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Nuclear Science and Techniques 2011年第1期22卷 18-24页

作者： LIU Ruiqin WEI Yuezhou Daisuke Tozawa XU Yuanlai Shigekazu Usuda Hiromichi Yamazaki Keizo Ishii yuichi Sano Yoshikazu Koma School of Nuclear Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China Cyclotron and Radioisotope Center Tohoku UniversityAoba 6-3Aramaki-Aoba-kuSendaiMiyagi980-8578Japan Japan Atomic Energy Agency (JAEA) TokaiIbaraki319-1195Japan

Basic properties of a silica-based octyl(phenyl)-N,N-diisobutylcarbamoyl-methylphosphine oxide (CMPO) extraction resin (CMPO/SiO2-P) was *** behavior for some rare earth elements (RE) which are constituents of high level liquid waste (HLLW) and the long-term stability of the extraction resin in nitric acid solution were *** CMPO extraction resin was significantly stable in 3 mol·L?1 HNO3 solution at ***,the RE(III) were efficiently separated from non-adsorptive fission product (FP) elements such as Sr(II) in a column experiment using a highly nitric acid *** separation behaviors of the elements are considered to result from the difference in their adsorption and elution selectivity based on the complex formation with *** was no strong dependency of RE(III) separation efficiency on feed solution flow *** from the perspectives of the acid-resistant behavior of CMPO extraction resin and the elution kinetics for the metal ions with the extraction resin,the CMPO extraction resin can be used in the modified MAREC process for HLLW partitioning.

关键词：萃取树脂高放废液锕系元素分离性能大孔硅提取基础选择性吸附

Static and dynamic evaluations of acoustic positioning system using TDMA and FDMA for robots operating in a greenhouse

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International Journal of Agricultural and Biological Engineering 2022年第5期15卷 28-33页

作者： Lok Wai Jacky Tsay Tomoo Shiigi Xunyue Zhao Zichen Huang Keiichiro Shiraga Tetsuhito Suzuki yuichi Ogawa Naoshi Kondo Laboratory of Bio-Sensing Engineering Division of Environmental Science and TechnologyGraduate School of AgricultureKyoto UniversityKyoto 606-8502Japan Department of Ocean Mechanical Engineering National Fisheries UniversityShimonoseki 759-6595Japan

Acoustic positioning system has great potential to be applied in a greenhouse due to its centimeter-level accuracy,low cost,and ability of extensive greenhouse *** Spectrum Sound-based local positioning system(SSSLPS)was proposed to be a navigation tool for multiple agricultural robots by the authors'research ***,to increase the system capacity for positioning multiple robots in a greenhouse,the near-far problem caused by the interference between speakers needs to be *** use of different access methods,Time Division Multiple Access(TDMA)or Frequency Division Multiple Access(FDMA),is essential in the SSSLPS system for solving the near-far *** static positioning in a greenhouse was first evaluated by setting different parameters to determine the optimal signal setting for a dynamic *** that,the moving robot tests were added with a motion capture system and tested the performance of TDMA and *** results demonstrated that TDMA can be used in a stationary sound-based positioning system with 12.2 mm accuracy,but it has a time delay problem in dynamic positioning.A simulation was designed to mimic the position error increases with different moving *** FDMA has the sound damping problem in high-frequency regions creating a peak detection issue,it achieved a higher accuracy with an average position error of 62.1 mm compared to 180.3 mm of *** study shows that the TDMA method is suitable for static measurements,while the FDMA method is suitable for measuring dynamic objects and controlling mobile robots.

关键词： greenhouse robots positioning system near-far problem TDMA FDMA

Meta-analysis of short-term outcomes after laparoscopy-assisted distal gastrectomy

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World Journal of Gastroenterology 2006年第47期12卷 7676-7683页

作者： Shunsuke Hosono yuichi Arimoto Hiroshi Ohtani Yoshitetsu Kanamiya Department of Surgery Osaka City Sumiyoshi Hospital 1-2-16 Higashi-Kagaya Suminoe-ku Osaka 559-0012 Japan

