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从古云梦泽的消亡看洞庭湖面临的危机——生态湖南视野中的洞庭湖治理

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湖南民族职业学院学报 2012年第2期33卷 44-49页

作者：蔡卓夫岳阳市一中

古云梦泽的消亡是自然规律发展的必然结果;洞庭湖面临的危机是自然灾害造成的偶发事件。只要遵循自然规律,恢复洞庭湖所固有的水文特性,洞庭湖就能恢复其强劲的生命力。

关键词：生态湖南古云梦泽洞庭湖自然规律自然灾害

Inhibitory Effect of S100A11 on Airway Smooth Muscle Contraction and Airway Hyperresponsiveness

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Current Medical Science 2022年第2期42卷 333-340页

作者： Mi CHENG Yang-lin SHI Pan-pan SHANG Yan-jiao CHEN Yu-dong XU Shanghai Research Institute of Acupuncture and Meridian Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai200030China

Objective S100A11 is a member of the S100 calcium-binding protein family and has intracellular and extracellular regulatory *** previously reported that S100A11 was differentially expressed in the respiratory tracts of asthmatic rats as compared with normal ***,we aimed to analyze the potential of S100A11 to regulate both allergen-induced airway hyperresponsiveness(AHR)as well as acetylcholine(ACh)-induced hypercontractility of airway smooth muscle(ASM)and contraction of ASM cells(ASMCs).Methods Purified recombinant rat S100A11 protein(rS100A11)was administered to OVA-sensitized and challenged rats and then the AHR of animals was *** relaxation effects of rS100A11 on ASM were detected using isolated tracheal rings and primary *** expression levels of un-phosphorylated myosin light chain(MLC)and phosphorylated MLC in ASMCs were analyzed using Western *** Treatment with rS100A11 attenuated AHR in the *** contraction assays showed that rS100A11 reduced the contractile responses of isolated tracheal rings and primary ASMCs treated with *** addition,rS100A11 markedly decreased the ACh-induced phosphorylation of the myosin light chain in ***,rS100A11 also suppressed the contractile response of tracheal rings in calcium-free buffer *** These results indicate that S100A11 protein can relieve AHR by relaxing ASM independently of extracellular *** data support the idea that S100A11 is a potential therapeutic target for reducing airway resistance in asthma patients.

关键词： S100A11 asthma airway hyperresponsiveness airway smooth muscle relaxation

Clinical Study with Randomized Control on the Therapy of Integrated Chinese and Western Medicine in Treating Neurological Autoimmune Diseases:A Meta-Analysis

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World Journal of Traditional Chinese Medicine 2018年第3期4卷 85-95页

作者： Xiao-Yan Peng Jin-Yun Ma Xiao-dong Cheng Institute of Clinical Immunology Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Shanghai University of Traditional Chinese Medicine

Objective: The main objective of this study is to evaluate the effects of integrated Chinese and Western medicine in the treatment of neurological autoimmune diseases. Materials and Methods: The literature was comprehensively searched to collect the randomized controlled trials about integrated Chinese and Western medicine in the treatment of neurological autoimmune diseases. Neurological autoimmune diseases mainly occur in the central nervous system(CNS) and peripheral nervous system. Therefore, multiple sclerosis(MS) was chosen as the representative in the CNS, and Guillain–Barre syndrome(GBS) was chosen as the representative in the peripheral nervous system. Extended Disability Status Scale(EDSS) score, effective rate, clinical symptom score, neurological functional sign score, recurrence frequency, and incidence rate of adverse reactions were chosen as the markers of outcome variables of MS, and the effective rate and Hughes score were also chosen as the markers of outcome variables of GBS. Results: For MS, the results showed that there was a significant difference in statistical analysis between the experimental group and the control group in EDSS score, the effective rate, and the recurrence frequency. However, through the comparison of clinical symptom score, neurological functional sign score, and incidence rate of adverse reaction of both two groups, the results showed that there was no significant difference in the statistical analysis. For GBS, through the comparison of effective rate and Hughes score of both two groups, the results showed that there was a significant difference in statistical analysis. Conclusions: The study demonstrated that compared with Western medicine, the therapy of integrated Chinese and Western medicine was more effective in treating neurological autoimmune diseases.

