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Enterogenic Stenotrophomonas maltophilia migrates to the mammary gland to induce mastitis by activating the calcium-ROS-AMPK-mTOR-autophagy pathway

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Journal of Animal Science and Biotechnology 2024年第1期15卷 236-252页

作者： Zhaoqi He Caijun Zhao yuhong He Zhuoyu Liu Guyue Fan Kun Zhu Yiqi Wang Naisheng Zhang Yunhe Fu Xiaoyu Hu Department of Clinical Veterinary Medicine College of Veterinary MedicineJilin UniversityChangchun 130062Jilin ProvinceChina

Background Mastitis is an inflammatory disease of the mammary gland that has serious economic impacts on the dairy industry and endangers food *** previous study found that the body has a gut/rumen-mammary gland axis and that disturbance of the gut/rumen microbiota could result in‘gastroenterogenic mastitis'.However,the mechanism has not been fully ***,we found that long-term feeding of a high-concentrate diet induced mastitis in dairy cows,and the abundance of Stenotrophomonas maltophilia(***)was significantly increased in both the rumen and milk ***,we hypothesized that‘gastroenterogenic mastitis'can be induced by the migration of endogenous gut bacteria to the mammary ***,this study investigated the mechanism by which enterogenic *** induces *** First,*** was labelled with superfolder GFP and administered to mice via *** results showed that treatment with *** promoted the occurrence of mastitis and increased the permeability of the blood-milk barrier,leading to intestinal inflammation and intestinal ***,tracking of ingested *** revealed that *** could migrate from the gut to the mammary gland and induce ***,mammary gland transcriptome analysis showed that the calcium and AMPK signalling pathways were significantly upregulated in mice treated with ***,using mouse mammary epithelial cells(MMECs),we verified that *** induces mastitis through activation of the calcium-ROS-AMPK-mTOR-autophagy *** In conclusion,the results showed that enterogenic *** could migrate from the gut to the mammary gland via the gut-mammary axis and activate the calcium-ROS-AMPK-mTOR-autophagy pathway to induce *** the gut-mammary gland axis may also be an effective method to treat mastitis.

关键词： Calcium-ROS-AMPK-mTOR-autophagy pathway Gut-mammary axis Mastitis S.maltophilia

Fucoidan protects against LPS-induced mastitis and enhances the integrity of blood-milk barrier by activating AMPK/Nrf2 and autophagy

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Food Science and Human Wellness 2024年

作者： Xiaoben Liang yuhong Chen Zhijie Zheng Yonghui Zheng Haichong Wu Longyan University & Fujian Provincial Key Laboratory for Prevention and Control of Animal Infectious Diseases and Biotechnology College of Animal Sciences and Veterinary Medicine， Guangxi University Department of Veterinary Medicine， College of Animal Sciences， Zhejiang University

Mastitis often occurs during women’s lactation period， causing great psychological and physical pain to women. Fucoidan， a sulfated polysaccharide obtained from brown algae， has much broader biological properties. However， the roles of fucoidan in lipopolysaccharides (LPS)-induced mastitis are still undiscovered. The present study was aimed to evaluate the influences of fucoidan on LPS-induced mouse mastitis and investigate its possible mechanisms. The expression profiles of fucoidan acting on mastitis were analyzed by Network pharmacology. Additionally， mechanism experiments verified the mechanism of fucoidan on mastitis. The results of in vivo study displayed that the treatment of fucoidan to LPS-stimulated mouse mastitis decreased the inflammatory damage， proinflammatory cytokines level and repaired the completeness of blood-milk barrier. In the study of mouse mammary epithelial cells， fucoidan suppressed the secretion of reactive oxygen species (ROS)and enhanced the activity of antioxidant enzymes. Molecular experiments suggested that fucoidan promoted Nrf2 nuclear import and autophagy via activating the AMPK signaling pathway. The above results indicated that in mastitis， fucoidan promoted Nrf2 nuclear import and autophagy via activating the AMPK signaling pathway， thereby suppressing oxidative stress and inflammatory injury to the mammary glands and protecting the blood-milk barrier.

