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基于联吡啶共价有机框架材料纳米片的插层结构设计及其在锂硫电池中的应用

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材料研究与应用 2024年第3期18卷 463-470页

作者：李鑫谢玉峰肖迎波张琪广东工业大学材料与能源学院广东广州510006

以单质硫为正极材料的锂硫电池(LSBs),因其高的理论比容量和能量密度,在储能领域中受到广泛地关注。然而,LSBs在充放电过程中会产生可溶性多硫化物(LiPSs),LiPSs在电极之间的穿梭效应会导致电池容量快速衰减,从而阻碍LSBs的实际应用。... 详细信息

以单质硫为正极材料的锂硫电池(LSBs),因其高的理论比容量和能量密度,在储能领域中受到广泛地关注。然而,LSBs在充放电过程中会产生可溶性多硫化物(LiPSs),LiPSs在电极之间的穿梭效应会导致电池容量快速衰减,从而阻碍LSBs的实际应用。为了有效地抑制LiPSs在LSBs中的穿梭效应,设计合成了一种基于联吡啶共价有机框架(COFs)材料的纳米片(Tp-Bpy),并将其用作LSBs的多功能插层。Tp-Bpy纳米片得益于联吡啶中均匀分散的氮位点的强吸附和催化活性,以及其纳米结构可提供更多活性位点等特性,能够很好地吸附LiPSs,并对LiPSs进行催化转化,从而抑制LiPSs的穿梭效应。Tp-Bpy纳米片插层在LiPSs氧化还原反应过程中具有更快的转化动力学,以及降低液固转化过程的电化学极化特性。相较于未修饰的传统聚丙烯(PP)隔膜,Tp-Bpy纳米片插层所组装的LSBs倍率性能和循环稳定性得到明显提升。实验结果表明,以Tp-Bpy纳米片插层所组装的LSBs,在0.1 C下的放电初始容量可达1223 mAh∙g^(−1),在1 C下循环500次后的放电比容量仍有452 mAh∙g^(−1),单圈衰减率低至0.093%。Tp-Bpy纳米片插层材料已成为解决LSBs中LiPSs穿梭效应的主要研究方向之一,本研究为开发新的多功能插层提供了理论支撑。

关键词：共价有机框架材料联吡啶纳米片锂硫电池插层穿梭效应倍率性能循环稳定性

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CD4^(+) T cell-released exosomes inhibit CD8^(+) cytotoxic T-lymphocyte responses and antitumor immunity

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Cellular & Molecular Immunology 2011年第1期8卷 23-30页

作者： Haifeng Zhang yufeng xie Wei Li Rajni Chibbar Sidong Xiong Jim Xiang Research Unit Health Research DivisionSaskatchewan Cancer AgencyDepartment of Oncology and ImmunologyUniversity of SaskatchewanSaskatoonSask.Canada Research Unit Health Research DivisionSaskatchewan Cancer AgencyDepartment of PathologyUniversity of SaskatchewanSaskatoonSask.Canada Institute of Biology and Medical Sciences Soochow UniversitySuzhouChina

