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The effects of rises in external K^+ on the hyperpolarization-activated cation current I_h in rat dorsal root ganglion neurons

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Science China Chemistry 2009年第8期52卷 1258-1263页

作者： DU ZhengQing WU WenJie zhou yufen Department of Environmental Science Shanxi University of Finance and EconomicsTaiyuan 030006China

The effects of rises in external K+(Kext) were examined on the hyperpolarization-activated cation current(Ih) in rat dorsal root ganglion neurons using the whole-cell patch clamp *** results showed that Kext increased Ih in a certain concentration and voltage-dependent *** the basal Kext level(4 mmol/L),Ih had a maximal amplitude of 1085 ± 340 pA which was enhanced by ～45% and ～92% at 8 and 16 mmol/L Kext,*** midpoint activation voltage was significantly shifted from -98 mV in the hyperpolarizing direction by 8 and 12 mV at 8 and 16 mmol/L Kext,respectively with alteration of the activation course of *** short time constants of activation became longer with the increasing amplitude of the command potential upon rises in *** long time constants became *** reversal potentials were shifted in the positive direction without significant alterations upon rises in *** to the functional role of Ih,Kext increased Ih,resulting in an enhanced neuronal excitability,which might produce activation potential abnormality and perhaps neuropathic pain involved.

关键词： hyperpolarization-activated inward current external potassium dorsal root ganglion neurons patch clamp

A Two-Dimensional Third-Order CESE Scheme for Ideal MHD Equations

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Communications in Computational Physics 2023年第6期33卷 94-115页

作者： yufen zhou Xueshang Feng SIGMA Weather Group State Key Laboratory for Space WeatherNational Space Science CenterChinese Academy of ScienceBeijing 100190China Shenzhen Key Laboratory of Numerical Prediction for Space Storm Institute of Space Science and Applied TechnologyHarbin Institute of TechnologyShenzhen 518055China

In this paper,we construct a two-dimensional third-order space-time conservation element and solution element(CESE)method and apply it to the magnetohydrodynamics(MHD)*** third-order CESE method preserves all the favorable attributes of the original second-order CESEmethod,such as:(i)flux conservation in space and time without using an approximated Riemann solver,(ii)genuine multi-dimensional algorithm without dimensional splitting,(iii)the use of the most compact mesh stencil,involving only the immediate neighboring cells surrounding the cell where the solution at a new time step is sought,and(iv)an explicit,unified space-time integration procedure without using a quadrature integration *** order to verify the accuracy and efficiency of the scheme,several 2D MHD test problems are *** result of MHD smooth wave problem shows third-order convergence of the *** results of the other MHD test problems show that the method can enhance the solution quality by comparing with the original second-order CESE scheme.

关键词： CESE method third-order MHD equations

A 3rd Order WENO GLM-MHD Scheme for Magnetic Reconnection

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空间科学学报 2006年第1期26卷 1-7页

作者： FENG Xueshang zhou yufen HU Yanqi Key Laboratory for Space Weather Center for Space Science and Applied Research Chinese Academy of Sciences Beijing 100080 Graduate School Chinese Academy of Sciences

A new numerical scheme of 3rd order Weighted Essentially Non-Oscillatory (WENO) type for 2.5D mixed GLM-MHD in Cartesian coordinates is proposed. The MHD equations are modified by combining the arguments as by Dellar and Dedner et al to couple the divergence constraint with the evolution equations using a Generalized Lagrange Multiplier (GLM). Moreover, the magnetohydrodynamic part of the GLM-MHD system is still in conservation form. Meanwhile, this method is very easy to add to an existing code since the underlying MHD solver does not have to be modified. To show the validation and capacity of its application to MHD problem modelling, interaction between a magnetosonic shock and a denser cloud and magnetic reconnection problems are used to verify this new MHD code. The numerical tests for 2D Orszag and Tang's MHD vortex, interaction between a magnetosonic shock and a denser cloud and magnetic reconnection problems show that the third order WENO MHD solvers are robust and yield reliable results by the new mixed GLM or the mixed EGLM correction here even if it can not be shown that how the divergence errors are transported as well as damped as done for one dimensional ideal MHD by Dedner et al.

