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Dual Functional Diblock Amino Acid Copolymer Displaying Synergistic Effect with Curcumin against MRSA and Encapsulation of Curcumin

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Chinese Journal of Chemistry 2023年第23期41卷 3333-3338页

作者： yueming wu Yuan Chen Haowen Yu Alideertu Dong Runhui Liu State Key Laboratory of Bioreactor Engineering East China University of Science and TechnologyShanghai200237 China Key Laboratory for Ultrafine Materials of Ministry of Education Frontiers Science Center for Materiobiology and Dynamic Chemistry Shanghai Frontiers Science Center of Optogenetic Techniques for Cell MetabolismResearch Center for Biomedical Materials of Ministry of EducationSchool of Materials Science and EngineeringEast China University of Science and TechnologyShanghai200237 China Engineering Research Center of Dairy Quality and Safety Control Technology Ministry of EducationInner Mongolia UniversityHohhotInner Mongolia010021 China

The intensive use of antibiotics intensifies the development of bacterial resistance,which has become a serious problem ***-resistant Staphylococcus aureus(MRSA)has resulted in significant morbidity and ***,it is an urgent need to develop new antimicrobial drugs and administration ***,we report a dual functional diblock copolymer PLL20-b-PBLG20,which was prepared by superfast and water-insensitive polymerization on N-carboxyanhydrides(NCA)initiated by tetraalkylammonium *** addition to direct antimicrobial activity,PLL20-b-PBLG20 also exerts a synergistic bactericidal effect against MRSA with curcumin,a plant extract with antibacterial ***,PLL20-b-PBLG20 successfully encapsulates curcumin to form nanoparticles via *** combination of dual functional PLL20-b-PBLG20 and curcumin holds promise in combating MRSA infections.

关键词： Amino acid polymer Antimicrobial Synergy Encapsulation MRSA

WEB-BASED VIRTUAL CNC MACHINE MODELING AND OPERATION

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Chinese Journal of Mechanical Engineering 2007年第6期20卷 109-113页

作者： HE Hanwu wu yueming GU Yaoda LU Yongming Faculty of Electromechanical Engineering Guangdong University of Technology Guangzhou 510090 China

A CNC simulation system based on intemet for operation training of manufacturing facility and manufacturing process simulation is proposed. Firstly, the system framework and a rapid modeling method of CNC machine tool are studied under the virtual environment based on PolyTrans and CAD software. Then, a new method is proposed to enhance and expand the interactive ability of virtual reality modeling language（VRML） by attaining communication among VRML, JavaApplet, JavaScript and Html so as to realize the virtual operation for CNC machine tool. Moreover, the algorithm of material removed simulation based on VRML Z-map is presented. The advantages of this algorithm include less memory requirement and much higher computation. Lastly, the CNC milling machine is taken as an illustrative example for the prototype development in order to validate the feasibility of the proposed approach.

关键词： Virtual reality CNC machine tools Machining simulation Virtual reality modeling language (VRML) Virtual operation

Synergistic Combination of Biodegradable Peptide Polymer and Curcumin as Promising Antibiotic Substitution in Aquaculture to Alleviate the Global Challenge of Antimicrobial Resistance

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Chinese Journal of Chemistry 2022年第24期40卷 2947-2955页

作者： Pengcheng Ma Yuan Chen Ning Shao Junyu Zhang yueming wu Runhui Liu State Key Laboratory of Bioreactor Engineering East China University of Science and TechnologyShanghai200237 China Key Laboratory for Ultrafine Materials of Ministry of Education Frontiers Science Center for Materiobiology and Dynamic ChemistryShanghai Frontiers Science Center of Optogenetic Techniques for Cell MetabolismResearch Center for Biomedical Materials of Ministry of EducationSchool of Materials Science and EngineeringEast China University of Science and TechnologyShanghai200237 China

The massive use of antibiotics in aquaculture and resulted antibacterial resistance problem urgently need antibiotic substitutions. Herein, we report a promising substitution of aquaculture antibiotics using a synergistic combination of biodegradable peptide polymers and curcumin, a natural compound from plant. The synergistic combination shows strong antibacterial activity against V. fluvialis and some other common bacteria in aquaculture. The membrane-damaging antibacterial mechanism echoes our finding that the synergistic combination will not induce bacteria to develop resistance after continuous use. The synergistic combination also displays effective cure on V. fluvialis-infected zebrafish. The biodegradability of the peptide polymer enables the combination to lose antibacterial activity and will not cause selective pressure on bacterial in the environment. Our study indicates potential application of synergistic composition, biodegradable peptide polymer and curcumin, as promising antibiotic substitution in aquaculture, which represents a promising strategy to address the global challenge of antimicrobial resistance.