T cells secrete bioactive exosomes(EXO),but the potential immunoregulatory effect of T-cell EXO is largely *** this study,we generated activated ovalbumin(OVA)-specific CD4^(+) T cells in vitro via coculture of OVA-pulsed dendritic cells(DC_(OVA))with naive CD4^(+) T cells derived from OVA-specific T-cell receptor(TCR)transgenic OTII ***4^(+) T-cell EXO were then purified from the CD4^(+) T-cell culture supernatants by differential ***4^(+) T-cell EXO exhibited the‘saucer’shape that is characteristic of EXO with a diameter between 50 and 100 nm,as assessed by electron microscopy,and contained the EXO-associated proteins LAMP-1,TCR and lymphocyte function associated antigen-1(LFA-1),as determined by western *** cytometric analysis showed that CD4^(+) T-cell EXO expressed CD4^(+) T-cell markers(CD4,TCR,LFA-1,CD25 and Fas ligand),but to a lesser extent than CD4^(+) T *** demonstrated that DC_(OVA) took up CD4^(+) T-cell EXO via peptide/major histocompatibility complex(pMHC)II/TCR and CD54/LFA-1 ***-specific CD4^(+) T-cell EXO from OTII mice,but not ConA-stimulated polyclonal CD4^(+) T-cell EXO from wild-type C57BL/6 mice inhibited DC_(OVA)-stimulated in vitro CD4^(+) T-cell proliferation and in vivo CD81 cytotoxic T lymphocyte(CTL)responses and antitumor immunity against OVA-expressing B16 melanoma BL6-10OVA *** addition,EXO derived from a T-cell hybridoma cell line,MF72.2D9,expressing an OVA-specific CD4^(+) TCR,had a similar inhibitory effect as OTII CD4^(+) T-cell EXO on CTL-mediated antitumor *** together,our data indicate that antigen-specific T-cell EXO may serve as a new type of immunosuppressive reagent for use in transplant rejection and treatment of autoimmune diseases.

关键词： antitumor immunity CTL T-cell exosome

胶西北大泽山岩体地球化学、锆石U-Pb年代学及Lu-Hf同位素特征

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地质科学 2024年第1期59卷 21-37页

作者：李增胜张晨西迟乃杰单伟刘传娥马祥县解玉凤申颖王秀凤山东省地质科学研究院自然资源部金矿成矿过程与资源利用重点实验室山东省金属矿产成矿地质过程与综合利用重点实验室济南250013 山东省地质矿产勘查开发局八〇一水文地质工程地质大队济南250014 潍坊市建筑设计研究院有限责任公司山东潍坊261041

胶东金矿集区是我国最重要的金矿集区,大规模金成矿作用发生于125~110 Ma。本文选择了与成矿作用同期的早白垩世晚期大泽山岩体为研究对象,通过详细的岩相学、岩石地球化学、锆石LA-ICP-MS U-Pb年代学研究,识别出中粒二长花岗岩和细粒... 详细信息

胶东金矿集区是我国最重要的金矿集区,大规模金成矿作用发生于125~110 Ma。本文选择了与成矿作用同期的早白垩世晚期大泽山岩体为研究对象,通过详细的岩相学、岩石地球化学、锆石LA-ICP-MS U-Pb年代学研究,识别出中粒二长花岗岩和细粒二长花岗岩两种主要的侵入岩类型,它们具有相似的岩相学和岩石地球化学特征,呈现同源岩浆演化特征。定年结果表明,中粒二长花岗岩中锆石U-Pb年龄分别为119.8±0.8 Ma和119.3±0.9 Ma,细粒二长花岗岩中锆石U-Pb年龄分别为109.2±0.7 Ma和109.9±0.7 Ma。岩石地球化学研究表明,二长花岗岩具有高的全碱(K_(2)O+Na_(2)O=8.14%~8.72%),高的Al_(2)O_(3)(12.42%~15.32%),属过铝质高钾钙碱性系列,轻稀土(LREE)富集、重稀土(HREE)相对亏损(LREE/HREE=8.46~18.87),具明显的稀土元素分馏((La/Yb)_(N)=8.52~24.08)和较强的Eu负异常(δEu=0.33~0.58)。大泽山岩体锆石ε_(Hf)(t)值为-26.4~-16.2,亏损地幔二阶段模式年龄(T_(DM2))为2812~2173 Ma,物源主要是古元古代和新太古代陆壳的部分熔融,有少量幔源物质的加入。大泽山岩体成岩期与胶东金矿的主成矿期一致,暗示岩浆活动与金成矿具有统一的地球动力学背景。