AIM： To elucidate the current status of laparoscopyassisted distal gastrectomy （LADG） with regard to its short-term outcomes by comparing it with conventional open distal gastrectomy （CODG）.METHODS： Original articles published from 3anuary 1991 to August 2006 were searched in the MEDLINE, EMBASE, and Cochrane Controlled Trials Register. Clinical appraisal and data extraction were conducted independently by 2 reviewers. A meta-analysis was performed using a random effects model.RESULTS： Outcomes of 1611 procedures from 4 randomized controlled trials and 12 retrospective studies were analyzed. Compared to CODG, LADG was a longer procedure （weighted mean difference [WMD] 54.3; 95% confidence interval [CI] 38.8 to 69.8; P 〈 0.001）, but was associated with a lower associated morbidity （odds ratio [OR] 0.54; 95% CI 0.37 to 0.77; P 〈 0.001）; this was most significant for postoperative ileus （OR 0.27; 95% CI 0.09 to 0.84; P = 0.02）. There was no significant difference between the two groups in anastomotic, pulmonary, and wound complications and mortality. Duration from surgery to first passage of flatus was faster （WMD -0.68; 95% CI -0.85 to -0.50; P 〈 0.001） and the frequency of additional analgesic requirement （WMD -1.36; 95% CI -2.44 to -0.28; P = 0.01）, and duration of hospital stay （WMD -5.51; 95% CI -7.61 to -3,42; P 〈 0,001） were significantly lower after LADG, However, a significantly higher number of lymph nodes were dissected by CODG （WMD -4.35; 95% CI -5.73 to -2.98; P 〈 0.001）. CONCLUSION： LADG for early gastric cancer is associated with a lower morbidity, less pain, faster bowel function recovery, and shorter hospital stay.

关键词： Laparoscopic gastrectomy Gastric cancer Postoperative complications Mortality Lymphadenectomy Meta-analysis

Combination therapy with daclatasvir and asunaprevir for dialysis patients infected with hepatitis C virus

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World Journal of Clinical Cases 2016年第3期4卷 88-93页

作者： Ken Sato yuichi Yamazaki Tatsuya Ohyama Takeshi Kobayashi Norio Horiguchi Satoru Kakizaki Motoyasu Kusano Masanobu Yamada Department of Medicine and Molecular Science Gunma University Graduate School of Medicine Department of Gastroenterology Heisei Hidaka Clinic Department of Endoscopy and Endoscopic Surgery Gunma University Hospital

The standard antiviral therapy for dialysis patients infected with hepatitis C virus(HCV) is(pegylated) interferon monotherapy, but its efficacy is insufficient. Oral direct-acting antiviral agents(DAAs) have recently been developed for chronic hepatitis C patients. However, some DAAs have contraindications for chronic renal failure(CRF). Daclatasvir and asunaprevir are metabolized largely in the liver and are not contraindicated in CRF. Combination therapy with daclatasvir and asunaprevir was used for 4 dialysis patients infected with genotype 1b HCV. One patient had viral breakthrough, and the 3 others had sustained virological response 12. One patient was admitted for heart failure and percutaneous coronary intervention due to concomitant ischemic disease. Heart failure was unlikely to be caused by the combination therapy, as it was probably due to water overload. The patient continued to receive the combination therapy after the remission of the heart failure. The combination therapy was well tolerated in the other patients.

关键词： Hepatitis C Oral drug Daclatasvir Asunaprevir Dialysis

A Flat Spectral Response AWG Demultiplexer Composed of Slabs with Islands and Peninsulas

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光学学报 2003年第S1期23卷 157-158页

作者： Yutaka Natsume Junji Yamauchi Ryoichi Tazawa Koji Ishikawa Shigeru Kawaguchi yuichi Yamamoto Hisamatsu Nakano R & D Department NHK Spring Co. Ltd. 3-10 Fukuura Kanazawa-ku Yokohama 236-0004 Japan Faculty of Engineering Hosei University 3 -7-2 Kajino-cho Koganei Tokyo 184-8584 Japan

Phase adjustment elements called islands and peninsulas are introduced to obtain an AWG demultiplexer with a flat spectral response. Use of the peninsulas enables us to achieve a IdB bandwidth of 0.5 nm.

关键词： spectral response

Preparation of bromfenac-loaded liposomes modified with chitosan for ophthalmic drug delivery and evaluation of physicochemical properties and drug release profile

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Asian Journal of Pharmaceutical Sciences 2013年第2期8卷 104-109页

作者： Toshimasa Tsukamoto Kohei Hironaka Takuya Fujisawa Daiki Yamaguchi Kohei Tahara yuichi Tozuka Hirofumi Takeuchi Laboratory of Pharmaceutical Engineering Gifu Pharmaceutical University1-25-4 Daigaku-nishiGifu 501-1196Japan Laboratory of Formulation Design and Pharmaceutical Technology Osaka University of Pharmaceutical SciencesOsakaJapan