关键词： Guillain-Barre syndrome integrated Chinese and Western medicine meta-analysis multiple sclerosis randomized controlled trial

Expression of ceramide galactosy transferase in sciatic nerve of rats with diabetic peripheral neuropathy after electroacupuncture at Zusanli and Shenshu points

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Neural Regeneration Research 2006年第4期1卷 335-338页

作者： Hongsheng dong Yunyun Zhang Yin Shi Min Zheng Qiujuan Zhang yueyang Hospital of TraditionalChinese ＆ Western Medicine.Shanghai University of Traditional Chinese Medicine. Shanghai 200437 China

BACKGROUND： Ceramide galactosyltransferase （CGT） protein and mRNA expression defect can cause the abnormal morphology and slowing conduction velocity of peripheral nerve. Morphologic change and functional disorder of myelin sheath and axon appear when diabetic peripheral neuropathy （DPN） occurs. Whether electroacupuncture at Zusanfi（ST 36） and Shenshu（BL 32） points can enhance the expression of CGT protein and mRNA in the DPN tissue？ OBJECTIVE： To observe the effect of electroacupuncture at Zusanfi and Shenshu points on motor, sensory conduction velocity and CGT mRNA and its protein expression of sciatic nerve in rats with DPN. DESIGN： A randomized and controlled animal experiment SETTING ： Department of Neurology and Central Laboratory, yueyang Hospital of Traditional Chinese ＆ Western Medicine, Shanghai University of Traditional Chinese Medicine. MATERIALS ： Totally 60 healthy male Wistar rats of clean grade, aged 4 month, with body mass of 200 to 220 g, were enrolled in this study. Streptozotocin （STZ, Sigma Company of USA, Batch No. S-0130）. METHODS： This study was carried out in the Animal Experimental Center and Central Laboratory, yueyang Hospital of Traditional Chinese ＆ Western Medicine during February 2005 to March 2006. （1） Fifteen rats were randomly chosen,serving as normal *** the other rats were intraperitoneally injected once with STZ to develop experimental diabetic rat models. If fasting blood glucose was ≥ 15 mmol/L,sensory nerve and motor nerve conduction velocity of sciatic nerve was obviously slowed, tail-swaying temperature threshold was increased and myelinated nerve fiber of sciatic nerve changed, DPN models were successful. The successful model rats were randomly assigned into 3 groups： model group, control group（electroacupuncture at non-meridian-non-acupoint）and electroacupuncture group [electroacupuncture at Zusan/i and Shenshu points], with 15 rats each. The rats in the normal group and model group were untouched. In the e

关键词： DPN Expression of ceramide galactosy transferase in sciatic nerve of rats with diabetic peripheral neuropathy after electroacupuncture at Zusanli and Shenshu points

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作为价值概念的恐怖主义犯罪的主体性

唐山师范学院学报 2011年第6期33卷 114-116页

作者：喻义东湖南理工学院社会科学教学部湖南岳阳414000

价值论把社会事实区分为"科学事实"与"价值事实",价值事实是主体性的事实。由于犯罪是一种价值事实,恐怖主义犯罪也是一种价值事实,因而,恐怖主义犯罪概念是具体主体的恐怖主义犯罪概念。作为最高层次主体的整个人类社会,因为存在一个... 详细信息

价值论把社会事实区分为"科学事实"与"价值事实",价值事实是主体性的事实。由于犯罪是一种价值事实,恐怖主义犯罪也是一种价值事实,因而,恐怖主义犯罪概念是具体主体的恐怖主义犯罪概念。作为最高层次主体的整个人类社会,因为存在一个普世接受的伦理与价值体系,以这种价值体系为基础对恐怖主义犯罪的定义就应当是人类社会普遍接受的恐怖主义犯罪的概念。

关键词：恐怖主义犯罪主体性价值事实

向家坝工程扰动区不同生态修复模式边坡土壤颗粒分形特征

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水土保持研究 2023年第4期30卷 83-89页

作者：马悦阳夏栋舒倩郭士维罗婷闫书星刘大翔水泥基生态修复技术湖北省工程研究中心(三峡大学) 湖北宜昌443002 三峡大学土木与建筑学院湖北宜昌443002 三峡大学水利与环境学院湖北宜昌443002 三峡大学生物与制药学院湖北宜昌443002

[目的]研究不同生态修复后边坡土壤颗粒分形特征,为分形维数作为评价修复后向家坝工程扰动区边坡土壤质量的综合指标提供科学依据。[方法]以向家坝工程扰动区6种不同生态修复模式下的0—10 cm边坡土壤为研究对象,通过野外采样和室内试验... 详细信息