关键词：地球化学锆石U-Pb年龄 Lu-Hf同位素大泽山岩体胶西北

针药结合调枢柔筋法治疗中重度颈源性头痛临床观察

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中国中医急症 2024年第3期33卷 494-497页

作者：黄剑浩谢宇锋王俏刘毅冯军广州中医药大学深圳医院(福田) 广东深圳518000 冯军名中医学术传承工作室广东深圳518000

目的比较针药结合调枢柔筋法与颈2背根神经节脉冲射频治疗中重度颈源性头痛(CEH)的临床疗效。方法将68例CEH患者随机分为针药组(36例,脱落2例)与射频组(36例,脱落2例)。针药组予颅项针联合瓜芍柴胡汤,射频组予颈2背根神经节脉冲射频治... 详细信息

目的比较针药结合调枢柔筋法与颈2背根神经节脉冲射频治疗中重度颈源性头痛(CEH)的临床疗效。方法将68例CEH患者随机分为针药组(36例,脱落2例)与射频组(36例,脱落2例)。针药组予颅项针联合瓜芍柴胡汤,射频组予颈2背根神经节脉冲射频治疗。分别于治疗前、治疗后、随访1个月、随访2个月时观察两组VAS评分、颈椎ROM评分、不良反应发生率及临床疗效。结果针药组总有效率为82.35%,高于射频组的55.88%(P<0.05)。针药组VAS评分比较,治疗后、随访1个月、随访2个月针药组均低于射频组(P<0.05),重复测量方差分析显示,评定时间主效应显著(F=483.024,P=0.000),两组治疗后、随访1个月、随访2个月的VAS评分均较治疗前降低,评定时间组别的交互作用显著(F=35.485,P=0.000),组间效应显著(F=18.342,P=0.000)。针药组颈椎ROM评分比较,治疗后、随访1个月、随访2个月针药组均低于射频组(P<0.05),重复测量方差分析显示,评定时间主效应显著(F=353.384,P=0.000),两组治疗后、随访1个月、随访2个月的颈椎ROM评分均较治疗前降低,评定时间组别的交互作用显著(F=7.972,P=0.000),组间效应显著(F=3.453,P=0.000)。结论针药结合调枢柔筋法治疗中重度CEH疗效显著。

关键词：颈源性头痛颅项针瓜芍柴胡汤调枢柔筋法针药结合

光动力疗法辅助治疗种植体周炎的短期非随机对照临床研究

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口腔医学 2024年第6期44卷 414-420页

作者：王依玮束蓉谢玉峰钱洁蕾林智恺上海交通大学医学院附属第九人民医院牙周病科上海交通大学口腔医学院国家口腔医学中心国家口腔疾病临床医学研究中心上海市口腔医学重点实验室上海市口腔医学研究所上海200011

目的探究使用光动力疗法(photodynamic therapy,PDT)辅助机械性龈下清创(mechanical debridement,MD)治疗种植体周炎(peri-implantitis)的短期临床疗效。方法根据2018牙周病新分类标准,纳入临床上诊断为种植体周炎的单颗种植体(单冠修复... 详细信息

目的探究使用光动力疗法(photodynamic therapy,PDT)辅助机械性龈下清创(mechanical debridement,MD)治疗种植体周炎(peri-implantitis)的短期临床疗效。方法根据2018牙周病新分类标准,纳入临床上诊断为种植体周炎的单颗种植体(单冠修复)患者,治疗前记录种植体周探诊深度(probing depth,PD)、改良龈沟出血指数(modified sulcus bleeding index,mSBI)和改良菌斑指数(modified plaque index,mPLI),以mSBI≥1的位点作为治疗位点。MD组为对照组,仅对治疗位点行机械性龈下清创;PDT组为治疗组,在龈下清创后即刻和治疗后1周,共行两次辅助性光动力治疗。结束治疗后6周、12周复查,检查所纳入患者种植体治疗位点的PD、mSBI和mPLI的变化。结果本研究共纳入35例患者,发生种植体周炎的植体38枚,共计154个治疗位点。PDT组和MD组各纳入20枚和18枚植体,其中PDT组纳入治疗位点共78个,PD≥6 mm的位点共51个,PD0.05)。结论光动力疗法辅助机械清创可以有效治疗种植体周炎,是一种安全有效的辅助治疗手段,对改善深种植体周袋(PD≥6 mm)的炎症以及mSBI具有显著疗效。