关键词：磁场重接三维空间 MHD数字模拟 Orszag-Tang涡旋

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外用本维莫德乳膏治疗掌跖脓疱病2例

临床皮肤科杂志 2024年第5期53卷 296-298页

作者：侯贻魁陆惠妮周玉芬王豫筑王贤沈爱玲郝飞贵州省安顺市人民医院皮肤科贵州安顺561000 重庆医科大学附属第三医院皮肤科重庆401120

报告2例掌跖脓疱病患者外用本维莫得乳膏治疗。例1.患者女,52岁。双手掌、足底反复脓疱、痒痛2年余,再发2个月。皮肤科检查:双手掌、足跖密集粟粒大脓疱,部分融合,皮肤干燥,散在白色糠状脱屑。手部皮损组织病理检查:表皮内单房脓疱,脓... 详细信息

报告2例掌跖脓疱病患者外用本维莫得乳膏治疗。例1.患者女,52岁。双手掌、足底反复脓疱、痒痛2年余,再发2个月。皮肤科检查:双手掌、足跖密集粟粒大脓疱,部分融合,皮肤干燥,散在白色糠状脱屑。手部皮损组织病理检查:表皮内单房脓疱,脓液内较多中性粒细胞及少量单核细胞。诊断:掌跖脓疱病。治疗:予1%本维莫德乳膏外用,早晚各1次,使用2个月,患者皮疹明显缓解。随访2个月,无明显复发。例2.患者男,48岁。双手掌、足底反复脓疱1年余。皮肤科检查:双手掌、足底散在多个米粒大脓疱,边缘脱屑,无水疱、渗出等。手部皮损组织病理检查:表皮内单个大脓疱,内有中性粒细胞,棘层轻度肥厚,真皮浅层血管丛周围淋巴细胞、中性粒细胞浸润。诊断:掌跖脓疱病。治疗:外用1%本维莫德乳膏,早晚各1次,连续使用20d,患者皮疹明显缓解,1个月后电话随访,无明显复发。

关键词：掌跖脓疱病本维莫德乳膏

Application of ADER Scheme in MHD Simulation

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空间科学学报 2012年第2期32卷 170-181页

作者： ZHANG Yanyan FENG Xueshang JIANG Chaowei zhou yufen State Key Laboratory of Space Weather Center for Space Science and Applied ResearchChinese Academy of SciencesBeijing 100190 Graduate University of Chinese Academy of Sciences Beijing 100049

The Arbitrary accuracy Derivatives Riemann problem method(ADER) scheme is a new high order numerical scheme based on the concept of finite volume integration,and it is very easy to be extended up to any order of space and time accuracy by using a Taylor time expansion at the cell interface *** far the approach has been applied successfully to flow mechanics *** objective here is to carry out the extension of multidimensional ADER schemes to multidimensional MHD systems of conservation laws by calculating several MHD problems in one and two dimensions: (ⅰ) Brio-Wu shock tube problem,(ⅱ) Dai-Woodward shock tube problem,(ⅲ) Orszag-Tang MHD vortex *** numerical results prove that the ADER scheme possesses the ability to solve MHD problem,remains high order accuracy both in space and time,keeps precise in capturing the ***,the compared tests show that the ADER scheme can restrain the oscillation and obtain the high order non-oscillatory result.

关键词： ADER scheme Generalized Riemann problem MHD numerical simulation HLL scheme

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门脉高压性胃病患者内镜下诊治临床特征分析

胃肠病学和肝病学杂志 2024年第10期33卷 1303-1307页

作者：陈平张梦茵周郁芬忻笑容吴云林上海交通大学医学院附属瑞金医院北部院区消化科上海201801

目的分析门脉高压性胃病患者的临床症状、内镜下表现及其与食管静脉曲张内镜下治疗的关系,为疾病预防性诊治提供依据。方法对肝硬化食管静脉曲张患者进行胃镜检查,记录食管静脉曲张和门脉高压性胃病的程度,收集患者的性别、体质量、血... 详细信息

目的分析门脉高压性胃病患者的临床症状、内镜下表现及其与食管静脉曲张内镜下治疗的关系,为疾病预防性诊治提供依据。方法对肝硬化食管静脉曲张患者进行胃镜检查,记录食管静脉曲张和门脉高压性胃病的程度,收集患者的性别、体质量、血生化指标、肝功能评分数据,行部分患者内镜下食管静脉曲张硬化剂或套扎治疗后随访,并对临床数据进行统计学分析。结果纳入肝硬化食管静脉曲张患者162例,检出门脉高压性胃病为53.7%,且血清白细胞、血红蛋白、血小板和血氨水平在门脉高压性胃病与不伴门脉高压性胃病组间差异有统计学意义(P<0.01)。在87例门脉高压性胃病患者中,严重程度组间比较肝功能评分差异有统计学意义(P<0.01)。门脉高压性胃病导致非食管胃静脉曲张破裂伴出血患者发生率为77.2%。内镜下治疗35例患者中,门脉高压性胃病中-重度占比由28.6%增至71.4%,与治疗前比较,差异有统计学意义(P<0.01)。结论肝硬化食管静脉曲张患者伴门脉高压性胃病发病率较高,已成为肝硬化患者主要的出血原因之一。重视食管静脉曲张内镜下治疗后对疾病的影响,将为门脉高压性胃病引起的消化道出血的诊治提供一定的依据。