The purpose of this study was to design a submicron-sized liposomal non-steroidal antiinflammatory drug(NSAID)preparation that targets the retina via topical instillation of eye ***(BRF)-loaded liposomes were prepared using the calcium acetate gradient *** sizes and encapsulation efficiencies were optimized by screening several liposome formulations of lipid,drug concentration,and buffer *** entrapment efficiency was greater than 90%using this method,and was low using conventional hydration *** initial BRF loading using the pH gradient method caused aggregation of *** circumvent aggregation,the negatively charged lipid dicetylphosphate was incorporated into liposomes,which formed anion layer preventing *** of BRF from liposomes was sustained for several hours depending on lipid concentration,inner water phase,initial drug amounts,and surface *** modification with chitosan(CS),a mucoadhesive cationic polymer,was achieved using electrostatic interactions of negatively charged *** optimal concentration of CS for evasion of liposome aggregation was 0.15%.

关键词： NSAIDs pH Gradient method Surface modification Chitosan Eye drop

Perioperative Patient Factors Related to 2-Year Outcome after Esophageal Cancer Surgery: A Retrospective Cohort Study

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Open Journal of Anesthesiology 2020年第4期10卷 101-112页

作者： Maiko Hasegawa-Moriyama yuichi Kanmura Department of Anesthesiology and Critical Care Medicine Graduate School of Medical and Dental Sciences Kagoshima University Sakuragaoka Kagoshima Japan Operating Suite Shinshu University Hospital Asahi Matsumoto Nagano Japan

Background: Surgical treatment for esophageal cancer is major invasive surgery. Recently, opioids have been implicated in the promotion of cancer recurrence and metastasis because of their immunosup-pressive effects. However, it has not been fully evaluated whether the intraoperative use of opioids is directly correlated with postoperative prognosis in the clinical setting. Therefore, this study aimed to identify perioperative factors related to postoperative complications and 2-year survival in patients undergoing esophageal cancer surgery. Methods: We retrospectively reviewed 105 patients who underwent surgery for esophageal cancer at Kagoshima University Hospital from January 2013 to December 2017. Patient parameters were compared between survivors and non-survivors for 2 years after surgery. Results: The 2-year survival rate after esophageal cancer surgery was 76.2% (80 survivors vs. 25 non-survivors). The incidence of postoperative pneumonia within 7 days after surgery was significantly higher in non-survivors compared with survivors (36.0% vs. 16.3%;odds ratio, 2.90;95% confidence interval, 1.06 - 7.96, P P = 0.029). The intraoperative dosage of opioids calculated as fentanyl equivalents was not correlated with any postoperative complications or 2-year survival. The preoperative albumin level and neutrophil-lymphocyte ratio were associated with the incidence of postoperative pneumonia. Conclusions: Postoperative pneumonia may be a possible predictor of 2-year prognosis in patients after esophageal cancer surgery, and is not correlated with intraoperative use of opioids. Preoperative physical status including immune and nutrient states may be more important for postoperative prognosis after esophageal cancer surgery.

关键词： Esophageal Cancer Prognosis Opioids

Subcutaneous mastectomy with or without breast reconstruction using latissimus dorsi myocutaneous（or latissimus dorsi muscle）flap and breast conserving treatment for stage Ⅰ and Ⅱ breast cancer

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Subcutaneous mastectomy with or without breast reconstructio...

Role of drug transporter studies in the drug discovery and development

2000全国肿瘤学术大会

作者： yuichi Iino MD Department of Emergency and Critical Care Medicine Gunma University School of MedicineMaebashiJapan

＜正＞The incidence of breast cancer is high in Western countries and relatively low in Japan and other Asian *** Japan,the incidence of breast cancer has gradually been *** is evident that a decreasing number of patients were treated by the Halsted mastectomy with a concomitant increase in breast conserving surgery,which marked 29.2% in 1997（from the data of the Japanese Breast Cancer Society,1998）.

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Role of drug transporter studies in the drug discovery and d...

Membrane transporters and drug response

第八次全国药物与化学异物代谢学术会议

作者： yuichi Sugiyama Graduate School of Pharmaceutical Sciences The University of TokyoHongoBunkyo-kuTokyo 113-0033Japan

General introduction Drug transporters are expressed in many tissues, such as the intestine, liver, kidney, and the brain, and play key roles in drug absorption, distribution and excretion. The information on the functional characteristics of drug transporters provides important information to allow improvements in drug delivery or drug design by targeting specific transporter proteins. In this presentation, I will summarize the significant role played by drug transporters in drug disposition, focusing particularly on their potential use during the drug discovery and development process. The use of transporter function offers the possibility of delivering a drug to the target organ, avoiding distribution to other organs (thereby reducing

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Membrane transporters and drug response