关键词：光动力疗法种植体周炎机械清创

Construction of chiral through-space luminophores via symmetry breaking triggered by sequenced chlorination

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Science China Chemistry 2023年第7期66卷 2083-2090页

作者： yufeng xie Huaying Liu Zhongliang Li Xin Zhang Lijuan Song Kang Zhou Feng Yuan Hengzhi You Engui Zhao Zikai He School of Science Harbin Institute of TechnologyShenzhen 518055China School of Chemical Engineering and Technology Harbin Institute of Technology HarbinHarbin 150001China Academy for Advanced Interdisciplinary Studies and Department of Chemistry Southern University of Science and TechnologyShenzhen 518055China Shenzhen Bay Laboratory Shenzhen 518055China Hoffmann Institute of Advanced Materials Shenzhen PolytechnicShenzhen 518055China

The construction of molecular chirality is crucial for exploring novel luminophores with chiroptical *** asymmetric synthesis of chiral center or axial is not powerful enough on through-space *** methodologies for breaking molecular symmetry could be promising but remain less ***,we report a novel methodology for constructing chiral through-space luminophores via simple chlorination on bridged carbazole *** chlorination breaks the molecular symmetry and thus results in molecular chirality by eliminating the mirror plane or rotating ***,continuous multiple chlorinations can rebuild and break the symmetry of the skeleton in *** chiral and achiral isomeric analogues are synthesized and characterized with impressive chiroptical *** of chiral high performance liquid chromatography(HPLC),single-crystal X-ray diffraction,kinetic racemization,and chiroptical property investigation demonstrate the effectiveness of our rational design *** provides a feasible methodology for exploring novel chiral luminescent materials based on versatile though-space skeletons.

关键词： symmetry breaking chiral through-space luminophore circularly-polarized luminescence kinetic racemization

Structural plasticity of human leptin binding to its receptor LepR

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hLife 2023年第2期1卷 115-123页

作者： yufeng xie Xiaoxiong Li Jianxun Qi Guijun Shang Defen Lu George Fu Gao CAS Key Laboratory of Pathogen Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijingChina Department of Basic Medical Sciences School of MedicineTsinghua UniversityBeijingChina Shanxi Academy of Advanced Research and Innovation ShanxiChina Shanxi Provincial Key Laboratory for Major Infectious Disease Response ShanxiChina College of Life Sciences Shanxi Agricultural UniversityShanxiChina

Leptin receptor(LepR)signaling plays an essential role in balancing food intake and energy *** architec-ture of LepR signaling assembly is critical for its *** this study,we determined the structures of three distinct conformations of human leptin–LepR using cryo-electron microscopy at resolutions of 3.88,3.77,and 3.58Å.Both 2:2 and 3:3 stoichiometric assemblies were observed,and the complexes exhibited asymmetric open ***-tin undergoes substantial rearrangement of its flexible regions to accommodate binding to *** assembled leptin–LepR complexes connect through a“hand-in-hand”*** open,interlocked 3:3 trimeric assembly results from the engagement of a third leptin–LepR heterodimer with a 2:2 *** asymmetric geometry of LepR is substantially distinct from that of other gp130 cytokine homologs,and that may be due to the twisted and rigid interface between the D3 and D4 *** results highlight the distinct engagement of leptin with LepR and provide important insights into the structural plasticity of LepR-signaling assemblies.