关键词：食管静脉曲张门脉高压性胃病出血内镜下治疗

Numerical study of successive CMEs during November 4―5, 1998

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Science China(Technological Sciences) 2008年第10期51卷 1600-1610页

作者： zhou yufen & FENG XueShang SIGMA Weather Group, State Key Laboratory for Space Weather, Center for Space Science and Applied Research, Chinese Academy of Sciences, Beijing 100190, China 1. SIGMA Weather Group State Key Laboratory for Space Weather Center for Space Science and Applied Research Chinese Academy of Sciences Beijing 100190 China

We present the solar-terrestrial transit process of three successive coronal mass ejections (CMEs) of November 4―5, 1998 originating from active region 8375 by using a time-dependent three-dimensional magnetohydrodynamics (MHD) simula-tion. These CMEs interacted with each other while they were propagating in inter-planetary space and finally formed a "complex ejecta". A newly developed SIP-CESE MHD model was applied to solve MHD equations numerically. The quiet solar wind was started from Parker-like 1D solar wind solution and the magnetic field map was calculated from the solar photospheric magnetic field data. In our simulation, the ejections were initiated using pulse in the real active region 8375. The interplanetary disturbance parameters, such as speed, direction and angular size of the expanding CME, were determined from the SOHO/LASCO data with the cone-model. We discussed the three-dimensional aspects of the propagation, in-teraction and merging of the three ejections. The simulated interplanetary shocks were compared with the nearby-Earth measurement. The results showed that our simulation could reproduce and explain some of the general features observed by satellite for the "complex ejecta".

关键词： complex ejecta three-dimensional MHD simulation SIP-CESE MHD model

3D numerical study of typical CME event: The 2010-04-03 event

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3D numerical study of typical CME event: The 2010-04-03 even...

The VAMP-associated protein VAP27-1 plays a crucial role in plant resistance to ER stress by modulating ER–PM contact architecture in Arabidopsis

2014年中国地球科学联合学术年会——专题29：空间天气与人类活动

作者： yufen zhou Xueshang Feng Xinhua Zhao SIGMA Weather Group State Key Laboratory of Space Weather Center for Space Science and Applied Research Chinese Academy of Science

The coronal mass ejection(CME)event on April 3,2010 is the first fast CME observed by STEREO SECCHI/HI for the full Sun-Earth *** an event provides us a good opportunity to study the propagation and evolution of CME from the Sun up to 1 *** this paper,we study the time-dependent evolution and propagation of this event from the Sun to Earth using the 3D SIP-CESE MHD *** CME is initiated by a simple spherical plasmoid model:a spheromak magnetic structure with high speed,high pressure and high plasma density *** find that the results can successfully reproduce the observations in the STEREO

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Plant Communications 2024年第7期5卷 261-279页

作者： Yi Man Yue Zhang Linghui Chen Junhui zhou yufen Bu Xi Zhang Xiaojuan Li Yun Li Yanping Jing Jinxing Lin National Engineering Research Center of Tree Breeding and Ecological Restoration College of Biological Sciences and TechnologyBeijing Forestry UniversityBeijing 100083China Key Laboratory of Genetics and Breeding in Fore These authors contributed equally to this article

The endoplasmic reticulum(ER)and the plasma membrane(PM)form ER–PM contact sites(EPCSs)that allow the ER and PM to exchange materials and ***-induced disruption of protein folding triggers ER stress,and the cell initiates the unfolded protein response(UPR)to resist the ***,whether EPCSs play a role in ER stress in plants remains ***-ASSOCIATED MEMBRANE PROTEIN(VAMP)-ASSOCIATED PROTEIN 27-1(VAP27-1)functions in EPCS tethering and is encoded by a family of 10 genes(VAP27-1–10)in Arabidopsis ***,we used CRISPR-Cas9-mediated genome editing to obtain a homozygous vap27-1 vap27-3 vap27-4(vap27-1/3/4)triple mutant lacking three of the key VAP27 family members in *** vap27-1/3/4 mutant exhibits defects in ER–PM connectivity and EPCS architecture,as well as excessive UPR *** further showed that relocation of VAP27-1 to the PM mediates specific VAP27-1-related EPCS remodeling and expansion under ER ***,the spatiotemporal dynamics of VAP27-1 at the PM increase ER–PM connectivity and enhance Arabidopsis resistance to ER *** addition,we revealed an important role for intracellular calcium homeostasis in the regulation of UPR *** together,these results broaden our understanding of the molecular and cellular mechanisms of ER stress and UPR signaling in plants,providing additional clues for improving plant broad-spectrum resistance to different stresses.

关键词： Arabidopsis VAP27-1 ER–PM contact sites ER stress unfolded protein response