关键词： Antimicrobial polymer Aquaculture Peptides Antibiotics Biological activity

Functional characterization of oligopeptide transporter 1 of dairy cows

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Journal of Animal Science and Biotechnology 2018年第2期9卷 391-398页

作者： Qingbiao Xu Zhixuan Liu Hongyun Liu Fengqi Zhao Xinbei Huang yueming wu Jianxin Liu Institute of Dairy Science MOE Key Laboratory of Molecular Animal Nutrition Zhejiang University College of Animal Sciences and Technology Huazhong Agricultural University Laboratory of Lactation and Metabolic Physiology Department of Animal and Veterinary Sciences University of Vermont

Background: It is wel known that peptides play a vital role in the nutrition and health of dairy cows. Bovine oligopeptide transporter 1(bP epT 1) is involved in the peptide transport process in the gastrointestinal tracts of dairy cows. However,little information is known in the characteristics of bP epT 1. Therefore, the purpose of this study was to characterize bP epT 1 functional y using a mammalian cel expression system. The uptake of radiolabeled dipeptide glycyl-sarcosine([3 H]-Gly-Sar)into the bP epT 1-transfected Chinese hamster ovary cel s was measured at various pH and substrate concentrations and with or without 15 other smal peptides that contained Met or ***: Western blot results showed that the abundance of bP epT 1 protein in the jejunum and ileum are the highest in the gastrointestinal tract of dairy cows. The uptake of [3 H]-Gly-Sar by b Pep T1-Chinese hamster ovary cells was dependent on time, p H, and substrate concentration, with a low Kmvalue of 0.94 ± 0.06 mmol/L and a maximum velocity of 20.80 ± 1.74 nmol/(mg protein · 5 min). Most of the di-and tripeptides were the substrates of b Pep T1,based on substrate-competitive studies. However, bP epT 1 has a higher affinity to the peptides with shorter chains, greater hydrophobicity, and negative or neutral ***: These results demonstrated for the first time the functional characteristics of bP epT 1, and they provide a new insight and better understanding into its vital role in absorbing a wide range of peptides from the digestive tract of dairy cows.

关键词： Bovine Kinetics PepT1 Peptide absorption Substrate specificity

Alkali-metal hexamethyldisilazide initiated polymerization on alpha-amino acid N-substituted N-carboxyanhydrides for facile polypeptoid synthesis

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Chinese Chemical Letters 2021年第5期32卷 1675-1678页

作者： yueming wu Min Zhou Kang Chen Sheng Chen Ximian Xiao Zhemin Ji Jingcheng Zou Runhui Liu State Key Laboratory of Bioreactor Engineering East China University of Science and TechnologyShanghai 200237China Key Laboratory for Ultrafine Materials of Ministry of Education Frontiers Science Center for Materiobiology and Dynamic ChemistryResearch Center for Biomedical Materials of Ministry of EducationSchool of Materials Science and EngineeringEast China University of Science and TechnologyShanghai 200237China

Polypeptoids have been explored as mimics of polypeptides,owing to polypeptoids'superior stability upon *** can be synthesized from one-pot ring-opening polymerization of amino acid N-substituted N-carboxyanhydrides(NNCAs).However,the speed of polymerization of NNCAs can be very slow,especially for NNCAs bearing a bulky N-substitution *** hindered the exploration on polypeptoids with more diverse structures and ***,it is in great need to develop advanced strategies that can accelerate the polymerization on inactive ***,we report that lithium/sodium/potassium hexamethyldisilazide(Li/Na/KHMDS)initiates a substantially faster polymerization on NNCAs than do commonly used amine initiators,especially for NNCAs with bulky N-substitution *** fast NNCA polymerization will increase the structure diversity and application of polypeptoids as synthetic mimics of polypeptides.

关键词： Polypeptoids Peptide mimics N-Substituted N-carboxyanhydrides(NNCA) Lithium hexamethyldisilazide Sodium hexamethyldisilazide Potassium hexamethyldisilazide Ring-opening polymerization Inactive NNCA

Nutritional value of detoxified Jatropha curcas seed cake protein isolates using rats as an animal model

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Animal Nutrition 2018年第4期4卷 429-434页

作者： Yinuo Zhao Yubao Wang Haifeng Wang yueming wu Harinder P.Makkar Jianxin Liu College of Animal Sciences Zhejiang University Institute for Animal Production in the Tropics and Subtropics (480b) University of Hohenheim

A bioassay study was conducted to investigate the effects of substituting casein with graded levels of detoxified Jatropha curcas seed cake protein isolates(JPI) as a protein source on the growth performance,feed efficiency ratio(FER) and its protein values using rats as an animal model. Thirty 21-day-old male Spraguee Dawley weaned rats were randomly divided into 5 groups, each group with 6 replications(n = 1). Each group consumed one of the following diets: protein-free, casein(CAS) and JPI diets(JPI20,JPI40 and JPI60; different levels of JPI to replace the casein at concentrations of 20%, 40% and 60% on crude protein basis). Feed intake and protein intake showed no difference among the rats fed JPI20, JPI40 and CAS diets(P > 0.05). However, these parameters were lower in the rats fed JPI60 than in rats fed CAS(P < 0.05). The rats fed diets containing JPI had lower body weight gain, protein efficiency ratio and net protein retention than those fed CAS diet(P < 0.05). When the level of JPI used to replace the casein was lower than 40%, protein efficiency ratio(PER) was close to or higher than 2.0, which suggests that JPI could be viewed as a high-quality protein. Inclusion of JPI in the diet decreased alkaline phosphatase activity. The values were significantly lower in rats fed JPI20 and JPI40than in rats fed CAS(P < 0.05). No histopathological changes were observed in livers and kidneys in the rats fed JPI diets. The results demonstrate that JPI could be used as an efficient protein source at a level of no more than 40% of dietary protein source.