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基于深度卷积自编码网络的图像融合

计算机应用研究 2020年第S1期37卷 414-417页

作者：苗宇宏杨卫莉李晖晖中国科学院西安光学精密机械研究所海洋光学技术研究室西安710119 93617部队北京101400 西北工业大学自动化学院西安710129

针对现有融合方法所用的多尺度变换模型均使用的通过手工设计的固定框架具有很强的人为先验性,提出了一种基于深度卷积自编码网络的图像融合方法。首先,通过构建一种深度卷积自编码网络来学习图像的有效分解与表示;然后,在该网络框架下... 详细信息

针对现有融合方法所用的多尺度变换模型均使用的通过手工设计的固定框架具有很强的人为先验性,提出了一种基于深度卷积自编码网络的图像融合方法。首先,通过构建一种深度卷积自编码网络来学习图像的有效分解与表示;然后,在该网络框架下通过设计基于红外图像显著性的融合规则进行图像融合。仿真实验表明,提出的算法在主观和客观评价上均具有明显优势。

关键词：图像融合深度卷积自编码网络图像显著性

The Time-Consistent Optimal Reinsurance Strategy of Insurance Group under the CEV Model

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Proceedings of Business and Economic Studies 2024年第2期7卷 205-221页

作者： yuhong Yang Aiyin Wang School of Statistics and Data Science Xinjiang University of Finance and EconomicsUrumqi 830012XinjiangChina

The article introduces proportional reinsurance contracts under the mean-variance criterion,studying the time-consistence investment portfolio problem considering the interests of both insurance companies and reinsurance *** insurance claims process follows a jump-diffusion model,assuming that the risk asset prices of insurance companies and reinsurance companies follow CEV models different from each *** the framework of game theory,the time-consistent equilibrium reinsurance strategy is obtained by solving the extended HJB equation ***,numerical examples are used to illustrate the impact of model parameters on equilibrium strategies and provide economic *** results indicate that the decision weights of insurance companies and reinsurance companies do have a significant impact on both the reinsurance ratio and the equilibrium reinsurance strategy.

关键词： Mean-variance Joint benefit Extended HJB equation Constant elastic variance model

The challenges of cervical cancer screening for women aged over 65 years

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Gynecology and Obstetrics Clinical Medicine 2024年第2期4卷 75-76页

作者： yuhong Ye Chengquan Zhao Department of Pathology the First Affiliated HospitalFujian Medical UniversityFuzhou FujianChina Department of Pathology UPMC Magee-Womens HospitalUniversity of Pittsburgh Medical Center Health SystemPittsburghPennsylvaniaUSA

The guidelines from the American College of Obstetricians and Gynecologists,'the American Cancer Society²and the United States Preventive Services Task Force’recommend that women aged>65 years discontinue cervical cancer screening if(a)they have had three consecutive negative cytology tests in the past 10 years or two recent consecutive negative HPV tests,and(b)they have not been diagnosed with cervical intraepithelial neoplasia grade 2 or more severe disease in the past 25 *** recommendation is founded on the consideration that the benefits of ongoing screening for women aged>65 years who receive regular screenings are outweighed by potential harms,which include discomfort during sampling,false positives and potentially unnecessary treatment.

关键词： cervical cancer Cancer

Unveiling the distinctive traits of functional rye centromeres:minisatellites,retrotransposons,and R-loop formation

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Science China(Life Sciences) 2024年第9期67卷 1989-2002页

作者： Chang Liu Shulan Fu Congyang Yi Yang Liu yuhong Huang Xianrui Guo Kaibiao Zhang Qian Liu James A.Birchler Fangpu Han State Key Laboratory of Plant Cell and Chromosome Engineering Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory for Plant Genetics and Breeding Sichuan Agricultural UniversityChengdu 611130China Division of Biological Science University of MissouriColumbia 65211-7400USA

Centromeres play a vital role in cellular division by facilitating kinetochore assembly and spindle *** their conserved functionality,centromeric DNA sequences exhibit rapid evolution,presenting diverse sizes and compositions across *** functional significance of rye centromeric DNA sequences,particularly in centromere identity,remains *** this study,we comprehensively characterized the sequence composition and organization of rye *** findings revealed that these centromeres are primarily composed of long terminal repeat retrotransposons(LTR-RTs)and interspersed *** systematically classified LTR-RTs into five categories,highlighting the prevalence of younger CRS1,CRS2,and CRS3 of CRSs(centromeric retrotransposons of Secale cereale)were primarily located in the core centromeres and exhibited a higher association with CENH3 *** minisatellites,mainly derived from retrotransposons,along with CRSs,played a pivotal role in establishing functional centromeres in ***,we observed the formation of R-loops at specific regions of CRS1,CRS2,and CRS3,with both rye pericentromeres and centromeres exhibiting enrichment in ***,these R-loops selectively formed at binding regions of the CENH3 nucleosome in rye centromeres,suggesting a potential role in mediating the precise loading of CENH3 to centromeres and contributing to centromere *** work provides insights into the DNA sequence composition,distribution,and potential function of R-loops in rye *** knowledge contributes valuable information to understanding the genetics and epigenetics of rye centromeres,offering implications for the development of synthetic centromeres in future plant modifications and beyond.