[目的]研究不同生态修复后边坡土壤颗粒分形特征,为分形维数作为评价修复后向家坝工程扰动区边坡土壤质量的综合指标提供科学依据。[方法]以向家坝工程扰动区6种不同生态修复模式下的0—10 cm边坡土壤为研究对象,通过野外采样和室内试验,采用单重和多重分形理论相结合的方法,研究自然演替与人工修复模式下土壤粒径分布(PSD)和分形特征及土壤养分特征并分析了其相关关系。[结果]不同生态修复模式下土壤颗粒组成以粉粒和砂粒为主,黏粒含量较少,粒径分布不均匀。天然林地土壤养分含量相对较高且土壤颗粒较细。黏粒与D v呈极显著正相关(p<0.01),与土壤有机碳和速效氮呈显著正相关(p<0.05),粉粒含量与D_(1),D_(2)呈极显著负相关(p<0.01),砂粒与D_(1),D_(2)呈极显著正相关(p<0.01)。土壤养分与黏粒、粉粒含量呈不显著正相关,与砂粒含量,D_(1),D_(2)呈不显著负相关。[结论]向家坝工程扰动区土壤颗粒以粉粒和砂粒为主,土壤质地较粗,而植被混凝土修复技术有利于细颗粒的积累,从而提高土壤均匀度,可以作为生态修复的参考。粉粒和砂粒不仅主导多重分形参数,还对养分有促进作用,可用来作为研究区域生态修复效果的标度。

关键词：土壤粒径分布分形维数土壤养分生态修复

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骨质疏松性椎体压缩骨折PVP术后早期脊柱矢状序列与Batherl指数的关系

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颈腰痛杂志 2024年第3期45卷 423-426页

作者：陆华栋王庚启周海燕王竹上海中医药大学附属岳阳中西医结合医院创伤骨科上海200072

目的探讨老年急性椎体压缩骨折接受椎体成形术后矢状面脊柱排列的短期变化及其与Batherl指数变化的关系。方法选择2020年1月至2021年12月在该院接受PVP治疗的单节段OVCF患者作为研究对象,观察患者术前、术后矢状垂直轴(SVA)、T1骨盆角... 详细信息

目的探讨老年急性椎体压缩骨折接受椎体成形术后矢状面脊柱排列的短期变化及其与Batherl指数变化的关系。方法选择2020年1月至2021年12月在该院接受PVP治疗的单节段OVCF患者作为研究对象,观察患者术前、术后矢状垂直轴(SVA)、T1骨盆角(TPA)、脊柱骶骨角(SSA)、腰椎前凸角(LL)、胸椎后凸角(TK),术前、术后2周、术后6周、术后12周时的疼痛视觉模拟评分(VAS)、改良Batherl指数(MBI)及其子项目床椅转移(MBI8,15分)、平地行走(MBI9,15分)、上下楼梯(MBI10,10分)的变化;控制混杂变量后,观察ΔSVA、ΔTPA、ΔSSA、ΔLL、ΔTK(Δ表示手术前后的差值)与MBI总分、MBI8、MBI9、MBI10的相关性。结果术后患者SVA、TPA、TK较术前显著降低(P0.05)。术前、术后2周、术后6周、术后12周时,患者MBI(总分、MBI8、MBI9、MBI10)逐渐升高、VAS均呈逐渐降低趋势(P0.05);ΔMBI8、ΔMBI9与ΔSVA、ΔSSA、ΔTPA、ΔLL、ΔTK均不存在相关性(P>0.05);ΔMBI10与ΔSVA存在显著负相关(P0.05)。结论急性OVCF患者PVP术前和术后SVA值与患者术后12周时MBI总分和上下楼梯功能相关。

关键词：骨质疏松性椎体压缩骨折经皮椎体成形术矢状面平衡改良Batherl指数

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补肾活血方对肾虚血瘀型早发性卵巢功能不全患者免疫平衡的调节作用

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天津中医药 2024年第5期41卷 559-564页

作者：王怡青黄宏丽夏艳秋眭瑾董莉上海市浦东新区中医医院妇科上海201200 上海中医药大学附属岳阳中西医结合医院妇科上海200437 上海中医药大学附属市中医医院中医妇科上海200071

[目的]观察补肾活血方调节免疫平衡治疗肾虚血瘀型早发性卵巢功能不全(POI)患者的临床疗效。[方法]将123例POI患者随机分为中药组(61例)和西药组(62例)。中药组给予补肾活血方治疗,西药组给予芬吗通口服治疗,连续治疗6个月经周期。比较... 详细信息