关键词： LepR leptin signaling cryo-electron microscopy(cryo-EM)

基于代谢组学研究埋线丰隆及其配穴对NAFLD大鼠的协同和拮抗作用

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针灸临床杂志 2024年第6期40卷 84-90页

作者：周遵明张建梅周宏余云进彭冲谢宇锋广州中医药大学深圳医院(福田) 广东深圳518000 广州中医药大学第一附属医院广东广州510405

目的:观察埋线丰隆穴、丰隆加足三里穴和丰隆加三阴交穴对高脂饲料(HFD)诱导的非酒精性脂肪性肝病(NAFLD)模型大鼠血脂4项(TG、TC、LDL-C及HDL-C)、肝脏病理及血清代谢物的影响。方法:将50只SD大鼠随机分为正常组、模型组、丰隆组、丰... 详细信息

目的:观察埋线丰隆穴、丰隆加足三里穴和丰隆加三阴交穴对高脂饲料(HFD)诱导的非酒精性脂肪性肝病(NAFLD)模型大鼠血脂4项(TG、TC、LDL-C及HDL-C)、肝脏病理及血清代谢物的影响。方法:将50只SD大鼠随机分为正常组、模型组、丰隆组、丰隆加足三里组和丰隆加三阴交组,每组10只。采用HFD喂养制备NAFLD模型大鼠,正常组和模型组大鼠不做任何干预,埋线组分别给予大鼠丰隆穴、丰隆加足三里穴和丰隆加三阴交穴进行埋线治疗,每周埋线1次,干预4周,造模同时给予埋线治疗。采用全自动生化分析仪检测血清TC、TG、HDL-C和LDL-C水平,用HE染色及油红染色观察大鼠肝脏病理变化,用非靶代谢组学分析各组大鼠血清代谢物变化。结果:与正常组比较,模型组血清TC、TG及LDL-C水平升高(P0.05),3组埋线组大鼠肝脏脂肪堆积均具有一定程度的改善,丰隆加三阴交组改善程度最为显著,丰隆组次之,丰隆加足三里穴组改善效果最差。丰隆加三阴交组和丰隆组对胆碱代谢通路影响较为显著,差异有统计学意义(P0.05)。结论:埋线丰隆穴及丰隆加三阴交穴均可改善NAFLD大鼠血脂水平,但丰隆加足三里未能显著改善NAFLD大鼠血脂水平,提示丰隆配伍三阴交对NAFLD大鼠具有协同作用,但丰隆配伍足三里可能具有一定的拮抗作用,代谢组学揭示了胆碱代谢通路可能是其协同和拮抗作用的内在机制。

关键词：非酒精性脂肪性肝病埋线疗法丰隆代谢组学

The endogenous antioxidant ability of royal jelly in Drosophila is independent of Keap1/Nrf2 by activating oxidoreductase activity

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Insect Science 2024年第2期31卷 503-523页

作者： Dongjing Wen Jiayu xie Yao Yuan Lirong Shen yufeng Yang Wenfeng Chen Institute of Life Sciences College of Biological Science and EngineeringFuzhou UniversityFuzhouChina School of Medicine Chongqing UniversityChongqingChina College of Biosystems Engineering and Food Science Zhejiang UniversityHangzhouChina

Royal jelly(RJ)is a biologically active substance secreted by the hypopharyngeal and mandibular glands of worker *** is widely claimed that RJ reduces oxidative ***,the antioxidant activity of RJ has mostly been determined by in vitro chemical detection methods or by external administration drugs that cause oxidative *** RJ can clear the endogenous production of reactive oxygen species(ROS)in cells remains largely ***,we systematically investigated the antioxidant properties of RJ using several endogenous oxidative stress models of *** found that RJ enhanced sleep quality of aging Drosophila,which is decreased due to an increase of oxidative damage with *** supplementation improved survival and suppressed ROS levels in gut cells of flies upon exposure to hydrogen peroxide or to the neurotoxic agent ***,RJ supplementation moderated levels of ROS in endogenous gut cells and extended lifespan after exposure of flies to heat *** deprivation leads to accumulation of ROS in the gut cells,and RJ attenuated the consequences of oxidative stress caused by sleep loss and prolonged ***,RJ prevented cell oxidative damage caused by heat stress or sleep deprivation,with the antioxidant activity in vivo independent of Keap1/Nrf2 *** supplementation activated oxidoreductase activity in the guts of flies,suggesting its ability to inhibit endogenous oxidative stress and maintain health,possibly in humans.

关键词： antioxidant biological oxidations Drosophila oxidative stress royal jelly sleep loss