关键词： Jatropha curcas Seed cake protein isolates Protein efficiency ratio Growth performance Rats

Sulfur mediated heavy metal biogeochemical cycles in coastal wetlands:From sediments,rhizosphere to vegetation

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Frontiers of Environmental Science & Engineering 2022年第8期16卷 165-182页

作者： yueming wu Zhanrui Leng Jian Li Chongling Yan Xinhong Wang Hui Jia Lingyun Chen Sai Zhang Xiaojun Zheng Daolin Du Institute of Environment and Ecology School of the Environment and Safety EngineeringJiangsu UniversityZhenjiang 212013China State Key Laboratory of Marine Environmental Science Xiamen UniversityXiamen 361102China Laboratory of Microbiota College of Life ScienceNorthwest Normal UniversityLanzhou 730070China Department of Physics and Electronic Engineering Jiangsu UniversityZhenjiang 212013China

The interactions and mechanisms between sulfur and heavy metals are a growing focus of biogeochemical studies in coastal *** issues underline the fate of heavy metals bound in sediments or released into the system through *** the fact that numerous published studies have suggested sulfur has a significant impact on the bioavailability of heavy metals accumulated in coastal wetlands,to date,no review article has systematically summarized those studies,particularly from the perspective of the three major components of wetland ecosystems(sediments,rhizosphere,and vegetation).The present review summarizes the studies published in the past four decades and highlights the major achievements in this *** and studies available thus far indicate that under anaerobic conditions,most of the potentially bioavailable heavy metals in coastal wetland sediments are fixed as precipitates,such as metal ***,fluctuations in physicochemical conditions may affect sulfur cycling,and hence,directly or indirectly lead to the conversion and migration of heavy *** the rhizosphere,root activities and microbes together affect the speciation and transformation of sulfur which in turn mediate the migration of heavy *** for plant tissues,tolerance to heavy metals is enhanced by sulfur-containing compounds via promoting a series of chelation and detoxification ***,to further understand the interactions between sulfur and heavy metals in coastal wetlands,some major future research directions are proposed.

关键词： Coastal wetland Heavy metal Sulfur Biogeochemical cycle

Microbiota of a seepage face at the mouth of a subterranean estuary:diversity,distribution and substrate dependence

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Acta Oceanologica Sinica 2023年第8期42卷 147-157页

作者： yueming wu Yongjun Wei Juan Severino Pino Ibánhez Danqing Sun Kaiqi Lu Qianqian Wang Jian Li Shan Jiang State Key Laboratory of Estuarine and Coastal Research East China Normal UniversityShanghai 200241China School of Pharmaceutical Sciences Zhengzhou UniversityZhengzhou 450001China Instituto de Investigacións Mariñas Consejo Superior de Investigaciones CientíficasVigo 36208Spain School of Environmental Science and Engineering Southern University of Science and TechnologyShenzhen 518055China School of Environment and Safety Engineering Jiangsu UniversityZhenjiang 212013China

Subterranean estuaries,i.e.,the mixing zone between terrestrial groundwater and recirculated seawater,host a wide range of ***,field campaigns were conducted at the mouth of the subterranean estuary at the Sanggou Bay(Shandong Province,China)over four consecutive seasons at a seepage face(0−20 cm depth).The diversity of benthic microbiome was characterized via 16S rRNA gene sequencing and metagenomics,combined with physic-chemical parameters,e.g.,organic carbon,total nitrogen and sulfate contents in *** spring,the dominant species were assigned to the phylum *** opportunistic species was assigned to Acidobacteria,Actinobacteria and *** key components were identified to be species of the genera Pseudoalteromonas,Colwellia and Sphingobium,indicating the involvement of sediment microbiota in the degradation of sedimentary organic carbon,particularly that of pelagic origin,e.g.,phytoplankton detritus and bivalve *** spring,the microbial community was statistically similar along the depth profiles and among the three sampled *** spatial distributions were obtained in the remaining *** contrast,the dominant species assemblages varied significantly among seasons,with key genera being Thioprofundum and Nitrosopumilus during summer and autumn and Thioprofundum and Ilumatobacter during *** analysis revealed a seasonal shift in benthic nitrogen and sulfur metabolism associated with these variations in microbial community ***,our findings suggested that macro elements derived from pelagic inputs,particularly detrital phytoplankton,shaped the microbial community compositions at the seepage face,resulting in significant seasonal variations,while the influence of terrestrial materials transported by groundwater on the sediment microbiota at the seepage face found to be minor.

关键词： subterranean estuary microbiota seepage face seasonal variation substrate

Every Dream Can Come True

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China Today 2008年第2期57卷 32-35页

作者： wu yueming

Wang Baoqiang was a farm boy before clawing his way into the film industry from the very bottom.

关键词：王宝强演员艺术生涯影视作品