[目的]观察补肾活血方调节免疫平衡治疗肾虚血瘀型早发性卵巢功能不全(POI)患者的临床疗效。[方法]将123例POI患者随机分为中药组(61例)和西药组(62例)。中药组给予补肾活血方治疗,西药组给予芬吗通口服治疗,连续治疗6个月经周期。比较两组患者治疗前后血清卵泡刺激素(FSH)、黄体生成素(LH)、雌二醇(E2)、抗苗勒管激素(AMH)、辅助性T细胞17(Th17)、调节性T细胞(Treg)、Th17/Treg、转化生长因子β(TGF-β)、生长分化因子-9(GDF-9)和骨形成蛋白-15(BMP-15)水平,评估月经症状疗效和中医证候疗效。[结果]1)治疗后,两组患者血清FSH水平较治疗前显著降低(P0.05)。2)治疗后,两组患者血清Treg水平均较治疗前升高(P<0.01),血清Th17、Th17/Treg水平均较治疗前降低(P<0.01);且中药组患者血清Th17、Treg、Th17/Treg水平改善情况优于西药组(P<0.01)。3)治疗后,两组患者血清TGF-β、GDF-9、BMP-15水平均较治疗前升高(P<0.05),且中药组患者血清BMP-15升高幅度优于西药组(P<0.05)。4)治疗后,中药组患者的月经症状疗效总有效率为60.66%,西药组为87.10%,西药组优于中药组(P<0.05)。5)治疗后,中药组患者的中医证候疗效总有效率为68.85%,西药组总有效率为48.39%,中药组优于西药组(P<0.05)。[结论]补肾活血方可有效改善肾虚血瘀型POI患者的血清性激素水平,调节Th17/Treg免疫平衡,改善临床证候。

关键词：早发性卵巢功能不全补肾活血方肾虚血瘀证免疫平衡

3种术式治疗无神经症状Ⅲ期Kümmell病的临床疗效比较

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重庆医学 2024年第16期53卷 2512-2519页

作者：孟旭东钟炯彪董超许胤李佳福湖南师范大学附属岳阳医院/岳阳市人民医院骨科湖南岳阳414000 岳阳县人民医院骨科湖南岳阳414100

目的比较3种术式治疗无神经症状Ⅲ期Kümmell病的临床疗效。方法选取2019年9月至2022年4月湖南师范大学附属岳阳医院骨科收治的69例无神经症状Ⅲ期Kümmell病患者。按手术方式分为3组:椎体成形术(PVP)组(A组)29例,经皮椎弓根螺钉联合病... 详细信息

目的比较3种术式治疗无神经症状Ⅲ期Kümmell病的临床疗效。方法选取2019年9月至2022年4月湖南师范大学附属岳阳医院骨科收治的69例无神经症状Ⅲ期Kümmell病患者。按手术方式分为3组:椎体成形术(PVP)组(A组)29例,经皮椎弓根螺钉联合病椎PVP组(B组)19例,经皮骨水泥强化椎弓根螺钉联合病椎PVP组(C组)21例,比较3组患者影像学、围手术期和随访指标。结果所有患者均顺利完成手术,术后未发生严重并发症,随访时间>1年。A组患者术后各时间点(术后1个月、3个月、1年)病椎矢状位指数(SI值)、视觉模拟评分法(VAS)评分、Oswestry功能障碍指数问卷表(ODI)评分较术前有改善(P<0.05);B、C组患者术后各时间点病椎SI值、后凸Cobb角、椎管狭窄率、VAS评分、ODI评分较术前均有改善(P<0.05);B、C组患者术后各时间点病椎SI值、后凸Cobb角、椎管狭窄率、VAS评分、ODI评分及均优于A组(P<0.05),而C组患者术后1年病椎SI值、后凸Cobb角及椎管狭窄率优于B组(P<0.05);A组患者在手术时间、术中出血量、术后住院时间及病椎骨水泥注入量方面均明显少于B、C组(P<0.05);B组患者手术时间短于C组(P<0.05)。结论3种术式治疗无神经症状Ⅲ期Kümmell病均能缓解症状及恢复功能,经椎弓根螺钉复位的两种术式相对于单纯PVP能更加有效恢复病椎高度、矫正后凸畸形及改善椎管狭窄,而椎弓根螺钉经骨水泥强化后在维持力学支撑及稳定性方面更有优势。

关键词： Kümmell病椎体成形术经皮椎弓根螺钉骨水泥强化