamatsu Taketoshi Suehiro Fumihiro Tanaka Keizo Sugimachi Department of Chest Surgery Onga Nakama Medical Association Onga Hospital Onga-gun Japan Department of Emergency Onga Nakama Medical Association Onga Hospital Onga-gun Japan Department of Surgery Onga Nakama Medical Association Onga Hospital Onga-gun Japan Department of Surgery Onga Nakama Medical Association Onga Hospital Onga-gun Japan Second Department of Surgery University of Occupational and Environmental Health School of Medicine Kitakyushu Japan.

We herein describe a rare case of multilocular thymic cysts (MTCs) with follicular hyperplasia. The patient was a 50-year-old man, who was symptom-free. A mediastinal mass was found on chest computed tomography (CT) followed after pancreatitis. Chest CT revealed a 30 × 10 mm anterior mediastinal mass with multiple cystic lesions. Magnetic resonance imaging showed an anterior mediastinal cystic mass with low-signal intensity on T1-weighted image and on high-signal intensity T2-weighted image. Thus we made a preoperative diagnosis of MTCs with thymoma within the cyst wall. The lesion was resected by thymectomy. Intraoperatively, multiple cysts and swelling of mediastinal lymph nodes were noted throughout the entire thymus. Histopathological findings revealed lymphoid follicular hyperplasia of thymic tissues but no neoplastic lesions. Based on these findings, a diagnosis of MTCs associated with thymic hyperplasia was made. This is a rare case that preoperatively was difficult to diagnose.

关键词： Multilocular Thymic Cyst Follicular Hyperplasia Surgery

Analysis of mandibular reconstruction with vascularized fibular osteocutaneous flaps using 3D-model surgery

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中国口腔颌面外科杂志 2008年第B5期6卷 95-96页

作者： Yasutsugu Yamanaka yuichiro Imai Hiroyuki Shimomura Masahide Inoue Kumiko Aoki Tadaaki Kirita Department of Oral and Maxillofacial Surgery Nara Medical University. Kashihara 634- 8522 Japan Department of Oral and Maxillofacial Surgery Takai Hospital. Tenri 632-0006 Japan

Indications and technique for laparoscopic liver resection in patients with hepatocellular carcinoma and liver cirrhosis

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Hepatoma Research 2016年第1期2卷 241-247页

作者： yuichiro Otsuka Masaru Tsuchiya Toshio Katagiri Yoshihisa Kubota Jun Ishii Tetsuya Maeda Hironori Kaneko Division of General and Gastroenterological Surgery Department of SurgeryToho University Faculty of MedicineTokyo 143-8541Japan

Liver resection is the preferred initial treatment option for solitary or limited multifocal hepatocellular carcinoma(HCC).However,because of the characteristics of HCC,including its high recurrence rate and the frequent presence of chronic hepatitis and cirrhosis,both curability and invasiveness must be considered when selecting a treatment for *** liver resection(LLR)is minimally invasive and increasingly performed worldwide as a curative surgical option for treatment of liver *** 2014 International Consensus Conference on LLR concluded that minor LLRs are now standard ***-analyses suggest that,as compared with open hepatectomy,LLR for patients with HCC,including those with cirrhosis,resulted in less blood loss,lower postoperative hospitalization rates,and similar oncological *** candidates for this procedure should be carefully evaluated,LLR appears to be a feasible option for treatment of HCC with liver *** review describes the indications for LLR in this patient subgroup and offers guidance on appropriate surgical technique.

关键词： Laparoscopic liver resection hepatocellular carcinoma liver cirrhosis