关键词： centromere LTR-RTs minisatellite rye R-loop

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不同燕麦品种的施氮效应差异

河南农业大学学报 2020年第5期54卷 755-761页

作者：苗玉红李慧韩燕来谭金芳河南农业大学资源与环境学院河南郑州450002

采用盆栽试验和室内分析相结合的方法,研究了24个燕麦品种在2个氮素水平下的生物学产量、氮素积累及氮素利用效率等方面的差异。结果表明,不同燕麦品种对低氮的忍耐能力不同,在低氮条件下,白燕7号、Vao-22006、蒙燕7726、白燕8号等4个... 详细信息

采用盆栽试验和室内分析相结合的方法,研究了24个燕麦品种在2个氮素水平下的生物学产量、氮素积累及氮素利用效率等方面的差异。结果表明,不同燕麦品种对低氮的忍耐能力不同,在低氮条件下,白燕7号、Vao-22006、蒙燕7726、白燕8号等4个品种产量性状良好,具有氮素积累强、氮经济利用效率高等特点;不同燕麦品种对氮素的响应程度也存在一定的差异,在低氮水平下,坝莜6号、坝莜9号、H 44、甘肃农家种为氮素敏感品种,产量水平相对较低,但施氮后产量显著提高。

关键词：燕麦品种氮积累量生物学产量氮利用效率

Patient Delay in the Diagnosis of Pulmonary Tuberculosis in the Elderly—China,2015-2023

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China CDC weekly 2024年第42期6卷 1075-1079页

作者： Yushu Liu Mingkuan Fan yuhong Li Jiaojie Kang Ybryim A Tianxin Yan Jun Cheng Hui Zhang National Center for Tuberculosis Control and Prevention ChineseCenter for Disease Control and PreventionBeijingChina Medical College of Xiangyang Polytechnic Xiangyang CityHubei ProvinceChina National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases Chinese Center for Disease Control and PreventionBeijingChina

What is already known about this topic?Patient delay in seeking medical care for pulmonary tuberculosis(PTB),especially among elderly individuals with weakened immune systems and mild symptoms,not only slows their recovery but also increases the risk of tuberculosis spread because cases are not identified *** is added by this report?In China,patient delays experienced by elderly PTB patients showed a modest decrease from 2015 to ***,longer patient delays were observed among agricultural workers and those identified through passive case-finding ***,the patient delay in the western regions was longer than in the eastern and central *** are the implications for public health practice?The study underscores the imperative of accessible healthcare for the elderly to minimize patient delay in pulmonary tuberculosis diagnosis and treatment.

关键词： tuberculosis diagnosis prompt

Comparative pharmacokinetics of six components in normal and rheumatoid arthritis rats after intragastrical administration of Qianghuo Shengshi Decoction granules by LC-MS/MS

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Chinese Herbal Medicines 2024年第3期16卷 457-465页

作者： Xin Li Min Wang yuhong Zhong Qianqian Yin Zheming Hu Wenli Tian Zhongyan Liu Zhidong Liu Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique Ministry of EducationTianjin University of Traditional Chinese MedicineTianjin 301617China State Key Laboratory of Component-based Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Haihe Laboratory of Modern Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China

Objective:To investigate the plasma pharmacokinetics of six representative components(nodakenin,osthole,5-O-methylvisammioside,ferulic acid,liquiritigenin,and liquiritin),which were the ingredients of Qianghuo Shengshi Decoction(QSD)granules,in normal and rheumatoid arthritis(RA)rats administrated QSD granules ***:A rapid and accurate ultra-high performance liquid chromatography-tandem mass spectrometry(LC-MS/MS)method was developed for the simultaneous determination of six components in plasma,and it showed a good specificity,linearity,intra-day and inter-day precision,intra-day and inter-day accuracy,extraction recovery,stability,and the less matrix ***:The validated LC-MS/MS method was successfully used to compare the plasma pharmacokinetics of six ingredients between normal and RA rats after intragastrical administration of QSD granules and differences in the pharmacokinetics were found in two types of *** absorption rate in the RA rats was lower for nodakenin,osthole,5-O-methylvisammioside,liquiritigenin and liquiritin than in the normal group,while the absorption rate of ferulic acid remained constant in two *** comparison with the normal rats,the exposure concentration of nodakenin was higher and that of other five components except for nodakenin was lower under pathological ***,the absorptive amount of nodakenin,osthole,5-O-methylvisammioside and liquiritin was increased and that of ferulic acid and liquiritigenin was reduced in the RA rats than in the normal *** with the normal rats,the retention time of nodakenin,ferulic acid and liquiritin was reduced in vivo,whereas the retention time of osthole,5-O-methylvisammioside and liquiritigenin was raised in the body for the RA *** contrast to the normal rats,the data demonstrated an increase in the elimination velocity of nodakenin and a decrease in the elimination velocity of the other five components except for nodakenin in the patho

关键词： LC-MS/MS pharmacokinetics Qianghuo Shengshi Decoction granules rheumatoid arthritis